• Analyses & Alternatives
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• v.6 no.1
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• pp.259-282
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• 2022

This article examines features and implications of 'new northeast phenomenon' in China's new normal period. Different from previous studies with economy as a single factor, this paper regards the northeast phenomenon as not an single economic phenomenon but a compound socio economic phenomenon that economic, demographic and financial issues are linked together. This study finds that since 2014 decline of economic growth, deepening of population decline and brain drain, accelerated aging, the increase in fiscal deficit and a surge in social security spending, these phenomena occur simultaneously and influence each other, forming a vicious cycle in northeast China, and also finds that the difficulty of 'new northeast phenomenon' lies in this compound features. If so, what are the implications of 'new northeast phenomenon's' these features for China as a whole? This study proposes two points. First, based on the recent changes in some relevant situations in China, northeast region can be regarded as a microcosm of China, northeast phenomenon is likely to spread to other regions of China in the near future, it will become a common phenomenon all over China. Second, the emergence of the 'new northeast phenomenon' in the new normal period requires deep reflection and rethinking about the fundamental effect of the regional development strategies, such as 'The Development of the Western Region', 'The Rise of Central China', 'The revitalization of the Northeast', implemented since the reform and development. The 'new northeast phenomenon' has become one of the most urgent problems to be solved by the Chinese government, if the solution is successful, it can be a very useful direction for reconstructing regional development strategies in contemporary China.

• Journal of Ginseng Research
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• v.47 no.4
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• pp.524-533
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• 2023

Background: Obesity is a risk factor for aging and many diseases, and the disorder of lipid metabolism makes it prominent. This study aims to investigate the effect of ginsenoside Rg1 on aging, lipid metabolism and stress resistance Methods: Rg1 was administered to Caenorhabditis elegans (C. elegans) cultured in NGM or GNGM. The lifespan, locomotory activity, lipid accumulation, cold and heat stress resistance and related mRNA expression of the worms were examined. Gene knockout mutants were used to clarify the effect on lipid metabolism of Rg1. GFP-binding mutants were used to observe the changes in protein expression Results: We reported that Rg1 reduced lipid accumulation and improved stress resistance in C. elegans. Rg1 significantly reduced the expression of fatty acid synthesis-related genes and lipid metabolism-related genes in C. elegans. However, Rg1 did not affect the fat storage in fat-5/fat-6 double mutant or nhr-49 mutant. Combined with network pharmacology, we clarified the possible pathways and targets of Rg1 in lipid metabolism. In addition, Rg1-treated C. elegans showed a higher expression of anti-oxidative genes and heat shock proteins, which might contribute to stress resistance Conclusion: Rg1 reduced fat accumulation by regulating lipid metabolism via nhr-49 and enhanced stress resistance by its antioxidant effect in C. elegans.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.1A
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• pp.45-54
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• 2006

To obtain realistic stress-strain relation in concrete, it is necessary to improve the constitutive model for creep and shrinkage of concrete. This study is made up with predicting model of creep using rheological approach and mathematical development which is solution for phenomenon of concrete creep. Long-term deformation components are combined based on traditional 4-parameters model. Creep deformation is obtained adequately using 4-parameters determined by considering aging effect and microprestress among gels. And coefficient of effective viscosity is able to represent both basic creep and total creep included drying creep. This study attempt to establish mathematical model considering effects of aging, hydration, and variations of pore humidity. It can predict both basic creep and total creep. Values of result between prediction and experiment have greater than correlation factor 99%. Additionally experimental results report bad consentaneity with highway design specification adopting FIB MC 90. Rather than those are similar to FIB MC 90 rev.99.

• Design & Manufacturing
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• v.16 no.2
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• pp.33-38
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• 2022

Currently, Korea is an aging society, and it is expected to enter a super-aging society in about 4 years. Accordingly, many X-ray technologies are being developed. In X-rays, 99% of X-rays are converted into heat energy and 1% into light energy (X-rays). 99% of the thermal energy raises the temperature of the anode and its surroundings, and the cooling system is an important factor as overheating can affect the deterioration of X-ray quality and shortened lifespan. There is a method of forced air cooling using natural convection. Therefore, in this study, when X-rays were taken 5 times, Flow analysis was performed on heat removal according to temperature rise and cooling time for the heat generated at the anode of the X-ray tube (input power 60kW, 75kW, 90kW). Based on one-shot, the most rapid temperature rise section increased by more than 57% to 0.03 seconds, A constant temperature rises from 0.03 seconds to 0.1 seconds, It is judged that the temperature rises by about 8.2% or more at one time. After one-shot cooling, the cooling drops sharply from about 60% to 0.03 seconds, It is judged that the temperature has cooled by more than 86% compared to the temperature before shooting. One-shot is cooled by more than 86% with cooling time after 0.1 seconds, As the input power of the anode increases, the cooling temperature gradually increases. Since the tungsten of the anode target inside the X-ray tube may be damaged by thermal shock caused by a rapid temperature rise, an improvement method for removing thermal energy is required when using a high-input power supply.

• Biomolecules & Therapeutics
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• v.31 no.6
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• pp.640-647
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• 2023

The skin, the largest organ in the body, undergoes age-related changes influenced by both intrinsic and extrinsic factors. The primary external factor is photoaging which causes hyperpigmentation, uneven skin surface, deep wrinkles, and markedly enlarged capillaries. In the human dermis, it decreases fibroblast function, resulting in a lack of collagen structure and also decreases keratinocyte function, which compromises the strength of the protective barrier. In this study, we found that treatment with γ-aminobutyric acid (GABA) had no toxicity to skin fibroblasts and GABA enhanced their migration ability, which can accelerate skin wound healing. UVB radiation was found to significantly induce the production of matrix metalloproteinase 1 (MMP-1), but treatment with GABA resulted in the inhibition of MMP-1 production. We also investigated the enhancement of filaggrin and aquaporin 3 in keratinocytes after treatment with GABA, showing that GABA can effectively improve skin moisturization. In vivo experiments showed that oral administration of GABA significantly improved skin wrinkles and epidermal thickness. After the intake of GABA, there was a significant decrease observed in the increase of skin thickness measured by calipers and erythema. Additionally, the decrease in skin moisture and elasticity in hairless mice exposed to UVB radiation was also significantly restored. Overall, this study demonstrates the potential of GABA as functional food material for improving skin aging and moisturizing.

• Tuberculosis and Respiratory Diseases
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• v.87 no.3
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• pp.338-348
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• 2024

Background: Increasing age has been observed among patients admitted to the intensive care unit (ICU). Age traditionally considered a risk factor for ICU mortality. We investigated how the epidemiology and clinical outcomes of older ICU patients have changed over a decade. Methods: We analyzed patients admitted to the ICU at a university hospital in Seoul, South Korea. We defined patients aged 65 and older as older patients. Changes in age groups and mortality risk factors over the study period were analyzed. Results: A total of 32,322 patients were enrolled who aged ≥65 years admitted to the ICUs between January 1, 2007, and December 31, 2017. Patients aged ≥65 years accounted for 35% and of these, the older (O, 65 to 74 years) comprised 19,630 (66.5%), very older (VO, 75 to 84 years) group 8,573 (29.1%), and very very older (VVO, ≥85 years) group 1,300 (4.4%). The mean age of ICU patients over the study period increased (71.9±5.6 years in 2007 vs. 73.2±6.1 years in 2017) and the proportions of the VO and VVO group both increased. Over the period, the proportion of female increased (37.9% in 2007 vs. 43.3% in 2017), and increased ICU admissions for medical reasons (39.7% in 2007 vs. 40.2% in 2017). In-hospital mortality declined across all older age groups, from 10.3% in 2007 to 7.6% in 2017. Hospital length of stay (LOS) decreased in all groups, but ICU LOS decreased only in the O and VO groups. Conclusion: The study indicates a changing demographic in ICUs with an increase in older patients, and suggests a need for customized ICU treatment strategies and resources.

• Annals of Occupational and Environmental Medicine
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• v.34
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• pp.24.1-24.13
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• 2022

Background: In modern society, depression is serious issue that causes socioeconomic and family burden. To decrease the incidence of depression, risk factors should be identified and managed. Among many risk factors for depression, this study examined socioeconomic risk factors for depression. Methods: We utilized first (2006), second (2008), and third (2010)-wave data from the Korean Longitudinal Study of Aging (KLoSA). Depressive symptom was measured with the 10-item Center for Epidemiological Studies Depression Scale, Short Form (CES-D-10) in the survey in 2008 and 2010. Three risk factors including job security, employment type and monthly income were measured in the survey in 2006. The association between risk factors and depressive symptom was analyzed by Cox proportional-hazard model. Results: We analyzed data from 1,105 workers and hazard ratios (HRs) for 3 risk factors were significant entirely. In addition, regular worker with high income group is the most vulnerable group of poor job insecurity on depression among male workers (HR: 1.73; 95% confidence interval [CI]: 1.07-2.81). Finally, HRs for 7 groups who had at least 1 risk factor had higher HRs compared to groups who had no risk factors after stratifying 3 risk factors. In the analysis, significantly vulnerable groups were total 5 groups and the group who had highest HR was temporary/daily workers with poor job security (HR: 2.51; 95% CI: 1.36-4.64). The results concerning women, regardless of job type, were non-significant. Conclusions: This study presented one or more risk factors among poor job security, low income, temporary/daily employment type increase hazard for depressive symptom in 2 or 4 years after the exposure. These results inform policy to screen for and protect against the risk of depression in vulnerable groups.

• Journal of Fashion Business
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• v.11 no.4
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• pp.29-41
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• 2007

This study is to research how women aging from 20 through 40 Apperance -Mnagement Bhavior and care of their outer looks from a beauty treatment perspective. This research should help satisfy the wants of women who are the main clients of the beauty products and help the beauty industry to produce new products and also to help out on their marketing strategy. In order to search the general characteristics of our target women, Frequency Analysis was used, to find out the sub-factor of interest in beauty Factor Analysis and Reliability Analysis was used. In order to divide the group according to Degree of Apperance Concern 'sub-factor, cluster analysis, analysis of variance, Scheffe'-test, $X^2-test$ was used, and to find out the difference on how they care of beauty analysis of variance was used, and further more to summarize the result of analysis of variance Scheffe'-test was used. As a result, in all different ways of beauty caring, weight resisting, skin care and plastic surgery summed up similarly among the self-care group, hair care ended up with similar results among all three groups: self-caring group, no interest in beauty at all group, and the too conscious of other eyes group, and results on the interest rate of clothing ended up similarly among the other-eye conscious group, beauty care interest group, and the self-care group.

• Journal of Korean Society of Transportation
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• v.29 no.6
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• pp.117-128
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• 2011

In this study, a model is developed to predict emission factors, which aims to objectively evaluate the impact of transport projects on air quality. Two emission prediction models for the years of 2015 and 2030 are developed using the historical trends in vehicle aging and vehicle deterioration factors. The analysis results show that the emission factors under the operating speed of 30km/h for the year 2030 are 5~37% and 2~83% less than those used in the current studies for passenger cars and bus/trucks, respectively. The statistically validated experiment results demonstrate the applicability of the proposed model to evaluation of the impact of transport policies on air quality.

• Journal of Nutrition and Health
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• v.42 no.3
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• pp.221-233
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• 2009

Korea's aging population has been remarkably increased. They want to have not only extension of life expectancy but also improving quality of life. To maintain the quality of life, it is essential to have good nutrition. However, nutritional status of elderly in Korea has problems qualitatively and quantitatively. Risk factors for poor nutrition are advanced age, woman, living alone and low economic status. Another risk factor in rural area is season because seasonal changes can affect food intake of elderly. Thus this study surveyed the health status and dietary intakes of elderly by season in rural area. In this study, the elderly were grouped as group 1 {elderly who have one risk factor for chronic diseases (obesity, hypertension, dyslipidemia, diabetes)} and group 2 (elderly who have more than 2 risk factors). Can-Pro 3.0 was used for dietary data analysis and SPSS 12.0 program was used for statistical analysis. Obesity had the highest percentage 62%, followed by hypertension 59.5%, dyslipidemia 21.5% and diabetes 11.6%. Obesity, hypertension, and dyslipidemia were high in winter and WHR, diabetes and anemia were high in summer. Mean intakes of energy and nutrients were less than RI. Nutrients which were changed most by season were vitamin A and Vitamin C. Intakes of calcium and folic acid were less than recommended in summer. The ratio of CPF for carbohydrate was higher and fat was lower than recommended. In conclusion, the nutrient intake of Group 2 was better in quality but Group 1 was better in quantity. Nutrient intakes were poor in summer. In rural area, more careful nutritional assesment and management are needed for aged population, especially in summer.