• Mass Spectrometry Letters
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• v.8 no.3
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• pp.49-52
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• 2017

Ibuprofen is one of the most popular analgesic and antipyretic drugs. An isotope dilution mass spectrometry method based on LC/MS was developed as a candidate reference method for the accurate determination of ibuprofen in pharmaceutical tablets. Isotope labelled ibuprofen, $ibuprofen-d_3$, was added as an internal standard into sample extracts. Ibuprofen and $ibuprofen-d_3$, was analysed by LC/MS in a selected ion monitoring (SIM) mode to detect ions at m/z 205 and 208, respectively. The repeatability and reproducibility of the developed ID-LC/MS method were tested for the validation and assessment of metrological quality of the method.

• Wind and Structures
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• v.2 no.4
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• pp.267-284
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• 1999

Multiple tuned mass dampers are proposed to suppress the vertical and torsional buffeting and to increase the aerodynamic stability of long-span bridges. Each damper has vertical and torsional frequencies, which are tuned to the corresponding frequencies of the structural modes to suppress the resonant effects. These proposed dampers maintain the advantage of traditional multiple mass dampers, but have the added capability of simultaneously controlling vertical and torsional buffeting responses. The aerodynamic coupling is incorporated into the formulations, allowing this model to effectively increase the critical speed of a bridge for either single-degree-of-freedom flutter or coupled flutter. The reduction of dynamic response and the increase of the critical speed through the attachment of the proposed dampers to the bridge are also discussed. Through a parametric analysis, the characteristics of the multiple tuned mass dampers are studied and the design parameters - including mass, damping, frequency bandwidth, and total number of dampers - are proposed. The results indicate that the proposed dampers effectively suppress the vertical and the torsional buffeting and increase the structural stability. Moreover, these tuned mass dampers, designed within the recommended parameters, are not only more effective but also more robust than a single TMD against wind-induced vibration.

• Nuclear Engineering and Technology
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• v.54 no.11
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• pp.4322-4328
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• 2022

The two-fluid model is widely used to describe two-phase flows in complex systems such as nuclear reactors. Although the two-phase flow was successfully simulated, the standard two-fluid model suffers from an ill-posed nature. There are several remedies for the ill-posedness of the one-dimensional (1D) two-fluid model; among those, artificial viscosity is the focus of this study. Some previous works added artificial diffusion terms to both mass and momentum equations to render the two-fluid model well-posed and demonstrated that this method provided a numerically converging model. However, they did not consider mass conservation, which is crucial for analyzing a closed reactor system. In fact, the total mass is not conserved in the previous models. This study improves the artificial viscosity model such that the 1D incompressible two-fluid model is well-posed, and the total mass is conserved. The water faucet and Kelvin-Helmholtz instability flows were simulated to test the effect of the proposed artificial viscosity model. The results indicate that the proposed artificial viscosity model effectively remedies the ill-posedness of the two-fluid model while maintaining a negligible total mass error.

• Structural Engineering and Mechanics
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• v.52 no.5
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• pp.997-1017
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• 2014

According to the structure characteristics of the non-uniform beam bridge, a practical model for calculating the vibration equation of the non-uniform beam bridge is given and the application scope of the model includes not only the beam bridge structure but also the non-uniform beam with added masses and elastic supports. Based on the Bernoulli-Euler beam theory, extending the application of the modal perturbation method and establishment of a semi-analytical method for solving the vibration equation of the non-uniform beam with added masses and elastic supports based is able to be made. In the modal subspace of the uniform beam with the elastic supports, the variable coefficient differential equation that describes the dynamic behavior of the non-uniform beam is converted to nonlinear algebraic equations. Extending the application of the modal perturbation method is suitable for solving the vibration equation of the simply supported and continuous non-uniform beam with its arbitrary added masses and elastic supports. The examples, that are analyzed, demonstrate the high precision and fast convergence speed of the method. Further study of the timesaving method for the dynamic characteristics of symmetrical beam and the symmetry of mode shape should be developed. Eventually, the effects of elastic supports and added masses on dynamic characteristics of the three-span non-uniform beam bridge are reported.

• Earthquakes and Structures
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• v.5 no.1
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• pp.83-109
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• 2013

A simple damper optimization method is proposed to find optimal damper allocation for shear buildings under both target added damping ratio and interstorey drift ratio (IDR). The damping coefficients of added dampers are considered as design variables. The cost, which is defined as the sum of damping coefficient of added dampers, is minimized under a target added damping ratio and the upper and the lower constraint of the design variables. In the first stage of proposed algorithm, Simulated Annealing, Nelder Mead and Differential Evolution numerical algorithms are used to solve the proposed optimization problem. The candidate optimal design obtained in the first stage is tested in terms of the IDRs using linear time history analyses for a design earthquake in the second stage. If all IDRs are below the allowable level, iteration of the algorithm is stopped; otherwise, the iteration continues increasing the target damping ratio. By this way, a structural response IDR is also taken into consideration using a snap-back test. In this study, the effects of the selection of upper limit for added dampers, the storey mass distribution and the storey stiffness distribution are all investigated in terms of damper distributions, cost function, added damping ratio and IDRs for 6-storey shear building models. The results of the proposed method are compared with two existing methods in the literature. Optimal designs are also compared with uniform designs according to both IDRs and added damping ratios. The numerical results show that the proposed damper optimization method is easy to apply and is efficient to find optimal damper distribution for a target damping ratio and allowable IDR value.

• Korean Journal of Applied Biomechanics
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• v.22 no.3
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• pp.325-332
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• 2012

This study aimed to analyze the effects of external load between male and female on angular velocity, moment, and absorbed energy of the lower-extremity joints during drop landing. The study subjects were 9 male($mass=70.82{\pm}4.64kg$, $height=1.71{\pm}0.04m$, $age=24.5{\pm}1.84years$), 9 female($mass=50.14{\pm}4.09kg$, $height=1.61{\pm}0.03m$, $age=23.6{\pm}2.62years$), without any serious musculoskeletal, coordination, balance, or joint/ligament problems for 1 year before the study. The angular velocity, flexion/extension and abduction/adduction moments, and absorbed energy of the lower-extremity joints were compared between the men and women during drop landing under 4 different conditions of external load(0%, 8%, 16%, and 24%) by using two-way repeated ANOVA(p < .05). The women landed with a greater peak angular velocity of the ankle joint, greater peak inversion moment, and lower peak hip-extension moment than the men did, under all 4 conditions. Additionally, the landing characteristics of the women were distinct from those of the men; the women showed a greater peak knee-adduction moment and greater absorbed energy of the knee joint. These differences indicate that anterior cruciate ligament(ACL) strain was greater in the women than in the men and therefore, women may be at a higher potential risk for noncontact injuries of the ACL with an increase in external load.

• Membrane and Water Treatment
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• v.2 no.3
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• pp.159-173
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• 2011

The air gap membrane distillation (AGMD) process was applied for water desalination. The main objective of the present work was to study the heat and mass transfer mechanism of the process. The experiments were performed on a flat sheet module using aqueous NaCl solutions as a feed. The membrane employed was hydrophobic PTFE of pore size 0.22 ${\mu}m$. A mathematical model is proposed to evaluate the membrane mass transfer coefficient, thermal boundary layers' heat transfer coefficients, membrane / liquid interface temperatures and the temperature polarization coefficients. The mass transfer model was validated by the experimentally and fitted well with the combined Knudsen and molecular diffusion mechanism. The mass transfer coefficient increased with an increase in feed bulk temperature. The experimental parameters such as, feed temperature, 313 to 333 K, feed velocity, 0.8 to 1.8 m/s (turbulent flow region) were analyzed. The permeation fluxes increased with feed temperature and velocity. The effect of feed bulk temperature on the boundary layers' heat transfer coefficients was shown and fairly discussed. The temperature polarization coefficient increased with feed velocity and decreased with temperature. The values obtained were 0.56 to 0.82, indicating the effective heat transfer of the system. The fouling was observed during the 90 h experimental run in the application of natural ground water and seawater. The time dependent fouling resistance can be added in the total transport resistance.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.5
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• pp.604-611
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• 2003

This study was concerned with the enhancement of mass transfer by surfactant added to the aqueous solution of LiBr. Different vertical inner tubes were tested with and without an additive of normal octyl alcohol. The test tubes were a bare tube, groove tube, corrugate tube and inserted spring tubes. The additive concentration of normal octyl alcohol as a surfactant is about 0.08mass%. The Sherwood number was measured as a function of film Reynolds number 20~200. The experimental results were compared with those which use no surfactant. The enhancement of mass transfer by Marangoni convection effect which was generated by addition of the surfactant is proved for each testing tube Especially, it is clarified that the tube with the spring has the highest enhancement effect. A correlation of the experimental mass transfer data for the bare, groove, corrugate and insert spring tubes results expressed as the form of Sh=cㆍ Re$_{f}$ $^{n}$ .

• Architectural research
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• v.14 no.3
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• pp.99-108
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• 2012

An innovative multi-story Semi-Active Tuned Mass Damper (SATMD) building system is proposed to control seismic response of existing structures. The application of adding new stories as large tuned mass and semi-active (SA) resettable actuators as central features of the control scheme is derived. For the effective control of the structures, the optimal tuning parameters are considered for the large mass ratio, for which a previously proposed equation is used and the practical optimal stiffness is allocated to the actuator stiffness and rubber bearing stiffness. A two-degree-of freedom (2-DOF) model is adopted to verify the principal efficiency of the suggested structural control concept. The simulations for this study utilizes the three ground motions, from SAC project, having probability of exceedance of 50% in 50 years, 10% in 50 years, and 2% in 50 years for the Los Angeles region. 12-story moment resisting frames, which are modified as '12+2' and '12+4' story structures, are investigated to assess the viability and effectiveness of the system that aims to reduce the response of the buildings to earthquakes. The control ability of the SATMD scheme is compared to that of an uncontrolled and an ideal Passive Tuned Mass Damper (PTMD) building system. From the performance results of suggested '12+2' and '12+4' story retrofitting case studies, SATMD systems shows significant promise for application of structural control where extra stories might be added.

• Journal of Ocean Engineering and Technology
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• v.11 no.2
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• pp.91-99
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• 1997

This paper presents theoretical formulations and numerical computations for predicting first-and second-order hydrodynamic force on a ship advvancing in waves. The theoretical formulation leads to linearized radiation and diffration problems solving the three-dimensional Green function integral equations over the mean wetted body surface. Green function representing a translating and pulsating source potantial for infinite water depth is used. In order to solve integral equations for three dimentional flows using Green function efficiently, the Hoff's method is adopted for numerical calculation of the Green function. Based on the first-order solution, the mean seconder-order forces and moments are obtained by directly integrating second-order pressure over the mean wetted body surface. The calculated items are carried out for analyzing the seakeeping characteristics of Series 60. The calculated items are hydrodynamic coefficients, wave exciting forces, frequency response functions and addd resistance in waves.