• Molecules and Cells
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• v.38 no.11
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• pp.950-958
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• 2015

BCS1L gene encodes mitochondrial protein and is a member of conserved AAA protein family. This gene is involved in the incorporation of Rieske FeS and Qcr10p into complex III of respiratory chain. In our previous study, AluYRa2-derived alternative transcript in rhesus monkey genome was identified. However, this transcript has not been reported in human genome. In present study, we conducted evolutionary analysis of AluYRa2-exonized transcript with various primate genomic DNAs and cDNAs from humans, rhesus monkeys, and crabeating monkeys. Remarkably, our results show that AluYRa2 element has only been integrated into genomes of Macaca species. This Macaca lineage-specific integration of AluYRa2 element led to exonization event in the first intron region of BCS1L gene by producing a conserved 3' splice site. Intriguingly, in rhesus and crabeating monkeys, more diverse transcript variants by alternative splicing (AS) events, including exon skipping and different 5' splice sites from humans, were identified. Alignment of amino acid sequences revealed that AluYRa2-exonized transcript has short N-terminal peptides. Therefore, AS events play a major role in the generation of various transcripts and proteins during primate evolution. In particular, lineage-specific integration of Alu elements and species-specific Alu-derived exonization events could be important sources of gene diversification in primates.

• 한국신재생에너지학회:학술대회논문집
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• 2011.05a
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• pp.123.1-123.1
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• 2011

기존의 p-type 태양전지 공정과 유사한 공정으로 제작되는 n-type $ALU^+$태양전지는 후면에 Al을 screen printing하여 emitter층을 형성한 구조이다. screen printing은 공정의 단순화와 제조 단가의 저비용으로 인해, metalization 공정에서 많이 쓰이고 있다. 본 연구에서는 양산 가능한 n-type $ALU^+$태양전지 제작을 위해, 후면 Al emitter 층을 single, dobule, triple로 변경하며 Al의 양을 가변하였고, 그에 따른 특성의 변화를 연구하였다. screen printing 횟수가 변경된 후면 Al emitter 층의 특성은 DIV와 LIV 측정을 통해 분석하였다. 실험 결과 Al을 single printing 하였을 때보다, double, triple printing을 통하여 Al의 양을 증가하였을 때, DIV 데이터에서 직렬저항(Rs)가 $24.44{\Omega}/cm^2$에서 $0.31{\Omega}/cm^2$으로 감소하였고, 단락전류(Jsc)는 1.26mA/$cm^2$에서 37.7mA/$cm^2$으로 약 300% 증가한 것을 확인할 수 있었다. 프린팅 횟수에 따른 LIV 데이터의 Fill Factor를 분석하게 되면, double printing이 64.35%로 54.75%의 triple printing보다 약 1.17배 더 향상된 것으로 확인하였다. 이러한 결과를 바탕으로 후면 Al emitter 형성시에 Al의 양이 적절하지 못한 이유로, Al emitter가 제대로 형성되지 못하거나 과하게 형성되면, 태양전지 내부에 누설 저항의 변화와 누설 전류의 증가로 인해, 단락전류(Jsc)와 Fill Factor 감소의 주요 원인이 된다는 것을 확인할 수 있었다.

• The Transactions of the Korea Information Processing Society
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• v.7 no.1
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• pp.252-265
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• 2000

In this thesis, the analysis of data processing method and the amount of computation in the whole geometry processing is conducted step by step. Floating-point ALU design is based on the characteristics of geometry processing operation. The performance of the devised ALU fitting with the geometry processing operation is analyzed by simulation after the description of the proposed ALU and geometry processor. The ALU designed in the paper can perform three types of floating-point operation simultaneously-addition/subtraction, multiplication, division. As a result, the 23.5% of improvement is achieved by that floating-point ALU for the whole geometry processing and in the floating-point division and square root operation, there is another 23% of performance gain with adding area-performance efficient SRT divisor.

• Proceedings of the Korea Institute of Applied Superconductivity and Cryogenics Conference
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• 2003.02a
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• pp.140-142
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• 2003

We have designed a SFQ (Single Flux Quantum) D2 Cell and Inverter(NOT) for a superconducting ALU (Arithmetic Logic Unit). To optimize the circuit, we have used Julia, XIC and Lmeter for simulations and layouts. We obtained the circuit margin of larger than $\pm$25%. After layout, we drew chip for fabrication of SFQ D2 Cell and Inverter. We connected D2 Cell and Inverter to jtl, DC/SFQ, SFQ/DC and RS flip-flop for measurement.

• Proceedings of the KIEE Conference
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• 1987.07b
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• pp.1481-1484
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• 1987

The ALU of CMOS microcomputer have been designed with the 3um design rule for CMOS polysilicon gate and Its cells were layed out. The operation of circuits were simulated with EDAS_P. The widths and lengths of gates In the circuit were determined using SPlCE. The carry delay of the ALU was Improved by Manchester carry method. The results of logic and circuit simulation were in good agreement with expected circuit characteristics.

• Proceedings of the KIEE Conference
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• 1987.07a
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• pp.226-229
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• 1987

This paper was aimed to, using a new data structure, develop a set of algorithms to execute the output function of Digital System. These functions were represented as directed, acyclic graphs. by applying many restrictions on vertices on graph, the efficient manipulation of boolean function was accomplished. The results were as follows; 1. A canonical representation of a boolean function was created by the reduction algorithm. 2. The operation of two functions was accomplished using t he apply algorithm, according to the binary operator. 3. The arguments having 1 as the value nf function were enumerated using the satisfy algorithm. 4. Composing TTL 74181 4-bit ALU and 74182 look-ahead carry generator, the ALU having 4-bit and 16-bit as word size was implemented.

• 한국초전도학회:학술대회논문집
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• v.13
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• pp.50-50
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• 2003

• 한국초전도학회:학술대회논문집
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• v.13
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• pp.53-53
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• 2003

• Korean Journal of Biological Psychiatry
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• v.23 no.4
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• pp.140-147
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• 2016

Objectives To determine the relationship between the Alu insertion/deletion (I/D) polymorphism in the tissue-type plasminogen activator (tPA) gene and the clinical outcome of mirtazapine treatment in Korean major depressive disorder (MDD) patients. Methods We enrolled 422 patients in this study. Symptoms were evaluated using the 21-item Hamilton Depression Rating (HAMD-21) Scale. After 1, 2, 4, and 8 weeks of mirtazapine treatment, the association between the Alu I/D polymorphism in the tPA gene and remission/response outcomes were evaluated. Results The proportion of I/I homozygotes in responders was higher than that in non-responders, whereas the proportion of D/D homozygotes in responders was lower than that in non-responders at 8 weeks of treatment (p = 0.032, OR = 1.57). The percentage decline of HAMD-21 scores in I allele carriers was larger than that of D/D homozygotes at 2 and 8 weeks of treatment (p = 0.035 and 0.007, respectively). I allele carriers were associated with remission at 8 weeks of treatment (p = 0.047, OR = 2.2). Conclusions These results show that treatment response and remission to mirtazapine were associated with the Alu I/D polymorphism of the tPA gene. This suggests the Alu I/D polymorphism may be a potential genetic marker for the prediction of therapeutic response to mirtazapine treatment in patients with MDD.

• Progress in Superconductivity
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• v.8 no.2
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• pp.181-185
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• 2007

For more than two decades Nb trilayer ($Nb/Al_2O_3/Nb$) process has been serving as the most stable fabrication process of the Josephson junction integrated circuits. Fast development of semiconductor fabrication technology has been possible with the recent advancement of the fabrication equipments. In this work, we took an advantage of advanced fabrication equipments in developing a superconducting Arithmetic Logic Unit (ALU) by using Nb trilayers. The ALU is a core element of a computer processor that performs arithmetic and logic operations on the operands in computer instruction words. We used DC magnetron sputtering technique for metal depositions and RF sputtering technique for $SiO_2$ depositions. Various dry etching techniques were used to define the Josephson junction areas and film pattering processes. Our Nb films were stress free and showed the $T{_c}'s$ of about 9 K. To enhance the step coverage of Nb films we used reverse bias powered DC magnetron sputtering technique. The fabricated 1-bit, 2-bit, and 4-bit ALU circuits were tested at a few kilo-hertz clock frequency as well as a few tens giga-hertz clock frequency, respectively. Our 1-bit ALU operated correctly at up to 40 GHz clock frequency, and the 4-bit ALU operated at up to 5 GHz clock frequency.