• 대한한의학회지
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• 제34권1호
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• pp.89-102
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• 2013

Objectives: This study aimed to evaluate the effects of root of Curcumin longa (RCL) on LPS-induced COPD (chronic obstructive pulmonary disease) model. Materials and Methods: Extract of RCL was treated to RAW 264.7 cells and LPS-induced COPD mouse model. Then, various parameters such as cell-based protective activity, airflow limitation, accumulation of immune cells and histopathological finding were analyzed. Results: RCL showed a protective effect on LPS-induced cytotoxicity in RAW 264.7 cells. RCL treatment also revealed a protective effect on LPS-induced lung injury in a COPD mouse model. This effect was demonstrated via the reduction of accumulation of immune cells and pathophysiological regulation of caspase 3, elastin and collagen in lung tissue. Conclusions: These data suggest that RCL has a pharmaceutical property on lung injury. This study provides scientific evidence for the efficacy of RCL for clinical application to COPD patients.

• 한국분무공학회지
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• 제1권3호
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• pp.37-50
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• 1996

Computational fluid dynamics was used to optimize an A/C duct. Three dimensional flow analysis in an automotive A/C duct was performed computationally using various turbulence models and compared numerical predictions such as outlet flow split, surface pressure distribution along the duct to experimental data. Additionally, we studied the effect of location variation of 2nd branch on exit flow ratio and could find optimal location of 2nd branch. The design of an A/C duct was modeled and calculated to enhance the airflow distribution in each outlet using the STAR-CD computational fluid dynamics software. In results, modified $k-\varepsilon$ turbulence model allows a successful prediction of static pressure distribution particulary at around strong curvature but little improvement flow split. In the future, adoption of CFD to design an A/C duct with modified $k-\varepsilon$ model will bring benefits of producing more accurate prediction, and also give designers more detail information much more than now.

• Wind and Structures
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• 제11권4호
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• pp.257-273
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• 2008

A number of passive aerodynamic drag reduction methods were applied separately and then in different combinations on an intercity bus model, through wind tunnel studies on a 1:20 scale model of a Mercedes Benz Tourismo 15 RHD intercity bus. Computational fluid dynamics (CFD) modelling was also conducted in parallel to assist with flow visualisation. The commercial CFD package $CFX^{TM}$ was used. It has been found that dramatic reductions in coefficient of drag ($C_D$) of up to 70% can be achieved on the model using tapered and rounded top and side leading edges, and a truncated rear boat-tail. The curved front section allows the airflow to adhere to the bus surfaces for the full length of the vehicle, while the boat-tails reduce the size of the low pressure region at the base of the bus and more importantly, additional pressure recovery occurs and the base pressures rise, reducing drag. It is found that the CFD results show remarkable agreement with experimental results, both in the magnitude of the force coefficients as well as in their trends. An analysis shows that such a reduction in aerodynamic drag could lead to a significant 28% reduction in fuel consumption for a typical bus on intercity or interstate operation. This could translate to a massive dollar savings as well as significant emissions reductions across a fleet. On road tests are recommended.

• 한국기계가공학회지
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• 제19권1호
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• pp.56-62
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• 2020

The purpose of this study is to observe the visualization of the flow field for air flow distributed in the car from the ventilation fan installed in the ceiling of the passenger elevator car through the numerical analysis using computational fluid dynamics. STAR-CCM+, which is a code used for the numerical analysis, was used to predict the airflow distribution inside the elevator car. The numerical analysis of the distribution of the air current in the elevator was carried out. As a result, the analysis results for each point and the visualization of the air current distribution and the temperature distribution in the elevator car and were obtained. It was found that heat transfer was actively occurring inside the car due to the influence of the flow field discharged from the ventilation vent installed in the ceiling in the elevator car, and especially the convection heat transfer of Model-2 was more active than that of Model-1. As a result, the temperature distribution inside the car was found to be relatively low. In addition, the temperature distribution at a cross-section of 1700mm height in the elevator car shows that Model-2 is the location of the ventilation vent which makes people feel more comfortable.

• 한국가시화정보학회:학술대회논문집
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• 한국가시화정보학회 2004년도 Proceedings of 2004 Korea-Japan Joint Seminar on Particle Image Velocimetry
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• pp.125-134
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• 2004

The improvement of artificial respiration method has brought about the decrease in mortality of pulmonary diseases patients. Various respiratory curative methods, inclusive of HFOV (High Frequency Oscillatory Ventilation), have been developed for more effectual and less harmful management of acute respiratory failure. However, the mechanism of gas transfer and diffusion in a bronchiole has not yet been clarified in detail. As a first approach to the problem, we measured oscillatory flows in a Y-shaped micro-channels as bronchiole model by micro Particle Image Velocimetry(micro PIV). In order to establish the fundamental technique of PIV measurements on oscillatory air flow in a micro-channel, we used about 500-nm-diameter incense smoke particles, a diode laser, a high speed camera including an objective lens, and a HFOV, which is effective technique for medical care of pulmonary disease patients, especially, infants. The bronchiole model size is that parent tube is $500\{mu}m$ width and $500\{mu}m$ depth, and daughter tubes are $450\{mu}m$ width and $500\{mu}m$ depth. From this study made on the phenomenon of fluid in micro size bronchus branch of a lung, we succeeded to get time series velocity distribution in a micro scale bronchial mode. The experimental results of velocity distribution changing with time obtained by micro PIV can give fundamental knowledge on oscillatory airflow in micro-channel.

• 대한한의학회지
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• 제39권4호
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• pp.126-135
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• 2018

Objectives: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and irreversible airflow. This study aimed to evaluate the effects of GHX02 in a COPD-induced mouse model. Methods: The COPD mouse model was established by exposure to cigarette smoke extract and lipopolysaccharide which were administered by intratracheal injection three times with a 7 day interval. GHX02 (100, 200, 400 mg/kg) and all other drugs were orally administrated for 14 days from Day 7 to Day 21. Results: GHX02 significantly decreased the neutrophil counts in bronchoalveolar lavage fluid (BALF) and the number of $CD4^+$, $CD8^+$, $CD69^+$, and $CD11b^+/GR1^+$ cells in BALF and lung cells. GHX02 also suppressed the secretion of tumor necrosis factor-alpha ($TNF-{\alpha}$), interleukin-17A, macrophage inflammatory protein 2 (MIP2), and chemokine (C-X-C motif) ligand 1 (CXCL-1) in BALF and ameliorated the lung pathological changes. Conclusions: Thus, GHX02 effectively inhibited airway inflammation by inhibiting migration of inflammatory cells and expression of pro-inflammatory cytokines. Therefore, GHX02 may be a promising therapeutic agent for COPD.

• 한국가시화정보학회지
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• 제19권3호
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• pp.115-122
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• 2021

Oral cancer surgery typically consists of resection of lesion, neck dissection and reconstruction, and it has an impact on the position of hyoid bone. Therefore, morphological change of airway can occur since the geometric parameter of airway is correlated with the hyoid bone. Airflow is affected by geometry of the airway. In this study, flow characteristics were compared between pre- and post-surgery models by both particle image velocimetry (PIV) and numerical simulation. 3D model of upper airway was reconstructed based on CT data. Velocity is accelerated by the reduced channel area, and vortex and recirculation region are observed in pre- and post-surgery models. For the post-surgery model, high pressure distribution is developed by significantly decreased hydraulic diameter, and the longitudinal flow stream is also interrupted.

• 한국전산유체공학회지
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• 제15권2호
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• pp.71-78
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• 2010

As a step toward accurate prediction of droplet impingement and ice accretion on aircraft, an Eulerian-based droplet impingement and ice accretion code for air flows around an airfoil containing water droplets is developed. A CFD solver based on the finite volume method was also developed to solve the clean airflow. The finite-volume-based approach for simulating droplet impingement on an airfoil was employed owing to its compatibility with the CFD solver and robustness. For ice accretion module, a simple model based on the control volume is combined with the droplet impingement module that provides the collection efficiency. To validate the present code, it is compared with NASA Glenn IRT (Icing Research Tunnel) experimental data and other well-known icing codes such as LEWICE and FENSAP-ICE. It is shown that the collection efficiency and shape of ice accretion are in good agreement with previous experimental and simulation results.

• Journal of Advanced Marine Engineering and Technology
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• 제25권1호
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• pp.182-190
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• 2001

The aerodynamics of the Wells turbine has been studied using 3-d, unstructured mesh flow solver for the Reynolds-averaged Navier-Stokes equations. The basic feature of the Wells turbine is that even though the cyclic airflow produces oscillating axial forces on the airfoil blades, the tangential force on the rotor is always in the same direction. Geometry used to define 3-D numerical grid is based upon that of an experimental test rig. The 3-D Wells turbine model, consisting of approximate 220,000 cells is tested of four axial flow rates. In the calculations the angle of attack has been varied between 10˚ and 30˚ of blades, Representative results from each case are presented graphically andy analysed. It is concluded that this technique holds much promise for future development of Wells turbines.

• 한국주거학회논문집
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• 제14권3호
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• pp.119-126
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• 2003

The purpose of this study is to evaluate the natural ventilation performance for variable external wind speed as a preliminary step to determining the seasonal operating modes of the Double-skin Facade System applied to apartment buildings. For this purpose, two simulation programs are used to compare the Double-Skin Facade System with the Double Sash Window. First, TAS is used to plan a schedule for natural ventilation during the intermediate season and to analyze the cooling loads. Second, CFD is used for a more detailed airflow analysis on a typical floor plan of the model building. The results of the simulations on natural ventilation performance show that the Double-Skin Facade System can reduce the cooling load by 10.5% compared to the Double Sash Window.