• 수산해양교육연구
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• 제27권3호
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• pp.656-671
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• 2015

The purpose of the present study is to examine relationships between disconnection and rejection schema, defense mechanism, and mental health in college students using structural equation modeling. The present study suggested a proposed model in which defense mechanism exerted a full mediating effect on the relation between disconnection and rejection schema and mental health. Goodness of fit tests were used to compare the proposed model against competing models. The subjects consisted of 304 college students. They completed the Young Schema Questionnaire(YSQ-SF), the Defense Style Questionnaire(DSQ), and the Mental Health Scale. The results showed that the second model had a better goodness of fit. Based on these findings, it is suggested that psychological interventions for mental health in college students should consider strategies to use more flexible and more adaptive defense mechanism style.

• 한국컴퓨터정보학회논문지
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• 제22권10호
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• pp.83-92
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• 2017

Reconnaissance is performed gathering information from a series of scanning probes where the objective is to identify attributes of target hosts. Network reconnaissance of IP addresses and ports is prerequisite to various cyber attacks. In order to increase the attacker's workload and to break the attack kill chain, a few proactive techniques based on the network-based moving target defense (NMTD) paradigm, referred to as IP address mutation/randomization, have been presented. However, there are no commercial or trial systems deployed in real networks. In this paper, we propose a threat model and the request for requirements for developing NMTD techniques. For this purpose, we first examine the challenging problems in the NMTD mechanisms that were proposed for the legacy TCP/IP network. Secondly, we present a threat model in terms of attacker's intelligence, the intended information scope, and the attacker's location. Lastly, we provide seven basic requirements to develop an NMTD mechanism for the legacy TCP/IP network: 1) end-host address mutation, 2) post tracking, 3) address mutation unit, 4) service transparency, 5) name and address access, 6) adaptive defense, and 7) controller operation. We believe that this paper gives some insight into how to design and implement a new NMTD mechanism that would be deployable in real network.

• BMB Reports
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• 제38권2호
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• pp.121-127
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• 2005

Drosophila protects itself from infection by microbial organisms by means of its pivotal defense, the so-called innate immunity system. This is its sole defense as it lacks an adaptive immunity system such as is found in mammals. The strong conservation of innate immunity systems in organisms from Drosophila to mammals, and the ease with which Drosophila can be manipulated genetically, makes this fly a good model system for investigating the mechanisms of virulence of a number of medically important pathogens. Potentially damaging endogenous and/or exogenous challenges sensed by specific receptors initiate signals via the Toll and/or Imd signaling pathways. These in turn activate the transcription factors Dorsal, Dorsal-related immune factor (Dif) and Relish, culminating in transcription of genes involved in the production of antimicrobial peptides, melanization, phagocytosis, and the cytoskeletal rearrangement required for appropriate responses. Clarifying the regulatory interactions between the various pathways involved is very important for understanding the specificity and termination mechanism of the immune response.

• 아시안잔디학회지
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• 제25권2호
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• pp.125-132
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• 2011

잔디가 건조 스트레스를 받은 상태에서 잔디의 생리학적 메커니즘과 건조 상태에서 식물이 회복하는 생리학적 메커니즘을 보다 깊이 이해하고자 한다. 증산작용과 Stomatal Conductance의 상호 관계로 인한 광합성량의 변화, 식물 세포 내부의 변화, 삼투압 조절능력의 변화, 호르몬의 변화, 단백질 변성 등의 생리학적 반응들을 이해하고 건조 스트레스 상태에서 회복하는데 세포내부의 적응 과정, 뿌리의 반응과 같은 생리학적인 측면에 대해 이해하고 건조 스트레스 상태에서 엽록소가 흡수하고 반사하는 Spectral Reflectance의 변화를 이해하고자 한다. 하지만 건조스트레스로 인한 식물의 생리학적 메커니즘에는 아직 많은 의문점을 가지고 있으며 향 후 외부환경 스트레스에 의한 식물의 Self-defense 메커니즘을 더욱 깊게 이해하여 보다 수준 높은 관리기법들을 연구하는데 초점을 맞추어야 할 것이다.

• IMMUNE NETWORK
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• 제4권4호
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• pp.205-215
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• 2004

In the early host defense system, effector function of natural killer (NK) cells results in natural killing against target cells such as microbe-infected, malignant, and certain allogenic cells without prior stimulation. NK cell cytotoxicity is selectively regulated by homeostatic prevalence between a repertoire of both activating and inhibitory receptors, and the discrimination of untransformed cells is achieved by recognition of major histocompatibility complex (MHC) class I alleles through inhibitory signals. Although it is well known that the bipotential T/NK progenitors are derived from the common precusor, functional mechanisms in terms of the development of NK cells remain to be further investigated. NK cells are mainly involved in innate immunity, but recent studies have been reported that they also play a critical role in adaptive immune responses through interaction with dendritic cells (DC). This interaction will provide effector functions and development of NK cells, and elucidation of its precise mechanism may lead to therapeutic strategies for effective treatment of several immune diseases.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권6호
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• pp.2160-2179
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• 2015

In many Radio Frequency Identification (RFID) applications, the reader recognizes the tags within its scope repeatedly. For these applications, some algorithms such as the adaptive query splitting algorithm (AQS) and the novel semi-blocking AQS (SBA) were proposed. In these algorithms, a staying tag retransmits its ID to the reader to be identified, even though the ID of the tag is stored in the reader's memory. When the length of tag ID is long, the reader consumes a long time to identify the staying tags. To overcome this deficiency, we propose a slot allocated blocking anti-collision algorithm (SABA). In SABA, the reader assigns a unique slot to each tag in its range by using a slot allocation mechanism. Based on the allocated slot, each staying tag only replies a short data to the reader in the identification process. As a result, the amount of data transmitted by the staying tags is reduced greatly and the identification rate of the reader is improved effectively. The identification rate and the data amount transmitted by tags of SABA are analyzed theoretically and verified by various simulations. The simulation and analysis results show that the performance of SABA is superior to the existing algorithms significantly.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권2호
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• pp.700-713
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• 2015

It is critical to design energy-efficient routing protocols for battery-limited mobile ad hoc networks, especially in which the energy-consuming MIMO techniques are employed. However, there are several challenges in such a design: first, it is difficult to characterize the energy consumption of a MIMO-based link; second, without a careful design, the broadcasted RREP packets, which are used in most energy-efficient routing protocols, could flood over the networks, and the destination node cannot decide when to reply the communication request; third, due to node mobility and persistent channel degradation, the selected route paths would break down frequently and hence the protocol overhead is increased further. To address these issues, in this paper, a novel Greedy Energy-Efficient Routing (GEER) protocol is proposed: (a) a generalized energy consumption model for the MIMO-based link, considering the trade-off between multiplexing and diversity gains, is derived to minimize link energy consumption and obtain the optimal transmit model; (b) a simple greedy route discovery algorithm and a novel adaptive reply strategy are adopted to speed up path setup with a reduced establishment overhead; (c) a lightweight route maintenance mechanism is introduced to adaptively rebuild the broken links. Extensive simulation results show that, in comparison with the conventional solutions, the proposed GEER protocol can significantly reduce the energy consumption by up to 68.74%.

• Biomolecules & Therapeutics
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• 제29권4호
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• pp.353-364
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• 2021

The gastrointestinal (GI) tract is a series of hollow organs that is responsible for the digestion and absorption of ingested foods and the excretion of waste. Any changes in the GI tract can lead to GI disorders. GI disorders are highly prevalent in the population and account for substantial morbidity, mortality, and healthcare utilization. GI disorders can be functional, or organic with structural changes. Functional GI disorders include functional dyspepsia and irritable bowel syndrome. Organic GI disorders include inflammation of the GI tract due to chronic infection, drugs, trauma, and other causes. Recent studies have highlighted a new explanatory mechanism for GI disorders. It has been suggested that autophagy, an intracellular homeostatic mechanism, also plays an important role in the pathogenesis of GI disorders. Autophagy has three primary forms: macroautophagy, microautophagy, and chaperone-mediated autophagy. It may affect intestinal homeostasis, host defense against intestinal pathogens, regulation of the gut microbiota, and innate and adaptive immunity. Drugs targeting autophagy could, therefore, have therapeutic potential for treating GI disorders. In this review, we provide an overview of current understanding regarding the evidence for autophagy in GI diseases and updates on potential treatments, including drugs and complementary and alternative medicines.

• 인터넷정보학회논문지
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• 제21권1호
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• pp.17-31
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• 2020

블록체인 기술이 급속도로 발전하고 있음에 따라 금융·물류 등 다양한 분야에서 블록체인 기술을 실용화하려는 시도들이 진행되고 있으며, 데이터 무결성이 매우 중요한 공공분야 또한 마찬가지이다. 국방분야 또한 네트워크 중심 작전환경(NCOE) 하에 작전운영을 위해서는 지휘통신 네트워크의 보안성 강화 및 완전무결성 확보가 매우 중요하다. 이를 위해 블록체인 네트워크를 적용한 지휘통신네트워크 구축이 필요하나, 현재까지의 블록체인 기술은 51% 공격 등의 보안 이슈들을 해결하지 못하고 있어, 국방에 접목하기 어려운 것이 현실이다. 특히, 현재 블록체인에서 많이 사용되고 있는 Practical Byzantine fault tolerance (PBFT)알고리즘은, 악의적인 행동을 하는 노드들에게 penalty 요소가 없고, 합의를 방해하는 노드가 전체 노드의 33%이상만 차지해도 합의 실패를 만드는 문제점이 있다. 본 논문에서는 블록체인의 주요 합의 알고리즘인 PBFT의 보안성 향상을 위해, Trust 모델을 접목하여 비정상 행위에 대한 penalty 메커니즘이 적용된 Adaptive Consensus Bound PBFT (ACB-PBFT) 합의 알고리즘을 제안한다.

• 생명과학회지
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• 제30권1호
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• pp.88-95
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• 2020

유기용매 내성 세균인 Pseudomonas sp. BCNU 106을 10%(v/v) 톨루엔에 노출시킨 후 8시간 동안 random arbitrarily primed polymerase chain reaction (RAP-PCR)기법을 이용하여 메신져 RNA 발현 레벨을 조사하였다. 총 100개의 상향발현된 발현 산물 중에서 50개의 상보적인 단편들이 반복적으로 재현성있게 발현되는 것으로 확인되어, 이들을 클로닝을 하였으며 나아가 유전자 염기서열을 결정하였다. Blast analysis 결과, 톨루엔은 LysR family transcriptional regulator 그리고 RNA polymerase factor sigma-32같은 전사와 관련된 유전자들의 발현 레벨을 적응적으로 증가시키는 것으로 확인되었다. 그리고 톨루엔 스트레스 존재 하에서 inorganic ion 수송과 대사와 관련된 catalase와 Mn²⁺/Fe²⁺ transporter 유전자의 발현이 증가되었으며, 신호전달과 대사와 기능적으로 관련된 type IV pilus assembly PilZ와 multi-sensor signal transduction histidine kinase 유전자들의 발현 증가도 확인되었다. 한편 톨루엔 노출 후 탄수화물 수송과 대사와 관련된 beta-hexosaminidase 유전자발현 레벨이 증가하였다. 나아가 DNA polymerase III subunit epsilon, DNA-3-methyladenine glycosylase II와 DEAD/DEAH box helicase domain-containing 유전자들과 같은 DNA 복제, 재조합 그리고 수복에 관련성이 있는 유전자들의 발현 레벨 그리고 심지어는 ABC transporter 유전자와 같은 방어 메커니즘에 관련성이 있는 유전자들의 발현 레벨이 적응적으로 증가되는 것으로 밝혀졌다. 특히 10% 톨루엔 존재하에서 ABC transportor, Mn²⁺/Fe²⁺ transporter 및 β-hexosaminidase 유전자에 해당하는 RNA들이 괄목하게 유도되는 것이 확인되었다. 그러므로 유기용매 내성 세균 Pseudomonas sp. BCNU 106이 유기용매에 대하여 내성을 나타내는데 있어서 방어 메커니즘, 세포내 이온 항상성 그리고 바이오 필름 형성이 필수적인 것으로 확인되었다.