• 가정∙방문간호학회지
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• 제25권2호
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• pp.184-196
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• 2018

Purpose: This study explored the adjustment experiences of spouses of elderly people with dementia in Korea. Methods: A grounded theory method was used. The data were collected by individual in-depth interviews with 11 spouses of elderly people with dementia. Results: In the analysis, 17 categories were derived. A core category emerged: Adjusting to daily life of providing love-based care. Eight major strategies for dealing with the psychosocial problems faced by spouses of elderly people with dementia: Feeling one's own responsibility in caring; halting personal activities; adopting a spouse-oriented daily lifestyle; caring with love; efforts for maintaining one's own health; efforts for maintaining spouse's health; depending on religious belief; and trying to have time for oneself. The consequences that resulted from applying these strategies were identified as "feeling worthwhile for caring," "maintaining a peaceful life," and "being grateful of the present." Conclusions: This study presents a holistic view of the adjustment experiences of spouses of elderly people with dementia. This study can also provide directions for developing interventions for enhancing the quality of life of spouses of elderly people with dementia.

• 가정과삶의질연구
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• 제23권2호
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• pp.49-61
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• 2005

The study reported a phenomenological analysis of the interviews with 19 mothers who had a child preparing a college entrance examination. The research question was what mothers experienced in supporting their child in his/her study for the examination. Results indicated that 'the senior year in a highschool' was described as the most stressful period affecting all the family members. Mothers' experiences were portrayed from three perspectives: mothers, as family members, experiencing the attachment to her child but conflicts with her husband; mothers, as individuals, adjusting by trying to setting realistic academic goals for her child while supporting him/her physically, emotionally, and spiritually; and mothers, as critics to extrafamily systems, blaming the inconsistency of educational policies. 1bis study was conducted with a holistic view, and highlighted the importance of interactions between traditional ideology about the mother roles and socioeconomic contexts when interpreting mothers' supporting their child in study for a college entrance examination.

• 한국보건간호학회지
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• 제29권3호
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• pp.426-440
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• 2015

Purpose: This qualitative study aimed to understand older adults' perspectives on successful aging and develop a model of a successful aging process, within the Korean socio-cultural context. Methods: This study used a Grounded Theory approach. Through theoretical sampling, 14 participants were selected from older adults at a public health center and a volunteer institution in Gyeonggi Province, South Korea. Results: The basic social process identified was "expanding the aging self", which was preceded by three phases, namely, adjusting to the changes, developing the valuable self, and embracing the environment. Participants used 2-3 strategies for successful aging in each phase. For adjusting to the changes, participants used strategies such as "adopting a positive attitude", "accepting the changes", and "being at the center of life". To develop the valuable self, "re-identifying capacities", "having something to do", and "advancing to a healthy lifestyle" were used. Participants embraced their environments with "sharing with others" and "embracing younger generations". The causal condition for expanding the aging self was the changes in participants' physical, mental, or psychosocial situations. Conclusion: These findings suggest a theoretical foundation for the development of potential nursing interventions to promote self-care management and the interpersonal relationship for successful aging among Korean elderly individuals.

• 한국전문물리치료학회지
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• 제18권2호
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• pp.35-42
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• 2011

Three hundred and fourteen low back pain patients completed the Korean version of the Oswestry Disability Questionnaire (KODQ) and the Rasch analysis was then applied to identify the inappropriate items and to determine ODQ item difficulties according to a subject's characteristics. For women and youths, the 'sex life' item showed misfit statistics, whereas for older subjects it was the 'pain intensity' and 'standing' items. Also, in the acute low back group the 'pain intensity', 'standing' and 'sex life' items showed misfit statistics. For all subjects, the most difficult item was 'pain intensity', whereas the easiest item was 'walking'. But for the older and acute groups 'lifting' was the most difficult item and for those who have a visual analogue scale score of 3 or less 'sitting' was the most difficult item. These results show that differential item functioning is present in several items according to sex, age, acute and chronic pain, and VAS score. This study may be useful for adjusting the KODQ item difficulties for low back pain patients with different characteristics.

• Journal of Microbiology and Biotechnology
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• 제29권3호
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• pp.454-464
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• 2019

Salmonellosis is a highly contagious bacterial disease that threatens both human and poultry health. Tests that can detect Salmonella in the field are urgently required to facilitate disease control and for epidemiological investigations. Here, we combined loop-mediated isothermal amplification (LAMP) with a chromatographic lateral flow dipstick (LFD) to rapidly and accurately detect Salmonella. LAMP primers were designed to target the Salmonella invA gene. LAMP conditions were optimized by adjusting the ratio of inner to outer primers, $MgSO_4$ concentration, dNTP mix concentration, amplification temperature, and amplification time. We evaluated the specificity of our novel LAMP-LFD method using six Salmonella species and six related non-Salmonella strains. All six of the Salmonella strains, but none of the non-Salmonella strains, were amplified. LAMP-LFD was sensitive enough to detect concentrations of Salmonella enterica subsp. enterica serovar Pullorum genomic DNA as low as $89fg/{\mu}l$, which is 1,000 times more sensitive than conventional PCR. When artificially contaminated feed samples were analyzed, LAMP-LFD was also more sensitive than PCR. Finally, LAMP-LFD gave no false positives across 350 chicken anal swabs. Therefore, our novel LAMP-LFD assay was highly sensitive, specific, convenient, and fast, making it a valuable tool for the early diagnosis and monitoring of Salmonella infection in chickens.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6547-6552
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• 2014

Background: Cancer is a major life event that imposes huge economic and mental burdens on patients and families. In addition, the diagnosis of cancer also causes significant family discordance that can lead to marital problems such as divorce or separation. The aim of this study was to investigate the association and any related gender differences between cancer diagnosis and marital disruption among cancer survivors. Materials and Methods: We used the recent cross-sectional Korea National Health and Nutrition Examination Survey ($4^{th}$ and $5^{th}$; Years 2008-2012). The study participants were 623 married cancer survivors over the age of 19. A multivariate logistic regression analysis was conducted to estimate odds ratios. Results: After adjusting for socioeconomic status and health-related behaviors, the odds ratio of marital disruption among female cancer survivors compared with male cancer survivors was 3.94 (95%CI 1.30-11.94; p=0.02). The odds ratio of marital disruption for the below-average economic level compared with the above-average economic level was 5.64 (95%CI: 1.03-31.02; p=0.05). When compared with the non-smoking cancer survivors, the smoking cancer survivors had an OR of marital disruption equal to 2.94 (95%CI: 1.08-8.00; p=0.03). Conclusions: The findings of this study suggest that the odds of marital disruption among female cancer survivors are higher than those among their male couterparts. Medical practitioners should be sensitive to early signs of marital discord in couples affected by a cancer diagnosis. Early identification and psychosocial intervention might reduce the frequency of divorce and separation and thus improve quality of life and quality of care for cancer survivors.

• Journal of Nutrition and Health
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• 제46권2호
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• pp.126-136
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• 2013

This study was conducted in order to investigate the association between hypertension and oxidative stress-related parameters and to evaluate these parameters in subclinical hypertensive patients and normotensive subjects living in Korea. We attempted to determine whether oxidative stress-related parameters would differ between two groups of 227 newly-diagnosed, untreated (systolic blood pressure (BP) ${\geq}$ 130 mmHg and diastolic BP ${\geq}$ 85 mmHg) and 130 normotensive subjects (systolic BP < 120 mmHg and diastolic BP < 80 mmHg). General characteristics of the subjects were collected using a simple questionnaire. From subjects' blood, degree of DNA damage in lymphocytes, the activities of erythrocyte superoxide dismutase, catalase, and glutathione peroxidase, level of plasma total radical-trapping antioxidant potential (TRAP), glutathione, and anti-oxidative vitamins, as well as plasma lipid profiles and conjugated diene (CD) were analyzed. Evaluation of the associations of oxidative stress-related parameters with blood pressure of the subjects was performed using Pearson partial correlation and multivariate logistic regression analysis after adjusting for confounding factors. Several oxidative stress-related parameters were higher in subclinical hypertensive patients than in normotensive subjects. Plasma levels of ${\alpha}$-tocopherol, ${\beta}$-carotene, TRAP, and activity of GSH-px were significantly lower in subclinical hypertensive patients than in normotensive subjects. Increased levels of DNA damage, lipid peroxidation, triglyceride, total cholesterol, and LDL-cholesterol were observed in subclinical hypertensive patients. These results confirm an association between blood pressure and oxidative stress-related parameters and suggest that the pathogenic role of oxidative stress in hypertension might be significant.

• 가정과삶의질연구
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• 제25권6호
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• pp.121-131
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• 2007

The purpose of this study was first to reveal the factors of time management behaviors of college students. The second purpose was to examine the effects of those factors on the satisfaction of time management. The data were collected from 400 college students in Seoul by a self-administered questionnaire. Frequencies, Cronbach's alpha, Factor analysis, Pearson's correlation analysis and Multiple linear regression were conducted by SPSS WIN12.0. The major findings were as follows. First, factor analysis of 20 items on the time management behaviors related questions revealed six factors: establishment of standards, reality, overlapping, checking, adjusting and facilitating. Second, many factors such as facilitating, establishment of standards, reality, overlapping were significant in the regression analyses for the satisfaction of time management. Especially, establishment of standards and facilitating had high levels of effort on the satisfaction of time management. In combination, these results suggest that establishment of standards and facilitating are very important factors for high satisfaction of time management.

• 지역사회간호학회지
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• 제6권2호
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• pp.250-258
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• 1995

The purpose of this study was to determine the level of health promotive behavior of adults and thereby to develope the health promotive behavior scale adjusting our sociocultural situation. The item for health promotive behavior was aquired from statements which was reported by Kim through deep interview with 164 Korean adults. The scale was measured with 4 points Likert type. Data was collected with questionnaire for population living in farm of Chungnam Province and Dae Jon City, from July to August 1994 by research assistant trained by researchers. Data was analysed using SPSS program with Cronbach $\alpha$ and factor analysis. The results are as follows : 1. For the reliability of the scale, Cronbach $\alpha$ was .8264 2. The factor analysis to examine the construct validity showed that health promotive behaviors included 9 factors: health management (16.0%), regular life style(7.4%), psychosomatic control(5.6%), moderation of living(4.6%), stress rnanagement(4.1%), abstain from favorite (3.9%), sanitary habit (3.8%), thought (3.2%), diet habit(3.1%). Nine factors explained 51.7% of varient.

• Journal of Korean Biological Nursing Science
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• 제14권2호
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• pp.129-138
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• 2012

Purpose: Cachexia is a complex metabolic syndrome associated with wasting of skeletal muscle which contributes to nearly one-third of all cancer deaths. Cachexia lowers the frequency of response to chemotherapy and radiation and ultimately can impact survival as well as quality of life during treatment. NF-kappa B is one of the most important molecular mediators of cachexia. In this study, therefore, possible candidates for inhibitors of NF-kappa B were searched. Methods: Amino acids that regulate cellular redox potential by adjusting the level of NAD/NADH ratio, such as aspartate, pyruvate, and isocitrate were selected. Results: Pyruvate effectively inhibited luciferase activity in TNF-stimulated 293T cells transfect with an NF-kB dependent luciferase reporter vector. Pyruvate also showed protective effect on muscle atrophy of differentiated C2C12 myocyte induced by TNF/IFN. Conclusion: We might be able to develop the nutritional management strategy for cancer cachexia patients with pyruvate supplementation.