• Journal of Microbiology and Biotechnology
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• v.26 no.10
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• pp.1808-1816
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• 2016

As a scaffolding subunit of the PIK3C3/VPS34 complex, Beclin 1 recruits a variety of proteins to class III phosphatidylinositol-3-kinase (VPS34), resulting in the formation of a distinct PIK3C3/VPS34 complex with a specific function. Therefore, the investigation of a number of Beclin 1 domains required for the protein-protein interactions will provide important clues to understand the PIK3C3/VPS34 complex, of which Beclin1-VPS34 interaction is the core unit. In the present study, we have designed a bacterial overexpression system for the Beclin 1 domain corresponding to VPS34 binding (Vps34-BD) and set up the denaturing purification protocol due to the massive aggregation of Vps34-BD in Escherichia coli. The expression and purification conditions determined in this study successfully provided soluble and functional Vps34-BD.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.21 no.9
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• pp.496-504
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• 2009

In order to investigate the feasibility of a direct ice slurry transporting system for the purpose of district cooling, a case study of field application is performed. The research aims include the field measurement of ice packing factor, the performance of coldness delivery, and the branching characteristics of ice slurry. Two representative types of pipe branch are dealt with in this work. For the slurry flow with ice volume fraction of 0.16 or less, the pipe blocking due to aggregation is not observed. Based on the time-wise variation of temperature in the storage tank, a calculating method of ice packing factor is newly developed, which seems to be useful when the brine concentration is unknown. It is confirmed that the mass flow rate of ice slurry per unit cooling load is markedly reduced with increasing the ice content. The pumping power also decreases, but remains unchanged for high ice fractions. The distribution of ice particle before and after branching shows a good uniformity within the range of 5% difference, but yields a unique trend depending on the flow rate.

• Journal of the Korea Society of Computer and Information
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• v.13 no.5
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• pp.69-76
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• 2008

In this thesis, we implemented the prototype system for the class code generator based on consistent code generation process and standard type, the class to be component unit. Particularly, we proposed relationship rule to solve the difficult problem by the object-oriented language to association and aggregation between classes based on component, through this method we can make to consistent code generation standard. Also it is adopted to component model construction which is generated code using code generation, and it can be basic assembly and deployment of business components to reusable target in developing application system.

• Journal of Intelligence and Information Systems
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• v.29 no.4
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• pp.229-256
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• 2023

The increase in telecommuting and household electricity demand due to the pandemic has led to significant changes in electricity demand patterns. This has led to difficulties in identifying KEPCO's PPA (power purchase agreements) and residential solar power generation and has added to the challenges of electricity demand forecasting and grid operation for power exchanges. Unlike other energy resources, electricity is difficult to store, so it is essential to maintain a balance between energy production and consumption. A shortage or overproduction of electricity can cause significant instability in the energy system, so it is necessary to manage the supply and demand of electricity effectively. Especially in the Fourth Industrial Revolution, the importance of data has increased, and problems such as large-scale fires and power outages can have a severe impact. Therefore, in the field of electricity, it is crucial to accurately predict the amount of power generation, such as renewable energy, along with the exact demand for electricity, for proper power generation management, which helps to reduce unnecessary power production and efficiently utilize energy resources. In this study, we reviewed the renewable energy generation forecasting system, its objectives, and practical applications to construct optimal aggregated power resources using data from 169 power plants provided by the Ministry of Trade, Industry, and Energy, developed an aggregation algorithm considering the settlement of the forecasting system, and applied it to the analytical logic to synthesize and interpret the results. This study developed an optimal aggregation algorithm and derived an aggregation configuration (Result_Number 546) that reached 80.66% of the maximum settlement amount and identified plants that increase the settlement amount (B1783, B1729, N6002, S5044, B1782, N6006) and plants that decrease the settlement amount (S5034, S5023, S5031) when aggregating plants. This study is significant as the first study to develop an optimal aggregation algorithm using aggregated power resources as a research unit, and we expect that the results of this study can be used to improve the stability of the power system and efficiently utilize energy resources.

• Korean Chemical Engineering Research
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• v.52 no.2
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• pp.261-265
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• 2014

As the need for miniaturization in water purification filter increases, the development of filter media for single filtration with multiple function was strongly required. In this study, the molded activated carbon composed of single unit was manufactured by extrusion-sintering process, and then the flow rate, density and porosity were investigated using the molded activated carbon manufactured at various extrusion temperature. We confirmed that it was possible to manufacture the single unit-molded activated carbon when the extrusion temperature was $140{\sim}230^{\circ}C$ more than $133^{\circ}C$ being of polymer binder melting point, and the optimal extrusion temperature for the molded activated carbon with maximum flow rate was $170^{\circ}C$ since the molded activated carbon had low density and high through porosity. Also we confirmed that the flow rate through the molded activated carbon was strongly dependent upon through pore porosity compared to total porosity for the molded activated carbon.

• Journal of the Korean Association of Geographic Information Studies
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• v.8 no.3
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• pp.44-54
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• 2005

Most advanced countries in GIS field have established and managed georeferenced socioeconomic data systematically and made a great profit on various social and economic areas. In Korea, however, socioeconomic geographical information is relatively poor compared to systems related to geographical and topographical features. This is mainly due to the characteristics of the process from the construction to the utilization of socioeconomic data. That is, from the stage of data construction, socioeconomic data require solutions for frequent changes compared to data on geographical and topographical features and, because of difficulties in marking the positions of individual entities, information is built up through setting appropriate spatial units of aggregation. In the stage of data utilization, the data often need to be combined with other types of socioeconomic data due to the complexity of socioeconomic phenomena. Thus, the this study examined usability of GIS in socioeconomic fields and the spatial dimension of socioeconomic information through representative cases of GIS in developed countries and, based on the results, derived data requirements for socioeconomic GIS found in the construction and utilization of data and proposed solutions for the requirements.

• Journal of the Korea Society of Computer and Information
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• v.17 no.1
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• pp.31-40
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• 2012

u-GIS DSMSs have been researched to deal with various sensor data from GeoSensors in ubiquitous environment. Also, they has been more important for high availability. The data from GeoSensors have some characteristics that increase explosively. This characteristic could lead memory overflow and data loss. To solve the problem, various load shedding methods have been researched. Traditional methods drop the overloaded tuples according to a particular criteria in a single server. Tuple deletion sensitive queries such as aggregation is hard to satisfy accuracy. In this paper a dual processing load shedding method is suggested to improve the accuracy of aggregation in clustering environment. In this method two nodes use replicated stream data for high availability. They process a stream in two nodes by using a characteristic they share stream data. Stream data are synchronized between them with a window as a unit. Then, processed results are merged. We gain improved query accuracy without data loss.

• Journal of the Korean Geographical Society
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• v.48 no.6
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• pp.879-896
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• 2013

The assessed land values and housing prices have been widely utilized as a basic information for the land and house trades and for evaluating governmental and local taxes. However, there exists a price difference in actual markets between the assessment level and assessed land values or housing prices. This paper emphasizes the spatial mismatch between the assessed land values and housing market prices and particularly addresses the following two aspects by focusing on spatial effects of the modifiable areal units, which would substantially affect the estimation of the assessed land values and housing prices. First, we examine the spatial distributions of the assessed land values and housing market prices, and the gap between those prices, on the basis of the aggregated spatial units(i.e., aggregation districts). Second, we explore the scale effect of the MAUP(modifiable areal unit problem) generally embedded in estimating the prices of the sampled standard lands and houses, and calibrating the correction index for the land values and housing prices for the individuals. For the application, we analysed the land values and housing prices in Seoul utilizing GIS and statistical software. As a result, some spatial clusters that the housing market prices are significantly higher than the assessed land values were identified at a finer geographic level. Also, it was empirically revealed that the statistical results from the regression of regional variables on the assessed land values for the individuals are significantly affected by the aggregation levels of the spatial units.

• Journal of Life Science
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• v.34 no.3
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• pp.153-159
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• 2024

Dioscorea alata L, commonly known as "tropical yam" is the most widely consumed yam species among the 650 yam species belonging to the Dioscoreacea family. It is extensively cultivated in tropical and subtropical regions and is a major food source in Africa and India. Also, it is used for medicinal purposes, particularly in China and Taiwan, for its anti-inflammatory properties. In comparison to other yam varieties such as D. batatas or D. opposita, the tropical yam has gained popularity in Korea due to its higher yield per unit area. In this study, the nutritional characteristics and anti-thrombosis activity of the aerial bulbils of D. alata L. tropical yam were compared to those of D. opposita. The results showed that the aerial bulbils of tropical yam exhibited nutritional characteristics and potent anticoagulant activity compared to those of domestic yam varieties. The bulbils extract of tropical yam showed superior anticoagulant activities against thrombin, prothrombin and blood coagulation factors. Furthermore, the bulbils extract of tropical yam exhibited strong platelet aggregation inhibition at 0.25 mg/ml and showed no hemolytic activity up to a concentration of 2.5 mg/ml. These findings suggest the potential development of high-value anti-thrombosis agents utilizing the aerial bulbils of tropical yam.

• Journal of Korean Neurosurgical Society
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• v.61 no.2
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• pp.201-211
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• 2018

Objective : The purpose of this study was to analyze the variability of clopidogrel responses according to duration of a clopidogrel drug regimen after stent-assisted coil embolization (SAC), and to determine the correlation between the variability of clopidogrel responses and thromboembolic or hemorrhagic complications. Methods : A total of 47 patients who underwent SAC procedures to treat unruptured intracranial aneurysms were enrolled in the study. Preoperatively, patients received more than seven days of aspirin (100 mg) and clopidogrel (75 mg), daily. P2Y12 reaction unit (PRU) was checked with the VerifyNow test one day before the procedure (pre-PRU) and one month after the procedure (post-PRU). PRU variability was calculated as the difference between the initial response and the follow-up response. Patients were sorted into two groups based on their response to treatment : responsive and hypo-responsive. Results : PRU variability was significantly greater in the hypo-responsive group when compared to the responsive group (p=0.019). Pre-PRU and serum platelets counts were significantly correlated with PRU variation (p=0.005 and p=0.004, respectively). Although thromboembolic complication had no significant correlated factors, hemorrhagic complication was correlated with pre-PRU (p=0.033). Conclusion : In conclusion, variability of clopidogrel responses during clopidogrel medication was correlated to serum platelet counts and the initial clopidogrel response. Thromboembolic and hemorrhagic complications did not show correlation with the variability of clopidogrel response, or the clopidogrel response after one month of medication; however, hemorrhagic complication was associated with initial clopidogrel response. Therefore, it is recommended to test patients for an initial clopidogrel response only, as further tests would be insignificant.