• Tuberculosis and Respiratory Diseases
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• 제84권1호
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• pp.1-12
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• 2021

Mycobacterium tuberculosis has infected more than two billion individuals worldwide, of whom 5%-10% have clinically active disease and 90%-95% remain in the latent stage with a reservoir of viable bacteria in the macrophages for extended periods of time. The tubercle bacilli at this stage are usually called dormant, non-viable, and/or non-culturable microorganisms. The patients with latent bacilli will not have clinical pictures and are not infectious. The infections in about 2%-23% of the patients with latent status become reactivated for various reasons such as cancer, human immunodeficiency virus infection, diabetes, and/or aging. Many studies have examined the mechanisms involved in the latent state of Mycobacterium and showed that latency modified the expression of many genes. Therefore, several mechanisms will change in this bacterium. Hence, this study aimed to briefly examine the genes involved in the latent state as well as the changes that are caused by Mycobacterium tuberculosis. The study also evaluated the relationship between the functions of these genes.

• The Plant Pathology Journal
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• 제38권4호
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• pp.261-271
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• 2022

Root-knot nematodes are the most important plant-parasitic nematodes worldwide. Many efforts have been made to find non-chemical, risk-free, and environmentally friendly methods for nematode control. In this study, the effects of compost and vermicompost of arugula (Eruca sativa) on Meloidogyne javanica were investigated in three glasshouse experiments. In addition, the expression of the defense-related genes nonexpressor of pathogenesis-related 1 (NPR1) and lipoxygenase 1 (LOX1) was detected in tomato plants treated with vermicompost of arugula at 0, 2, 7, and 14 days after nematode inoculation. The result showed that the vermicompost of arugula significantly reduced the reproduction factor of the nematode by 54.4% to 70.5% in the three experiments and increased the dry weight of shoots of infected tomato plants. Gene expression analysis showed that LOX1 expression increased on the second and seventh day after nematode inoculation, while NPR1 expression decreased. The vermicompost of arugula showed stronger nematode inhibitory potential than the vermicompost of animal manure. The vermicompost of arugula is superior to arugula compost in suppressing the activity of M. javaniva and reducing its impact. It manipulates the expression of resistance genes and could induce systemic resistance against root-knot nematodes.

• 대한약침학회지
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• 제25권2호
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• pp.88-100
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• 2022

Gastric cancer (GC) is a significant cause of cancer mortality which has led to focused exploration of the pathology of GC. The advent of genome-wide analysis methods has made it possible to uncover genetic and epigenetic fluctuation such as abnormal DNA methylation in gene promoter regions that is expected to play a key role in GC. The study of gastric malignancies requires an etiological perspective, and Helicobacter pylori (H. pylori) was identified to play a role in GC. H. pylori infection causes chronic inflammation of the gastric epithelium causing abnormal polyclonal methylation, which might raise the risk of GC. In the last two decades, various pathogenic factors by which H. pylori infection causes GC have been discovered. Abnormal DNA methylation is triggered in several genes, rendering them inactive. In GC, methylation patterns are linked to certain subtypes including microsatellite instability. Multiple cancer-related processes are more usually changed by abnormal DNA methylation than through mutations, according to current general and combined investigations. Furthermore, the amount of acquired abnormal DNA methylation is heavily linked to the chances of developing GC. Therefore, we investigated abnormal DNA methylation in GC and the link between methylation and H. pylori infection.

• Geomechanics and Engineering
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• 제25권3호
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• pp.253-266
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• 2021

In this paper, we discuss a mathematical method for determining the return energy of the wave from the sample and comparing it with the mechanical energy consumed to change the dimension of the sample in the triaxial test of the rock. We represent a method to determine the mechanical energy and then we provide how to calculate the return energy of the wave. However, the static energy and pulse return energy will show higher amounts with axial pressure increase. Three types of clastic sedimentary rocks including sandstone, pyroclastic rock, and argillitic tuff were selected. The sandstone showed the highest strength, Young's modulus and ultrasonic P and S waves' velocities versus others in the triaxial test. Also, from the received P wavelet, the calculated pulse wave returning energy indicated the best correlation between axial stress compared to wave velocities in all specimens. The fact that the return energy decreases or increases is related to increasing lateral stress and depends on the geological characteristics of the rock. This method can be used to determine the stresses on the rock as well as its in-situ modulus in projects that are located at high depths of the earth.

• Advances in materials Research
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• 제11권1호
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• pp.59-73
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• 2022

In the construction industry, thin-walled frame elements with very slender open cross-sections and low torsional stiffness are often subjected to a complex loading condition where axial, bending, shear and torsional stresses are present simultaneously. Hence, these often fail in instability even before the yield capacity is reached. One of the most common instability conditions associated with thin-walled structures is Lateral Torsional Buckling (LTB). In this study, a first order Generalized Beam Theory (GBT) formulation and numerical analysis of cold-formed steel lipped channel beams (C80×40×10×1, C90×40×10×1, C100×40×10×1, C80×40×10×1.6, C90×40×10×1.6 and C100×40×10×1.6) subjected to uniform moment is carried out to predict pure Lateral Torsional Buckling (LTB). These results are compared with the Finite Element Analysis of the beams modelled with shell elements using ABAQUS and analytical results based on Euler's buckling formula. The mode wise deformed shape and modal participation factors are obtained for comparison of the responses along with the effect of varying the length of the beam from 2.5 m to 10 m. The deformed shapes of the beam for different modes and GBTUL plots are analyzed for comparative conclusions.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제16권8호
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• pp.2801-2815
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• 2022

With the advent and realization of Software Defined Network (SDN) architecture, many organizations are now shifting towards this paradigm. SDN brings more control, higher scalability, and serene elasticity. The SDN spontaneously changes the network configuration according to the dynamic network requirements inside the constrained environments. Therefore, a monitoring system that can monitor the physical and virtual entities is needed to operate this type of network technology with high efficiency and proficiency. In this manuscript, we propose a real-time monitoring system for data collection and visualization that includes the Prometheus, node exporter, and Grafana. A node exporter is configured on the physical devices to collect the physical and virtual entities resources utilization logs. A real-time Prometheus database is configured to collect and store the data from all the exporters. Furthermore, the Grafana is affixed with Prometheus to visualize the current network status and device provisioning. A monitoring system is deployed on the physical infrastructure of the KOREN topology. Data collected by the monitoring system is further pre-processed and restructured into a dataset. A monitoring system is further enhanced by including machine learning techniques applied on the formatted datasets to identify the elephant flows. Additionally, a Random Forest is trained on our generated labeled datasets, and the classification models' performance are verified using accuracy metrics.

• Structural Engineering and Mechanics
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• 제82권4호
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• pp.445-458
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• 2022

Some of the control systems used in engineering structures that use sensors and decision systems have some time delay reducing efficiency of the control system or even might make it unstable. In this research, in addition to considering the effect of the time delay in vibration control process, predictive control is used to compensate the time delay. A semi-active vibration control approach with the help of magneto-rheological dampers is implemented. In addition to using fuzzy inference system to determine the appropriate control voltage for MR damper, structural behavior prediction system and specifying future responses are also used such that the time delays occurring within control process are overcome. For this purpose, determination of prediction horizon is conducted for one, five, and ten steps ahead for single degree of freedom structures with periods ranging from 0.1 to 4 seconds, subjected to twenty earthquake excitations. The amount of time delay applied to the control system is 0.1 seconds. The obtained results indicate that for 0.1 second time delay, average prediction error values compared to the case without time delay is 3.47 percent. Having 0.1 second time delay in a semi-active control system reduces its efficiency by 11.46 percent; while after providing the control system with structure behavior prediction, the difference in the results for the control system without time delay is just 1.35 percent on average; indicating a 10.11 percent performance improvement for the control system.

• Safety and Health at Work
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• 제14권3호
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• pp.243-249
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• 2023

Background: Southeast Asia has many people who work in the agriculture sector. Not many stakeholders pay special attention to the health of farmers, even though they are exposed to various types of hazards. One of the most common health complaints among farmers is related to work-related musculoskeletal disorders (WMSDs). This study aims to assess the prevalence of WMSDs and factors associated with them among farmers in Southeast Asia. Methods: A literature search on PubMed, ScienceDirect, Scopus, and EBSCO was conducted. Articles were included if they studied ergonomic problems among farmers from 11 countries in the Southeast Asia region and were published during 2015-2022. The Critical Appraisal Skills Program was used to evaluate the quality of the articles. The search process and retrieval process reflected PRISMA's recommendation. Result: There were 14 studies found from 3 countries that had published articles in PubMed and ScienceDirect, including Thailand [8], Indonesia [4], and Malaysia [2]. The prevalence of WMSDs in Thailand, Indonesia, and Malaysia was 78,31%, 81,27%, and 88,39%, respectively. Common factors associated with WMSDs include age, sex, smoking habits, drinking alcohol habits, working period (years), type of work, awkward position, non-ergonomic equipment, repetitive movements, and lifting heavy loads. Conclusion: The prevalence of WMSDs among farmers in Southeast Asia is considerably high. Effective intervention is essential for reducing the prevalence and protecting workers' health and well-being.

• Structural Engineering and Mechanics
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• 제88권5호
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• pp.463-480
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• 2023

The buckling-restrained braced frames with eccentric configurations (BRBF-Es) exhibit stable cyclic behavior and possess a high energy absorption capacity. Additionally, they offer architectural advantages for incorporating openings, much like Eccentrically Braced Frames (EBFs). However, studies have indicated that significant residual drifts occur in this system when subjected to earthquakes at the Maximum Considered Earthquake (MCE) hazard level. Consequently, in order to mitigate these residual drifts, it is recommended to employ self-centering systems alongside the BRBF-E system. In our current research, we propose the utilization of the Direct Displacement-Based Seismic Design method to determine the design base shear for a hybrid system that combines BRBF with an eccentric configuration and a self-centering frame. Furthermore, we present a methodology for designing the individual components of this composite system. To assess the effectiveness of this design approach, we designed 3-, 6-, and 9-story buildings equipped with the BRBF-E-SCF system and developed finite element models. These models were subjected to two sets of ground motions representing the Maximum Considered Earthquake (MCE) and Design Basis Earthquake (DBE) seismic hazard levels. The results of our study reveal that although the combined system requires a higher amount of steel material compared to the BRBF-E system, it substantially reduces residual drift. Furthermore, the combined system demonstrates satisfactory performance in terms of story drift and ductility demand.

• Fisheries and Aquatic Sciences
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• 제27권1호
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• pp.35-47
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• 2024

The aim of this study was to analyze the income and productivity of seaweed farmers based on farmed land ownership status. This research was conducted in three provinces on the Sulawesi Island which are ranked among the 10 largest seaweed producers in Indonesia: Central Sulawesi, South Sulawesi and Southeast Sulawesi. The twelve study sites were determined based on 5 special criteria and 792 respondents fulfilled the criteria for seaweed farmers. Data were collected through field surveys and analyzed using qualitative and quantitative methods. Results showed that the seaweed farming areas are considered as private property with 4 types of marine land tenure or ownership status: own land, inherited land, leasehold land and purchased land. The productivity of seaweed farming land had a positive value greater than 1 in South Sulawesi and Southeast Sulawesi, and a positive value of less than 1 in Central Sulawesi. Seaweed cultivation in Central Sulawesi has not been managed effectively. At all sites, the maximum number of growing season cycles was 5 cycles/year. Optimal growing season conditions gave the highest marginal returns at 2-3 cycles/year with additional costs exceeding additional income for more than 3 cycles/year.