• Journal of the Society of Cosmetic Scientists of Korea
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• v.42 no.2
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• pp.145-152
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• 2016

Epidermis is continuously regenerated by keratinocyte stem cells (KSCs) residing in basement membrane, which is critical to the survival of an organism. KSCs are believed to persist during the whole lifetime and generate an enormous number of keratinocytes, required for the maintenance of epidermis, through transit amplifying cells dividing definite times until they become differentiated. In this report, we have developed a phenolic compound, paeonol, purified from Moutan Cortex, as a KSC proliferation activator, by screening about 350 herbal compounds. The cell proliferation activation by paeonol is specific for KSC not for keratinocyte, and no significant difference in the expression of p63 protein, a KSC marker, in KSCs treated with paeonol was observed in FACS analysis with anti-p63 antibody. In the colony forming assay, paeonol-treated KSC showed improved colony forming activity more than 1.3 fold. In addition, the result of PCR array shows that the activity of paeonol is through several signal pathways involving stem cell functions. These results suggest that paeonol could enhance KSC proliferation activity without reduction in stemness and could be applied to cosmetics as a KSC activating ingredient.

• Journal of Convergence for Information Technology
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• v.11 no.11
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• pp.172-177
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• 2021

As part of the digital era, a digital twin that simulates the weak part of a product by performing a stress test that reduces the lifespan of some expensive equipment that cannot be done in reality by accurately moving the real world to virtual reality is being actively used in the manufacturing industry. Due to the development of IoT, the digital twin, which accurately collects data collected from the real world and makes it the same in the virtual space, is mutually beneficial through accurate prediction of urban life problems such as traffic, disaster, housing, quarantine, energy, environment, and aging. Based on its action, it is positioned as a necessary tool for smart city construction. Although digital twin is widely applied to the manufacturing field, this study proposes a smart city model suitable for the 4th industrial revolution era by using it to smart cities and increasing citizens' safety, welfare, and convenience through the proposed model. In addition, when a digital twin is applied to a smart city, it is expected that more accurate prediction and analysis will be possible by real-time synchronization between the real and virtual by maintaining realism and immediacy through real-time interaction.

• The Journal of Engineering Geology
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• v.31 no.3
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• pp.343-355
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• 2021

Agricultural reservoirs seek human convenience by supplying agricultural water and providing flood damage effects and rest areas at the same time, but preventing them from aging reservoirs and earthquakes is important. The safety of levees is influenced by field material properties such as soil parameter values of the granular materials that make up the levees, but since precision safety diagnosis or general literature values are diverted, the final safety factors are limited to material properties alone. Since safety factors are determined by physical characteristic values and embankment shapes and have a significant impact on safety factors, accurate contemplation is required when examining reinforced cross sections. Therefore, this study analyzed the case of reasonable and economical reinforcement intersections when designing '◯◯reservoir' in Goheung-geun, Jeollanam-do using the GEP-SLOPE program to enable rational economic design of reinforcement intersections through repeated reviews. As a result of reducing and analyzing the first, second, and third seismic reinforcement of the levees, it was confirmed that the safety ratio was secured even with a significantly smaller amount of reinforcement than the first, second, and lower slopes by obtaining design standards of 1.20. In addition, when determining all seismic reinforcement cross-sectional shapes, it was confirmed that the shape that reinforces only the lower side rather than the upper side of the slope and the entire slope was economical with minimized cross-sectional reinforcement.

• The Journal of Bigdata
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• v.6 no.1
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• pp.37-49
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• 2021

The number of dementia patients in Korea is estimated to be over 800,000, and the severity of dementia is becoming a social problem. However, no treatment or drug has yet been developed to cure dementia worldwide. The number of dementia patients is expected to increase further due to the rapid aging of the population. Currently, early detection of dementia and delaying the course of dementia symptoms is the best alternative. This study presented a methodology for early diagnosis of dementia by measuring and analyzing amyloid plaques. This vital protein can most clearly and early diagnose dementia in the retina through AI-based image analysis. We performed binary classification and multi-classification learning based on CNN on retina data. We also developed a deep learning algorithm that can diagnose dementia early based on pre-processed retinal data. Accuracy and recall of the deep learning model were verified, and as a result of the verification, and derived results that satisfy both recall and accuracy. In the future, we plan to continue the study based on clinical data of actual dementia patients, and the results of this study are expected to solve the dementia problem.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.3
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• pp.265-271
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• 2021

Nanoparticles are substances that are smaller in size and smaller than cells that make up the skin. Therefore, they are very suitable as mediators for transmitting drugs or genes across cell membranes, and also deliver specific ingredients into the skin.In this study, nanoparticles were extracted from mugwort and particles of around 100 nm were obtained through dynamic light scattering (DLS), and the results of concentration-dependent enhancement of cell viability in fibroblasts were obtained through MTT assay. In addition, it was confirmed that the COL1A1 mRNA expression level was increased and the IL-6 mRNA expression level was decreased through the quantitative real-time PCR analysis method. Moreover, as these nanoparticles were confirmed to be stable, they can be applied not only to cell experiments but also to cosmetic formulations. While the demand for plant-derived ingredients continues to increase, excluding chemical ingredients from the recent cosmetics industry trend, there is a limitation in that there are few research results suggesting the application field of plant-derived nanoparticles. Therefore, in order to overcome the limitations of the cosmetic industry at the present time, the results obtained in this study present nanoparticles derived from Artemisia princeps (NDAP) as a highly functional cosmetic material.

• Journal of the Society of Disaster Information
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• v.17 no.2
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• pp.254-265
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• 2021

Purpose: Inspection and diagnosis on the performance and safety through domestic port facilities have been conducted for over 20 years. However, the long-term development strategies and directions for facility renewal and performance improvement using the diagnosis history and results are not working in realistically. In particular, in the case of port structures with a long service life, there are many problems in terms of safety and functionality due to increasing of the large-sized ships, of port use frequency, and the effects of natural disasters due to climate change. Method: In this study, the maintenance history data of the gravity type quay in element level were collected, defined as big data, and a predictive approximation model was derived to estimate the pattern of deterioration and aging of the facility of project level based on the data. In particular, we compared and proposed models suitable for the use of big data by examining the validity of the state-based deterioration pattern and deterioration approximation model generated through machine learning algorithms of GP and SGP techniques. Result: As a result of reviewing the suitability of the proposed technique, it was considered that the RMSE and R² in GP technique were 0.9854 and 0.0721, and the SGP technique was 0.7246 and 0.2518. Conclusion: This research through machine learning techniques is expected to play an important role in decision-making on investment in port facilities in the future if port facility data collection is continuously performed in the future.

• Journal of the Korea Convergence Society
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• v.12 no.5
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• pp.373-383
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• 2021

Our society is aging rapidly. In this super-aged society, the increase in healthcare costs are considered a national problem that undermines the sustainability of social security. Various services for healthcare for the elderly have been promoted to address this. However, most of them have focused on healthcare after the outbreak of chronic diseases and lack preventive healthcare. Most of the preventive healthcare projects are only pilots. In this paper, the current status of health care services for senior citizens at home and abroad was analyzed and based on this, the limitations and improvements were analyzed to propose the establishment of IoT-based Total Silver Care Center. IoT-based Total Silver Care Center may be conveniently monitored the health status of the elderly through various sensors, medical devices, and smart bands. And based on this, it can improve the quality of nursing services through time-saving and work efficiency of nursing providers. In addition, health care interventions may be provided in a timely manner if there is a change in the health status of users. And real-time imaging systems can help overcome mental difficulties.

• Journal of the Korean Institute of Landscape Architecture
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• v.49 no.2
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• pp.41-50
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• 2021

This study was conducted to see the differences of park users by classifying them with their park use frequency in terms of park use, management policy and perception, using the same survey results conducted in 2014 and 2020. Research was conducted on urban parks in Yangju, South Korea, and 740 in 2014 and 431 in 2000 survey results were used. After classifying the high-use and low-use groups according to park use frequency, this study compared the demographic differences and park use method differences according to the group, the recognition differences for the future park management direction between the two groups were analyzed and compared using statistical analysis by year. The results showed that the park's quantitative expansion and accessibility improvements were the most important issues in 2014, while the importance of park management, such as checking and improving aging facilities, providing various programs, and creating a themed neighborhood park that could reveal the identity of the area, was increased in 2020. Despite recognizing the importance of persistent management in the case of high-use groups, the results showed that they were less willing to participate in park management programs compared to less-use groups, which showed the need for a discussion of how to involve high-use groups for long term park management. This study contribute the body of literature that it seeks to understand differences of park user in terms of their park use frequency. However, in future studies, analyzing the differences of park users through a short-term study is required.

• Journal of the Korea institute for structural maintenance and inspection
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• v.25 no.5
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• pp.102-113
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• 2021

The deterioration environments caused by de-icing salt and airborne chlorides in the seashore, evaluated in the "Detailed guideline for safety and management practice of facilities (performance evaluation)", were reviewed in terms of penetrated chlorides into concrete on various road facilities. Target concrete structures, in this study, were 4 concrete barriers in Gangwon area, 3 concrete barriers and 1 retaining wall in Busan area, and 4 bridges in Gangwon-do, Seoul, Gyeonggi-do, and Busan. The deterioration environments were classified into three categories: direct and indirect de-icing salt attack, and airborne salt attack depending on the distance to seashore and the height of pier, and the penetrated chlorides in to concrete were analyzed. The results showed that (1) the regional deterioration environments were clearly classified by de-icing salt sprayed days (snowfall days), (2) the penetrated chlorides increased significantly when leakage occurred through slabs or expansion joints, and (3) the airborne chlorides affected to a height of 20 m concrete in the seashore, Busan. From these, it could be confirmed that the chloride ion penetration properties depend on the exposed aging environment, member location and height, and deterioration status, even on the same structure, so the selection of target members and location is very important in the inspection and maintenance. If the database of penetrated chlorides properties in various deterioration environments is constructed, it is expected that the proactive durability management on concrete structures will be possible in the field.

• Korean Public Health Research
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• v.44 no.4
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• pp.35-49
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• 2018

Objective : The purpose of this study was to investigate the risk factors of dehydration from the subjects who underwent anthropometric and blood parameters testing during a comprehensive health screening. Methods : For the study analysis, 5,391 samples with valid data of the levels of Sodium($Na^+$), BUN (Blood Urea Nitrogen) and FBS(Fasting Blood Sugar) were selected to calculate a dehydration indicator of plasma osmolality. The study data was collected from the health screening examinees who visited Sahmyook Medical Center Seoul Adventist Hospital Comprehensive Health Check-up Center from 2014.01.01 to 2015.12.31. The relationship between dehydration and age group, BMI, disease exposures(hypertension, diabetes mellitus, dyslipidemia, kidney disorder) were analyzed by gender. Results : The odds ratio of dehydration showed statistical significance from age ${\geq}50$ in both male and female, respectively. The female obese group was vulnerable to dehydration while the male study group showed no statistical significance in the BMI difference. The disease exposed groups(hypertension, diabetes mellitus, dyslipidemia, kidney disorder) were vulnerable to dehydration. Also, the more types of disease carried by the exposed patients, the higher odds ratio and susceptibility to dehydration. Conclusions : Aging, increasing BMI, and exposed to diseases were found to be the risk factors for vulnerability to dehydration. To prevent dehydration, special caution to be taken for those in the ${\geq}50s$ group, along with controlling BMI and chronic diseases. Further studies are suggested to investigate the risk factors of dehydration that may affect increasing plasma osmolality as a potential stimulus mechanism in disease outbreaks.