• 식물분류학회지
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• 제43권3호
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• pp.165-167
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• 2013

한국의 조개나물속은 주로 해발 50-1000 m의 낮은 산지 또는 저지대에 분포하며 5분류군이 알려져 있다. 한국산 조개나물속의 미기록 식물로 Ajuga nipponensis Makino를 보고한다. 본 분류군은 충청남도 보령시 녹도의 마을 주변 길가에서 확인하였다. A. nipponensis는 직립하거나 기며, 줄기는 뿌리부터 여러 갈래로 나뉘며, 화통은 길이 10-12 mm, 연한 흰분홍색으로 한국산 조개나물속 다른 분류군들과 구분이 된다. 국명은 화통의 색깔을 고려하여, '분홍꽃조개나물'로 신칭하였다. 한국산 조개나물속 분류군에 대한 검색표를 제시하였다.

• 생약학회지
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• 제29권4호
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• pp.318-322
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• 1998

Continuing to previous report, seven compounds were isolated from the aerial parts of Ajuga multiflora. The structures of them were established as Di-2-ethylhexyl phthalate (1), ursolic acid (2), sterol glucoside (3), 20-hydroxyecdysone (4), makisterone A (5). cyasterone (6) and apigenin 7-glucuronide (7), respectively.

• 생약학회지
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• 제16권3호
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• pp.160-164
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• 1985

Ajuga multiflora Bunge is a perennial herb in the family of Labiatae. The iridoid glycoside was isolated from the ethylacetate fraction and the n-butanol fraction of the plant. The structure of the substance was identified as 8-O-acetylharpagide by UV, IR, NMR spectra and several chemical reactions.

• 생약학회지
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• 제29권2호
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• pp.75-78
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• 1998

In the course of phytochemical studies for the aerial parts of Ajuga multiflora, one flavonoid and two iridoid glycosides were isolated and identified as apigenin (1), 8-O-acetylharpagide (2) and harpagide (3) on the basis of spectroscopic evidence.

• 생약학회지
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• 제31권1호
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• pp.72-76
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• 2000

This study was carried out to evaluate cytotoxic effects of Ajuga multiflora Bunge extracts on murine leukemia tumor $(P388D_1)$ cell lines. Disruptions in cell organelles were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazoliumbromide (MTT) assay. The comparison of $IC_{50}$ values of Ajuga multiflora Bunge extracts in L1210 and $P388D_1$ cell lines showed that their susceptibility to these extracts decreased in the following order: Adriamycin>methanol extract>chloroform extract>ethyl acetate extract>hexane extract>water extract by the MTT assay. In order to develop an antimicrobial agent, dried Ajuga multiflora Bunge was extracted with several solvents, and then antimicrobial activity was investigated. The minimal inhibitory concentration (MIC) of the extract against microorganisms were also examined. Antimicrobial activities of amocla and ketoconazole as references were compared to those of extracts of $H_2O$, n-hexane, chloroform, ethyl acetate and methanol. The antimicrobial activity of all extracts from the sample had growth inhibition activity against gram-negative bacteria, gram-positive bacteria and fungi $(MIC>200\;{\mu}g/ml)$. These results suggest that the methanol soluble extract of Ajuga multiflora Bunge may be a valuable choice for the studies on the treatment of murine leukemia tumor cell lines.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2007년도 춘계학술발표회
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• pp.263-264
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• 2007

• 농업생명과학연구
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• 제44권6호
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• pp.61-67
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• 2010

중부지방에서 동절기에 월동가능한 상록지피식물의 이용가능성을 알아보고자 Ajuga reptans와 Carex morrowii 'Variegata', Dianthus 'Night Star', Hedera helix 'Ivalace', Pachysandra terminalis, Sedum rupestre 등 총 6종의 실험재료를 대상으로 0, 30, 70%의 차광처리에 따른 내한성 증진실험을 실시한 결과, 모든 처리구에서 40% 이하의 생존율을 나타낸 Dianthus 'Night Star'를 제외하고는 차광처리에 관계없이 Ajuga reptans와 Carex morrowii 'Variegata', Sedum rupestre은 50% 이상의 생존율과 상록의 잎을 유지했다. 그러나 Hedera helix 'Ivalace'와 Pachysandra terminalis는 0% 조건에서 전부 고사하였으나 70% 광조건에서는 40% 이상의 생존율을 나타냈다. 따라서 일부 내한성이 떨어지는 상록지피종들도 광조건의 조절에 따라서 상록의 잎을 유지하면서 월동 가능할 것으로 사료된다.

• 아시안잔디학회지
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• 제7권1호
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• pp.19-30
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• 1993

Experiments were conducted to investigate propagation, shade tolerance, cold resistance and growth rate of evergreen ground cover plants ; Vinca minor K , Ajuga reptans L., Ophiopogon japonicus ker. f nanus hort , and Hedera helix.. The results were as follows : 1.It is convenient to use the growing case for rice seed to grow and transplant Vinca minor seed-ling. The most proper density of transplanting Vinea was 180 plants per 1m$^2$. At the end of growing season, the coverage came up to 90% The rooting ability of Hedera helix was best to cut from April to May (temperature 15~23˚C). The seedling length of Parthenocissus quinguefohlia were irregular and ranged from 5 cm of 200cm. 2. Ajuga reptans L., Ophiopogon j. and Vinca minor L. grew better under 50% light intensity than full sunlight. Particularly, under full sunlight and aestival high temperature, there were a few withering plants in Ajuga reptans L. , and V Vilica minor L. 3. Of Vinca minor K., Ajuga reptans L. , Ophiopogon japonicus ker. f. nanus hort. and Hedera helix. acclimatized in open field, where temperature was from -7~8˚C. There were few plants had damage in low temperature incubator to -16˚C after field acclimatization. 4.Tendrils of Parthenocissus quinguefolia strongly clung to the wire netting stone fence but intruded into the gap and cranny of the precast concrete fence and so clung to, so that it needed to install the bending net on the precast concrete fence.

• 약학회지
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• 제14권3_4호
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• pp.51-53
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• 1970

Alcohol extracts of six plant namely Coix agrestis L$_{OUREIRO}$, Chloranthus Japonicus (Siebi) N$_{AKAI}$, Ajuga Spectabilis N$_{AKAI}$, Juglans mandsuria Max., Cirsium Macki var Ussuriense $K_{ITA}$ and Sasamorpha Purpurascense (Hack) N$_{AKAI}$ were subjected to the screening tests for anti-tumor activities against SN-36 Leukemia, Sarcoma 180 and Ehrlich ascites carcinoma. Of the six extracts, Ajuga Spectabilis N$_{AKAI}$ and Coix agrestis L$_{OUREIRO}$ were found to be potential in survival effect of tumor transplanted mice.

• Applied Biological Chemistry
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• 제41권4호
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• pp.251-256
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• 1998

The analytical method of ${\beta}-ecdysone$, the insect moulting hormone, by high performance liquid chromatograph (HPLC) with UV detector was developed using boronic ester derivatization and applied to the extracts of Ajuga iva, Silene otites and Schistocerca egg. Derivatization of yield with methyl-, butyl-, and phenyl-boronate was completed under mild conditions with 20-hydroxyecdysone. The conversion ratios of boronate were estimated to be 70% in methylboronic acid, 89% in butylboronic acid and 93% in phenylboronic acid. Phenylboronate showed a high sensitivity and demonstrated an effective separation on HPLC. The optimum temperature and reaction time for derivative formation were $25^{\circ}C$ and 20 min. respectively. ${\beta}-Ecdysone$ was effectively identified in extracts of Ajuga iva, Silene otites and Schistocerca egg by the HPLC method.