• Title/Summary/Keyword: Adverse Event

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Proposal of the Pharmacoepidemiologic Methodology Application to Research for Sasang Constitutional Pharmacology (약물역학연구 방법론의 체질약리연구 적용에 대한 제안)

  • Kim, Sang-Hyuk;Yoo, Jong-Hyang;Lee, Si-Woo
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.24 no.5
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    • pp.753-757
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    • 2010
  • The objectives of this paper is to propose the pharmacoepidemiologic methodology to Research for Sasang Constitutional Pharmacology. We mainly searched "Journal of Pharmacoepidemiology and Risk Management". And we also searched "J Korean Oriental Med.", "J of Sasang Constitutional Med.", "J. Oriental Physiology & Pathology", "Korean J Orient Int Med." using these kew words - "adverse event" or "side effect" and "Sasang Contitution" or "Constitution" or "Constitutional medicine". Through the examination of the Pharmacoepidemiologic methodology and current research for sasang constitiutional pharmacology, we could establish the proposal to collect objective constitutional medical reaction. For the actualization of this proposal, the more advanced studies will have to be carried out continuously.

Development of STI/AOT Optimization Methodology and an Application to the AFWPs with Adverse Effects

  • You, Young-Woo;Yang, Hui-Chang;Chung, Chang-Hyun;Moosung Jae
    • Nuclear Engineering and Technology
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    • v.29 no.3
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    • pp.211-217
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    • 1997
  • Adverse effects caused by the surveillance test for the components of nuclear power plant involve plant transients, unnecessary wear, burden on licensee's time, and the radiation exposure to personnel along with the characteristics of each component. The optimization methodology of STI and AOT has been developed and applied to AFWPs of a reference plant. The approach proposed in this paper consist of the resole in minimal mean unavailability of the two-out-of-four system with adverse effects are analytically calculated for the example system. The surveillance testing strategy are given by the sequential test, the staggered test and the train staggered test which is a mined test scheme. In the system level, the sensitivity analyses for the STI and AOT, are performed for the measure of the system unavailability of the top event in the fault tree developed for the example system. This methodology may contribute to establishing the basis for the risk-based regulations.

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Pembrolizumab-related autoimmune hemolytic anemia in a patient with metastatic lung adenocarcinoma: a case report

  • Baek, Dong Won;Chae, Yee Soo
    • Journal of Yeungnam Medical Science
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    • v.38 no.4
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    • pp.366-370
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    • 2021
  • Immune checkpoint inhibitors (ICIs) have become the main drugs for programmed cell death receptor-1 or ligand-1 expressing non-small cell lung cancer (NSCLC) combined with conventional chemotherapy. ICIs are generally more tolerable than cytotoxic chemotherapies in terms of toxicity, and ICI-related adverse events are mild and manageable. However, these drugs may lead to unexpected severe adverse events such as immune-related hematologic toxicities, which could be life-threatening. Here, a rare case of a pembrolizumab-related adverse event in a patient with NSCLC who showed early-onset hemolytic anemia and recovered by high-dose steroid and a series of plasma exchanges is reported.

Prospective Observational Study of Acupuncture Adverse Events: 50 Patients Hospitalized for Peripheral Facial Palsy Treatments (침치료 이상반응에 대한 전향적 관찰: 말초성 안면신경마비 입원 환자 50명을 대상으로)

  • Kim, Dong-Hyuk;Kim, Kyung-Wook;Kim, Jong-Han;Kim, Hyun-Ho;Park, Ji-Min;Yoo, Je-Hyuk;Nam, Dong-Woo;Lee, Sang-Hoon;Choi, Do-Young
    • Journal of Acupuncture Research
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    • v.28 no.4
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    • pp.65-76
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    • 2011
  • Objectives : The aim of this study is to survey adverse events of acupuncture in the course of peripheral facial palsy treatments. Methods : The prospective observational study included patients hospitalized to receive acupuncture treatments for peripheral facial palsy. All patients were surveyed daily for adverse events associated with the acupuncture treatments applied the day before. Results : A total of 50 patients received $37.68{\pm}20.37$ acupuncture treatments in average. 36 patients reported experiencing at least one adverse event. Total 163 adverse events were reported. Common adverse events were bleeding(62), bruise(33), pain(30), tiredness(11), hematoma(7). The others were paresthesia(4), erythema(3), delay of removing needles(2), edema(2), aggravation of symptoms(2), declining of appetite(2), pruritus(1), drowsiness(1), anxiety(1), sweating(1), headache(1). Conclusions : Acupuncture has adverse events, like any therapeutic approaches. However, it is a relatively safe treatment. In future study, organized large scale prospective survey should be carried out to fully prove that acupuncture is safe.

The Impact of Global Financial Crisis 2008 on Amman Stock Exchange

  • Ajlouni, Moh'd Mahmoud;Mehyaoui, Wafaa;Hmedat, Waleed
    • Journal of Distribution Science
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    • v.10 no.7
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    • pp.13-22
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    • 2012
  • The effect of the September 2008 global financial crisis weighed heavily on stock markets around the world. The purpose of this study is to empirically investigate the impact of the crisis on Amman Stock Exchange. Event study methodology has been adopted on a period of 24 months, from January 2008 to December 2009. Monthly average abnormal returns across a sample of 52 industrial and services companies have been tested separately. The results reveal that Amman Stock Exchange experienced significant negative abnormal returns in the fourth quarter of the year 2008. However, there were no significant abnormal returns observed thereafter. This means that Amman Stock Exchange managed to overcome its adverse consequences. Since the event study tests for market efficiency, as well, the results show that Amman Stock Exchange reaction is consistent with the semi-strong form of the efficient market hypothesis.

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An adverse event following 2009 H1N1 influenza vaccination: a case of acute disseminated encephalomyelitis

  • Lee, Sang-Teak;Choe, Young-June;Moon, Won-Jin;Choi, Jin-Woo;Lee, Ran
    • Clinical and Experimental Pediatrics
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    • v.54 no.10
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    • pp.422-424
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    • 2011
  • Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system that typically follows an infection or vaccination and has a favorable long-term prognosis. We describe the first reported case of ADEM after vaccination against novel influenza A (H1N1). A previously healthy 34-month-old boy who developed ADEM presented with a seizure and left-sided weakness 5 days after vaccination against novel influenza A (H1N1). Cerebrospinal fluid examination revealed elevated cell counts. T2-weighted images and fluid-attenuated inversion recovery images revealed multiple patchy hyperintense lesions in the frontal and parietal subcortical white matter and the left thalamus. After the administration of intravenous corticosteroid, the patient's clinical symptoms improved and he recovered completely without neurologic sequelae.

Proposal of Checklists for Patient Safety in Miniscalpel Acupuncture Treatment of Cervical and Lumbar Spine: Pilot Trial (환자 안전을 위한 경추 및 요추부 도침시술 전후 체크리스트 제안: 예비연구)

  • Jo, Hee-Geun;Song, Min-Yeong;Yoon, Sang-Hoon;Jeong, Sin-Yeong;Kim, Jong-Hwan;Baek, Eun-Hye;Leem, Jungtae
    • Journal of Korean Medicine Rehabilitation
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    • v.28 no.1
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    • pp.61-72
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    • 2018
  • Objectives The authors propose a new checklist model adapted for safety miniscalpel acupuncture procedure of cervical and lumbar spine. Methods On the basis of available literature and expert opinion, a prototype checklist was developed. The checklist was adapted on the basis of observation of daily practice. Results The checklist has three parts: 1. prevention and management of healthcare associated infections, 2. verification list before and after miniscalpel acupuncture treatment, 3. adverse event monitoring after procedure. We presented a summary checklist based on the above contents. Conclusions We propose the first patient safety checklist for minicalpel acupuncture treatment of cervical and lumbar spine. The checklist will be complemented using further research methodologies.