The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

Effect of Bupleuri Radix on c-Fos and c-Jun Expression in Ischemic Damaged Hippocampus of the Aged BCAO Rats

시호(柴胡)가 뇌허혈유발 노령(老齡) 흰쥐의 해마 c-Fos 및 c-Jun 발현에 미치는 영향

  • Park, Soon-Il (Dept. of Oriental Medicine The Graduate School, Dongguk University) ;
  • Oh, Kyung-Hwan (Dept. of Oriental Medicine The Graduate School, Dongguk University) ;
  • Ryu, Do-Kyun (Dept. of Oriental Medicine The Graduate School, Dongguk University) ;
  • Han, Chang-Ho (Dept. of Oriental Medicine The Graduate School, Dongguk University) ;
  • Chung, Sung-Hyun (Dept. of Oriental Medicine The Graduate School, Dongguk University) ;
  • Shin, Gil-Cho (Dept. of Oriental Medicine The Graduate School, Dongguk University) ;
  • Lee, Won-Chul (Dept. of Oriental Medicine The Graduate School, Dongguk University) ;
  • Hwang, Joo-Won (Dept. of Oriental Medicine The Graduate School, Dongguk University)
  • 박순일 (동국대학교 한의과대학 내과학교실) ;
  • 오경환 (동국대학교 한의과대학 내과학교실) ;
  • 유도균 (동국대학교 한의과대학 내과학교실) ;
  • 한창호 (동국대학교 한의과대학 내과학교실) ;
  • 정승현 (동국대학교 한의과대학 내과학교실) ;
  • 신길조 (동국대학교 한의과대학 내과학교실) ;
  • 이원철 (동국대학교 한의과대학 내과학교실) ;
  • 황주원 (동국대학교 한의과대학 내과학교실)
  • Published : 2005.09.30
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Abstract

Objectives : In this study, aged BCAO rats were used to observe the effect of Bupleuri Radix on brain ischemic injury because aging is an important factor in storke. Methods : The brain ischemic injury was induced by temporary closing carotids on both sides in a low blood pressure state, and Bupleuri Radix was orally administered to 18 month-old BCAO rats. The ischemic damaged hippocampus and c-Fos and c-Jun expression were analyzed by the immunohistochemical staining. Result and Conclusions : Results are summarized as fellows; 1. The c-Fos expression after inducing a brain ischemic injury in the hippocampus was more inhibited in the experimental group than in the control group. 2. The normalized optical density of c-Fos expression was more reduced in cornu ammonis(CA)1, dentate gyrus(DG) areas in the experimental group than in the control group. 3. The c-Jun expression after inducing a brain ischemic injury in the hippocampus was more inhibited in the experimental group than in the control group. 4. The normalized optical density of c-Jun expression was more reduced in CA1 and DG areas in the experimental group than in the control group.

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