• Journal of Animal Science and Technology
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• 제48권2호
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• pp.287-292
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• 2006

연도증진의 가장 일반적인 방법인 숙성을 통해 말고기의 육질과 관능적 특성이 어떻게 변화하는지를 조사하여 말고기의 적정 숙성기간을 제시하고, 국내 말고기의 냉장 유통에 대비한 기초자료를 확보하고자 제주마 24두의 등심을 4℃에서 25일간 숙성시키면서 육질과 관능적 특성을 조사하였다. 말고기 pH는 숙성기간에 따라 차이가 없었으며, 전단력은 저장 12일까지 유의적으로 감소하다가(P<0.05) 12일 이후 차이를 나타내지 않았다. 보수력, 가열감량 및 포장감량은 숙성기간이 경과할수록 증가하는 경향이였으며, 육색특성은 숙성기간이 경과할수록 명도(L*)와 적색도(a*) 값이 증가하는 경향을 보였다. 관능적 특성 중 풍미는 저장 7일에 가장 높은 수치를 나타내었고, 다즙성은 숙성 12일에 패널에 의해 가장 좋은 점수를 받았으며, 연도는 숙성 7일에 유의적인 증가를 보였으며(P<0.05) 이후 숙성기간에는 차이가 없었다. 숙성기간별 말고기에 대한 전체기호도는 숙성 7일에 유의적인 증가를 보인 후 숙성 18일까지 지속하다가 25일에 다소 감소하였다(P<0.05). 이상의 결과로 볼 때 말고기 등심의 최적숙성기간은 도축 후 9～14일로 나타났으며, 도축 후 20일 이후에는 기호성과 육질이 저하되는 결과를 보였다.

• 보존과학회지
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• 제36권1호
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• pp.1-14
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• 2020

This study investigates the crystallinity distribution of ancient silk. Owing to the inherent multi-hierarchical structure of silk protein and the complicated structural changes that occur due to various burial environments, it is challenging but worthwhile to study ancient silk ageing behavior, which is based on the fact that ageing begins with a single fiber and then spreads to a whole fabric. Crystallinity was one of the most effective indicators found to reveal the ageing status of silk. Therefore, a synchrotron radiation-based X-ray diffraction(SR-XRD) method was employed to study the crystallinity distribution of single fibers of ancient silk unearthed from seven archaeological sites in China from historical periods including the warring states, Han dynasty, Song dynasty, and Ming dynasty. In comparison, the conventional X-ray diffraction method, which uses large amounts of samples, was also performed to determine the integral crystallinity of ancient silk. Thermal stability experiments by thermogravimetry(TG) as well as morphology observations by scanning electron microscopy(SEM) and optical microscopy(OM) all confirmed the deterioration of ancient silk. Moreover, the ageing mechanism of ancient silk was proposed with the assistance of an artificial ageing study. The results confirmed the effectiveness of SR-XRD as an ageing indicator, revealing the crystallinity distribution. This research could provide motivation to determine the deterioration status of ancient silk, and would also aid in explaining the fragility of ancient silk due to ageing.

• Korean Journal of Acupuncture
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• 제20권1호
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• pp.45-55
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• 2003

Backgrounds : It has been investigated about ageing theory. However, ageing mechanism still remains to be unknown. Since Harman proposes that ageing and ageing related diseases might be due to oxidative damage and these are modifiable by genetic and environmental factors. For designing an optimal nutritional countermeasure against ageing and ageing related disease, it is necessary to understand the ageing mechanism and other reactive species. Objectives : Schizandra Chinesis has been clinically used to treat brain disease, respiratory or inflammatory disease etc. in Oriental medicine. The purpose of this study is to investigate the scavenging effect of Schizandrae Fructus herbal-acupuncture solution(SFHA) on NO, DPPH and IL-4. Results : The results are summarized as follows; (1) There is a significant scavenging effect of SFHA on NO in 0.1, 1, 10mg/ml group after 24hrs. (2) There is a significant scavenging effect of SFHA on DPPH in 1, $10{\mu}g/ml$ group. (3) There is a significant inhibitory effect of SFHA on IL-4 in 1, 10, $100{\mu}g/ml$ group. Conclusions : These findings indicate that SFHA can be used as antioxidant or antiimflammatory drug. But further study is needed about the effect of SFHA.

• BMB Reports
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• 제53권6호
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• pp.311-316
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• 2020

Cholestasis is a condition in which the bile duct becomes narrowed or clogged by a variety of factors and bile acid is not released smoothly. Bile acid-induced liver injury is facilitated by necrotic cell death, neutrophil infiltration, and inflammation. Metformin, the first-line treatment for type 2 diabetes, is known to reduce not only blood glucose but also inflammatory responses. In this study, we investigated the effects of metformin on liver injury caused by cholestasis with bile acid-induced hepatocyte injury. Static bile acid-induced liver injury is thought to be related to endoplasmic reticulum (ER) stress, inflammatory response, and chemokine expression. Metformin treatment reduced liver injury caused by bile acid, and it suppressed ER stress, inflammation, chemokine expression, and neutrophil infiltration. Similar results were obtained in mouse primary hepatocytes exposed to bile acid. Hepatocytes treated with tauroursodeoxycholic acid, an ER stress inhibitor, showed inhibition of ER stress, as well as reduced levels of inflammation and cell death. These results suggest that metformin may protect against liver injury by suppressing ER stress and inflammation and reducing chemokine expression.

• Nuclear Engineering and Technology
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• 제8권1호
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• pp.19-27
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• 1976

질칼로이-4의 가공시효(strain ageing) 현상을 173-575$^{\circ}C$의 온도구간에서 소입된 시편과 소둔된 시편에 대해 각각 조사하였다. 소입된 질칼로이-4의 가공시효가 175-50$0^{\circ}C$구간체서 난타났으며, 3$25^{\circ}C$에서 극대값의 가공시효가 조사였었다. 반면 소둔된 시편의 경우엔 175-575$^{\circ}C$ 구간에 걸쳐 가공시효가 나타났으며, 이 온도구간 사이에 3$25^{\circ}C$ 및 45$0^{\circ}C$의 두 지점에서 극대값이 나타나는 것을 확인했다. 소입된 경우와 소둔된 경우에 모두 3$25^{\circ}C$에서 보인 가공시효의 극대값은 시효동안에 전위조직 속으로 침입형 산소원자들의 응집에 의한 결과로 고려되며 45$0^{\circ}C$에서 보이는 극대값은 철원자와 전위간의 작용에 기인된 것으로 해석된다. 질코늄 합금의 30$0^{\circ}C$ 근처에서 보이는 가공시효값은 첨가된 산소량의 평방근에 비례한다는 것이 확인됐다.

• 해양환경안전학회:학술대회논문집
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• 해양환경안전학회 2018년도 공동국제학술발표회
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• pp.73-74
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• 2018

• Journal of Dairy Science and Biotechnology
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• 제23권2호
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• pp.107-114
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• 2005

The trend towards ageing populations has been observed over many years in Europe and the US but has accelerated significantly in developed countries in Asia including Japan and South Korea. In the latter country the elderly population (65+) has increased 5-fold between 1960 and 2000 and this group will comprise 40% of the population by 2050. This creates a new socio-economic group with specific demands and considerable spending power. As ageing occurs a range of changes occur in the body that can be moderated by adjustments in nutrition. A significant body of evidence points to changes in the balance of glutathione synthesis and utilisation as people age. Glutathione is tile most important natural anti-oxidant of the body and the amounts present can become limited by available cysteine in the diet. A cysteine-enriched peptide product, Cysteine Peption$^{TM}$ has been developed by DMV International for dietary supplement and food applications. A qualitative consumer trial has indicated benefits including improved sleep and more energy. Animal and clinical trial will be described that provide indications on bioavailability and possible mechanisms of action of Cysteine Peption$^{TM}$ with particular focus on the ageing population.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2001년도 춘계학술발표대회
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• pp.49-49
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• 2001

To elucidate overall changes in DNA methylation that occurs by inappropriate epigenetic control during ageing, we compared fetal bovine fibroblasts and their aged neomycin-resistant versions using bisulfite-PCR technology. Reduction in DNA methylation was observed in euchromatic repeats (18S-rRNA/art2) and promoter regions of sing1e-copy genes (the cytokeratin/-lactoglobulin/interleukin-13 genes). Contrastingly, a stable maintenance of DNA methylation was revealed in various heterochromatic sequences (satellite I/IIalphoid and Bov-B). The differential inheritance modes of DNA methylation was confirmed through the analysis of individual neomycin-resistant clones. These global, multi-loci analyses provide evidence on the tendency of differential epigenetic modification between genomic DNA regions during ageing.

• 한국직업건강간호학회지
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• 제20권2호
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• pp.185-194
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• 2011

Purpose: Global shortages in nursing and strong demand for nursing services provided Korean nurses with more overseas employment opportunities, especially in the developed countries such as the United States and Canada. The purpose of this study was to explore the ageing experiences of the Korean nurses dispatched to Germany in the 1960s and 1970s. Methods: The researcher interviewed 10 Korean nurses living in four cities in Germany. Interviews were performed twice in January and July, 2010, and the data, in the form of field notes and interview transcripts, were analyzed using the Agar's (1980) ethnographic method. Results: The ageing experiences of the participants can be summarized into three theme stages: coming upon old age, reluctantly realizing getting old, and finally accepting being old. The first stage is characterized by 'wiring money to homeland all throughout youth', second 'still feeling like a stranger anywhere', and finally 'burying homeland in heart'. Conclusion: The research findings not only suggest crucial materials for training prospective nurses overseas for their successful settlement, but also shed lights on related problems and solutions with ageing experience in overseas employment.

• 대한지리학회지
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• 제43권3호
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• pp.337-357
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• 2008

본 논문은 서울의 인구고령화 현상을 살펴보고 이들 고령자 취업의 지역적 특성을 고찰하는 연구이다. 서울시 구별 자료를 토대로 노령화지수와 장수도를 산출하여 시 공간적 변화와 차이를 확인하였다. 또한 고령자취업알선센터의 자료를 통해 구인처와 구직자, 취업자에 대한 분석을 시도하였다 그 결과, 서울의 인구고령화는 다른 지역에 비해 최근 들어서 빠른 속도로 진행되었고, 서울 내에서 각 구별로 지역적 차별화를 보였다. 고령자의 취업현황을 살펴보면 단순노무직 비율이 전국 평균에 비해 높게 나타나고, 고용의 지역적 차별화로 인해, 몇몇 지역을 제외하고는 고령자를 위한 고용기회가 충분하게 주어지지 않았다. 결과적으로, 구인처와 구직자, 취업자간에는 지리적 부조응(geographical mismatch)이 나타났는데, 이는 고령구직자가 자신의 주거지 주위에서 적절한 일자리를 얻기 힘들다는 것을 의미하며, 고령자의 낮은 이동성을 고려할 때 정책적 제도적 지원 및 개선이 필요하다고 생각된다.