• Journal of Animal Science and Technology
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• v.63 no.4
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• pp.766-777
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• 2021

Bezafibrate, a fibrate drug used as a lipid-lowering agent to treat hyperlipidemia, is a pan-agonist of peroxisome proliferator-activated receptor alpha. It can enhance mitochondrial fatty acid oxidation, oxidative phosphorylation, and mitochondrial biogenesis. After ovulation, oocytes may get arrested at the metaphase II (MII) stage until fertilization beyond optimal timing, which is termed as post-ovulatory aging. Post-ovulatory aging is a disease that degrades DNA, mitochondria, and oxidative system, and has a negative impact on embryo development and quality; however, the impact of bezafibrate during post-ovulatory aging has not been fully defined. In the present study, we assessed the ability of bezafibrate to prevent the progression of aging in in vitro conditions as well as the underlying mechanisms in pigs. An appropriate concentration of this drug (50 µM) was added, and then oxidative stress, reactive oxygen species downstream, mitochondrial biogenesis, and mitochondrial function were analyzed via immunofluorescence staining and real-time polymerase chain reaction. Bezafibrate significantly alleviated reactive oxygen species and ameliorated glutathione production simultaneously in oocytes and embryos. Moreover, it diminished H2A.X and attenuated CASPASE 3 expression produced by oxidative stress in oocytes and embryos. Furthermore, bezafibrate remarkably improved the mitochondrial function and blastocyst quality as well as markedly reduced the mitochondria/TOM20 ratio and mtDNA copy number. The elevated PARKIN level indicated that mitophagy was induced by bezafibrate treatment after post-ovulatory aging. Collectively, these results suggest that bezafibrate beneficially affects against porcine post-ovulatory oocyte aging in porcine by its antioxidant property and mitochondrial protection.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.12 no.4
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• pp.49-57
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• 1992

This study was conducted to evaluate physical property change of asphalt cement chromatograms (by HP-GPC) were experimentally obtained from 3 types of AC-20 virgin ACs, 5 and 24-hour artificially aged ACs, and naturally aged 4 ACs that were recovered from 4 different roads. Absolute viscosity, kinematic visoosity and penetration were the physical properties tested. THF was used for mobil phase and RI detector was used as a detector for Hp-GPC testing. Correlation between each physical property change and the chromatogram variation was evaluated. Each chromatogram was divided into ten-equal-time slices. The percentage areas of 10 slices and each physical property were used for statistical correlation evaluation. Statistical analysis results showed that eaoh physical property had a strong correlation with the chromatogram characteristics. Aging was identified as a mechanism of change of molecular size distribution - increasing large size molecules and reducing coresponding samll size molecules.

• Proceedings of the Korean Nuclear Society Conference
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• 2005.10a
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• pp.993-994
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• 2005

• Nuclear Engineering and Technology
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• v.43 no.3
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• pp.279-286
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• 2011

The aging degradation and lifetime assessment of a domestic class 1E Ethylene-Propylene-Diene-Monomer (EPDM), which is a popular insulating elastomer for electrical cables in the nuclear power plants, were studied for equipment qualification verification under the Loss of Coolant Accident (LOCA) conditions. The specimens were acceleratively aged, underwent a LOCA environment, as well as tested mechanically, thermo-gravimetrically, and spectroscopically according to the American Society of the Testing of Materials (ASTM) procedures. The tensile test results revealed that the elongation at break gradually decreased with an increasing aging temperature. The lifetime of EPDM aged isothermally at $140^{\circ}C$ was 1,316 hours and reduced to 1,120 hours after experiencing the severe accident test. The activation energies of the elongation reduction were $1.10{\pm}0.196$ eV and $0.93{\pm}0.191$ eV before and after the LOCA condition, respectively. The TGA test results also showed that the activation energy of the aging decomposition decreased from 1.35 eV to 1.02 eV after undergoing the LOCA environment. Although the mechanical property changes were discernibly observed during the aging process, along with the LOCA simulation, the FT-IR analysis showed that the spectroscopic peaks and their intensities did not alter significantly. Therefore, it can be concluded that the degradation of the domestic class 1E EPDM due to aging can be tolerable, even in severe accident conditions such as LOCA, and thus it qualifies as a suitable insulating material for electrical cables in the nuclear power plants.

• Journal of Power System Engineering
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• v.21 no.6
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• pp.13-20
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• 2017

Ni-base superalloy Haynes 282 was developed as a gas turbine material for use in the ultra-super-critical stage (USC) of next-generation coal-fired power plants. Temperatures in the USC stage exceed $700^{\circ}C$ during operation. In spite of its important role Haynes 282 in increasing the performance of high-pressure turbines, as a result of its high-temperature capability, there is little information on the microstructure, deformation mechanism, or mechanical properties of the cast condition of this alloy. The aim of present study is to examine the creep properties of cast alloy and compare with wrought alloy. The ${\gamma}^{\prime}-precipitates$ were coarsen with the increase of aging time ranging from 8 to 48 hrs. A creep test performed at $750^{\circ}C$ showed faster minimum creep rate and shorter rupture lifetime with the aging time. A creep test performed showed only a slight difference in the rupture life between cast and wrought products. Based on the creep test results, the deformation mechanism is discussed using fractographs.

• Carbon letters
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• v.28
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• pp.9-15
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• 2018

In the aerospace field, Carbon/Cork composites have been used for rocket propulsion systems as a light weight structural component with a high bending stiffness and high thermal insulation properties. For the fabrication of a carbon composite with a heat insulation cork part, the bonding properties between them are very important to determine the service life of the Carbon/Cork composite structure. In this study, the changes in the interfacial adhesion and mechanical properties of Carbon/Cork composites under accelerated aging conditions were investigated. The accelerated aging experiments were performed with different temperatures and humidity conditions. The properties of the aged Carbon/Cork composites were evaluated mainly with the interfacial strength. Finally, the lifetime prediction of the Carbon/Cork composites was performed with the long-term property data under accelerated conditions.

• Proceedings of the KIEE Conference
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• 2004.11d
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• pp.77-79
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• 2004

It is caused that insulation paper, which had got a lot of thermal stress by over-load after installation, should have been deteriorated in electrical and mechanical characteristics. Beside, insulation material is decreased the insulating property and accelerated aging of them in case of dielectric loss when transformers are manufactured with some moisture or transformers would have been them because of moisture-permeation. Therefore, in this study we experienced the influence of moisture content in case of the thermal aged insulation paper. we have measured tan 6 and breakdown voltage in the ratio of paper' moisture content before the aging and then taken the same tests again after insulation paper thermally accelerating-aged. There is a purpose to gain data for a life-design and to establish aging mechanism in order to continuously study life expectancy of the insulation paper

• Transactions of Materials Processing
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• v.8 no.3
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• pp.309-309
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• 1999

Effects of rare earth metals addition and aging treatment on corrosion resistance and mechanical properties of super duplex stainless steels were investigated using optical/SEM/TEM metallographic examination, an X-ray diffraction test, a potentiodynamic anodic polarization test and a tensile test. The performance of the experimental alloy with 0.32% REM addition was compared with commercial super duplex stainless steel such as SAF 2507 when they were exposed to solution annealing heat treatment and aging treatment. The corrosion resistance in CF environments and mechanical properties of the experimental alloy were found superior to those of the commercial duplex stainless steel. The REM with larger atomic radii than those of Cr, Mo and W may fill vacancies inside the matrix and around the grain boundaries, retarding formation of harmful intermetallic σ and χ phases. In addition, fine REM oxides/oxy-sulfides (1-3㎛) seemed to enhance the retardation effects. With REM additions, strength and ductility increased due to the phase and grain refinement caused by fine REM oxides and oxy-sulfides.

• Transactions of the Korean Society of Automotive Engineers
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• v.10 no.2
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• pp.110-116
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• 2002

At elevated temperature, very complex precipitations occur in STS316. To investigate the effect of the precipitation on mechanical properties in SIS316, tensile tests and fatigue crack growth tests were carried out at $650^{\circ}C$ using artificially degraded materials. The material degradation was simulated by aging for up to 20000 hrs. at $750^{\circ}C$, which is equal to 179000hrs (about 20yrs) of service life at $650^{\circ}C$, after conducting solution treatment for 20 min. at $11300^{\circ}C$. The result of the hardness test and the tensile test showed that both properties are closely related to the mean free distance of carbides. Also, from the results of fracture tests at $650^{\circ}C$, ${\triangle}K_{th}$, after values were found to decrease as aging time and microstructure, as the volume fraction of $\sigma$ phase increased.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.11a
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• pp.484-487
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• 2002

The mold transformers have been widely used in underground substations in large building and have some advantages in comparison to oil-transformer, that is low fire risk, excellent environmental compatibility, compact size and high reliability. In addition, the application of mold transformer for outdoor is possible due to development of epoxy resin. The mold transformer generally has cooling duct between low voltage coil and high voltage coil. A mold transformer made by one body molding method has been developed for small size and low loss. In this paper, the proto type mold transformer of 50kVA class is investigated by routine, type, special test. The outdoor energized aging test is investigated by back-to-back method to verify the long time performance of pole mold transformer. The aging process of transformer is analyzed by various diagnosis method such as DC voltage-current test, $tan{\delta}$, Meggar measurement, winding temperature and etc.