• 디지털융복합연구
• /
• 제15권5호
• /
• pp.505-515
• /
• 2017

이 연구는 한국 신노년층의 생산적 노화를 위한 회복탄력형 여가 프로그램 알고리즘을 검증하는데 목적이 있다. 연구의 목적을 달성하기 위해서 2014년 대도시와 중/소도시 그리고 농촌지역에 예비노인(56세-64세)을 모집단으로 설정하여 525명을 대상으로 설문조사를 실시하였으며, 수집된 자료는 SPSS 20.0프로그램을 이용하여 설문지의 신뢰도와 타당도검사, 의사결정나무분석을 실시한 결과 다음과 같은 결과를 도출하였다. 첫째, 의사결정나무분석을 이용한 회복탄력형 여가프로그램에 영향을 미치는 요인은 주관적 건강상태, 활동욕구, 대인관계교류, 가계소득으로 나타났다. 둘째, 의사결정 나무분석을 이용하여 회복탄력성 변인의 알고리즘을 분석한 결과, 대인관계성, 자기조절성, 긍정성 요인 순으로 나타났다. 회복탄력성의 구성요인들 간의 구조적 알고리즘은 대인관계성에 따라 대인관계성이 낮은 집단의 경우는 긍정성과 관련이 있고, 높은 집단은 자기조절성과 관련이 있음을 알 수 있었다.

• Journal of Microbiology and Biotechnology
• /
• 제34권3호
• /
• pp.596-605
• /
• 2024

Anthocyanins belong to phenolic pigments and are known to have various pharmacological activities. This study aimed to investigate whether anthocyanins could inhibit hydrogen peroxide (H₂O₂)-induced oxidative damage in human retinal pigment epithelial ARPE-19 cells. Our results indicated that anthocyanins suppressed H₂O₂-induced genotoxicity, while inhibiting reactive oxygen species (ROS) production and preserving diminished glutathione. Anthocyanins also suppressed H₂O₂-induced apoptosis by reversing the Bcl-2/Bax ratio and inhibiting caspase-3 activation. Additionally, anthocyanins attenuated the release of cytochrome c into the cytosol, which was achieved by interfering with mitochondrial membrane disruption. Moreover, anthocyanins increased the expression of heme oxygenase-1 (HO-1) as well as its activity, which was correlated with the phosphorylation and nuclear translocation of nuclear factor-erythroid-2 related factor 2 (Nrf2). However, the cytoprotective and anti-apoptotic effects of anthocyanins were significantly attenuated by the HO-1 inhibitor, demonstrating that anthocyanins promoted Nrf2-induced HO-1 activity to prevent ARPE-19 cells from oxidative stress. Therefore, our findings suggest that anthocyanins, as Nrf2 activators, have potent ROS scavenging activity and may have the potential to protect ocular injury caused by oxidative stress.

• 대한간호학회지
• /
• 제27권3호
• /
• pp.601-613
• /
• 1997

This project was conducted using a survey method and through interviewing with four persons aged 60 years and over. An interview with an open-ended questionnaire was also used for elderly persons, families, oriental medicine doctor and nurses. topic-related literature review was also done. In total, 382 statements were derived. For content validity, nursing professionals were involved in this study, From that 48 items are developed. The subjects were 340 elderly persons over 60 years old. Data were collected duicing February and March 1997 and analyzed using the SPSS package The result are as follows. 1. Items with low Cronbach Coefficient alpha which means low correlation with total items were removed. 2. Factor analysis was done in order to confirm construct validity and eight factors were obtained from the results. The first factor, 'positive cognition of the aging process', the second factor, 'relationship network' the third factor, 'maintanence of physical functioning, the fourth factor', 'maintanence of peaceful mind' the fifth factor, 'keeping up with daily tasks' the sixth factor, 'continuous adequate body movement' the seventh factor,'involvement of religion in the elderly person's life and the eight factor', 'appropriate resting'. Cronbach Coefficient alpha for the 33 items was .9127 Based on the result, the following is suggested 1. It is anrticipated that the fundamental health of elderly person could be promoted by assessing healthy behaviors of elderly person with this assessment tool. 2. Further studies could be derived from this research. 3. Validity of this assessment tool should be further tested with and a larger sample of elderly person including in-patient elderly persons as well as nursing home residents.

• 한국가정과교육학회지
• /
• 제23권3호
• /
• pp.161-183
• /
• 2011

본 연구는 변화하는 고령화사회에 대응하고 노인문제에 대비하기 위하여 교육적 차원에서 고등학생들이 자신의 노후를 준비할 수 있도록 '성공적인 노후생활 준비교육'을 위한 가정과 수업을 설계하고 개발하는데 그 목적이 있다. 이를 위해 실천적 문제 중심 교수 학습 과정안을 개발하였다. 2007년 개정 교육과정과 해설서를 분석하여 실천적 문제를 설정하고, 2007년 개정 교육과정과 제 7차 교육과정의 기술 가정, 가정과학, 인간발달 교과서, 청소년 대상 노인교육에 관한 선행연구의 내용 요소를 분석하여 5개의 공통 주제를 선정하였으며, 이를 바탕으로 수업의 최종목표를 설정하였다. 실천적 문제는 '노후에 성공적이고 자립적인 생활을 하기 위해 우리는 무엇을 해야 하는가?이고, 주제는 고령화사회와 인구변화, 노인의 특성, 노후준비, 노인돌보기, 노인복지서비스이며, 선정된 5개의 주제는 다시 고령화사회와 노인에 대한 이해, 노후에 대한 개인 가족 사회의 준비 영역으로 나누어 재구성하였다. 수업의 최종 목표는 '고령화사회와 노인의 특성을 이해하고 자신의 행복한 노년의 삶을 준비하기 위해 현재 노인 문제가 발생한 배경을 비판적으로 추론하여 원인을 규명하고, 성공적이고 자립적인 노후를 준비할 수 있는 대안을 합리적으로 모색하며, 대안의 파급효과를 추론하여 가장 최선의 방법을 선택할 수 있는 문제해결능력을 기를 수 있다'로 설정하였다. 실천적 문제 중심 교수 학습 과정안은 총 5차시의 실천적 추론 수업으로 개발되었다. 이에 따라 실천적 문제 중심 '노후생활 준비교육'의 후속 연구로서, 고등학생의 노후준비교육을 일반화 할 수 있도록 보다 많은 학교 현장에서 정규 교과목 수업에 적용하여 그 효과를 검증하는 연구가 실시되기를 바라며, 실천적 추론 수업과 강의식 수업과의 비교 연구가 이루어져 실천적 추론 수업의 효과를 검증할 수 있는 후속연구가 필요함을 제언하였다.

• 한국해양바이오학회지
• /
• 제13권2호
• /
• pp.86-93
• /
• 2021

A high salt diet contributes to kidney damage by causing hypoxia and oxidative stress. Recently, an increase in dietary salt has been reported to induce an inflammatory phenotype in immune cells, further contributing to kidney damage. However, studies on the exact mechanism and role of a high salt diet on the inflammatory response in the kidneys are still insufficient. In this study, a cisplatin-induced acute kidney injury model using C57BL/6 mice was used to analyze the effect of salt intake on kidney injury. Results showed that high salt administration aggravated kidney edema in mice induced by treatment with cisplatin. Moreover, the indicators of kidney and liver function impairment were significantly increased in the group cotreated with high salt compared with that treated with cisplatin alone. Furthermore, the exacerbation of kidney damage by high salt administration was also associated with a decrease in the number of cells in the immune regulatory system. Additionally, high salt administration further decreased renal perfusion functions along with increased cisplatin-induced damage to proximal tubules. This was accompanied by increased expression of T cell immunoglobulin, mucin domain 1 (a biomarker of kidney injury), and Bax (a pro-apoptotic factor). Moreover, cisplatin-induced expression of proinflammatory mediators and cytokines, including cyclooxygenase-2 and tumor necrosis factor-α in kidney tissue, was further increased by high salt intake. Therefore, these results indicate that the kidney's inflammatory response by high salt treatment can further promote kidney damage caused by various pathological factors.

• Nutrition Research and Practice
• /
• 제16권5호
• /
• pp.549-564
• /
• 2022

BACKGROUND/OBJECTIVES: Oxidative stress is caused by an imbalance between harmful free radicals and antioxidants. Long-term oxidative stress can lead to an "exhausted" status of antioxidant defense system triggering development of metabolic syndrome and chronic inflammation. Green perilla (Perilla frutescens) is commonly used in Asian cuisines and traditional medicine in southeast Asia. Green perilla possesses numerous beneficial effects including anti-inflammatory and antioxidant functions. To investigate the potentials of green perilla leaf extract (PE) on oxidative stress, we induced oxidative stress by high-fat diet (HFD) in aging mice. MATERIALS/METHODS: C57BL/6J male mice were fed HFD continuously for 53 weeks. Then, mice were divided into three groups for 12 weeks: a normal diet fed reference group (NDcon), high-fat diet fed group (HDcon), and high-fat diet PE treated group (HDPE, 400 mg/kg of body weight). Biochemical analyses of serum and liver tissues were performed to assess metabolic and inflammatory damage and oxidative status. Hepatic gene expression of oxidative stress and inflammation related enzymes were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). RESULTS: PE improved hepatopathology. PE also improved the lipid profiles and antioxidant enzymes, including hepatic glutathione peroxidase (GPx) and superoxide dismutase (SOD) and catalase (CAT) in serum and liver. Hepatic gene expressions of antioxidant and anti-inflammatory related enzymes, such as SOD-1, CAT, interleukin 4 (IL-4) and nuclear factor erythroid 2-related factor (Nrf2) were significantly enhanced by PE. PE also reduced the levels of hydrogen peroxide (H₂O₂) and malondialdehyde (MDA) in the serum and liver; moreover, PE suppressed hepatic gene expression involved in pro-inflammatory response; Cyclooxygenase-2 (COX-2), nitric oxide synthase (NOS), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6). CONCLUSIONS: This research opens opportunities for further investigations of PE as a functional food and possible anti-aging agent due to its attenuative effects against oxidative stress, resulting from HFD and aging in the future.

• 대한산업공학회지
• /
• 제36권2호
• /
• pp.108-116
• /
• 2010

The maintenance of a deteriorating system is often imperfect. Previous studies have shown that the imperfect preventive maintenance (PM) can reduce the wear out and aging effects of deteriorating systems to a certain level between the conditions of as good as new and as bad as old. In this paper, we employ the concept of the improvement factor in investigating two optimal PM policies; failure limit policy and periodic PM policy. We redefine the improvement factor model as a function of the cost of PM, using this concept, we derive the conditions of optimal PM policies and formulate expressions to compute the expected cost rate. Based on this information, the determination of the maintenance policies which minimize the cost rate is examined. Numerical examples for the Weibull distribution case are also given.

• 한국의류학회지
• /
• 제19권3호
• /
• pp.463-470
• /
• 1995

Anthropological measurements concerning 29 items were made on 37 adult males aged from 20 to 60. Factor analysis was applied in all 36 items. The main results are as gallows 1. Neck girth and need base girth are smaller. in the elder croup than the gouger group. 2. These decrease occur in the frontal part of the neck. 3. Neck frontal width decreases with age, but side depth increases. 4. The back part of the body depth at the level of the shoulder increases with age. 5. For the factor analysis, the third factor is a factor of forms, the variations of which has a relation with age.

• 한국식품위생안전성학회지
• /
• 제9권1호
• /
• pp.31-36
• /
• 1994

The acute toxicity of recombinant human epidermal growth factor, DWP-401 was evaluated in SD rats. Male and female rats aging 6 weeks were administered orally or subcutaneously with 0, 0.125, 0.25, 0.5, 1 and 2 mg/kg of DWP-401. No deaths and no toxic symptoms related to the DWP-401 were observed. The body weights of treated animals were not significantly different from the controls. The results of necropsy revealed no abnormal gross findings of the organs in treated animals. LD50 values of DWP-401 for male and female rats were estimated to be over 2 mg/kg, which is approximately 2, 000 times of expected clinical dose.

• 한국콘텐츠학회논문지
• /
• 제18권3호
• /
• pp.509-519
• /
• 2018

이 연구의 목적은 지역사회 노인들이 자신의 노화에 대해 어떤 태도를 지니고 있는지 파악하고, 개인자원, 사회적 지지, 사회참여를 중심으로 노화에 대한 태도에 영향을 미치는 관련 요인을 규명하는 것이다. 이를 위해 대전광역시에 소재한 노인복지관, 경로당, 노인회 등의 협조를 받아 유의표집으로 60세 이상 노인 198명을 대상으로 자료를 수집하였고 SPSS 22.0을 이용해 기술분석, 상관관계분석, 위계적 회귀분석을 실시하였다. 분석결과 첫째, 조사대상인 지역사회 노인들은 자신의 노화에 대해 부정적으로 인식하고 있는 편으로 나타났다. 둘째, 노화태도의 유의미한 영향 요인은 개인자원 중에서는 자아존중감이 높을수록, 경제력이 좋을수록 자신의 노화에 대한 태도가 긍정적인 것으로 나타났다. 셋째, 사회적 지지 변수 중에는 가족의 정서적 지지만 유의미한 영향 요인으로 밝혀졌는데, 가족의 정서적 지지 정도가 높을수록 노화태도가 긍정적이었다. 넷째, 사회참여를 많이 할수록 자신의 노화에 대한 태도가 긍정적이었다. 다섯째, 모든 독립변수를 포함시킨 모델에서 가족의 정서적 지지와 사회참여 수준의 유의성이 사라져 자아존중감과 경제력만 유의미한 영향 요인이었다. 이러한 연구 결과를 바탕으로 지역사회 노인들의 자신의 노화에 대한 태도에 긍정적 변화를 가져오기 위한 실천적, 정책적 제언을 하였다.