• Biomedical Science Letters
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• v.14 no.1
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• pp.7-12
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• 2008

We examined the prevalence of sarcopenia and age-related changes in body composition in Korean older persons. Community dwelling 77 men and 65 women($60{\sim}88\;yr$) were recruited for this study. Fat-free mass and the percent body fat were determined using bioelectrical impedance analysis. Isometric grip strength was measurement using grip strength dynamometer. Serum levels of fasting glucose, total cholesterol, HDL-cholesterol, and triglyceride were assayed. The prevalence of sarcopenia was found to increase with aging (men in their sixties 82.6%, seventies 96.6% and eighties 100%, and women in their sixties 47.4%, seventies 63%). In both gender groups, handgrip strength was inversely correlated with age and positively correlated with height, lean mass, and fat free mass. Better handgrip strength was related with higher weight in the men and with lower heart rate in the women. Fat free mass, age, and gender were found to be independent factors significantly associated with handgrip strength in the multivariate analysis. In summary, results of the present study suggest that handgrip strength is well associated with age, gender, and fat free mass and the prevalence of sarcopenia is increased with age and is exceeded by 40% among Korean persons older than 60 years.

• Journal of the Korean Society for Precision Engineering
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• v.26 no.12
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• pp.131-137
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• 2009

Recent technological advances made a vehicle more intelligent to increase safety and comfort. An intelligent vehicle provides drivers with safety warning information through audible sounds, visual displays, and tactile devices. However, elderly drivers have been known to decrease the physical and cognitive abilities such as muscular strength, hearing, eyesight, short term memory, and spatial perception. Therefore, possible age-related deficits should be considered to design an effective warning system. This paper aims to evaluate the impact of advancing age on response performance on audible safety warnings which are widely used for alerting driving hazards. In order to understand the effect of age-related hearing loss and movement slowing, three sound characteristics (frequency, intensity, and period) and three age groups (younger, middle, and older) are considered. Data was drawn from 38 drivers who drove a simulated rural road in a driving simulator. Experimental results show that age influences driver's response performance. In conclusion, the appropriate range of a warning sound is suggested.

• Korean Journal of Community Nutrition
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• v.7 no.2
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• pp.232-244
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• 2002

This study investigated the correlation between health-related habits and the biochemical characteristics of the blood of Korean bus drivers. A total of 178 bus drivers working in the Masan area participated in this study. The general characteristics and health-related habits of the subjects were surveyed using a serf-administered questionnaire. The biochemical date were collected from regular health check-ups done through their workshop health insurance company in lune, 1999. The results were as follows : The average age of the subjects was 38 years, and 44.2% had a driving career of between 10 and 19 years. About 90% of the subjects ate irregularly, and 36% ate. health floods. Their rates of drinking, smoking and exercise were 74.6%, 83.6% and 70.8%, respectively. Their frequency of drinking was significantly increased as the length of their driving career increased (p < 0.001). Their levels of total serum cholesterol, in relation to the length of their driving career was significantly higher in the over 20 year group than in the below 10 year group (p < 0.05). Their systolic blood pressures, according to age, were significantly higher in the 51 to 60 age group than in the other groups (p < 0.05). Their total um cholesterol levels signiscantly increased with increasing age (p < 0.001). Their diastolic blood pressures (p < 0.001) and blood glucose levels (p < 0.05) were significantly higher among the subjects who drinking alcohol almost everyday, than among other subjects. Their systolic blood pressures who significantly increased with increasing frequency of their drinking (p < 0.001). The systolic blood pressure and diastolic blood pressure were positively related to age, the amount of drinking, the frequency of drinking and the obesity index, and negatively related to exercise and the duration of exercise. The hemoglobin was positively related to age, preference for a meat diet and the obesity index. The blood glucose was positively related to the amount of drinking, and the total serum cholesterol was positively related to age, length of driving career, period of smoking and the obesity index. The results of this study indicated that bus drivers need regular exercise, moderation of their drinking and smoking, and control of their body weights so as to prevent chronic diseases.

• Journal of the Korean Society of School Health
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• v.17 no.1
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• pp.55-69
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• 2004

Purpose ： To describe epidemiological characteristics and related factors in school personnel with hypertension. Method ： 5,384 school personnel (2,638 males and 2,746 females) received physical examination at the Seoul School Health Center in 2002. blood pressure(BP) was classified by JNC 7th report. Normal BP is systolic BP <120 and diastolic BP<80, prehypertension BP is 120-139 or 80-89mmHg, stage 1 hypertension BP is 140-159 or 90-99, and stage 2 hypertension >=160 or >=100 mmHg. each group was evaluated by gender. We used multiple regression and logistic regression. Results ： Normotension was 20.13% in males and 48.65% in female, prehypertension 43.4% in males and 38.06% in females, stage 1 hypertension 26.38% in males and 10.99% in females, stage2 hypertension 9.59% in males and 3.2% in females. the older age group had higher distribution of stage 1 hypertension and stage 2 hypertension. The means and abnormal rates of BMI, blood sugar, total cholesterol, GOT, GPT, and GTP was higher when their blood pressure was higher. However, an alcohol habit among lifestyle factors had an inverse effect. Higher Bp was correlated to a higher BMI, FBS, and cholesterol-like dose response. In stage 1 hypertension, the related factors of hypertension for males were BMI, amount of cigarettes smoked, exercise, blood sugar, total cholesterol, and GTP. In stage 1 hypertension, age, BMI, exercise, blood sugar, total cholesterol were related factors in female. In stage 2 hypertension, age and smoking were related factors in male, and age, BMI, and cholesterol in female. Conclusions ： It is possible to intervene in all related factors of hypertension except age through life-style modification and appropriate medical management. Active health promotion is needed in School personnel.

• Molecules and Cells
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• v.46 no.11
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• pp.675-687
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• 2023

Accumulation of pathogenic amyloid-β disrupts the tight junction of retinal pigment epithelium (RPE), one of its senescence-like structural alterations. In the clearance of amyloid-β, the autophagy-lysosome pathway plays the crucial role. In this context, mammalian target of rapamycin (mTOR) inhibits the process of autophagy and lysosomal degradation, acting as a potential therapeutic target for age-associated disorders. However, efficacy of targeting mTOR to treat age-related macular degeneration remains largely elusive. Here, we validated the therapeutic efficacy of the mTOR inhibitors, Torin and PP242, in clearing amyloid-β by inducing the autophagy-lysosome pathway in a mouse model with pathogenic amyloid-β with tight junction disruption of RPE, which is evident in dry age-related macular degeneration. High concentration of amyloid-β oligomers induced autophagy-lysosome pathway impairment accompanied by the accumulation of p62 and decreased lysosomal activity in RPE cells. However, Torin and PP242 treatment restored the lysosomal activity via activation of LAMP2 and facilitated the clearance of amyloid-β in vitro and in vivo. Furthermore, clearance of amyloid-β by Torin and PP242 ameliorated the tight junction disruption of RPE in vivo. Overall, our findings suggest mTOR inhibition as a new therapeutic strategy for the restoration of tight junctions in age-related macular degeneration.

• Korean Journal of Community Nutrition
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• v.18 no.6
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• pp.611-625
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• 2013

The purpose of this study was to investigate dietary behaviors and health-related lifestyles of adult visitors at a public health center in Gyeonggi urban area. A survey using questionnaire was conducted with 949 visitors at Seongnam public health centers from June to August, 2012. The data from 905 respondents were analyzed by gender, consisting of 322 males and 583 females, and age group, consisting of 243 low-age group (LA), 312 middle-age group (MA), 350 high-age group (HA), aged 20 to 30 years, 31 to 50 years, and 51 to 69 years, respectively. Average Body Mass Index was 23.0, which increased with age, and education level was high in LA. 59.0 percent of the subjects had various diseases, and the incidence of hypertension was the highest, followed by allergy, hyperlipidemia, diabetes mellitus, joint rheumatism. Incidence rates of chronic disease increased with age, which were lower than those from 2011 Korea National Health and Nutrition Examination Survey (KNHANES). Weekly drinking frequency rate and smoking rate decreased with age, and exercise performing rate was high at male and HA, which showed the same tendency as KNHANES. Female and HA showed more healthy dietary behaviors such as restricting salt, sugar, oily foods, foods containing food additives, calorie, caring for balanced diet, and referring to nutrition label. Subjects chose stress as the first factor, followed by diet, exercise, etc., among 13 suggested factors which strongly influence on human's life-span. In general, public health center visitors, especially female and HA, showed better dietary behaviors and health-related lifestyles compared with KNHANES.

• Journal of Preventive Medicine and Public Health
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• v.48 no.4
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• pp.216-224
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• 2015

Objectives: Decreased fertility and impaired health owing to early menopause are significant health issues. Smoking is a modifiable health-related behavior that influences menopausal age. We investigated the effects of smoking-associated characteristics on menopausal age in Korean women. Methods: This study used data from the Korea National Health and Nutrition Examination Survey from 2007 to 2012. Menopausal age in relation to smoking was analyzed as a Kaplan-Meier survival curve for 11 510 women (aged 30 to 65 years). The risk of entering menopause and experiencing early menopause (before age 48) related to smoking were assessed using a Cox proportional hazards model. Results: The menopausal age among smokers was 0.75 years lower than that among non-smokers (p<0.001). The results of the Cox proportional hazards model showed pre-correction and post-correction risk ratios for entering menopause related to smoking of 1.26 (95% confidence interval [CI], 1.09 to 1.46) and 1.27 (95% CI, 1.10 to 1.47), respectively, and pre-correction and post-correction risk ratios for experiencing early menopause related to smoking of 1.36 (95% CI, 1.03 to 1.80) and 1.40 (95% CI, 1.05 to 1.85), respectively. Conclusions: Smokers reached menopause earlier than non-smokers, and their risk for experiencing early menopause was higher.

• Journal of Trauma and Injury
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• v.19 no.1
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• pp.1-7
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• 2006

Purpose: Injury is a leading cause of morbidity and mortality for children. As an injury prevention measure, the differences in external causes of severe pediatric injuries based on ICECI were analyzed according to age groups. Methods: A retrospective study was performed for pediatric patients under 15 years of age, who had been admitted to the emergency department with severe injuries from January 1998 to December 2004. The external causes of injury were investigated according to the ICECI: intent, mechanisms, places of occurrence, objects/substances producing injury, and related activities. The patients were divided into four groups based on age: infant (<0 year), toddler (1~4 years), preschool age (5~8 years), and school age (9~15 years). Results: The injury mechanisms, the places of occurrence and the related objects/substances vary with the age groups. The most common subtype of traffic accidents was pedestrian injury in pre-school age group. Falls most frequently occurred in the toddler group. But falls from a height of less than l meter height (6 patients) occurred only in the infant group. The most common place of occurrence in the infant group was the home, and that of other groups was the road. The related objects/substances for falls, for example, household furnitures and playground equipment depended on the age group. Conclusion: The age-group specific characteristics of severe pediatric injury were analyzed successfully through the ICECI. Therefore, when establishing a plan for the prevention of pediatric injury, consideration must be given to the differences in the external causes of injuries according to age group.

• Korean Journal of Child Studies
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• v.13 no.2
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• pp.65-81
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• 1992

The purpose of this study was to investigate children's conceptions about gender and the relation between gender conceptions and preference for gender related tasks. 130 children were interviewed about gender and gender related tasks. Data were analyzed with the component model of gender schema. Results indicated that children's gender schema in the attitudes domain was significantly different with age in all components but not different with sex. The gender schema in the knowledge domain was significantly different with age in within component and between component links, and with sex in the gender label-component and within component links. The difference between the gender inhibitory score and gender facilitative score was significantly different with age, sex, and children's gender schema. The findings that gender schema influenced the children's preferences for gender related tasks suggests a theoretical rationale of gender schema theory.

• Journal of Korean Clinical Health Science
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• v.3 no.4
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• pp.466-475
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• 2015

Purpose. The purpose of this study was conducted to identify the elders' general quality of life and oral health-related quality of life. Method. Questionnaire survey was conducted on 241 elders' living in Pohang area from August to September 2014. The results were obtained from t-test, one-way ANOVA analysis, pearson correlation coefficients and multiple regression analysis. Results. Oral health status had significant correlations with gender, age, education, income, drink and hypertension. Oral health-related quality of life showed the highest relationships with age; oral health status and general quality of life showed the highest relationships with monthly income; and, age and education period also showed influence on general quality of life. Conclusions. Therefore, it is required to strengthen oral health improvement program and oral health education for improvement of elders' quality of life.