Metformin ameliorates bile duct ligation-induced acute hepatic injury via regulation of ER stress |
Lee, Chi-Ho
(Department of Pharmacology and Smart-Ageing Convergence Research Center, Yeungnam University College of Medicine)
Han, Jung-Hwa (Department of Pharmacology and Smart-Ageing Convergence Research Center, Yeungnam University College of Medicine) Kim, Sujin (Department of Pharmacology and Smart-Ageing Convergence Research Center, Yeungnam University College of Medicine) Lee, Heejung (Department of Pharmacology and Smart-Ageing Convergence Research Center, Yeungnam University College of Medicine) Kim, Suji (Department of Pharmacology and Smart-Ageing Convergence Research Center, Yeungnam University College of Medicine) Nam, Dae-Hwan (Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University) Cho, Du-Hyong (Department of Pharmacology and Smart-Ageing Convergence Research Center, Yeungnam University College of Medicine) Woo, Chang-Hoon (Department of Pharmacology and Smart-Ageing Convergence Research Center, Yeungnam University College of Medicine) |
1 | Cai SY, Ouyang X, Chen Y et al (2017) Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight 2, e90780 |
2 | Tamaki N, Hatano E, Taura K et al (2008) CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury. Am J Physiol Gastrointest Liver Physiol 294, G498-505 DOI |
3 | Gujral JS, Farhood A, Bajt ML and Jaeschke H (2003) Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice. Hepatology 38, 355-363 |
4 | Schroder M and Kaufman RJ (2005) ER stress and the unfolded protein response. Mutat Res 569, 29-63 DOI |
5 | Lee DH, Lee B, Park JS et al (2019) Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation. BMB Rep 52, 190-195 DOI |
6 | Kwon MY, Hwanf N, Lee SJ and Chung SW (2019) Nucleotide-binding oligomerization domain protein 2 attenuates ER stress-induced cell death in vascular smooth muscle cells. BMB Rep 52, 665-670 DOI |
7 | Woudenberg-Vrenken TE, Conde de la Rosa L, Buist-Homan M, Faber KN and Moshage H (2013) Metformin protects rat hepatocytes against bile acid-induced apoptosis. PLoS One 8, e71773 DOI |
8 | Tag CG, Sauer-Lehnen S, Weiskirchen S et al (2015) Bile duct ligation in mice: induction of inflammatory liver injury and fibrosis by obstructive cholestasis. J Vis Exp 96, e52438 |
9 | Georgiev P, Jochum W, Heinrich S et al (2008) Characterization of time-related changes after experimental bile duct ligation. Br J Surg 95, 646-656 DOI |
10 | Afonso MB, Rodrigues PM, Simao AL et al (2016) Activation of necroptosis in human and experimental cholestasis. Cell Death Dis 7, e2390 DOI |
11 | Noguchi H, Yamada S, Nabeshima A et al (2014) Depletion of apoptosis signal-regulating kinase 1 prevents bile duct ligation-induced necroinflammation and subsequent peribiliary fibrosis. Am J Pathol 184, 644-661 DOI |
12 | Bailey CJ and Turner RC (1996) Metformin. N Engl J Med 334, 574-579 DOI |
13 | Rena G, Pearson ER and Sakamoto K (2013) Molecular mechanism of action of metformin: old or new insights? Diabetologia 56, 1898-1906 DOI |
14 | Wheaton WW, Weinberg SE, Hamanaka RB et al (2014) Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. Elife 3, e02242 DOI |
15 | Kossor DC, Goldstein RS, Ngo W et al (1995) Biliary epithelial cell proliferation following alpha-naphthylisothiocyanate (ANIT) treatment: relationship to bile duct obstruction. Fundam Appl Toxicol 26, 51-62 DOI |
16 | Sadeghi H, Jahanbazi F, Sadeghi H et al (2019) Metformin attenuates oxidative stress and liver damage after bile duct ligation in rats. Res Pharm Sci 14, 122-129 DOI |
17 | Lien F, Berthier A, Bouchaert E et al (2014) Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk. J Clin Invest 124, 1037-1051 DOI |
18 | Kim J, Kwak HJ, Cha JY et al (2014) Metformin suppresses lipopolysaccharide (LPS)-induced inflammatory response in murine macrophages via activating transcription factor-3 (ATF-3) induction. J Biol Chem 289, 23246-23255 DOI |
19 | Dai J, Liu M, Ai Q et al (2014) Involvement of catalase in the protective benefits of metformin in mice with oxidative liver injury. Chem Biol Interact 216, 34-42 DOI |
20 | Jung TW, Lee MW, Lee YJ and Kim SM (2012) Metformin prevents endoplasmic reticulum stress-induced apoptosis through AMPK-PI3K-c-Jun NH2 pathway. Biochem Biophys Res Commun 417, 147-152 DOI |
21 | Trauner M, Meier PJ and Boyer JL (1998) Molecular pathogenesis of cholestasis. N Engl J Med 339, 1217-1227 DOI |
22 | Kaplowitz N (2004) Drug-induced liver injury. Clin Infect Dis 38 Suppl 2, S44-S48 DOI |