• BMB Reports
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• v.44 no.5
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• pp.298-305
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• 2011

Most intracellular reactive oxygen species (ROS), especially superoxide anion ($O_2^{{\bullet}_-}$) that is converted from oxygen, are overproduced by excessive electron leakage from the mitochondrial respiratory chain. Intracellular oxidative stress that damages cellular components can contribute to lifestyle-related diseases such as diabetes and arteriosclerosis, and age-related diseases such as cancer and neuronal degenerative diseases. We have previously demonstrated that the excessive mitochondrial $O_2^{{\bullet}_-}$ production caused by SDHC mutations (G71E in C. elegans, I71E in Drosophila and V69E in mouse) results in premature death in C. elegans and Drosophila, cancer in mouse embryonic fibroblast cells and infertility in transgenic mice. SDHC is a subunit of mitochondrial complex II. In humans, it has been reported that mutations in SDHB, SDHC or SDHD often result in inherited head and neck paragangliomas (PGLs). Recently, we established Tet-mev-1 conditional transgenic mice using our uniquely developed Tet-On/Off system, which equilibrates transgene expression to endogenous levels. These mice experienced mitochondrial respiratory chain dysfunction that resulted in $O_2^{{\bullet}_-}$ overproduction. The mitochondrial oxidative stress caused excessive apoptosis leading to low birth weight and growth retardation in the neonatal developmental phase in Tet-mev-1 mice. Here, we briefly describe the relationships between mitochondrial $O_2^{{\bullet}_-}$ and aging phenomena in mev-1 animal models

• Toxicological Research
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• v.6 no.2
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• pp.167-182
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• 1990

Dietary restriction (caloric restriction) is the only intervention which has been reliably shown to extend the maximum life span of warm-blooded animals and delay the many phenomena associated with aging. It is also one of the most effective modulators of toxicity, especially cancer endpoints. In spite of the known modulator effects of caloric restriction, the biological mechanisms responsible for these effects had not been in vestigated until recently. The National Center for Toxicological Research (NCTR), in a collaborative effort with the National Institute of Aging (NIA), initiated a project whereby nine (9) combinations of rodent species/strains and diets were fed both restricted and ad libitum. The NIA's initiative was to identify biomarkers of aging whereas NCTR's initiative was to identify the biological effects associated with the profound effects caloric restriction has in protecting against both spontaneous (age-related) and chemically-induced toxic endpoints. Independent of sex or species, caloric restriction has similar effects on body temperature, oxygen consumption and $CO_2$production. Caloric restriction also decreased lipid glycolysis and metabolism in rats and mice, which suggest decreased production of metabolites which could lead to fatty acid epoxide formation. The age-associated loss of ciradian regulation of intermediate enzymes is also significantly reduced. Moreover, caloric restriction reduced the age-associated feminization of sexually dimorphic liver isozymes, increased several glucocorticoid responsive isozymes, elevated glucagon/insulin ratios, produced less microsomal superoxide and enhanced the capacity for utilzing detoxicating metabolic pathways. Calorically restricted rats have less than half the number of aflatoxin ($AFB_1$)-DNA adducts than ad libitum animals and urinary excretion of $AFB_1$ was increased significantly. Finally, DNA repair mechanisms are enhanced and oncogene expression is decreased in calorically restricted animals.

• Journal of Korean Academy of Nursing
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• v.26 no.1
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• pp.223-247
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• 1996

This study was done to provide information which would lead to nursing care of the elderly being more holistically through an understanding of the phenomena of powerlessness based on the lived experience of powerlessness by the elderly, the meaning the elderly give to such phenomena, and what essence of powerlessness is. The methodology used in this study was Max Van Manen's phenomenological method based on the philosophy of Merleu-Ponty and a concerted approach was realized through the 11 steps suggested in the Van Manen's method. Data collection was done from March 2, 1995 to December 30, 1995. The subjects for this study were four elderly persons who lived with their families and who were over 60 years of age. Data were collected about the lived experience of the elderly, this researcher's experience of powerlessness, the linguistic meaning of powerlessness, idioms of the word or a feeling of powerlessness, and descriptions of powerlessness in the elderly as they appeared in the literature, are works, and phenomenological literature. All data were used to provide insights into the phenomena of powerlessness. Data about the experience of powerlessness by the elderly were collected through open interviews, participation, and observation. In the analysis of the theme of this study, the aspects of the theme, powerlessness in the elderly were clarified, thereby abstracting and finding meaningful statements by the elderly about their feeling of powerlessness, and then those significant statements were expressed as linguistic transformations. The summarized findings from the study are as follows : 1. Five meanings of powerlessness in the elderly were defined. 〈weakness〉, 〈dependence〉, 〈frustration〉, 〈worthlessness〉 and 〈giving up〉. 2. 〈Weakness〉 means that the elderly experience, not only their aging but also, their becoming weak and the loss of physical function frequently caused by diseases. 〈Dependence〉 means that the elderly experience dependence without any influence from the surroundings and that elderly patients who are hospitalized lose their autonomy, follow entirely their doctor's prescriptions, use aid equipment and directions, and depend only on those things. 〈Frustration〉 means that the elderly experience the loss of their roles from the past, there by feeling that there is no work for them to do anymore and therefore feel unable to do anything. 〈Worthlessness〉 means that the elderly experience the feeling of losing their social roles from the past, having no financial ability, thereby being a burden to their children or the people around them, and therefore regarding themselves useless. 〈Giving up〉 means that the elderly experience the feeling of closeness to death in the final stage of their lifetime, lose hope to be healed from their disease, and recognize the incontrollability of their own body. 3. From a general view of the meaning of the theme the powerlessness in the elderly-the most essential meaning of the theme is the 〈sense of loss〉. For the elderly are experiencing a sense of loss in the situation of being elderly and therefore being often hospitalized. Brief definitions of the five phenomena could be 〈weakness〉 meaning the loss of physical strength, 〈dependence〉 the loss of mentality caused by disease and hospitalization, 〈frustration〉 and 〈worthlessness〉 the loss of social performance caused by the loss of social functions from the past, and lastly 〈giving up〉 the loss of the controllability of such situations of aging and suffering disease. In light of the discussion above, it is understandable that the hospitalized elderly experience powerlessness not only as it related to their diseases but also to their normal aging, and this related to other characteristics of being elderly means that the 〈sense of loss〉 is the very essence of their powerlessness. 4. While most cases are of the normal elderly experiencing powerlessness in relation to their social network, cases of elderly who are hospitalized are of those experiencing powerlessness in relation to the loss of their physical desire. 5. The findings discussed above can serve as guidelines for nurses who take care of the ill elderly who are hospitalized and that can provide cues to appropriate nursing service, recognizing that the subjective experience of the objective age of the elderly is so important. Nurses can provide highly qualitative nursing service, based on their deep understanding of the suffering of the elderly due to feelings of powerlessness.

• Journal of the Korean Applied Science and Technology
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• v.34 no.1
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• pp.12-24
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• 2017

The main purpose of this research is for the investigation on the impact of engine oil aging on PM and DPF. It is widely known that lubricant specifications and consumption from an ICE have significantly influenced on the regulated and unregulated harmful emissions as the engine operating conditions. Considering DPF clogging phenomena with lubricant-derived soot/ash components, simulated aging mode for the DPF was newly designed for engine dynamometer testing. PM/ash accumulation cycle were developed in reflecting real-world engine operating conditions for the increment of engine oil consumption and natural DPF regeneration for the ash accumulation. The test duration for DPF aging reached around 100hrs with high- and low-SAPS engine oils, respectively. Using high SAPs engine oil made more PM/ash accumulation compared with low SAPs engine oils and it could accelerate fouling of EGR in engine. Fouling of EGR made effects on more harmful exhaust gases emissions. The test results on engine lubricant under engines operating conditions will deliver for the establishment of regulated and unregulated toxic emissions policy, lubricant quality standard.

• Proceedings of the KIEE Conference
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• 1992.07b
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• pp.969-972
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• 1992

It is shown that the ac breakdown strength, treeing phenomena, oxidation level, and crystallinity of unaged and aged distribution CV cables vary with XLPE insulations (characterizing anti-oxidation) and curing process. The maximum size of bow-tie tree in insulation influenced on the decrease of ac breakdown strength and the increase of oxidation level and crystallinity of XLPE according to aging time lead to increase the size and density of bow-tie trees.

• The Transactions of the Korean Institute of Electrical Engineers
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• v.40 no.8
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• pp.799-807
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• 1991

The various degradation phenomena, such as the evolution of gases, tan e, moisture content and total acid number in insulation oils of power transformer have been measured and analyzed as a function of aging temperatures and periods. The insulation oils have been degraded at laboratory in the period of 17, 34, and 72 days. We have also extracted the insulation oils from the working power transformers. The dissolved gases (such as CO, CO2, H2, CH4 C2H2---), tane, moisture content and total acid number in laboratory samples and field samples have been measured and characterized. It has been found that gases increase with degradation temperature and tane increases with total acid number while the moisture content does not increase with tane.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2001.07a
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• pp.481-484
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• 2001

High voltage induction motors are widely used in industrial factory because have many benefits. But the insulated materials of induction motor are aged by using time, electrical, thermal, circumstantial stresses and so on. Motor failures are occurred by these deterioration phenomena and give rise economic problems to user. In many motor failures, insulated material problems of stator winding happen frequently and occupy high percentages in the failure source. In this paper, the testing specimen(motorette) is manufactured by modeling of stator winding of high voltage induction motor and accelerating test is carried out. Partial discharge signals detected by RF sensor are used to analyze deterioration condition of stator windings. According to aging time, the 3D ( ${\Phi}$-Q-N) distribution and skewness of partial discharge signals are changed.

• Korean Journal of Materials Research
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• v.7 no.8
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• pp.650-653
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• 1997

In large generators in power plants, stator winding insulations is exposed to a combination of thermal, electrical, mechanical, environmental stresses in service. These combined stresses cause insulation aging which leads to final insulation breakdown. In order to identify the breakdown mechanism, the stator winding insulation materials which are composed of mica-epoxy is analyzed by the component of materials with EDS, SEM techniques. We concluded that the potassium ions of mica are replaced by hydrogen ions at boundary area of mica-epoxy and/or mica-mica. It is proposed that through these phenomena, the conductive layers of potassium ions enable high voltage fields of multiple stresses to create voids and microcracks.

• The Journal of Internal Korean Medicine
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• v.19 no.2
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• pp.208-218
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• 1998

To clarify the activating effects of Buthus martensi Karsch on immunological function, its effect on primary and secondary antibodies production in mice of various ages was investigated. Buthus martensi Karsch increased the number of both antibody producing cells(anti-IgM and anti-IgG producing plaque forming cells, PFC) and phagocytic activity of peritoneal macrophage. Futhermore, these phenomena were significantly increased with aging in mice. Buthus martensi Karsch also increased natural killer cell activity concerning to cancer immunology. These results suggest that Buthus martensi Karsch markedly increases the reduced activity in the elderly and activates the immune response in senescence mice.

• Proceedings of the KIEE Conference
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• 1989.11a
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• pp.159-163
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• 1989

The various degradation phenomena, such as the evolution of gases, tan $\delta$, moisture content and total acid number in power transformer insulation oil, have been measured and analyzed. Mineral oil has been degraded at laboratory by the forced thermal stress of $60^{\circ}C$ and $90^{\circ}C$ respectively. Thermal aging oil has been degraded about 17, 34, 72 days. Also, we extracted insulation oil from working transformers. We measured gases dissolved in samples, tan $\delta$, moisture content, total acid number. Activation energy and resistivity is calculated from them. It is found that gases and tan $\delta$ increases as partial discharge and total acid number increases and that conductivity of the sample increases as activation energy increases.