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http://dx.doi.org/10.7586/jkbns.2012.14.2.129

Safe Nuclear Factor-kappa B Inhibitor for Cachexia Management  

Park, Jeong-Soo (Department of Biochemistry, Dankook University College of Medicine)
Publication Information
Journal of Korean Biological Nursing Science / v.14, no.2, 2012 , pp. 129-138 More about this Journal
Abstract
Purpose: Cachexia is a complex metabolic syndrome associated with wasting of skeletal muscle which contributes to nearly one-third of all cancer deaths. Cachexia lowers the frequency of response to chemotherapy and radiation and ultimately can impact survival as well as quality of life during treatment. NF-kappa B is one of the most important molecular mediators of cachexia. In this study, therefore, possible candidates for inhibitors of NF-kappa B were searched. Methods: Amino acids that regulate cellular redox potential by adjusting the level of NAD/NADH ratio, such as aspartate, pyruvate, and isocitrate were selected. Results: Pyruvate effectively inhibited luciferase activity in TNF-stimulated 293T cells transfect with an NF-kB dependent luciferase reporter vector. Pyruvate also showed protective effect on muscle atrophy of differentiated C2C12 myocyte induced by TNF/IFN. Conclusion: We might be able to develop the nutritional management strategy for cancer cachexia patients with pyruvate supplementation.
Keywords
NF-${\kappa}B$; Pyruvate; Cachexia; Cancer patient nursing; Nutrition;
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