• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6343-6348
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• 2012

Objective: The NAD(P)H:quinone oxidoreductase 1 (NQO1) rs1800566 polymorphism, leading to proline-toserine amino-acid and enzyme activity changes, has been implicated in bladder cancer risk, but individually published studies showed inconsistent results. We therefore here conducted a meta-analysis to summarize the possible association. Methods: A systematic literature search up to August 27, 2012 was carried out in PubMed, EMBASE and Wanfang databases, and the references of retrieved articles were screened. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were analyzed for homozygote contrast (TT vs. CC), additive model (T vs. C), dominant model (TT+CT vs. CC), and recessive model (TT vs. CC+CT) to assess the association using fixed- or random-effect models. Results: We identified 12 case-control studies including 3,041 cases and 3,128 controls for the present meta-analysis. Significant association between NQO1 rs1800566 genetic polymorphism and risk of bladder cancer was observed in the additive model (OR = 1.15, 95% CI = 1.01-1.30, p = 0.030). Moreover, in the subgroup analysis stratified by ethnicity, significant associations were observed in Asians (OR = 1.26, 95% CI = 1.08-1.47, p = 0.003 for T vs. C; OR = 1.68, 95% CI = 1.21-2.32, p = 0.002 for TT vs. CC; OR = 1.50, 95% CI = 1.13-1.98, p = 0.005 for TT vs. CT+CC) but not in Caucasians. Conclusions: The results suggest that NQO1 rs1800566 genetic polymorphism may contribute to bladder cancer development, especially in Asians.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2005년도 추계 학술발표회 제17권2호
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• pp.789-792
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• 2005

Development of high-strength concrete and improved durability has brought new opportunities to the construction industry. However, some attention was given to characteristics of such concrete, in particular with respect to their cracking sensitivity. It has been argued and demonstrated experimentally that a low water/cement ratio concrete undergoes shrinkage due to self-desiccation. This so-called autogenous shrinkage cracking is a major concern for concrete durability. One possible method to reduce cracking due to autogenous shrinkage is the addition of expansive additive. Tests conducted by many researches have shown the beneficial effects of addition of expansive for reducing the risk of shrinkage-introduced cracking. This paper aimed at forecasting deformation of high strength cement paste with expansive additive for early age.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1145-1149
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• 2012

Aim: To clarify any association between the hOGG1 Ser326Cys polymorphism and susceptibility to gastric cancer. Methods: A meta-analysis based on 11 eligible case-control studies involving 5,107 subjects was carried out to summarize the data on the association between hOGG1 Ser326Cys polymorphism and gastric cancer risk. Results: No association was found between hOGG1 Ser326Cys polymorphism and gastric cancer risk (dominant model: OR = 0.95, 95% CI: 0.83-1.09, p = 0.486, ph (p values for heterogeneity) = 0.419; additive model: OR = 1.02, 95% CI: 0.81-1.30, p = 0.850, ph = 0.181; recessive model: OR = 1.09, 95% CI: 0.80-1.48, p = 0.586, ph = 0.053). Subgroup analysis based on ethnicity (Asian and Caucasian) and smoking status (ever smoker and never smoker) did did notpresent any significant association. Sensitivity analysis did not perturb the results. Conclusions: This study strongly suggested there might be no association between the hOGG1 Ser326Cys polymorphism and gastric cancer risk. However, larger scale studies are needed for confirmation.

• 한국환경과학회지
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• 제28권7호
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• pp.617-627
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• 2019

This study investigated the relationship between heat-related illnesses obtained from healthcare big data and daily maximum temperature observed in seven metropolitan cities in summer during 2013~2015. We found a statistically significant positive correlation (r = 0.4~0.6) between daily maximum temperature and number of the heat-related patients from Pearson's correlation analyses. A time lag effect was not observed. Relative Risk (RR) analysis using the Generalized Additive Model (GAM) showed that the RR of heat-related illness increased with increasing threshold temperature (maximum RR = 1.21). A comparison of the RRs of the seven cities, showed that the values were significantly different by geographical location of the city and had different variations for different threshold temperatures. The RRs for elderly people were clearly higher than those for the all-age group. Especially, a maximum value of 1.83 was calculated at the threshold temperature of $35^{\circ}C$ in Seoul. In addition, relatively higher RRs were found for inland cities (Seoul, Gwangju, Daegu, and Daejeon), which had a high frequency of heat waves. These results demonstrate the significant risk of heat-related illness associated with increasing daily maximum temperature and the difference in adaptation ability to heat wave for each city, which could help improve the heat wave advisory and warning system.

• 콘크리트학회논문집
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• 제17권4호
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• pp.581-586
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• 2005

고성능 콘크리트는 단위 시멘트량이 많기 때문에 초기재령에 있어서 시멘트의 급속한 수화반응으로 인해 시멘트 경화체는 자기수축이 발생하게 된다. 이러한 자기수축 변형이 발생한 부재가 외부 또는 내부 구속 상태에 있을 경우에는 수축균열이 발생하게 되며, 이러한 초기재령에 발생한 수축균열은 콘크리트 구조물의 미관 및 내구성 저하를 초래하기 때문에 이를 억제하는 것은 매우 중요하다. 한편, 이러한 고성능 콘크리트의 자기수축을 저감시키는 방법으로서 팽창재의 혼입에 의한 수축보상이 있는데 자기수축 저감에 유효한 것으로 알려져 있다. 그러나 지금까지의 팽창재에 의한 고성능 콘크리트의 자기수축에 관한 연구는 실험에 근거한 연구로서 정량적인 연구가 아닌 정성적인 연구가 대부분 이었다. 이러한 팽창재에 의한 고성능 콘크리트의 자기수축 저감량을 정량적으로 평가하기 위해서는 팽창재의 수화반응 모델부터 시작하여 팽창재에 의한 시멘트 경화체의 팽창 모델을 구축할 필요가 있다. 따라서, 본 연구에서는 초기 재령의 자기수축 저감을 목적으로 초기재령에서 빠른 팽창력을 발휘하도록 재료 설계된 에트링가이트-석회 복합계를 대상으로하여, 팽창재의 입도분포 및 수화의 진행에 따른 인접겔과의 접촉을 고려한 팽창재의 수화반응모델을 제안하였다. 또한, 제안된 팽창재의 수화반응모델을 실험적으로 모델의 타당성에 대해서 검토한 결과, 본 연구에서 제안한 팽창재의 수화반응 모델은 실험치를 양호하게 평가할 수 있을 것으로 판단된다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.579-583
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• 2012

Background: The SULT1A1 Arg213His polymorphism is reported to be associated with lung cancer risk. However, this relationship remains controversial. For better understanding a meta-analysis was therefore performed. Methods: An extensive search was performed to identify all case-control studies investigating association between SULT1A1 Arg213His polymorphism and lung cancer risk. The strength was assessed by odds ratio (OR) with the corresponding 95% confidence interval (95%CI). Results: A total of five publications covering 1,669 cases and 1,890 controls were included in this meta-analysis. No significant association between SULT1A1 Arg213His polymorphism and lung cancer risk was observed in overall comparisons in all genetic models (dominant model: OR=1.33, 95%CI=1.00-1.76, P=0.05; additive model: OR=1.30, 95%CI=0.93-1.81, P=0.12; recessive model: OR=1.21, 95%CI=0.89-1.66, P=0.23). However, on subgroup analysis, an elevated risk in mixed populations with variant His allele was revealed in the dominant model (OR=1.66, 95% CI=1.06-2.62, P=0.03). Furthermore, the SULT1A1 Arg213His polymorphism was associated with an increased risk of lung cancer in both females and males in the dominant model (females: OR=1.72, 95%CI=1.29-2.27, P=0.00; males: OR=1.46, 95%CI=1.19-1.78, P=0.00). No significant association between this polymorphism and different smoking status (smokers and non-smokers) and the other ethnicities (Asians and Caucasians) was shown. Conclusions: The results of this meta-analysis indicate that the SULT1A1 Arg213His polymorphism is not associated with lung cancer risk in Asians and Caucasians, but possible elevation for genotype (GA/AA) in mixed populations and males and females needs further investigation.

• Journal of Preventive Medicine and Public Health
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• 제52권2호
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• pp.82-91
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• 2019

Objectives: Many studies have explored the relationship between short-term weather and its health effects (including pneumonia) based on mortality, although both morbidity and mortality pose a substantial burden. In this study, the authors aimed to describe the influence of meteorological factors on the number of emergency room (ER) visits due to pneumonia in Seoul, Korea. Methods: Daily records of ER visits for pneumonia over a 6-year period (2009-2014) were collected from the National Emergency Department Information System. Corresponding meteorological data were obtained from the National Climate Data Service System. A generalized additive model was used to analyze the effects. The percent change in the relative risk of certain meteorological variables, including pneumonia temperature (defined as the change in average temperature from one day to the next), were estimated for specific age groups. Results: A total of 217 776 ER visits for pneumonia were identified. The additional risk associated with a $1^{\circ}C$ increase in pneumonia temperature above the threshold of $6^{\circ}C$ was 1.89 (95% confidence interval [CI], 1.37 to 2.61). Average temperature and diurnal temperature range, representing within-day temperature variance, showed protective effects of 0.07 (95% CI, 0.92 to 0.93) and 0.04 (95% CI, 0.94 to 0.98), respectively. However, in the elderly (65+ years), the effect of pneumonia temperature was inconclusive, and the directionality of the effects of average temperature and diurnal temperature range differed. Conclusions: The term 'pneumonia temperature' is valid. Pneumonia temperature was associated with an increased risk of ER visits for pneumonia, while warm average temperatures and large diurnal temperature ranges showed protective effects.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2713-2717
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• 2015

Background: Possible associations between the single nucleotide polymorphism (SNP) rs8034191 in the aminoglycosidephosphotransferase domain containing 1 (AGPHD1) gene and lung cancer risk have been studied by many researchers but the results have been contradictory. Materials and Methods: A computerized search for publications on rs8034191 and lung cancer risk was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between rs8034191 and lung cancer risk with 13 selected case-control studies. Sensitivity analysis, test of heterogeneity, cumulative meta-analysis, and assessment of bias were also performed. Results: A significant association between rs8034191 and lung cancer susceptibility was found using the dominant genetic model (OR=1.344, 95% CI: 1.285-1.406), the additive genetic model (OR=1.613, 95% CI: 1.503-1.730), and the recessive genetic model (OR=1.408, 95% CI: 1.319-1.503). Moreover, an increased lung cancer risk was found with all genetic models after stratification of ethnicity. Conclusions: The association between rs8034191 and lung cancer risk was significant using multiple genetic models, suggesting that rs8034191 is a risk factor for lung cancer. Further functional studies of this polymorphism and lung cancer risk are warranted.

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5673-5679
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• 2014

Background: Previous published data on the association between CYP1A2 rs762551, rs2069514, rs2069526, and rs2470890 polymorphisms and lung cancer risk have not allowed a definite conclusion. The present meta-analysis of the literature was performed to derive a more precise estimation of the relationship. Materials and Methods: 8 publications covering 23 studies were selected for this meta-analysis, including 1,665 cases and 2,383 controls for CYP1A2 rs762551 (from 8 studies), 1,456 cases and 1,792 controls for CYP1A2 rs2069514 (from 7 studies), 657 cases and 984 controls for CYP1A2 rs2069526 (from 5 studies) and 691 cases and 968 controls for CYP1A2 rs2470890 (from 3 studies). Results: When all the eligible studies were pooled into the meta-analysis for the CYP1A2 rs762551 polymorphism, significantly increased lung cancer risk was observed in the dominant model (OR=1.21, 95 % CI=1.00-1.46). In the subgroup analysis by ethnicity, significantly increased risk of lung cancer was observed in Caucasians (dominant model: OR=1.29, 95%CI=1.11-1.51; recessive model: OR=1.33, 95%CI=1.01-1.75; additive model: OR=1.49, 95%CI=1.12-1.98). There was no evidence of significant association between lung cancer risk and CYP1A2 rs2069514, s2470890, and rs2069526 polymorphisms. Conclusions: In summary, this meta-analysis indicates that the CYP1A2 rs762551 polymorphism is linked to an increased lung cancer risk in Caucasians. Moreover, our work also points out the importance of new studies for rs2069514 associations in lung cancer, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the rs2069514 polymorphism in lung cancer development.

• 응용통계연구
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• 제18권3호
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• pp.543-553
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• 2005

선형 로지스틱 모형은 신용위험 관리를 위한 신용평점 모형 구축에 있어서 널리 쓰이고 있는 방법론이다. 본 논문에서는 신용평점화를 위하여 로지스틱 회귀 방법에 기초한 스플라인 방법론을 다루고자 한다. 선형 스플라인과 자동적인 변수선택 방법을 채택하였다. 모의 실험을 통하여 스플라인 방법의 성능을 규명하였다.