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http://dx.doi.org/10.4014/jmb.1601.01047

Lipoteichoic Acid Isolated from Weissella cibaria Increases Cytokine Production in Human Monocyte-Like THP-1 Cells and Mouse Splenocytes  

Hong, Yi-Fan (Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University)
Lee, Yoon-Doo (Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University)
Park, Jae-Yeon (Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University)
Kim, Seongjae (Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University)
Lee, Youn-Woo (Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University)
Jeon, Boram (Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University)
Jagdish, Deepa (Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University)
Kim, Hangeun (Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University)
Chung, Dae Kyun (Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University)
Publication Information
Journal of Microbiology and Biotechnology / v.26, no.7, 2016 , pp. 1198-1205 More about this Journal
Abstract
Lactic acid bacteria (LAB) have beneficial effects on intestinal health and skin diseases. Lipoteichoic acid (LTA), a cell wall component of gram-positive bacteria, is known to induce the production of several cytokines such as TNF-α, IL-1β, and IL-8 and affect the intestinal microflora, anti-aging, sepsis, and cholesterol level. In this study, Weissella cibaria was isolated from Indian dairy products, and we examined its immune-enhancing effects. Live and heat-killed W. cibaria did not induce the secretion of immune-related cytokines, whereas LTA isolated from W. cibaria (cLTA) significantly increased the secretion of TNF-α, IL-1β, and IL-6 in a dose-dependent manner. cLTA increased the phosphorylation of nuclear factor kappa-light-chain-enhancer of activated B cells, p38 mitogen-activated protein kinases, and c-Jun N-terminal kinases in THP-1 cells. The secretion of TNF-α and IL-6 was also increased in the cLTA-treated mouse splenocytes. These results suggest that cLTA, but not W. cibaria whole cells, has immune-boosting potential and can be used to treat immunosuppression diseases.
Keywords
Weissella cibaria; cytokine; lipoteichoic acid; immune regulation;
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