• Title/Summary/Keyword: Aging Factor

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시호(柴胡)가 뇌허혈 유발 노령 흰쥐의 해마 손상 및 HSP70 발현에 미치는 영향 (Effect of Bupleuri Radix on HSP70 Expression and Hippocampus of Ischemically Damaged Aged BCAO Rats)

  • 배철환;정승현;신길조;이원철;김진수
    • 대한한방내과학회지
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    • 제25권4호
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    • pp.105-116
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    • 2004
  • Objective : In this study, we used the aged bilateral common carotid artery occlusion (BCAO) rats were used to measure the effect of Bupleuri Radix (Si-Ho) on the brain ischemic injury, because aging is an important factor in storke, Method : The brian ischemic injury was induced by temporary closing of carotids on both sides in a low blood pressure state. Bupleuri Radix (Si-Ho) was orally administered in 18-month-old BCAO rats. Result : The Ischemic Damaged Hippocampus and HSP expression were analyzed by the immunohistochemical staining and the result were as follows: 1. The low numbers of pyramid cells in the hippocampus CA1 area for the ischemically injured experimental group rose to numbers simillar to those of the control group. 2. The thin neuronal cell layer in the hippocampus CA1 area for the ischemically injured experimental group returned to thickness simillar to those of the control group. 3. The normalized optical density of HSP70 expression was suppressed in CA2, DG and CA1 expression was significantly suppressed in the experimental group compared to the control group. Conclusion : These results suggested that Bupleuri Radix (Si-Ho) has a neuroprotective effect by reducing neural cell injury in the initial ischemic state.

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지역난방 열배관 강화를 위한 실증시험 연구 (Experimental Study for the Reinforcement of District Heating Pipe)

  • 김재민;김주용;조종두
    • 대한기계학회논문집A
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    • 제40권3호
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    • pp.245-252
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    • 2016
  • 본 논문은 벤드(bend)부의 노후 문제를 경감시키기 위한 대안으로 폼패드를 없앤 이중보온관의 형상 설계를 제안하였다. 전 관경에 대해 유한요소해석을 수행하였으며, 이를 토대로 전단제어링 형상을 결정하였다. 제안된 전단제어링 사양 강화이형관에 대한 현장 시공 시험은 진행하였으며, 온도와 응력 데이터를 취득 및 분석하였다. 강화이형관의 제작과 현장 시범시공을 통하여 강화이형관이 폼패드를 시공하지 않으면서도 강관의 열응력이 허용치 기준내에 있음을 확인하였다. 특히 보온재의 전단강도가 강화되어 폼패드를 적용한 기존 벤드보다 낮은 최대 전단응력이 발생함을 확인함으로써, 강화이형관 적용에 따른 구조 안전성 향상 효과를 확인하였다.

유료노인장기요양보호서비스 이용의사 결정요인 (Determining Factors of Intention to Actual Use of Charged Long-term Care Services for the Aged)

  • 유진영;전진호
    • Journal of Preventive Medicine and Public Health
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    • 제38권1호
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    • pp.16-24
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    • 2005
  • Objectives : To help develop strategies to cope with the changes arising from the rapid aging process by predicting the determining factors of intention to actual use of the charged long-term care services for elderly as perceived by the middle aged who play the major role of supports. Methods : Subjects were the parents (men 177, women 507) in their 40s of the students selected from a university of Busan city. A questionnaire survey was conducted for 4 weeks in October 2003 about the knowledge for long-term care service, the intention of actual use, and the preferences about the type of service suppliers. Data analysis was performed with frequency, chi-square test, and t-test using SPSS program (ver 10.0K), along with data mining using decision tree of Enterprise Miner V8.2 by SAS. Results : About half of the subjects (53.7%) had the actual experiences of elderly supports. Intentions to use the charged services were relatively high in home visiting nursing care service (40.1%) and long-term care facilities service (40.4%), and were influenced by previous knowledge about the services. The intentions were stronger in women, those with higher education, and those with greater income levels. Actual elderly supports were mostly (80%) done by women, and the perceived burdens for the supports were bigger in women and those of lower socioeconomic level. Desired charges were about 10,000 won for the bath service, 20,000 won for the rests services per day, and about 500,000 won for the long-term care facilities service per month. From the result of decision tree analysis, the job professionalism was the most important determining factor of intention to actual use of the services with validation as $63{\sim}71%$. Health and welfare mixed type facilities were preferred, and the most important consideration was the level of professionalism. Conclusions : Intention to actual use of the charged services was largely determined by the aspects of time and cost. Polices to increase the number of service suppliers and to decrease the burdens perceived by actual supporters were strongly recommended.

Moringa oleifera Prolongs Lifespan via DAF-16/FOXO Transcriptional Factor in Caenorhabditis elegans

  • Im, Jun Sang;Lee, Ha Na;Oh, Jong Woo;Yoon, Young Jin;Park, Jin Suck;Park, Ji Won;Kim, Jung Hoon;Kim, Yong Sung;Cha, Dong Seok;Jeon, Hoon
    • Natural Product Sciences
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    • 제22권3호
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    • pp.201-208
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    • 2016
  • Here in this study, we investigated the lifespan-extending effect and underlying mechanism of methanolic extract of Moringa olelifa leaves (MML) using Caenorhabditis elegans (C. elegans) model system. To define the longevity properties of MML we conducted lifespan assay and MML showed significant increase in lifespan under normal culture condition. In addition, MML elevated stress tolerance of C. elegans to endure against thermal, oxidative and osmotic stress conditions. Our data also revealed that increased activities of antioxidant enzymes and expressions of stress resistance proteins were attributed to MML-mediated enhanced stress resistance. We further investigated the involvement of MML on the aging-related factors such as growth, food intake, fertility, and motility. Interestingly, MML significantly reduced growth and egg-laying, suggesting these factors were closely linked with MML-mediated longevity. We also observed the movement of aged worms to estimate the effects of MML on the health span. Herein, MML efficiently elevated motility of aged worms, indicating MML may affect health span as well as lifespan. Our genetic analysis using knockout mutants showed that lifespan-extension activity of MML was interconnected with several genes such as skn-1, sir-2.1, daf-2, age-1 and daf-16. Based on these results, we could conclude that MML prolongs the lifespan of worms via activation of SKN-1 and SIR-2.1 and inhibition of insulin/IGF pathway, followed by DAF-16 activation.

농촌마을 정주환경분석을 통한 과소마을 임계규모 결정지표 개발 (Development of the Marginal Scale of Rural Over-Depopulated Village by Analysing the Rural Residential Conditions)

  • 배연정;이지민;서교;이정재
    • 농촌계획
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    • 제19권1호
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    • pp.109-122
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    • 2013
  • The rapid rural urban migration and aging has generated an over-depopulation problems in rural areas since the 1980s. The purpose of this study constructs the marginal size of rural over-depopulated village through the analysis of the residential disparities such as farmer's ratio, basic life service accessibility, and levels of social and economic factors for each village community. This marginal scale could support evaluating diverse rural policies, which have been planned to apply to the rural development programs at the village level. The major challenges for over-depopulated villages are the lack of basic facilities, production infrastructures and inactive communities in the village. Therefore, the quantitative analysis of rural residential disparities according to rural village scale can provide the criteria for rural over-depopulated villages. We utilized Korea Agricultural Survey Data(2010) including specific residential condition of village level. The present study adopt multinomial-logit model for quantitative analysis of different village scales and decomposition techniques to separate the direct effect by the village scale factor from the endowment effects by regional or area characteristics, and residual effect by unknown factors. The present study found that the minimum scale of a rural over-depopulated village was 40 and 60 houses for the respective conditions of farmer's ratios less than 50% and greater than 75%. It was concluded based on the study findings that threshold scale could support evaluating the diverse rural policies, which have been planned to apply to the rural development programs at the village level.

I형 골다공증의 요인분석과 다랑어골분 복합제제의 pilot study를 통한 평가 (Factor Analysis of Type I Osteoporosis and Evaluation on Tuna Bone Powder Compounds through Small Scale Pilot Study)

  • 지규용;김영만
    • 동의생리병리학회지
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    • 제18권1호
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    • pp.93-100
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    • 2004
  • This study was carried out for analyzing pathological and epidemiological factors of osteoporosis and doing pilot test using trial compounds of tuna bone and oriental herbs based on the factors. Osteoporosis is originated from osteoblast, osteoclast, organic and inorganic factors etc. Therefore the pathology of osteoporosis is not simple because the cytokine, growth factors and hormones of the components are various a lot. Taking a view of epidemiological factors of type I osteoporosis, ageㆍmenarcheㆍcholesterolㆍBMI etc. have definite relation to them. So we can approach to aging or consumptive disease in oriental medicine, specifically differential diagnosis of blood depletion with deficiency of qi, deficiency of kidney, deficiency of yin, bony weakness etc. And it should be considered together with rules for maintaining good health or habit concomitantly. Therefore IL1ㆍ6 or TNF αㆍβ are generally used as molecular biological index for osteoblast and osteoclast because the most important index is bone mineral density and strength, but the factors like collagen and noncollagen protein must be accounted as biomarkers. Trial compounds generally showed favorable effects on accompanying subjective symptoms of osteoporosis in the pilot test for menopausal woman. But if she didn't have specific symptoms of osteoporosis there wasn't any specific change. And osteocalcin was increased in case of being under standard level, but wasn't changed in case of normal level. Therefore these trial compounds can be used as a funcdonal diet for type I osteoporotic patients or preventive measures.

양돈장 내의 환경 요인에 따른 내부 유해인자의 변동 모니터링 (Monitoring of Internal Harmful Factors According to Environmental Factors in Pig Farm)

  • 이성원;김효철;서일환
    • 한국농공학회논문집
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    • 제62권1호
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    • pp.105-115
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    • 2020
  • With the decrease of the agricultural population in Korea, the workers who is vulnerable to labor are increasing in agricultural industry because of aging, feminization of population. They are exposed in poor working environment with higher temperature and concentrations of dust, gas. Higher concentration of harmful gas and dust can cause chronic and acute disease to workers depending on exposure intensity and frequency. In order to improve the working environment in the livestock facilities, It is important to secure monitoring data of the thermal environment and the concentration of harmful gases and fine dust. Multi-point measurement was performed to analyze the regional environmental conditions in the pig rooms. When analyzing the working environment, video monitoring was conducted to analyze the concentration changes of ammonia, hydrogen sulfide and fine dust according to worker movement and work type. Ammonia and hydrogen sulfide monitoring result showed 1.5~2 times higher concentrations than other work when working in the pigs living zone, and 2~4 times higher than other work when working to increase the activity of pigs. In the case of fine dust, the result was 1.3 times higher than the worker's exposure standard in a specific work. The concentrations of gases and dusts from pig farms are not of concern for acute poisoning in normal work, but there is a risk of chronic respiratory disease if they are continuously exposed. Accordingly, there is a need for development of work environment monitoring device tailored to workers and preparation of alternatives.

외부활동에 따른 자외선 노출이 피부에 미치는 영향 연구 -피부물리치료를 위한 기초 연구- (A study on the effect of UV exposure on the skin due to external activities)

  • 이광재;최영인
    • 대한물리치료과학회지
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    • 제21권1호
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    • pp.37-43
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    • 2014
  • Background : The purpose of this study is to verify the type of influence on the skin color according to the photoaging symptoms depending on the degree of external activities among the factors that influence the skin due to UV exposure and to obtain the basic study data on the physical therapy of the skin. Methods : In this study, in order to investigate the type of influence on the skin color according to the photoaging symptoms when the body is exposed to the UV rays having various effects on our body, a study was conducted using questionnaires and skin color measurement tool targeting 20 male college soccer students with many external activities and the senior high school students who has relatively less external activities due to the preparation for college entrance. The skin color was measured and the results were compared. Result : In the test group having relatively higher external activities, while they had less use of the sunscreen, they had more degree of UV exposure, and for the recognition of ultraviolet hazard, more were aware that it was harmful. In addition, in the skin color measurement test conducted targeting the son and the father in order to investigate the association between the skin color and the genetic factors, the experimental group showed a significant difference(p<.05) but the control group did not show any significant difference(p>.05). Conclusion : Based on such study results, the UV exposure time and the use of sunscreen are thought to be an important factor in the skin care.

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실버소비자들의 라이프스타일에 따른 의류제품과 미용서비스 구매행동 (The Elderly's Lifestyle and Their Purchasing Behavior of Apparel Products and Hairdressing Services)

  • 강은미;박은주
    • 한국의류학회지
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    • 제31권11호
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    • pp.1542-1553
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    • 2007
  • Recently, the growing of the aging population resulting from the medical and science development has made the elderly consumer as a new market. The purposes of this study were 1) to examine the purchase behavior of apparel products and hairdressing services of elderly consumers, 2) to investigate the purchase behavior in the apparel store and hairdressing shop on lifestyle types. Data were collected from 853 women in their 50s and 60s living in Busan. Data were analyzed by frequency analysis, descriptive analysis, factor analysis, Cronbach#s alpha, Chi-square analysis, cluster analysis, one-way ANOVA and Duncan test using SPSS WIN 12.0. The results of the study were as follows: First. when elderly consumers purchased apparel product, they were likely to use credit cards, to shop alone or with friends at a department store, and to use the store as information source. In their purchases of hairdressing services, they tended to visit the near shop for a permanent service bimonthly and to depend on their past experiences for hairdressing. Second, elderly consumers were classified by the lifestyle into the Active self-fidelitist, Economy family-oriented, and Passive-stagnant. The purchase behaviors in the apparel store and hairdressing shop were different among lifestyle types. Implications were suggested for the consumer behavior researchers and retailers of the elderly fashion market.

일 개 대학 치위생과 학생들의 노인관련 경험이 노인에 대한 태도에 미치는 영향 (Influence of elderly-related experience on attitude toward elderly in dental hygiene students)

  • 전보혜;최영숙
    • 한국치위생학회지
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    • 제15권6호
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    • pp.1019-1026
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    • 2015
  • Objectives: The purpose of the study is to investigate the influence of elderly-related experience on attitude toward elderly in dental hygiene students. Methods: A self-reported questionnaire was completed by 213 dental hygiene students in Suwon from November 21 to 30, 2012. The questionnaire consisted of general characteristics of the subjects, elderly-related experience, knowledge on elderly, and attitude toward elderly by Likert 7 points scale. The instrument for knowledge on elderly was adapted from facts on aging quiz-I by Palmore and modified by Kim et al. Data were analyzed by t test, one way ANOVA, and multiple regression analysis using SPSS 21.0 program. Results: The attitude toward the elderly was $2.79{\pm}0.42$. The elderly-related experience had a positive influence on the attitude toward elderly(p=0.019) according to the level of experiencing the elderly(r=0.161, p<0.05). The influence of elderly-related experience on attitude toward the elderly showed that an experiencing variable is key factor in predicted variable of the attitude toward the elderly(${\beta}$=0.177 p=0.015). Conclusions: Elderly-related experience had an effect on positive attitude toward the elderly people in the dental hygiene students. It is necessary to develop and implement the education program for the exact knowledge and attitude toward the elderly.