• Journal of the Korean Society of Tobacco Science
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• v.32 no.2
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• pp.77-87
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• 2010

Traditional simultaneous distillation extraction(SDE) and solid-phase micro extraction(SPME) methods using GC/MS were compared for their effectiveness in the extraction of volatile flavor compounds from different tobacco leaves types(flue-cured, burley, oriental). The major volatile flavor compounds of flue-cured and burley tobacco were similar such as neophytadiene, solanone, megastigmatrienone isomers, ${\beta}$-damascenone and ${\beta}$-ionone. On the other hand, volatile flavor compounds such as norambreinolide, sclareolide were specifically identified in oriental tobacco. Each method was used to evaluate the responses of some analytes from real samples and standards in order to provide sensitivity comparisons between two techniques. Among three types of SPME fibers such as PDMS(Polydimethylsiloxane), PA(Polyacrylate) and PDMS/DVB (Polydimethylsiloxane/Divinylbenzene) which were investigated to determine the selectivity and adsorption efficiency, PDMS/DVB fiber was selected for the extractions of the volatile flavor compounds due to its effectiveness. The qualitative analysis showed that the total amount of volatile flavor compounds in SDE method(130 species) was much more than that in SPME method(85 species). SPME method was more efficient for all the highly volatile compounds than SDE method, but on the other hand, low-volatile compounds such as fatty acids or high-molecular hydrocabons were detected in SDE method. SPME method based on a short-time sampling can be adjusted to favor a selected group compounds in tobacco. Furthermore this results could be used to estimate the aroma characteristics of cigarette blending by using a different type of tobacco with more effectiveness and convenience.

• Women's Health Nursing
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• v.17 no.1
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• pp.77-87
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• 2011

Purpose: This study aimed to identify differences in contraception behavior and related factors between unmarried female and male. Methods: A cross-sectional survey design with a convenient sampling was used. From Seoul, 107 women and 96 men were recruited. A structured questionnaire was self-administered from July 14, 2008 to September 2, 2008. Results: The average ages of women and men were 26.9 and 27.8 years old, respectively. Fiftysix percent of women and 85.4% of men have experienced sexual intercourse. There were no differences between female and male in attitude toward contraception, subjective norm, and contraception behavior, while female had higher score of self-efficacy for contraception (p=.02) and intention of contraception (p=.02). There was positive correlation with subjective norm (r=.22, p<.05), self-efficacy (r=.53, p<.01) in male and attitude (r=.32, p<.05), selfefficacy (r=49, p<.01) in female. According to the result of multiple regression, the significant factor of contraception behavior was self-efficacy for both female (${\beta}$=.49, p=.00) and male (${\beta}$=.53, p=.00). Conclusion: To improve contraception behavior for unmarried female and male, it is necessary to develop proper sex education program to enhance self-efficacy for contraception. Adjusted education program by this result will contribute to increase sexual health for female and male.

• Tuberculosis and Respiratory Diseases
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• v.82 no.3
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• pp.190-193
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• 2019

Inhaled corticosteroids (ICSs) have been widely used as a key medication for asthma control. However, ICSs have been known to cause respiratory infections, such as pneumonia and pulmonary tuberculosis. Consequently, a dilemma exists regarding recommendation of persistent lifetime use of ICSs to mild asthma patients. Short-acting ${\beta}$-agonists (SABAs) have also been widely used for symptom relief. However, SABAs have been reported to increase the risk of asthma-related death, though incidences have been very rare. Consequently, a dilemma exists regarding recommendation of a SABA alone without an ICS or a controller to asthma patients even with very mild disease. In the real world, asthma patients tend to intermittently use ICS and more likely to be dependent on SABA since many patients want immediate relief of their symptoms. Consequently, a dilemma exists regarding the underuse of ICSs but the overuse of SABAs. One strategy for solving the presented dilemma would be identification of patients with asthma who require persistent use of asthma controllers. Such patients, who may be referred to as "persistent controller users," should continuously receive ICSs, even under controlled states of asthma. Another strategy would be a patient-adjusted, symptom-driven, intermittent-to-regular treatment combining low-dose ICS/rapid-onset long-acting ${\beta}$-agonists instead of using a SABA alone or with low-dose ICS for the asthma patients with mild disease. Both of these two strategies could avoid the risky treatment of a SABA alone without an ICS and could reduce the dose of ICS with the maintenance of asthma control.

• Journal of agricultural medicine and community health
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• v.43 no.1
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• pp.18-30
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• 2018

Objectives: This study was conducted to examine the association of serum Vitamin D with insulin resistance and ${\beta}-cell$ function in Korean health checkup examinees. Methods: This study subjects were 374 healthy adults (199 males, 175 females) over the age of 20, who visited a general hospital medical center located in Haenam-gun, Jeollanam-do. To find the association of Vitamin D with HOMA-IR and $HOMA-{\beta}$, the used statistical analysis were ANOVA and ANCOVA. Results: Of the study subjects, the level of serum Vitamin D defined by deficient group, insufficient group and sufficient group was 38.5%, 48.1% and 13.4%, respectively. According to the level of serum Vitamin D, the mean values of HOMA-IR were $1.92{\pm}1.08$ in sufficient group, $1.99{\pm}1.04$ in the insufficient group and $2.91{\pm}1.05$ in deficient group and there were statistically significant different(p<0.001). The mean values of $HOMA-{\beta}$ were $84.69{\pm}1.07$ in sufficient group, $78.41{\pm}1.04$ in the insufficient group and $80.48{\pm}1.04$ in deficient group, and there were not significant. As a result of ANCOVA, adjusted mean of HOMA-IR were statistically significant different (p<0.001), but those of $HOMA-{\beta}$ were not statistically significant according to the level of serum Vitamin D. Conclusion: The insufficient level of serum Vitamin D was relatively high in healthy adults who live in rural area, and it was found that HOMA-IR significantly increased when Vitamin D was deficient. To prevent insulin resistance or diabetes, it is necessary to provide sufficient information related to sufficient production of Vitamin D such as Vitamin D supplement, sun exposure, food intake and etc.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.59 no.8
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• pp.1429-1435
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• 2010

In this paper, a double lorentz composite right left handed(DL-CRLH) transmission line is designed using defected ground structure (DGS) and varactor diodes. Previously, the diode has been adopted only selectively for one of parallel or series resonators, and the balanced frequency as well as triple band frequencies were fixed. However in the proposed DL-CRLH transmission line, the balanced frequency, where the resonant frequencies of the series-connected parallel resonator and shunt-connected series resonator are the same, is adjustable. In addition, the triple band frequencies are controlled, too. The measured balanced frequency varies between 3.42~4.8GHz according to the controlled bias voltage. Under the same bias condition for the balanced frequency, the adjusted frequencies are 2.22~2.77GHz, 3.7~5.2GHz, 7.32~8.23GHz, 3.42~4.8GHz, and 4.44~5.92GHz for the conditions that ${\beta}d=+0.5{\pi}$, $-0.5{\pi}$, 2nd $+0.5{\pi}$, ${\omega}_{\infty}$, and ${\omega}_o$, respectively.

• The Korean Journal of Pharmacology
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• v.10 no.1 s.15
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• pp.47-52
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• 1974

The isolated rabbit gall bladder strips were prepared according to the technique described by Amer and Becvar (1969). The strips were placed in a bath containing 100 ml of Locke-Ringer solution maintained at $38^{\circ}C$. Oxygen was continuously bubbled through the solution. The tension of the muscle strip was initially adjusted to 0.7g. The contractile response was measured isometrically by a force-displacement transducer connected to a polygraph. The effect of a number of autonomic drugs were studied for their interaction with caerulein (Prof. V. Erspamer, F.I. 6934 Caerulein, Farmitalia, Italia), a gastrin or CCK.PZ like peptide, on isolated rabbit gall bladder strips. In this preparation caerulein produced contractions of CCK-PZ type, but the relative potency on a weight basis was 40 times that of CCK-PZ. The response of caerulein was not modified by either cholinergic or alpha or beta adrenergic blockade. However, the response of caerulein and of barium on the strips were prevented by papaverine or aminophylline. Isoproterenol, papaverine or aminophylline alone relaxed the preparation whereas caerulein, CCK-PZ, acetylcholine, serotonin, histamine or barium chloride contracted the preparation. In summary, it is concluded that caerulein on the gall bladder strip seems to act independently of the autonomic nervous system and mediated via mechanisms apparently similar to those involved in the action of barium chloride.

• Wind and Structures
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• v.19 no.4
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• pp.389-404
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• 2014

The flow characteristics of a circular cylinder surrounded by an outer permeable cylinder were experimentally investigated using Particle Image Velocimetry Technique in deep water flow. In order to consider the effects of diameter and porosity of the outer cylinder on flow structures of the inner cylinder, five different outer cylinder diameters (D=37.5, 52.5, 60, 75 and 90 mm) and eight different porosities (${\beta}$=0.4, 0.5, 0.6, 0.65, 0.7, 0.75, 0.8 and 0.85) were selected. During the experiments, the diameter of inner cylinder was kept constant as d=30 mm. The depth-averaged free-stream velocity was adjusted as U=0.156 m/s, which corresponds to the Reynolds number of Re=5000 based on the inner cylinder diameter. It has been concluded that both the outer permeable cylinder diameter and the porosity have important influences on the attenuation of vortex shedding in the wake region. The presence of outer permeable cylinder decreases the magnitude of Reynolds shear stress and turbulent kinetic energy compared to the bare cylinder case. Moreover, the spectral analysis of vortex shedding frequency has revealed that the dominant frequency of vortex shedding downstream of the cylinder arrangement also reduces substantially due to the weakened Karman shear layer instability.

• Molecules and Cells
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• v.42 no.2
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• pp.161-165
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• 2019

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide and has high rates of metastasis. Transforming growth factor beta-inducible protein (TGFBI) is an extracellular matrix component involved in tumour growth and metastasis. However, the exact role of TGFBI in NSCLC remains controversial. Gene silencing via DNA methylation of the promoter region is common in lung tumorigenesis and could thus be used for the development of molecular biomarkers. We analysed the methylation status of the TGFBI promoter in 138 NSCLC specimens via methylation-specific PCR and evaluated the correlation between TGFBI methylation and patient survival. TGFBI promoter methylation was detected in 25 (18.1%) of the tumours and was demonstrated to be associated with gene silencing. We observed no statistical correlation between TGFBI methylation and clinicopathological characteristics. Univariate and multivariate analyses showed that TGFBI methylation is significantly associated with poor survival outcomes in adenocarcinoma cases (adjusted hazard ratio = 2.88, 95% confidence interval = 1.19-6.99, P = 0.019), but not in squamous cell cases. Our findings suggest that methylation in the TGFBI promoter may be associated with pathogenesis of NSCLC and can be used as a predictive marker for lung adenocarcinoma prognosis. Further large-scale studies are needed to confirm these findings.

• Asia-Pacific Journal of Business
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• v.11 no.4
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• pp.243-254
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• 2020

Purpose - This paper explores whether overnight returns measured from the last closing price to today's opening price explain the cross-section of stock returns. Design/methodology/approach - This study is conducted using the Korean stock market data from 1998 to 2018, obtained from DataGuide database. The analysis begins with portfolio-level tests, followed by firm-level cross-sectional regressions. Findings - First, when decile portfolios sorted on the daily average of overnight returns in the previous months, the highest decile portfolio exhibits a significant negative risk-adjusted return. This suggests that stocks with higher average overnight returns are temporarily overvalued due to buying pressure from investors. Second, at least 6 months of persistence exists in average overnight returns, which is in line with the results reported by Barber, Odean and Zhu (2009) that investor sentiment persists over several weeks. Finally, Fama-MacBeth cross-sectional regression of expected returns after controlling for a variety of firm characteristic variables such as firm size, book-to-market ratio, market beta, momentum, liquidity, short-term reversal, the slope coefficient for overnight returns remains negative and statistically significant. Research implications or Originality - Overall, the evidence consistently suggests that overnight return is considered as a new priced factor in the cross-section of expected returns. The findings of this paper not only adds to finance literature, but also could be useful to practitioners in making stock investment decision.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.283.2-283.2
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• 2002

Organochlorine pesticides and polychlorinated biphenyls (PCBs) have been used intensively in agriculture and industry for a long time. They belong to a group of contaminants whose occurrence in the environment is a serious concern to environmental chemists and toxicologists due to their resistance to degradation in the environment as well as their potential toxicity. Also. the lipophilic characteristics of these substances are responsible for their ability to bioaccumulate in tissues and organs rich in lipids of men and animals through food chain. Therefore, the measure of the levels of organochlorine pesticides and PCBs in human tissues are good markers in detemining the extent to exposure and evaluating the hazards. This study was preformed to compare concentrations of organochlorine pesticides(${\alpha}-BHC, {\beta}-BHC, {\gamma}-BHC, {\delta}-BHC$, p.p'-DDT,p.p'-DDD,p.p.'-DDE. endrin. dieldrin. aldrin) and seven marker PCBs(PCB nos. 28. 52. 101. 118. 138. 153. 180) in liver. kidney cortex, lung blood and adipose tissue collected at autopsies of 10men and 10 women using gas chromatography equipped with electron capture detector to express the data on a lipid adjusted basis. From the results, the significant differences in the levels of organochlorines of PCBs between sexes, districts where they had lived and ages were also investigated.