• Korean Journal of Plant Resources
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• v.20 no.6
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• pp.540-543
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• 2007

We have investigated the vegetation in the peninsula located in Ongjeong-Li Seomyeon in Youngweol-gun. Since this is a limestone area, boxtrees, Abelia mosanensis T. H. Chung ex Nakai, and Selaginella stauntoniana Spring were abundant, as these are types of vegetation characteristic of limestone areas. Pinus densiflora S. et Z. was the most dominant woody plant, but vegetational changes, such as the dominance of Quercus variabilis Blume, Quercus dentata Thunb, and Quercus mongolica Fischer, were observed in spots. In particular, the growth of nursery plants of pinus densiflora S. et Z. was not observed, and young trees like Quercus mongolica Fischer grow as low vegetation of Pinus densiflora S. et Z.. Thus, the ecological succession of Quercus mongolica Fischer is predicted. Outside the investigation area, as herbaceous plants, various vegetations were observed, including Selaginella stauntoniana Spring, Thalictrum coreanum H. Lev., Mukdenia rossii(Oliv.) Koidz., Platanthera freynii Kraenzl., Cephalanthera longibracteata Blume, Potentilla dickinsii Franch., Patrinia rupestris(Pall.) Juss., Swertia pseudochinensis H. Hara, Vicia venosa(Willd.) Maxim., Pyrola japonica Klenze ex Alef., Disporum smilacinum A. Gray, Artemisia stolonifera(Maxim.) Kom. for. Stolonifera, Smilax nipponica Miq., Adenophora triphylla var. japonica(Regel) H. Hara, Isodon inflexus(Thunb.) Kudo, Gentiana scabra Bunge for. Scabra, Polygonatum odoratum var. pluriflorum(Miq.) Ohwi, Dioscorea quinqueloba Thunb., Syneilesis palmata(Thunb.) Maxim., Asparagus schoberioides Kunth, Eupatorium japonicum Thunb. ex Murray, Galium kinuta Nakai & Hara, Saxifraga fortunei var. incisolobata, Lilium amabile Palib., Siberian iris, Dictamnus dasycarpus Turcz., Atractylodes ovata(Thunb.) DC., and Lysimachia clethroides Duby.

• Korean Journal of Plant Resources
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• v.30 no.2
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• pp.240-264
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• 2017

The present study was carried out to identify traditional konwledges on Korean Campanulaceae plants and conduct a comprehensive review of them through analyzing phytochemistry and pharmacology of Korean Campanulaceae plants. According to the literature study, the ethnobotanical plants of Korean Campanulacae consisted of a total 18 taxa. Of them, 12 taxa including Platycodon grandiflorus, Adenophora triphylla var. japonica, Codonopsis lanceolata and others have been used as ethnomedicinal plants. These plants have been used for the treatment of 49 diseases such as cold, asthma and postnatal care. Phytochemical studies have identified the constituents present from Korean Campanulaceae (Adenophora, Codonopsis, Platycodon, Campanula and Asyneuma). A wide range of chemical compounds comprised 109 triterpenes, 8 sterols, 4 polyacetylenes, 21 alkaloids, 14 flavonoids, 14 phenolic acids, 11 phenolic glycosides, 8 phenylpropanoids and 22 other compounds. Pharmacological studies of these compounds have demonstrated immuno-stimulating, anti-inflammatory, anti-asthmatic, apophlegmatic and anti-allergic effects. They have also shown antioxidant, estrogenic, anti-diabetic, hepatoprotective, neuroprotective, antinociception and anti-tumor activities, as well as anti-obesity and cardiovascular effects. In light of traditional knowledge and phytochemical and pharmacological studies summarized, uses of Korean Campanulaceae based on traditional knowledge (for the treatment diseases and conditions of respiratory, pregnancy, childbirth, puerperium, genitourinary, circulatory, musculoskeletal and other systems) have been supported by phytochemical and pharmacological studies.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.10 no.1
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• pp.44-56
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• 2007

The flora was summarized as 195 taxa; 73 families, 138 genera, 168 species, 23 varieties and 4 forms in Jangsoo-ri windbreak forest and 151 taxa; 63 families, 118 genera, 131 species, 18 varieties and 2 forms in Pyeongsa-ri windbreak forest. Based on the list of the rare plants by the Forest Research Institute, 3 taxa and based on the list of Korean endemic plant 4 taxa were recorded in the studied areas; Puccinellia coreensis (Gramineae), Asarum maculatum (Aristolochiaceae), Prunus yedoensis (Rosaceae), Koelreuteria paniculata (Sapindaceae), Adenophora triphylla var. hirsuta (Campanulaceae). The Specific Plant Species which is categorized by the Ministry of Environment, Korea, was summarized as 23 taxa for the 1 degree of 17 taxa, 3 degree of 5 taxa, 5 degree of 1 taxa in Jangsoo-ri windbreak forest and 22 taxa for the 1 degree of 18 taxa, 3 degree of 3 taxa, 5 degree of 1 taxa in Pyeongsa-ri windbreak forest. From the enlisted the flora surveyed, the naturalized plants were 17 taxa in Jangsoo-ri windbreak forest and 19 taxa in Pyeongsa-ri windbreak forests with the Naturalization rate was 8.7 percent and 12.6 percent, respectively. In Jangsoo-ri windbreak forest, there has been occurred many man-made impair and development without legal institution and control. So, it needs in haste institutional conservation measures and systemic database construction about function and necessity of windbreak forest. In Pyeongsa-ri windbreak forest, recently many people visited here. So, if we make eco-tour place connecting nearby coast and windbreak forest, it will contribute resident's economic profit and opportunity, concerns about windbreak forest, and necessity of conservation measures. Recently, the windbreak forests in Jangsoo-ri and Pyeongsa-ri should be bereaved windbreak forest of function by the human activities.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.11 no.2
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• pp.66-74
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• 2008

In recent years, the view centered conservation for eco-system is getting important rather than development from human oriented perspective. As a result, the concept "Sustainable development", that is seeking harmony between conservation and development, appeared so that we researched distribution and status of vascular plants a site of project in the Bukkyungnam substation. The main findings from the study is as follows. The vascular plants a site of project in the Bukkyungnam substation area was listed 435 taxa; 93 families, 269 genera, 377 species, 1 subspecies, 51 varieties and 6 forms. Specific plant species by floral region were total 25 taxa; Acer palmatum (Planted species), Asperula lasiantha in Class III, Caryopteris incana, Cirsium schantarense in Class II, 21 taxa (Dryopteris erythrosora, Chloranthus japonicus, Salix glandulosa, Alnus hirsuta, Quercus variabilis, Ulmus parvifolia, Clematis patens, Rubus hirsutus, Euphorbia pekinensis, Cayratia japonica, Grewia biloba var. parviflora, Vaccinium oldhami, Microstegium japonicum, Hosta capitata, Polygonatum falcatum, etc.) in Class I. Based on the list of Korean endemic plants, 10 taxa were recorded; Cephalotaxus koreana, Populus tomentiglandulosa (Planted species), Indigofera koreana, Forsythia koreana (Planted species), Paulownia coreana (Planted species), Asperula lasiantha, Weigela subsessilis, Adenophora triphylla var. hirsuta, Carex okamotoi, Lilium amabile and based on the list of the rare plants by the Forest ResearchInstitute, 2 taxa were recorded in the studied areas; Lilium callosum (Preservation priority order; No. 191), Aristolochia contorta (No. 151). The naturalized plants in this site were 13 families, 22 genera, 28 taxa and naturalization rate was 6.4% of all 435 taxa vascular plants.

• Korean Journal of Pharmacognosy
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• v.46 no.4
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• pp.334-341
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• 2015

HAE series (HAE 01 - 06), are the mixtures of medicinal plants; Lonicerae Folium et Caulis (Lonicera japonica), Scutellariae Radix (Scutellaria baicalensis), Adenophorae Radix (Adenophora triphylla var. japonica), Polygonati Oddorati Rhizoma (Polygonatum odoratum var. pluriflorum), Platycodi Radix (Platycodon grandiflorum), Liriopis seu Ophiopogonis Tuber (Liriope platyphylla). HAE 06 showed the significant antitussive effect in HAE series. HAE 04, 05, and 06 increased the effect of expectorant measured by secretion of phenol red in rats. All tested HAE series were observed to have the anti-oxidant activity determined by the scavenging activity. HAE 01, 03 and 06 were significantly reduced the production of nitric oxide (NO) and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) increased by LPS. HAE 06 was selected based on the results and done further experiments. HAE 06 inhibited the number of coughing induced by citric acid in dose dependent manner. HAE 06 effectively increased the effect of expectorant. HAE 06 exhibited anti-inflammatory effects by inhibiting the production of NO and TNF-${\alpha}$. In addition, HAE 06 significantly suppressed inducible Cyclooxygenase-2 (COX-2). Especially HAE 06 has the highest effect in alleviating the respiratory symptoms. Moreover, the enhancement antioxidant activity and reduction inflammation partly were attributed to it. HAE 06 may become the promising candidate for the treatment of respiratory symptom in the future.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.10a
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• pp.97-97
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• 2019

사삼(沙蔘, Adenophorae Radix)은 "대한민국약전외한약(생약)규격집(KHP)"에 잔대 Adenophora triphylla var. japonica Hara 또는 사삼(당잔대, A. stricta Miq.)의 뿌리로 수재되어 있으나, 형태학적으로 유사한 제니(모시대, A. remotiflorus Miquel), 층층잔대(윤엽사삼, A. tetraphylla (Thunb.) Fisch), 더덕 Codonopsis lanceolata (Sieb. et Zucc.)과 오 혼용 우려가 있어 이들을 구별하기 위한 종 감별법이 필요하다. 본 연구에서는 '사삼'과 오 혼용 우려가 있는 종들을 구별할 수 있는 유전자 마커 개발을 위하여 DNA 바코드로 활용되고 있는 유전자 부위를 분석하여 ITS (25%), atpB-rbcL (15%), atpF-atpH (14%), rpl16 (13%), trnL-F (10%), matK (9%), rpoC1 (7%)에서 변이율(percent of variable sites)을 확인하였다. 또한, 분석한 유전자 부위 중 종간 차이를 확인하기 용이한 matK 구간을 활용해 기원종인 잔대, 당잔대와 형태적으로 유사하여 오 혼용될 우려가 있는 층층잔대, 모시대 및 더덕을 감별 할 수 있는 유전자 마커를 개발하였다. 본 연구를 통해 얻어진 염기서열과 분자 마커는 '사삼'의 품질관리에 유용하게 활용 가능할 것으로 사료된다.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.10a
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• pp.98-98
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• 2019

제니(薺苨, Adenophorae Remotiflori Radix)는 "대한민국약전외한약(생약)규격집(KHP)"에 모시대(Adenophora remotiflorus Miquel)의 뿌리로 수재되어있으나, 형태학적으로 유사한 잔대(A. triphylla), 당잔대(A. stricta) 및 더덕(Codonopsis lanceolata)과 오 혼용 우려가 있어 이들을 구별하기 위한 정확하고 객관적인 종 감별법이 필요하다. 본 연구에서는 '제니'의 기원인 모시대와 오 혼용 우려가 있는 종들을 구별 할 수 있는 유전자 마커를 개발하기 위하여 Genbank에 등록된 ycf2 구간을 활요하여 모시대와 잔대, 당잔대를 구분 할 수 있는 INDEL (insertion/deletion) 마커를 개발하였다. 또한, 보다 정확한 종감별을 위해 DNA 바코드로 활용되고 있는 유전자 부위의 염기서열을 분석하여 ITS (25%), atpB-rbcL (15%), atpF-atpH (14%), rpl16 (13%), trnL-F (10%), matK (9%), rpoC1 (7%)에서 변이율(percent of variable sites)을 확인하였다. 향후, 본 연구에서 개발된 INDEL 마커와 더불어 추가적으로 개발을 진행 중인 분자 마커는 한약재 '제니'의 품질관리에 활용 가능할 것으로 사료된다.

• Journal of Physiology & Pathology in Korean Medicine
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• v.36 no.6
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• pp.235-241
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• 2022

The purpose of this study was to investigate the immune activation effect of Sasamsaengmaek-san (SSSMS) consisted of a mixture of Adenophora triphylla var. japonica, Liriope platyphylla, Panax ginseng C. A. Meyer and Schisandra chinensis. in Balb/c mice. Measuring alanine aminotransferase (ALT) and aspartic acid transaminase (AST) levels in Balb/c mice was performed to analyze the cytotoxicity. Cytokines (IFN-γ, IL-2, IL-12) which regulate the immune activation in Balb/c mice were measured by enzyme-linked immunosorbent assay (ELISA). Activated T lymphocytes in peripheral blood mononuclear cell (PBMC), spleen, lymph nodes were analyzed by flow cytometry using percentages. All tests were compared with red ginseng 100 ㎍/mL (RG 100), which is the most used for immune activity. As a result, cytokine activity was significantly increased at SSSMS 300 group. Activated T lymphocytes in PBMC, spleen, lymph nodes were significantly increased at SSSMS 300 group. These results suggest that there is a possibility of SSSMS activating an immune system by activating the cytokines, and it is confirmed that SSSMS also effective for generation and differentiation of T, B lymphocytes which activate the immune response.

• Korean Journal of Environmental Biology
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• v.24 no.4
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• pp.359-367
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• 2006

The vascular plants of this site were identified as 641 taxa through field investigation; 101 families, 340 genera, 547 species, 80 varieties, 12 forms, 1 subspecies and 1 hybrid. Based on the Rare plants of the Forest Service and Korea Forest Research Institute, 9 taxa were listed except implanted species; Loranthus tanakae, Aristolochia manshuriensis, Aristolochia contorta, Viola albida, Cypripedium macranthum, Schpolia japonioa, Acanthopanax chiisanensis, Rhododendron micranthum. Based on the Korean endemic plants, 18 taxa were listed; Salix purpurea var, japonica, Asarum sieboldii var. mandshuricum for. misnadrum, Persicaria lapathifolia for. alba, Pseudostellaria sylvatica, Aconitum pseudolaeve var. erectum, Corydalis maculata, Corydazis albipetala, Corydalis grandicazyx, Cardamine amaraeiormis, Chrysosplenium barbatum, Filipendula glaberrima, Lespedeza x tomentella, Acanthopanax chiisanensis, Melampyrum setaceum var. nakaianum, Weigela subsessilis, Adenophora triphylla var. hirsute, Cirsium setidens, Saussurea pseudogracilis. Specific plant species by floral region were total 81 taxa (12.6%); Prunus yedoensis in class V, 13 taxa (Thuja orientalis, Cimicifuga heracleiiolia, Sedum middendorffianutn, Rhododendron micranthum, etc.) in class IV, 17 taxa (Equisetum palustre, Aceriphyllum rossii, Angelica gigas, Cirsium setidens, etc.) in class III, 15 taxa (Heloniopsis orientalis, Lychnis cognata, Saxifraga oblongifolia, Viola orientalis, etc.) in class II, 35 taxa (Hosta capitata, Cimicifuga simplex, Chrysosplenium flagelliferum, Campanula punctata, etc.) in class I. So, the naturalized plants were listed 53 taxa and the naturalization index was 8.2%, urbanization index was 20.7%.

• Korean Journal of Plant Resources
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• v.20 no.2
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• pp.201-211
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• 2007

The vascular plants at the nature every second year in Wolchulsan National Park was listed 325 taxa: 86 families, 205 genera, 283 species, 1 subspecies, 36 varieties and 5 forms. Based on the list of the rare plants by the Forest Research Institute, 3 taxa were recorded in the studied areas; Lilium callosum (Preservation priority order; No. 191), Viola albida (No. 202), Wikstroemia trichotoma (No. 120) and based on the list of Korean endemic plants, 8 taxa were recorded; Carex okamotoi, Lilium amabile, Carpinus coreana, Clematis trichotoma, Stewartia koreana, Ajuga spectabilis, Weigela subsessilis, Adenophora triphylla var. hirsute. Specific plants by floral region were total 44 taxa; Prunus davidiana, Wistaria floribunda in class IV, 9 taxa (Neolitsea aciculata, Vaccinium bracteatum, Utricularia racemosa, etc.) in class III, 5 taxa (Bupleurum longiradiatum, Ostericum melanotilingia, Cirsium schantarense) in class II, 28 taxa (Polygonatum falcatum, Eurya japonica, Ajuga spectabilis, etc.) in class I. The naturalized plants in this site were 4 families, 6 genera, 9 taxa and naturalization rate was 2.8% of all 325 taxa vascular plants.