• Tuberculosis and Respiratory Diseases
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• 제51권6호
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• pp.603-608
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• 2001

저자들은 속립성 폐결핵과 연관되어 급성 경과를 보인 결핵성 뇌수막뇌염 환자에서 뇌혈관 자기공명영상으로 혈관염 소견을 확인하고, 스테로이드의 투여와 중단, 재투여에 따라 뇌증의 증세가 뚜렷히 변하는 임상경과, 증상이 호전된 후 추적한 뇌혈관 자기공명영상에서 혈관 영상이 정상화된 것을 확인할 수 있었던 사례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• International Journal of Automotive Technology
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• 제7권1호
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• pp.25-34
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• 2006

For decades, simulation technique has been well validated in areas such as computer and communication systems. Recently, the technique has been much used in the area of transportation and traffic forecasting. Several methods have been proposed for investigating complex traffic flows. However, the dynamics of vehicles and diversities of driver characteristics have never been considered sufficiently in these methods, although they are considered important factors in traffic flow analysis. In this paper, we propose a traffic simulation tool called Multi-Agent for Traffic Simulation with Vehicle Dynamics Model (MATDYMO). Road transport consultants, traffic engineers and urban traffic control center managers are expected to use MATDYMO to efficiently simulate traffic flow. MATDYMO has four sub systems: the road management system, the vehicle motion control system, the driver management system, and the integration control system. The road management system simulates traffic flow for various traffic environments (e.g., multi-lane roads, nodes, virtual lanes, and signals); the vehicle motion control system constructs the vehicle agent by using various vehicle dynamic models; the driver management system constructs the driver agent capable of having different driving styles; and lastly, the integrated control system regulates the MATDYMO as a whole and observes the agents running in the system. The vehicle motion control system and driver management system are described in the companion paper. An interrupted and uninterrupted flow model were simulated, and the simulation results were verified by comparing them with the results from a commercial software, TRANSYT-7F. The simulation result of the uninterrupted flow model showed that the driver agent displayed human-like behavior ranging from slow and careful driving to fast and aggressive driving. The simulation of the interrupted flow model was implemented as two cases. The first case analyzed traffic flow as the traffic signals changed at different intervals and as the turning traffic volume changed. Second case analyzed the traffic flow as the traffic signals changed at different intervals and as the road length changed. The simulation results of the interrupted flow model showed that the close relationship between traffic state change and traffic signal interval.

• Tuberculosis and Respiratory Diseases
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• 제77권1호
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• pp.38-41
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• 2014

Malignant rhabdoid tumor was first discovered in the kidney, and rhabdoid tumor of the lung was first reported in 1995. These were included as the variants of large-cell carcinoma, according to the 1999 World Health Organization classification of lung tumors. The rhabdoid tumor of the lung exhibits aggressive biological behavior and has a poor prognosis, and only a few reports of this tumor exist. We report a case of lung carcinoma with a rhabdoid phenotype, initially misdiagnosed as an aspergilloma, in a 48-year-old man who presented with recurrent hemoptysis. The chest computed tomography scans showed a huge consolidative lesion with an air crescent sign in the left upper lung and no contrast-enhancing lesion. An aspergilloma was diagnosed by the radiologist. However, after surgical excision and pathological examination, rhabdoid carcinoma was diagnosed. A surgical resection helps to make it possible to pathologically distinguish a malignancy from an aspergilloma.

• 대한두경부종양학회지
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• 제13권1호
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• pp.74-80
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• 1997

We have experienced 5 cases of unusual well differentiated thyroid carcinoma with insular component during the past 5 years. 4 cases were presented with cervical masses but I case (patient 2.) was initiallty with lung and brain metastasis. The tumors from 4 cases showed invasive growths but that of 1 cases(patient 1.) showed intrathyroidal. Total thyroidectomy and cervical lymphnode dissection(CCND or RND) was performed in 4 cases but only RND was performed in spite of mediastinal metastasis of the tumor in patient 5 under the patient's choice. During the follow-up period, we also performed radical nephrectomy and metastatectomy for the kidney and iliac bone metastasis respectively, in patint 2. Microcsopically, the tumors showed the insular growth patterns, focally(less than 50%) in 3 cases and predominantly(more than 75%) in 2 cases. And the insular componentas were combined with papillary carcinoma in 2 cases and follicular carcinoma in 3 cases. Cervical lymphnode metastases were confirmed in 4 cases. Patient 2 died of disease with metastases to lung, brain, bone and kidney, 52 months after initial therapy. Patient 1, 3 and 4 are alive and have no recurrence and distant metastasis. Patient 5 is also alive with the mediastinal metastasis. In our experience, the well differentiated thyroid carcinomas with insular component showed characteristic histologic features, aggressive behavior in initial presentation and unfavorable prognosis regardless of the percentage of the insular component.

• 대한두경부종양학회지
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• 제24권1호
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• pp.64-68
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• 2008

Purpose：The chronic use of immunosuppressive therapy in transplant recipients can increase the long-term risk of carcinoma. The aim of this study was to determine the incidence, biological behaviors, and treatment outcomes in PTC(papillary thyroid carcinoma) in renal allograft recipients. Material and Methods：The present study examined the incidence and biological behavior of PTCs in RA recipients. A total of 1,739 RA patients treated between January 1986 and December 1999 were followed-up for a median 137(84-238) months. During the follow-up period, 129(7.4%) recipients were identified as having posttransplant malignancies. Of those, 12(0.7%) had PTCs, and these comprised six male and six female patients with a median age of 41(23-57) years. Results：Nine cases(incidentalomas) were diagnosed based on ultrasonography(US) screening. Eight of those nine were TNM stage I, and two of the three clinical carcinomas were TNM stage IVa. During a median follow-up of 94(18-159) months, two(16.7%) PTC patients developed loco-regional recurrence, but no patients showed distant metastasis. Posttransplant PTC showed no gender bias, and was often associated with aggressive lymphatic metastasis. However, most incidentalomas showed a favorable treatment outcome. Conclusion：In conclusion, routine surveillance of the thyroid gland using US screening is recommended to ensure early detection, treatment and favorable prognosis in RA patients with PTC.

• Journal of Yeungnam Medical Science
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• 제23권1호
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• pp.82-89
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• 2006

최근 여러 종양에서 단백분해효소의 분비와 암의 악성도에 대한 연구가 이루어져 왔으며, 이를 신세포암종 환자의 예후 측정인자로 사용하려는 시도가 진행되고 있다. 이에 저자들은 제 4형 collagenase 중 대표적인 MMP-9의 발현정도를 정상 신조직과 신세포암종 조직에서 비교하였고, 또 암의 침윤 및 전이정도와의 관계와 다른 임상적 인자들과의 상관성을 분석하여 암의 단계적 진행과정에서의 MMP-9의 발현변화에 대하여 조사하였다. 그 결과 정상 신 조직에 비해 신세포암종 조직에서 MMP-9의 발현이 증가되며 암의 크기가 크고 혈관침범이 있으며 병기가 높을수록 MMP-9의 발현이 증가됨을 관찰할 수 있었다. 이는 MMP-9 발현의 증가가 신세포암종의 발생과정 및 암의 후기 진행에 관여함을 시사하므로 향후 신세포암종의 예후척도로 사용되어 치료방침을 결정하는데 도움을 줄 수 있을 것으로 생각한다.

• Asian-Australasian Journal of Animal Sciences
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• 제32권3호
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• pp.452-458
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• 2019

Objective: The study was carried to determine the interaction effects of pen enrichment and sex on behavioral activities, skin lesions and physiology of Windsnyer pigs. Methods: Forty-eight growing Windsnyer pigs of both sex, with an average initial body weight of 21.6 (${\pm}9.01$) kg were used. Four pigs were randomly assigned to either enriched or barren pens at a stocking density of $0.35m^2/pig$. Enriched pens contained 2 L bottles filled with stones and suspended at head level on ropes stretching across the pens. In addition, two plastic balls (90 mm in diameter) and 500 mL bottles (235 mm long) were placed on the floor of each enriched pen. Results: Pigs in barren environments had higher heart rates (p<0.001) than those in enriched pens. There was an interaction of pen environment and sex on rectal temperature (p<0.001). Females in enriched pens had higher rectal temperatures (p<0.05) than females in barren pens. There was no interaction of pen environment and sex on time spent eating and drinking (p>0.05). Time spent bullying was influenced (p<0.05) by pen environment and sex. Female pigs in barren environment spent more time on bullying than females in enriched pens. There was an interaction of pen environment and sex on time spent lying down and walking (p<0.05). Female pigs in enriched pens spent more time lying down than females in barren pens. Males in barren pens spent more time walking than males in enriched pens while no effect of pen environment was observed in females. There was an interaction of pen environment and sex on the number of skin lesions in the head, neck and shoulder region and other parts of the body (p<0.05). Conclusion: It was concluded that pen enrichment reduced the number of skin lesions and anti-social behaviors, especially for female pigs. There is a need, therefore of housing indigenous pigs under confinement.

• Molecules and Cells
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• 제44권1호
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• pp.50-62
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• 2021

Among all cancer types, lung cancer ranks highest worldwide in terms of both incidence and mortality. The crosstalk between lung cancer cells and their tumor microenvironment (TME) has begun to emerge as the "Achilles heel" of the disease and thus constitutes an attractive target for anticancer therapy. We previously revealed that crosstalk between lung cancer cells and endothelial cells (ECs) induces chemoresistance in multicellular tumor spheroids (MCTSs). In this study, we demonstrated that factors secreted in response to crosstalk between ECs and lung cancer cells play pivotal roles in the development of chemoresistance in lung cancer spheroids. We subsequently determined that the expression of hypoxia up-regulated protein 1 (HYOU1) in lung cancer spheroids was increased by factors secreted in response to crosstalk between ECs and lung cancer cells. Direct interaction between lung cancer cells and ECs also caused an elevation in the expression of HYOU1 in MCTSs. Inhibition of HYOU1 expression not only suppressed stemness and malignancy, but also facilitated apoptosis and chemosensitivity in lung cancer MCTSs. Inhibition of HYOU1 expression also significantly increased the expression of interferon signaling components in lung cancer cells. Moreover, the activation of the PI3K/AKT/mTOR pathway was involved in the HYOU1-induced aggression of lung cancer cells. Taken together, our results identify HYOU1, which is induced in response to crosstalk between ECs and lung cancer cells within the TME, as a potential therapeutic target for combating the aggressive behavior of cancer cells.

• 인터넷정보학회논문지
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• 제22권3호
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• pp.45-52
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• 2021

사이버 보안의 침입탐지 시스템에서 알려지지 않는 공격을 식별하기 위한 많은 연구가 이루어지고 있지만, 그 중에서도 이상치를 기반으로 하는 연구가 주목받고 있다. 이에 따라 우리는 알려지지 않는 공격에 대한 범주를 정의하여 이상치를 식별한다. 알려지지 않는 공격은 2가지 범주로 조사하였는데, 첫째는 변종 공격을 생성하는 사항이 있고, 두 번째는 새로운 유형으로 분류하는 연구로 나누었다. 우리는 변종 공격을 생성하는 연구 범주에서 변종과 같이 유사 데이터를 식별할 수 있는 이상치 연구를 수행하였다. 침입탐지 시스템에서 이상치를 식별하는 큰 문제는 정상행동과 공격행동이 같은 공간을 공유하는 것이다. 이를 위해 우리는 이산 웨이블릿 변환으로 정상과 공격에 대해 명확한 유형으로 나눌 수 있는 기법을 적용하고 이상치를 탐지하였다. 결과로 우리는 이산 웨이블릿 변환으로 재구성된 데이터에서 One-Class SVM을 통한 이상치를 식별 할 수 있음을 확인하였다.

• 산업진흥연구
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• 제7권3호
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• pp.71-75
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• 2022

본 연구는 산만 및 충동성향 6세 여아에 대한 아동중심놀이치료 이론을 기반으로 한 아동상담 사례이다. 아동의 산만 및 충동성향으로 인하여 어머니는 양육에 어려움을 겪고 있었다. 아동상담은 Full Battery 심리검사를 실시한 후, 2020년 11월 19일부터 2022년 6월 16일까지 주 1회 회기별 아동상담 40분 부모상담 10분씩 총 63사례회기 진행하였다. 아동은 상담과정에서 아동의 주도적인 놀이를 통해 애정욕구 및 공격적이고 충동적인 모습을 나타냈으며, 상담을 통해 안정감을 느끼며 산만 및 충동성향이 감소하는 행동을 보였다. 또한 아동은 부모에게 자신의 감정을 언어로써 구체적으로 표현하고, 초등학교 입학 후 학교적응이 원만한 모습을 보였다. 어머니는 아동양육이 전보다 훨씬 수월해졌다고 보고했으며, 한달에 한번 추후 상담을 하기로 결정하며 상담을 종료하였다. 본 연구는 유아기 아동상담의 시작으로 1년 8개월가량 진행된 사례연구로서, 그 결과로 아동이 초등학교에 입학하여 1, 2학년 시기 동안의 적응적 생활양식을 확인한 연구라는 점에서도 의의가 있다.