• Environmental Engineering Research
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• v.22 no.1
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• pp.61-74
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• 2017

This study investigated the effect of various cations ($Ca^{2+}$, $Mg^{2+}$, $Al^{3+}$, $Mn^{2+}$, $Zn^{2+}$) on the autoaggregation (AAg) and surface hydrophobicity (SHb) of three different bacteria (Brevibacillus panacihumi strain (ZB1), Lysinibacillus fusiformis strain (ZB2) and Enterococcus faecalis strain (ZL)) using a 2-level factorial design. The AAg ratio was measured from the changes in the absorbance of the media. Results show that ZB2 had maximum AAg for the three bacteria investigated. A microscopic clustering of cells was observed when $Ca^{2+}$ was added to ZB2. The AAg was in the range of 62%, 58% and 34% for ZB2, ZB1 and ZL, respectively and correlated to the SHb. The aggregation and SHb of the microbial cells increased with increasing ionic strength due to the repulsive steric or overlap forces between the polymer covered surfaces. $Ca^{2+}$ demonstrated a more significant effect on aggregation and SHb of microbial cells due to an attractive binding force.

• Toxicological Research
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• v.13 no.3
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• pp.229-235
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• 1997

The elevation of intracellular calcium in various tissues due to oxidative stress induced by either menadione or adriamycin has been well documented. The increase of calcium level in platelets results in aggregation of platelets. To test the hypothesis that chemically induced calcium elevations can play a role in platelet aggregation, we have studied the effects of menadione and adriamycin on aggregation of platelets isolated from female rats. Treatment with menadione and adriamycin to platelet rich plasma (PRP) appeared to induce platelet aggregations up to 60%, as determined by aggregometry. However, exposure of PRP to rnenadione or adriamycin led to a loss of viability, as measured by lactate dehydrogenase (LDH) leakage. Morphological studies of platelets revealed that, when PRP was treated with menadione, aggregates of platelets were not observed and the numbers of platelets were decreased significantly. This suggests that menadione and adriamycin decreased turbidity by inducing platelet lysis rather than platelet aggregation. These cellular toxicities induced by menadione or adriamycin was not correlated with oxygen consumption rate but with depletion of protein thiols, suggesting that protein thiols might play an important role in chemical-induced platelet toxicity.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.3
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• pp.490-508
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• 2013

One of the most important scalability issues facing the current Internet is the rapidly increasing rate of BGP updates (BGP churn), to which route flap and path exploration are the two major contributors. Current countermeasures would either cause severe reachability loss or delay BGP convergence, and are becoming less attractive for the rising concern about routing convergence as the prevalence of Internet-based real time applications. Based on the observation that highly active prefixes usually repeatedly explore very few as-paths during path exploration, we propose a router-level mechanism, Path Exploration Aggregation (PEA), to scale BGP without either causing prefix unreachable or slowing routing convergence. PEA performs aggregation on the transient paths explored by a highly active prefix, and propagates the aggregated path instead to reduce the updates caused by as-path changes. Moreover, in order to avoid the use of unstable routes, PEA purposely prolongs the aggregated path via as-path prepending to make it less preferred in the perspective of downstream routers. With the BGP traces obtained from RouteViews and RIPE-RIS projects, PEA can reduce BGP updates by up to 63.1%, shorten path exploration duration by up to 53.3%, and accelerate the convergence 7.39 seconds on average per routing event.

• Bulletin of the Korean Chemical Society
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• v.33 no.7
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• pp.2255-2259
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• 2012

Aggregation of titania nanotubes (TNTs) fabricated by hydrothermal method were calcined in air and dry nitrogen; Changes in morphology and crystallinity of the nanotubes were studied by means of TEM, EDX, and XPS. EDX patterns and XPS spectra proved that there were a certain densities of oxygen vacancies in TNTs annealed in $N_2$. The photocatalysis experiments revealed TNTs/$N_2$ possesses significantly higher photocatalytic efficiency than TNTs annealed in dry air to degrade methylene blue. The correlation between oxygen vacancies and photocatalytic property may be attributed to: 1) oxygen vacancies might have affected results on water molecules adsorption and increase of the hydroxyl concentration; and 2) oxygen vacancies resulted in some changes in electronic structure of TNTs/$N_2$ aggregation and Fermi level extends into the conducting band.

• The Korean Journal of Blood Transfusion
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• v.29 no.3
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• pp.229-239
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• 2018

The circulatory system is closely related to the inter-relationship between the anatomy of the heart and blood vessels, and the fluid dynamic properties of blood. The physical properties of blood, which affect blood flow, are called hemorheologic factors. Hemorheologic factors, such as blood viscosity and erythrocyte aggregation, are influenced mainly by hematocrit. A higher hematocrit level results in an increase in blood viscosity, erythrocyte aggregation, which impedes the circulation itself, and tissue oxygenation. An excess of serum ferritin causes injury to vascular endothelial cells and erythrocytes via oxygen free radicals. In addition, an excess of blood can aggravatee the adverse effects of the hemorheologic parameters and induce atherogenesis, microcirculatory disturbances, and major cardiovascular events. A preventive and therapeutic approach with a phlebotomy or blood donation has been stimulated by the knowledge that blood loss, such as regular donations, is associated with significant decreases in key hemorheologic variables, including blood viscosity, erythrocyte aggregation, hematocrit, and fibrinogen. Major cardiovascular events have been improved in regular blood donors by improving blood flow and microcirculation by decreasing the level of oxidative stress, improving the hemorheologic parameters, and reducing the serum ferritin level. Confirmation of the positive preventive and therapeutic effects of blood donations on cardiovascular disease by a well-designed and well-controlled Cohort study may be good news to patients with cardiovascular disease or at risk of these diseases, as well as patients who require a transfusion.

• Journal of Broadcast Engineering
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• v.20 no.2
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• pp.300-309
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• 2015

In IEEE 802.11n WLANs(Wireless Local Area Networks), to support high throughput, MAC(Media Access Control) layer adopts A-MSDU(Aggregate-MAC Service Data Unit) and A-MPDU(Aggregate-MAC Protocol Data Unit). Generally, as the A-MPDU uses a selective retransmission capability, A-MPDU provides higher throughput than A-MSDU. However, although A-MPDU uses the selective re-transmission capability, if the size of MPDU within A-MPDU is smaller than the size of minimum MPDU starting spacing, A-MPDU can reduce throughput because of the overhead of retransmission owing to the addition of delimiter, that is a dummy MPDU. Therefore, to overcome the above problem, two-level Aggregation method, where the small MPDU within A-MPDU is replaced by not delimiter but A-MSDU, has been introduced. In the two-level Aggregation method, the existing re-transmission scheme retransmits only A-MPDU, but if the size of retransmission data is smaller than the size of the minimum MPDU starting spacing, the proposed retransmission scheme retransmits the aggregated retransmission data and MSDUs. Therefore, we know that the proposed retransmission scheme have better throughput that the existing retransmission scheme.

• Proceedings of the Korea Information Processing Society Conference
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• 2007.05a
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• pp.870-872
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• 2007

Sensor networks have been widely applied for data collection. Due to the energy limitation of the sensor nodes and the most energy consuming data transmission, we should allocate as much work as possible to the sensors, such as data compression and aggregation, to reduce data transmission and save energy. Querying extreme values is a general query type in wireless sensor networks. In this paper, we propose a novel querying method called Two-Level Filter (TLF) for querying extreme values in wireless sensor networks. We first divide the whole sensor network into domains using the Distributed Data Aggregation Model (DDAM). The sensor nodes report their data to the cluster heads using push method. The advantages of two-level filter lie in two aspects. When querying extreme values, the number of pull operations has the lower boundary. And the query results are less affected by the topology changes of the wireless sensor network. Through this method, the sensors preprocess the data to share the burden of the base station and it combines push and pull to be more energy efficient.

• Proceedings of the KOR-KST Conference
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• 2007.11a
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• pp.163-169
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• 2007

• Korean Journal of Veterinary Research
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• v.36 no.4
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• pp.873-886
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• 1996

For better understanding the interrelationship of hemorrhage and aggregation mechanism, cyclopiazonic acid(CPA) known as promoting the aggregation of platelet, aflatoxin $B_1(AFB_1)$ inhibiting platelet aggregation were used as toxic mycotoxins in these studies. In order to investigate the potential role of prostaglandin metabolism on the platelet aggregation, a variety of prostaglandin metabolites such as $PGF_{2{\alpha}}$, $PGE_2$ and $TXB_2$ were measured in homogenized rabbit platelets by TLC and LSC. And the role of $Ca^{{+}{+}}$ on the platelet aggregation was investigated by flow cytometer. Finally, the morphological effects of mycotoxins on platelet were determined by transmission electron microscope. The results and conclusions obtained from these studies are: 1) CPA induced no changes but $AFB_1$ increased $PGE_2$ and $TXB_2$. 2) CPA promoted ADP, collagen, thrombin, A.A., and PAF-induced $Ca^{{+}{+}}$ release. $AFB_1$, however, decreased $Ca^{{+}{+}}$ level except collagen-induced $Ca^{{+}{+}}$ release. When the calcium blocker, verapamil, was used, CPA decreased thrombin-induced $Ca^{{+}{+}}$ release and increased collagen, ADP, PAF and A.A.-induced $Ca^{{+}{+}}$ release. $AFB_1$ in contrast decreased the all factors induced $Ca^{{+}{+}}$ release. 3) $AFB_1$ did not induce any ultrastructural changes except large vacuole formation in a few platelets. And CPA also did not induce any changes except moderate shape change, indicator of platelet activation. In conclusion, CPA promoted platelet aggregation by the increases of $Ca^{{+}{+}}$ release but had no changes in A.A. metabolites. Antiaggregating effects of $AFB_1$ may be due to decreases of $Ca^{{+}{+}}$ release and increases of $PGE_2$ and $PGF_{2{\alpha}}$ formation. These data provide the basis for the future study of mobilization and function of $Ca^{{+}{+}}$ in platelet aggregation.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.1
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• pp.34-41
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• 2019

Platelet aggregation is essential for the formation of a hemostatic plug in the case of blood vessel damage. On the other hand, excessive platelet aggregation may cause cardiovascular disorders, such as thrombosis, atherosclerosis, and myocardial infarction. Scopoletin, which found in the root of plants in the genus Scopolia or Artemisia, has anti-coagulation and anti-malaria effects. This study examined the effects of scopoletin on human platelet aggregation induced by collagen. Scopoletin had anti-platelet effects via the down-regulation of thromboxane $A_2$ ($TXA_2$) production and intracellular $Ca^{2+}$ mobilization ($[Ca^{2+}]_i$), which are aggregation-inducing molecules produced in activated platelets. On the other hand, scopoletin increased both the cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) levels, which are known as intracellular $Ca^{2+}$-antagonists and aggregation-inhibiting molecules. In particular, scopoletin increased the potently cAMP level more than cGMP, which led to suppressed fibrinogen binding to ${\alpha}IIb/{\beta}_3$ in collagen-induced human platelet aggregation. In addition, scopoletin inhibited collagen-elevated adenosine triphosphate (ATP) release in a dose-dependent manner. The results suggest that aggregation amplification through granule secretion is inhibited by scopoletin. Therefore, scopoletin has potent anti-platelet effects and may have potential for the prevention of platelet-derived vascular diseases.