• Archives of Pharmacal Research
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• 제24권4호
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• pp.342-348
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• 2001

In a course of obtaining more amount of bioactive costunolide and successive phytochemical isolation from Magnolia sieboldii (Magnoliaceae), a novel acyclic monoterpene 1 named deoxygeraniol (2,6(E)-dimethyl-2,6-octadiene) was isolated along with $\beta$-sitosterol 3-O-linoleate (2), trilinolein (3) and high amount of costunolide (4) in the pure state. The structure of compound 1 was determined on the basis of spectroscopic data. Costunolide was found to induce apoptotic cell death in a dose-dependent manner by nucleosomal DNA ladder and flow cytometric analysis. Immunoblot analysis showed that the level of the anti-apoptotic protein, Bcl-2, was decreased, whereas the cleavage of poly-(ADP-ribose) polymerase was, activated furthermore, the N-acetyl-L-cysteine antioxidant effectively prevented costunolide-induced cytotoxicity. These results suggest that costunolide-induced cell death is mediated by reactive oxygen species.

• The Journal of Asian Finance, Economics and Business
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• 제9권7호
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• pp.135-144
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• 2022

The relationship between applying knowledge management and accepting environmentally managed accounting is more complicated than previous studies suggested. Knowledge management is both an antecedent and a consequence of implementing environmentally managed accounting in the workplace. Nonetheless, none of the prior studies have systematically investigated this relationship. The current article attempted to scrutinize the reciprocated multifaceted tie between environmental managerial accounting and knowledge management by utilizing the methods of directed graph searches as well as directed acyclic graphs. The research data was gathered from 342 publicly-listed corporations in Vietnam's key stock markets. The empirical findings disclose that implementing knowledge management can lead to adopting environmental managerial accounting in business, which is, in turn, an antecedent of accepting knowledge management. More importantly, the current research found that the adoption of knowledge management is the first factor to affect the research model. Nonetheless, the usage of knowledge management in business can, in turn, have a positive effect back to the implementing extent of environmental managerial accounting. The findings are beneficial to scientists and particularly to executives by shedding new insight into this reciprocated bond, which can lead executives to make sound decisions regarding knowledge management and environmental managerial accounting for businesses to acquire competitive advantages.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2021년도 춘계학술발표대회
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• pp.25-28
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• 2021

블록체인은 탈집중화, 위변조 방지, 추적 가능, 노드 간 공동 유지 및 보수가 가능한 데이터베이스로서 서로 신뢰하지 않은 노드 간 통신 신뢰 문제를 해결할 수 있는 점 대 점 통신 네트워크를 실현할 수 있다. 최근 몇 년 동안, 블록체인 기술은 지속적으로 발전하여 데이터 보안 문제를 해결하기 위한 중요한 기술로 주목받고 있다. 블록체인의 응용은 최초의 디지털 화폐 영역에서 금융·정무·공업 제조 영역으로 확대되고 있다. 블록체인의 특성에 따라 블록체인의 성능은 분산형 데이터 통신에 비해 크게 떨어지고 처리량이 제한되는 문제점이 존재한다. 본 논문에서는 최근 연구되고 있는 블록체인의 보안 구조 및 성능 분석에 대해 조사하고, 기존에 연구되었던 기술과 비교하여 블록체인의 안전성을 유지하며 성능을 향상시키는 방법에 대해 고찰한다. 이후 유향 비순환 그래프 (DAG: Directed Acyclic Graph) 및 샤딩 (Sharding)을 이용하여 안전성과 성능을 강화시키는 방법에 대해 제안한다. 제안하는 시스템은 DAG를 사용하여 위변조 방지 및 처리 속도 향상의 이점을 가지고 있으며, 샤딩을 사용함으로써 데이터 처리량을 향상시킨다. 마지막으로 제안하는 시스템은 기존 블록체인과 비교하여 안정성과 데이터 처리량 측면에서 비교 분석을 진행한다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.338-341
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• 2005

In this paper, a real-time communication method using a PICNET-NP(Plant Instrumentation and Control Network for Nuclear Power Plant) is proposed with an analysis of the control network requirements of DCS (Distributed Control System) in nuclear power plants. The method satisfies deadline in case of worst data traffics by considering aperiodic and periodic real-time data and others. In addition, the method was used to analyze the data characteristics of the DCS in existing nuclear power plant. The result shows that use of this method meets the response time requirement(100ms).

• 응용통계연구
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• 제36권1호
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• pp.63-83
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• 2023

기존의 많은 연구에서 도시공원을 비롯한 녹지와 유아 행복감 간에 유의미한 상관관계를 도출했다. 또한 이를 통해 간접적으로 도시공원의 면적/근접성이 유아기의 행복감 증진에 효과가 있을 것이라 유추하였다. 하지만 관찰된 자료를 통한 인과효과 추정은 교란 변수의 적절한 조정을 필요로하고, 이런 관점에서 도시공원의 면적과 유아 행복감의 인과관계는 명확히 밝혀지지 않았다고 할 수 있다. 본 연구에서는 한국아동패널 자료를 이용하여 도시공원의 면적이 유아 행복감에 미치는 영향에 대한 인과효과를 추정하였다. 교란 변수를 조정하기 위한 방법으로 회귀 모형을 이용한 조정(regression adjustment), 가중치 기법(weighting), 그리고 매칭(matching) 등을 이용하였고, 각 방법들의 중요 개념을 분석 결과에 앞서 기술하였다. 교란 변수의 선택에 있어서 유향 비순환 그래프(directed acyclic graph)를 사용하였다. 분석 결과, 기존의 상관관계를 이용한 결론과는 다르게 도시공원의 면적과 유아 행복감 간에는 유의미한 인과효과가 존재하지 않았다.

• Molecular & Cellular Toxicology
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• 제1권4호
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• pp.281-283
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• 2005

Extraction of biologically meaningful data and their validation are very important for toxicogenomics study because it deals with huge amount of heterogeneous data. BINGO is an annotation mining tool for biological interpretation of gene groups. Several statistical modeling approaches using Gene Ontology (GO) have been employed in many programs for that purpose. The statistical methodologies are useful in investigating the most significant GO attributes in a gene group, but the coherence of the resultant GO attributes over the entire group is rarely assessed. BINGO complements the statistical methods with graph-theoretic measures using the GO directed acyclic graph (DAG) structure. In addition, BINGO visualizes the consistency of a gene group more intuitively with a group-based GO subgraph. The input group can be any interesting list of genes or gene products regardless of its generation process if the group is built under a functional congruency hypothesis such as gene clusters from DNA microarray analysis.

• 한국통계학회:학술대회논문집
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• 한국통계학회 2003년도 춘계 학술발표회 논문집
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• pp.157-162
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• 2003

Estimates from an EM algorithm are somewhat sensitive to the initial values for the estimates, and it is more likely when the model becomes larger and more complicated. In this article, we examined how the estimates fluctuate during an EM procedure for a recursive model of categorical variables. It is found that the fluctuation takes place mostly during the first half of the procedure and that it can be subdued by applying the Bayesian method of estimation. Both simulation data and real data are used for illustration.

• 산업경영시스템학회지
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• 제32권4호
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• pp.192-202
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• 2009

Disassembly of products at their end-of-life (EOL) is a prerequisite for recycling or remanufacturing, since most products should be disassembled before being recycled or remanufactured as secondary parts or materials. In disassembly sequence planning of EOL products, considered are the uncertainty issues, i.e., defective parts or joints in an incoming product, disassembly damage, and imprecise net profits and costs. The paper deals with the problem of determining the disassembly level and corresponding sequence, with the objective of maximizing the overall profit under uncertainties in disassembly cost and/or revenue. The solution is represented as the longest path on a directed acyclic graph where parameter (arc length) uncertainties are modeled in the form of intervals. And, a heuristic algorithm is developed to find a path with the minimum worst case regret, since the problem is NP-hard. Computational experiments are carried out to show the performance of the proposed algorithm compared with the mixed integer programming model and Conde's heuristic algorithm.

• 대한전자공학회논문지
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• 제23권5호
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• pp.681-691
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• 1986

To represent the relations of the data dependency and resource conflict among micro-operations(MOP's) in the compaction process of microprograms, we propose a DDM (data dependent matrix) representation method instead of the DAG (conventional directed acyclic graph). Also, we propose a global compaction algorithm of microprograms to prevent a kind of block copying by cutting the trace at a junction block. The DDM method and compaction algoristhm have been applied to the Lah's example. The results shows that the proposed algorithm is more efficient than the conventional algorithms in reducing in reducing the total execution time and control memory space.

• 한국컴퓨터정보학회논문지
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• 제12권6호
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• pp.105-113
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• 2007

유전자 조절망은 유전자의 발현이 다른 유전자에게 영향을 주는 것을 표현하는 유전자 망이다. 오늘날 마이크로 어레이 실험으로부터 유전자의 발현량을 측정한 대용량의 데이터가 이용 가능하다. 전형적인 데이터중의 하나는 특정 유전자를 제거한 후 다른 유전자의 발현량을 측정한 steady-state data이다. 본 논문은 이런 측정 데이터를 이용하여 중복 정보를 최소화하는 유전자 조절망을 재구성하는 방법을 제시한다. 제시한 모델은 기존 연구에서는 고려되지 않았던 사이클 형태로 나타나는 자동 조절 기능을 고려하였고, 또한 유전자의 억제자 또는 촉진자 역할을 고려하였다.