• Tuberculosis and Respiratory Diseases
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• v.69 no.5
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• pp.323-330
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• 2010

A key mechanism in the pathogenesis of chronic obstructive pulmonary disease is thought to be an abnormal inflammatory response in the lungs to the inhalation of toxic particles and gases, derived from tobacco smoke, air pollution, and/or occupational exposures. This review highlights the potential participation of several alternative pathogenetic processes, particularly involving the potential participation of biological and pathobiological processes related to aging, including oxidative stress and enhanced expression of markers of senescence/aging in emphysematous lungs, and the potential for enhanced tissue destruction involving alveolar cell apoptosis.

• Proceedings of the Korea Concrete Institute Conference
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• 2000.04a
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• pp.275-278
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• 2000

In this paper, we carried out fundamental experiments to use steel manufacturing slag as a concrete aggregate. Generally, there are two types of slag, the blast-furnace slag and the steel manufacturing slag. The latter is classified by the difference of manufacturing method of steel into the convertor slag and the electric-furnace slag. The steel manufacturing slag mainly contains $SiO_2$ and CaO as the chemical composition. The reaction with water and a little of free CaO in the steel manufacturing slag made the expansion of volume change, Therefore, we primarily investigated physical properties, expansion mechanism, pH value, aging effect and aging methods in the steel manufacturing slag, Then compressive strength of concrete with steel slag aggregate is measured.

• Proceedings of the KSME Conference
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• 2001.06a
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• pp.316-321
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• 2001

A previous feasibility study for the Korean lead plant, PLiM Phase I, showed a strong possibility of continued operation beyond the original licensed period. In 1998, PLiM Phase II study was initiated aimed at performing additional detailed evaluations on a wider range of components. The objective of this paper is to present the Korean PLiM efforts for Class 1 piping which is identified as one of the critical components with regard to long-term operation. The key findings such as typical design features, degradation mechanisms, technical issues, draft results from the lifetime evaluation for Class 1 piping of the lead plant are briefly described.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.6 no.4
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• pp.285-290
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• 2005

Mechanical properties of rubber mat are influenced by many factors such as compounding ingredients and states of cure, process of rubber, and fillers. Our study aim is to investigate influence of N-isopropyl-N'-chloro-P-phenylene diamine antioxidant on the thermal aging and ozone cracking. In this work, the degradation of antiblastic rubber mat was studied and suggested mechanism to involve two-types of degradation, thermal-aging and ozone-cracking both of which can be contained antioxidant or non-antioxidant.

• Health Policy and Management
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• v.30 no.4
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• pp.513-521
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• 2020

Aging populations and the increasing mental health issues among them have set a new challenge for the international community, governments, and people. Given this, society's role is very important, and involving the local community in resolving the problems can play a pivotal role. The current study presented the systematic review of the financing mechanism and cost-effectiveness of the "social prescribing" (SP) project in the United Kingdom and how SP can be adapted for other settings. The data showed comparatively low running costs and the overall effectiveness of SP projects. The running cost of SP projects varied between £54,525 and £1.1 million. The cost-effectiveness of the projects reported as 12% and the return of investment was about 50% depending on the type of analysis and the activities implemented. This type of intervention can be one of the options that support solving the issues of aging populations and their accompanying mental disorders.

• Elastomers and Composites
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• v.57 no.4
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• pp.165-174
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• 2022

The effect of fumed silica loading on the thermal stability and mechanical properties of fluorosilicone (FVMQ) rubber was investigated. The distribution of fumed silica inside FVMQ was characterized using scanning electron microscopy, and the thermal stability of composites was evaluated using thermogravimetric analysis and by the changes in mechanical performance during thermo-oxidative aging. The function mechanism of fumed silica was studied by Fourier transform infrared spectroscopy. The results show that with increasing silica content, the crosslink density of composites, the modulus at 100%, and tensile strength also increased, whereas the elongation at break decreased. Furthermore, increasing the silica content of composites increased the initial decomposition temperature (T_d) and residual weight of the composite after exposure to nitrogen. In addition, the thermal oxidative aging experiment demonstrated improved aging resistance of the FVMQ composites, including lower change in tensile strength, elongation at break, and modulus at 100%.

• Journal of Welding and Joining
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• v.14 no.3
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• pp.93-104
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• 1996

This study evaluated relative hot cracking susceptibility of commercial aluminum alloy welds, and then suggested possible mechanisms operated in the weld fusion zone and in the heat affected zone based on the observed cracking morphologies, fractography and microstructural features. The fusion zone solidification cracking was found to be mainly due to a microsegregation of Cu, Si, and Mg in grain boundaries, while liquation cracking in the HAZ was by the incipient melting of the segregated grain boundaries and the consitutional liquation of large aging precipitates and intermetallic compounds in the partially melted zone adjacent to the fusion line which experienced a rapid thermal excursion during welding.

• Journal of Technologic Dentistry
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• v.34 no.4
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• pp.345-352
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• 2012

Purpose: The age-hardening mechanism of an Au-Ag-Cu-Pt-Zn alloy for crown and bridge fabrication was investigated by means of hardness test, X-ray diffraction study and field emission scanning electron microscopic observation. Methods: Before hardness testing, the specimens were solution treated and then were rapidly quenched into ice brine, and were subsequently aged isothermally at $400-450^{\circ}C$ for various periods of time in a molten salt bath and then quenched into ice brain. Hardness measurements were made using a Vickers microhardness tester. The specimens were examined at 15 kV using a field emission scanning electron microscope. Results: By the isothermal aging of the solution-treated specimen at $450^{\circ}C$, the hardness increased rapidly in the early stage of aging process and reached a maximum hardness value. After that, the hardness decreased slowly with prolonged aging. However, the relatively high hardness value was obtained even with 20,000 min aging. By aging the solution-treated specimen, the f.c.c. Au-Ag-rich ${\alpha}_0$ phase was transformed into the Au-Ag-rich ${\alpha}_1$ phase and the AuCu I ordered phase. Conclusion: The hardness increase in the early stage of aging process was attributed to the formation of lattice strains by the precipitation of the Cu-rich phase and then subsequent ordering into the AuCu I-type phase. The decrease in hardness in the later stage of aging process was due to the release of coherency strains by the coarsening of tweed structure in the grain interior and by the growth and coarsening of the lamellar structure in the grain boundary. The increase of inter-lamellar space contributed slightly to the softening compared to the growth of lamellar structure toward the grain interior.

• BMB Reports
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• v.47 no.12
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• pp.673-678
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• 2014

During Xenopus early development, FGF signaling is involved in mesoderm formation and neurogenesis by modulating various signaling cascades. FGF-MAPK signaling induces Xbra expression, which maintains mesodermal fate through an autocatalytic-loop. Interestingly, previous reports have demonstrated that basic FGF (bFGF) treatment alone does not induce neurogenesis in ectodermal explants, even though FGF signaling inhibits BMP signaling via phosphorylation in Smad1 linker region. In addition, the overexpression of dominantnegative Xbra induces neurogenesis in ectodermal explants. However, the detailed mechanism underlying these phenomena has not yet been clarified. In this work, we showed that bFGF-Xbra signaling increased the PV.1 expression. DN-Xbra was found to decrease PV.1 expression, and the co-injection of PV.1 with DN-Xbra reduced neurogenesis in ectodermal explants. Furthermore, the knockdown of PV.1 induced neurogenesis in bFGF-treated ectodermal explants. Taken together, our results demonstrate that FGF-Xbra signaling induces PV.1 expression and that PV.1 functions as a neural repressor in the FGF-treated ectoderm.

• Elastomers and Composites
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• v.53 no.4
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• pp.213-219
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• 2018

The degradation mechanism and physical properties of an FKM O-ring were observed with thermal aging in this experiment. From X-ray photoelectron spectroscopy (XPS) analysis, we could observe carbon (285 eV), fluoro (688 eV), and oxygen (531 eV) peaks. Before thermal aging, the concentration of fluoro atoms was 51.23%, which decreased to 8.29% after thermal aging. The concentration of oxygen atoms increased from 3.16% to 20.39%. Under thermal aging, the FKM O-ring exhibited debonding of the fluoro-bond by oxidation. Analysis of the C1s, O1s, and F1s peaks revealed that the degradation reaction usually occurred at the C-F, C-F2, and C-F3 bonds, and generated a carboxyl group (-COOH) by oxidation. Due to the debonding reaction and decreasing mobility, the glass transition temperature of the FKM O-ring increased from $-15.91^{\circ}C$ to $-13.79^{\circ}C$. From the intermittent CSR test, the initial sealing force was 2,149.6 N, which decreased to 1,156.2 N after thermal aging. Thus, under thermal aging, the sealing force decreased to 46.2%, compared with its initial state. This phenomenon was caused by the debonding reaction and decreasing mobility of the FKM O-ring. The S-S curve exhibited a 50% increase in modulus, with break at a low strain and stress state. This was also attributed to the decreasing mobility due to thermal aging degradation.