Clopidogrel Response Variability in Unruptured Intracranial Aneurysm Patients Treated with Stent-Assisted Endovascular Coil Embolization : Is Follow-Up Clopidogrel Response Test Necessary? |
Kim, Min Soo
(Department of Neurosurgery, Ulsan University Hospital, University of Ulsan College of Medicine)
Park, Eun Suk (Department of Neurosurgery, Ulsan University Hospital, University of Ulsan College of Medicine) Park, Jun Bum (Department of Neurosurgery, Ulsan University Hospital, University of Ulsan College of Medicine) Lyo, In Uk (Department of Neurosurgery, Ulsan University Hospital, University of Ulsan College of Medicine) Sim, Hong Bo (Department of Neurosurgery, Ulsan University Hospital, University of Ulsan College of Medicine) Kwon, Soon Chan (Department of Neurosurgery, Ulsan University Hospital, University of Ulsan College of Medicine) |
1 | Akpek S, Arat A, Morsi H, Klucznick RP, Strother CM, Mawad ME : Selfexpandable stent-assisted coiling of wide-necked intracranial aneurysms: a single-center experience. AJNR Am J Neuroradiol 26 : 1223-1231, 2005 |
2 | Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Ramirez C, Cavallari U, Trabetti E, et al. : Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel. Arterioscler Thromb Vasc Biol 26 : 1895-1900, 2006 DOI |
3 | Roy D, Milot G, Raymond J : Endovascular treatment of unruptured aneurysms. Stroke 32 : 1998-2004, 2001 DOI |
4 | Ryu CW, Park S, Shin HS, Koh JS : Complications in stent-assisted endovascular therapy of ruptured intracranial aneurysms and relevance to antiplatelet administration: a systematic review. AJNR Am J Neuroradiol 36 : 1682-1688, 2015 DOI |
5 | Siasos G, Tousoulis D, Stefanadis C : Multiple mechanisms affect the clopidogrel response. J Am Coll Cardiol 53 : 900-901; author reply 901, 2009 |
6 | Delgado Almandoz JE, Crandall BM, Scholz JM, Fease JL, Anderson RE, Kadkhodayan Y, et al. : Pre-procedure P2Y12 reaction units value predicts perioperative thromboembolic and hemorrhagic complications in patients with cerebral aneurysms treated with the pipeline embolization device. J Neurointerv Surg 5 Suppl 3 : iii3- iii10, 2013 DOI |
7 | Tousoulis D, Siasos G, Zaromitidou M, Oikonomou E, Maniatis K, Kioufis S, et al. : The impact of CYP2C19 genotype on cardiovascular events and platelet reactivity in patients with coronary artery disease receiving clopidogrel. Int J Cardiol 168 : 1594-1596, 2013 DOI |
8 | Wanke I, Forsting M : Stents for intracranial wide-necked aneurysms: more than mechanical protection. Neuroradiology 50 : 991-998, 2008 DOI |
9 | Weisz G, Smilowitz NR, Kirtane AJ, Rinaldi MJ, Parvataneni R, Xu K, et al. : Proton pump inhibitors, platelet reactivity, and cardiovascular outcomes after drug-eluting stents in clopidogrel-treated patients: the ADAPT-DES study. Circ Cardiovasc Interv 8 : e001952, 2015 |
10 | Delgado Almandoz JE, Crandall BM, Scholz JM, Fease JL, Anderson RE, Kadkhodayan Y, et al. : Last-recorded P2Y12 reaction units value is strongly associated with thromboembolic and hemorrhagic complications occurring up to 6 months after treatment in patients with cerebral aneurysms treated with the pipeline embolization device. AJNR Am J Neuroradiol 35 : 128-135, 2014 DOI |
11 | Delgado Almandoz JE, Kadkhodayan Y, Crandall BM, Scholz JM, Fease JL, Tubman DE : Variability in initial response to standard clopidogrel therapy, delayed conversion to clopidogrel hyper-response, and associated thromboembolic and hemorrhagic complications in patients undergoing endovascular treatment of unruptured cerebral aneurysms. J Neurointerv Surg 6 : 767-773, 2014 DOI |
12 | Drazin D, Choulakian A, Nuno M, Kornbluth P, Alexander MJ : Body weight: a risk factor for subtherapeutic antithrombotic therapy in neurovascular stenting. J Neurointerv Surg 3 : 177-181, 2011 DOI |
13 | Fifi JT, Brockington C, Narang J, Leesch W, Ewing SL, Bennet H, et al. : Clopidogrel resistance is associated with thromboembolic complications in patients undergoing neurovascular stenting. AJNR Am J Neuroradiol 34 : 716-720, 2013 DOI |
14 | Geyik S, Yavuz K, Yurttutan N, Saatci I, Cekirge HS : Stent-assisted coiling in endovascular treatment of 500 consecutive cerebral aneurysms with long-term follow-up. AJNR Am J Neuroradiol 34 : 2157-2162, 2013 DOI |
15 | Brisman JL, Song JK, Newell DW : Cerebral aneurysms. N Engl J Med 355 : 928-939, 2006 DOI |
16 | Kim MS, Jo KI, Yeon JY, Kim JS, Kim KH, Jeon P, et al. : Safety and efficacy of antiplatelet response assay and drug adjustment in coil embolization: a propensity score analysis. Neuroradiology 58 : 1125-1134, 2016 DOI |
17 | Giustino G, Kirtane AJ, Genereux P, Baber U, Witzenbichler B, Neumann FJ, et al. : Relation between platelet count and platelet reactivity to thrombotic and bleeding risk: from the assessment of dual antiplatelet therapy with drug-eluting stents study. Am J Cardiol 117 : 1703-1713, 2016 DOI |
18 | Hwang G, Huh W, Lee JS, Villavicencio JB, Villamor RB Jr, Ahn SY, et al. : Standard vs modified antiplatelet preparation for preventing thromboembolic events in patients with high on-treatment platelet reactivity undergoing coil embolization for an unruptured intracranial aneurysm: a randomized clinical trial. JAMA Neurol 72 : 764-772, 2015 DOI |
19 | Hwang G, Kim JG, Song KS, Lee YJ, Villavicencio JB, Suroto NS, et al. : Delayed ischemic stroke after stent-assisted coil placement in cerebral aneurysm: characteristics and optimal duration of preventative dual antiplatelet therapy. Radiology 273 : 194-201, 2014 DOI |
20 | Kim MS, Jo KI, Yeon JY, Kim JS, Kim KH, Jeon P, et al. : Association between postprocedural infarction and antiplatelet drug resistance after coiling for unruptured intracranial aneurysms. AJNR Am J Neuroradiol 37 : 1099-1105, 2016 DOI |
21 | Maruyama H, Fukuoka T, Deguchi I, Ohe Y, Kato Y, Horiuchi Y, et al. : Response to clopidogrel and its association with chronic kidney disease in noncardiogenic ischemic stroke patients. Intern Med 53 : 215-219, 2014 DOI |
22 | Pierot L, Wakhloo AK : Endovascular treatment of intracranial aneurysms: current status. Stroke 44 : 2046-2054, 2013 DOI |
23 | Mehran R, Rao SV, Bhatt DL, Gibson CM, Caixeta A, Eikelboom J, et al. : Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium. Circulation 123 : 2736-2747, 2011 DOI |
24 | Mocco J, Fargen KM, Albuquerque FC, Bendok BR, Boulos AS, Carpenter JS, et al. : Delayed thrombosis or stenosis following enterprise-assisted stent-coiling: is it safe? Midterm results of the interstate collaboration of enterprise stent coiling. Neurosurgery 69 : 908-913; discussion 913-914, 2011 DOI |
25 | Nakagawa I, Park HS, Yokoyama S, Wada T, Hironaka Y, Motoyama Y, et al. : Influence of diabetes mellitus and cigarette smoking on variability of the clopidogrel-induced antiplatelet effect and efficacy of active management of the target P2Y12 reaction unit range in patients undergoing neurointerventional procedures. J Stroke Cerebrovasc Dis 25 : 163-171, 2016 DOI |
26 | Ojeifo O, Wiviott SD, Antman EM, Murphy SA, Udell JA, Bates ER, et al. : Concomitant administration of clopidogrel with statins or calciumchannel blockers: insights from the TRITON-TIMI 38 (trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-thrombolysis in myocardial infarction 38). JACC Cardiovasc Interv 6 : 1275-1281, 2013 DOI |
27 | Oxley TJ, Dowling RJ, Mitchell PJ, Davis S, Yan B : Antiplatelet resistance and thromboembolic complications in neurointerventional procedures. Front Neurol 2 : 83, 2011 |
28 | Park KW, Park JJ, Kang J, Jeon KH, Kang SH, Han JK, et al. : Paraoxonase 1 gene polymorphism does not affect clopidogrel response variability but is associated with clinical outcome after PCI. PLoS One 8 : e52779, 2013 DOI |
29 | Pierot L, Biondi A : Endovascular techniques for the management of wide-neck intracranial bifurcation aneurysms: a critical review of the literature. J Neuroradiol 43 : 167-175, 2016 DOI |
30 | Qureshi Z, Hobson AR : Clopidogrel "resistance": where are we now? Cardiovasc Ther 31 : 3-11, 2013 DOI |
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