• 대한약침학회지
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• 제14권2호
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• pp.81-91
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• 2011

Objectives & Methods: This suggestion was attempted to be elevated the recognition of common characteristics in disease. So, we performed to analyze the correlation of common cause of disease, characteristics of human body, and medical treatment. And the results are as follows. Results: 1. The cause of disease is consist of genetic factor, aging, habit, food of not good in health, weather, environment, deficit of the physical activity, stress and so on. 2. Generally, human has common and individual weakness. Individual weakness is appeared similar to the occurrence of volcano and lapse. 3. The correlation of disease and medical treatments is possible to explain using the quotation of the law of motion made by Isaac Newton, the great physicist. 4. When the process of the medical treatment was not progressed, the prognosis is determined by the correlation of the homeostasis(H') in human body and the homeostasis(H) of disease. 5. The prognosis of disease is determined by the relationship between the energy of disease(F) and medical treatment(F'). 6. The exact diagnosis is possible to predict the treatment sequence, and the facts that homeostasis in human body and disease, relationship between the energy of disease(F) and medical treatment(F'), action and reaction are important to determine the prognosis. 7. The careful observation of improving response and worsening action of disease becomes available for exact prognosis. Conclusion: The above described contents may be useful in clinical studies, and the concrete clinical reports about this will be made afterward.

• 조명전기설비학회논문지
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• 제21권10호
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• pp.141-149
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• 2007

본 논문은 유도전동기 고정자권선의 절연물에 대하여 비파괴 및 파괴시험을 실시하여 절연물의 비파괴특성과 내전압강도와의 상호관계를 비교, 평가, 분석함으로써, 향후 전동기의 절연상태 평가시 수명 및 절연진단의 신뢰성을 도모하고자 제안하였다. 본 논문에서는 비파괴시험과 파괴시험과의 상관관계를 평가하기위하여 비파괴시험으로 절연저항시험, 성극지수시험, 유전정접시험, 부분방전시험을 실시하였으며, 파괴시험은 60[kV] AC 내전압를 이용하여 실시하였다. 또한 장기간 사용된 전동기 권선의 절연물에 대한 연구결과로부터 기존 선진국의 진단방법 및 판정기준이 국내에서 제작된 전동기에 대한 절연특성 평가 및 분석에도 타당함을 증명하였으며, 향후 본 논문에서 제시한 자료들은 유사조건의 산업현장에서 운용중인 유도전동기의 수명 및 상태 평가를 위한 기초자료로 유용하게 사용될 수 있으리라 기대된다.

• 대한한방내과학회지
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• 제26권3호
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• pp.533-542
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• 2005

Objectives : In this study, aged BCAO rats were used to observe the effect of Bupleuri Radix on brain ischemic injury because aging is an important factor in storke. Methods : The brain ischemic injury was induced by temporary closing carotids on both sides in a low blood pressure state, and Bupleuri Radix was orally administered to 18 month-old BCAO rats. The ischemic damaged hippocampus and c-Fos and c-Jun expression were analyzed by the immunohistochemical staining. Result and Conclusions : Results are summarized as fellows; 1. The c-Fos expression after inducing a brain ischemic injury in the hippocampus was more inhibited in the experimental group than in the control group. 2. The normalized optical density of c-Fos expression was more reduced in cornu ammonis(CA)1, dentate gyrus(DG) areas in the experimental group than in the control group. 3. The c-Jun expression after inducing a brain ischemic injury in the hippocampus was more inhibited in the experimental group than in the control group. 4. The normalized optical density of c-Jun expression was more reduced in CA1 and DG areas in the experimental group than in the control group.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.131-136
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• 1994

In the present study, in order to make an in vitro model of gastric mucosa for physiological and pharmacological studies, we established two immortalized gastric surface mucous cell lines (GSM06 and GSM10), which produce periodic acid-Schiff (PAS)-and concanavalin A (Con A)-positive glycoproteins, from a primary culture of gastric fundic mucosal cells of adult transgenic mice harboring a temperature-sensitive simian virus 40 large T-antigen gene 〔1]. Gastric fundic mucosal cells were isolated as a modification of a previously described method for rats by Schepp et al. (2). The isolated gastric fundic mucosal cells were cultured in DME/F12 medium supplemented with 2% fetal bovine serum (FBS), 1% ITES (consisting of 2 mg/1 insulin, 2 mgg/1 transferrin, 0.122 mg/1 ethanolamine and 0.00914 mg/1 sodium selenite) and 10 ng/ml recombinant epidermal growth factor (EGF) in a collagen-coated culture dish. To remove fibroblastic cells from the culture, gastric mucosal cells were incubated in the culture medium containing dispase (25 U/ml) for 24 h. The cells, uncontaminated with fibroblastic cells, were then cloned by colony formation. In our series of three attempts, two cell lines (GSM06 and GSM10) have been established at last. The cells proliferated, attached to the dish ana grew until confluent monolayers were formed, and maintained tight contact with neighboring cells. Both GSM06 and GSM10 cells have now been in culture for more than 9 months with regular passaging. The either cell produced

• Journal of Microbiology and Biotechnology
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• 제25권9호
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• pp.1532-1536
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• 2015

To investigate the memory-enhancing effect of lactic acid bacteria, we selected the probiotic mixture KF, which consisted of Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 (1 × 10¹¹ CFU/g of each strain), and investigated its antilipidemic and memoryenhancing effects in aged Fischer 344 rats. KF (1 × 10¹⁰ CFU/rat/day), which was administered orally once a day (6 days per week) for 8 weeks, significantly inhibited age-dependent increases of blood triglyceride and reductions of HDL cholesterol (p < 0.05). KF restored agereduced spontaneous alternation in the Y-maze task to 94.4% of that seen in young rats (p < 0.05). KF treatment slightly, but not significantly, shortened the escape latency daily for 4 days. Oral administration of KF restored age-suppressed doublecortin and brain-derived neurotrophic factor expression in aged rats. Orally administered KF suppressed the expression of p16, p53, and cyclooxygenase-2, the phosphorylation of Akt and mTOR, and the activation of NF-κB in the hippocampus of the brain. These findings suggest that KF may ameliorate age-dependent memory deficit and lipidemia by inhibiting NF-κB activation.

• 한국콘텐츠학회논문지
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• 제16권2호
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• pp.387-397
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• 2016

본 연구의 목적은 실버세대를 대상으로 하는 그림동화책의 필요성과 특성을 학문적 고찰을 통해 실버세대를 위한 그림동화책의 디자인적 특성들을 실증적으로 제시한 것이다. 고령화 현상과 문헌정보학, 교육학, 문학치료학 등 문헌자료의 분석결과를 통해 그림동화책은 실버세대들의 심신건강에 도움이 된다는 결과를 얻게 되었지만 실버세대를 위한 동화책은 수요에 비해 부족한 것이 현실이다. 그러므로 실버세대를 위한 동화책 연구개발에 대한 이론적 근거가 절실하게 필요하다. 따라서 본 연구는 실버세대의 시각기관, 몸 기능, 심리적 요인 등 특성을 반영한 그림동화책의 개발이 필요함을 제언하면서 동시에 실버세대를 위한 동화책을 디자인 할 때 그림의 특징 요소 중 스토리내용, 그림(표현방법, 크기, 레이아웃, 구도, 색채), 타이포 등에서 실버세대들의 독서 장애에 대한 문제점을 해결하기 위한 실버세대의 특성에 맞춰진 세심한 주의가 필요함을 제시하였다. 또한 향후에는 실버세대를 대상으로 한 실증분석을 통해 실버세대를 위한 그림동화책의 구성에 적합한 디자인적 특성이 입체적인 분석 데이터를 연구함에 있어 선행 자료의 일부분으로 활용되길 기대한다.

• 산경연구논집
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• 제10권8호
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• pp.25-32
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• 2019

Purpose - This study aims to explore women's beauty industry market and growth development by identifying the main factors of women's perception of skin health care. Research design, data, and methodology - The survey was conducted on women aged 20 to 60 living in Seoul. For the statistical analysis, frequency analysis, t-test and one-way ANOVA were conducted, and significant differences in p<0.05 were tested through the multiple range test of the Scheffe. The factor analysis was conducted to verify the validity of questions, and the reliability was determined by the coefficient of Cronbach's α. Results - The lower the age, the higher the perception of the skin, and women pay a higher price for skin health as a provisional customer. 'Acne care' was the most common skin condition (32.8%), 'life style' (79.8%) was the most important part of skin care. Final education was the highest level of skin care for women with a professional background (M=3.41) (F=4.028, p<.05). Conclusions - The differences in the recognition of health knowledge by age, marital status, and household monthly income were significant, but there was no difference between jobs and final education. Customers who use less skin care than customers who frequently use the skin care center were more aware of skin health, and women who have a high awareness of skin are more interested in aging and regenerating due to the skin care.

• Journal of Microbiology and Biotechnology
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• 제26권7호
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• pp.1198-1205
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• 2016

Lactic acid bacteria (LAB) have beneficial effects on intestinal health and skin diseases. Lipoteichoic acid (LTA), a cell wall component of gram-positive bacteria, is known to induce the production of several cytokines such as TNF-α, IL-1β, and IL-8 and affect the intestinal microflora, anti-aging, sepsis, and cholesterol level. In this study, Weissella cibaria was isolated from Indian dairy products, and we examined its immune-enhancing effects. Live and heat-killed W. cibaria did not induce the secretion of immune-related cytokines, whereas LTA isolated from W. cibaria (cLTA) significantly increased the secretion of TNF-α, IL-1β, and IL-6 in a dose-dependent manner. cLTA increased the phosphorylation of nuclear factor kappa-light-chain-enhancer of activated B cells, p38 mitogen-activated protein kinases, and c-Jun N-terminal kinases in THP-1 cells. The secretion of TNF-α and IL-6 was also increased in the cLTA-treated mouse splenocytes. These results suggest that cLTA, but not W. cibaria whole cells, has immune-boosting potential and can be used to treat immunosuppression diseases.

• 한국재료학회지
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• 제13권5호
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• pp.333-337
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• 2003

We report a new fabrication process for carbon nanotube field emitters with high performance. The key of the fabrication process is trim-and-leveling the carbon nanotubes grown in trench structures by employing a planarization process, which leads to a uniform distance from the carbon nanotube tip to the electrode. In order to enable this processing, spin-on-glass liquid is applied over the CNTs grown in trench to have them stubborn adhesion among themselves as well as to the substrate. Thus fabricated emitters reveal an extremely stable emission and aging characteristics with a large current density of 40 ㎃/$\textrm{cm}^2$ at 4.5 V/$\mu\textrm{m}$. The field enhancement factor calculated from the F-N plot is $1.83${\times}$10^{5}$ $cm^{－1}$ , which is a very high value and indicates a superior quality of the emitter originating from the nature of open-tip and high stability of the carbon nanotubes obtained new process.

• 한국도로학회논문집
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• 제3권3호
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• pp.147-158
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• 2001

콘크리트포장의 구조적 능력을 평가하는 가장 중요한 요소 중의 하나는 하중전달효과이다. 하중전달효과는 슬래브 상 하부 온도차, 다우월바 시공여부, 포장 노후도, 그리고 균열틈 등에 영향을 받는다. 본 연구의 목적은 콘크리트 포장의 하중전달효과 특성을 파악하고 하중전달효과에 영향을 주는 요소를 정량화하고 적절한 하중전달효과 조사방법을 제시하는 것이다. 연구결과 하중전달효과는 슬래브 표면온도가 아닌 슬래브 평균온도 영향을 받는 것으로 나타났다. 하중전달효과는 온도가 내려가고 균열틈이 벌어질수록 감소하는 것으로 나타났다. 다우월바를 시공한 구간의 경우 온도변화에 따라 하중전달효과는 큰 차이를 보이지 않은 반면, 다우월바를 시공하지 않은 구간에서는 온도가 내려갈수록 하중전달효과는 급격히 감소하였다. 다우월바를 시공한 구간이라도 포장이 노후화되면 하중전달효과는 온도가 하락함에 따라 감소하는 것으로 나타났다. 본 조사대상 구간에서는 슬래브 단위온도 하락시 하중전달효과는 1.4% 감소하는 것으로 나타났다.