• Archives of Pharmacal Research
• /
• 제16권3호
• /
• pp.254-256
• /
• 1993

For the evaluation of the role of .alpha., .betha.-unsaturated ketone portion of ar-tumerone for its activity, the structural variation of this structural unit was performed to omit its alkylating propery. Thus compounds 2, 3, and 4 were prepared and their cytotoxicities were determined against three different leukemiz cell lines (HL-60, K-562, and $L_{1210})$ in vitro. The biological inactivity against three different cell lines of these analogues implies that the $\alpha, \beta$-unsaturated ketone of ar-tumerone is the essential pharmacophore for its activity.

• 한국정보처리학회:학술대회논문집
• /
• 한국정보처리학회 2019년도 춘계학술발표대회
• /
• pp.542-544
• /
• 2019

Changes in a person's health affect one's lifestyle and work activities. According to the World Health Organization (WHO), abnormal activity is growing faster in people aged 60 or more than any other age group in almost every country. This trend steadily continues and expected to increase further in the near future. Abnormal activity put these people at high risk of expected incidents since most of these people live alone. Human abnormal activity analysis is a challenging, useful and interesting problem among the researchers and its particularly crucial task in life and health care areas. In this paper, we discuss the problem of abnormal activities of old people lives alone at home. We propose Convolutional Neural Network (CNN) based model to detect the abnormal behaviors of elderlies by utilizing six simulated action data from daily life actions.

• 한국음향학회:학술대회논문집
• /
• 한국음향학회 1999년도 학술발표대회 논문집 제18권 1호
• /
• pp.269-273
• /
• 1999

Combination of mental stress task with noise background is a traditional tool employed in psychophysiology. However, intensity of background noise is a factor affecting both performance on test and psychophysiological responses associated with stress evoked by mental load in noisy environment. In the current study on 7 subjects we analyzed the influence of white noise (WN) intensity (55, 70, and 85 dB[A] ) on psychophysiological responses during word recognition test performed on noise background. There were recorded following physiological variables: electrodermal activity (EDA) , namely, skin conductance level (SCL), skin conductance response (SCR) amplitude (SCR-A), rise time and total number of SCRs (N-SCR); cardiovascular activity, e.g., heart rate (HR), respiratory sinus arrhythmia (RSA) index, pulse transit time (PTT), finger pulse volume (PV), skin temperature (SKT) and respiratory activity, such as respiration rate (RESP-R) and inspiration wane amplitude (RESP-A) during baseline resting state and 40 s long performance on 3 similar Korean word recognition tests with different WN intensity (55, 70, and 85 dB). Electrodermal responses (SCR-A, SCL, N-SCR) demonstrated gradual increment with increased intensity of noise, and this increase of response magnitude with higher intensity of noise was typical also for r skin temperature (phasic SKT decrease) and pulse volume (phasic and tonic PV decrease). However, some cardiovascular and respiratory responses did not exhibit same tendency of gradual increase of reactivity , namely HR, as well as RESP-R and RESP-A showed decrement of response magnitudes. Important finding in terms of cardiovascular reactivity was that 55 and 70dB evoked similar profiles, while 85dB WN resulted in significantly different profile of reactions, suggesting that there exists a threshold level after which intensive auditory stimulation elicits psychophyslological responses pattern of different quality. There are discussed potential autonomic mechanism involved in mediation of observed physiological responses.

• 한국산학기술학회논문지
• /
• 제13권5호
• /
• pp.2038-2044
• /
• 2012

본 연구는 대학생들의 레크리에이션 인식에 대한 조사로 D광역시 대학교에 재학 중인 학생 188명을 대상으로 레크리에이션 수업(강습)을 참여한 그룹과 그렇지 않은 그룹을 설문하여 SPSS 12.0 통계분석프로그램을 이용하여 빈도분석과 카이제곱검정을 실시한 결과는 다음과 같다. 첫째, 성별은 수업(강습) 경험과 유의하지 않으나 계열은 유의한 결과가 나왔고, 레크리에이션 인식은 수업(강습) 유무와 상관없이 오락이라 하였다. 여가와 레크리에이션 관계는 여가에 레크리에이션이 포함된다고 답하였다. 둘째, 대학생들의 레크리에이션 활동에 대한 인식으로 대학MT나 OT, 축제, 체육대회, 수련회 등과 같은 내용을 레크리에이션 활동이라고 기재하였으며, 프로그램의 일부라고 생각하는 대학생도 있는 것으로 나타났다. 셋째, 레크리에이션 지도자에 관해서는 결과는 진행자나 사회자라는 칭호를 선호하는 것으로 조사되었다. 본 연구 결과는 우리나라에서 레크리에이션의 개념은 예년에 비해 이해도가 높아졌으나 아직까지도 협소한 내용으로 인지되고 있어 보다 적극적인 교과 내용 개발과 지도자 양성이 필요하다.

• 미생물학회지
• /
• 제39권3호
• /
• pp.141-147
• /
• 2003

여러 항진균 활성 관련 유전자들의 발현 수준을 동시에 연구하기 위하여 DNA microarray를 이용하여 유전자들의 발현 패턴을 비교 분석하였다. 본 연구에서는 항진균활성을 가지는Bacillus lentimorbus WJ5의 genomic DNA를 무작위 하게 제한효소로 절단하여 2,000개의 DNA단편을 microarray하였으며, 감마선($^{60}Co$)조사로 유도된 7종의 항진균 활성 결핍 돌연변이체와 발현양상을 정량적으로 비교하였다. Gene Cluster (Michael Risen, Stanford Uniy.)를 이용한 DNA microarray의 분석 결과, 총 408개의 DNA 단편이 발현되는 것을 확인할 수 있었으며, 이들 중 20개의 DNA단편이 항진균 활성 결핍 돌연변이체에서 발현이 억제되는 것으로 나타났다. 특히,pbuX (xanthine permease, K222), ywbA (phosphotransferase system enzyme II, K393), ptsG (PTS glucose specific enzyme II ABC component, K877), yufO (ABC transporter(ATP-binding protein), K1301), 그리고 ftsY (signal recognition particle (docking protein), K868)는 모든 돌연변이체에서 동시에 발현되는 down-regulation된 유전자들로서 물질 이동과 관련된 것으로 보고되어 있으며, 항진균 활성 관련 신호 및 물질의 이동에 관여할 것으로 사료되어진다.

• 사상체질의학회지
• /
• 제34권3호
• /
• pp.1-20
• /
• 2022

Objective The Constitutional Seong-Jeong therapy is one of the important ways to prevent Sasang constitutional symptomatology. But, there are various interpretations and unclear aspects of the content and meaning, so there are many difficulties in applying it concretely in actual clinical practice. The purpose of this study is to clarify the physiology, pathology, treatment mechanism and its specific meaning. Method The pathology associated with constitutional symptomatology is known as Deepening-Seong and Exploding-Jeong. Therefore, related pathologies and corresponding treatment and prevention mechanisms were reviewed, focusing on the related contents of Donguisusebowon, and their specific meanings were considered. Results and Conclusions 1. Constitutional Seong-Jeong therapy is a regimen to prevent and manage Deepening-Seong and Exploding-Jeong. 2. Deepening-Seong and Exploding-Jeong are the inappropriate occurrences of Seong and Jeong in the poor area of the Heavenly-frame recognition and in the vulnerable area of Humanly-activity practice, and the antecedent cause is covetous desire. 3. Deepening-Seong and Exploding-Jeong cause the weakening in the power of ears-eyes-nose-mouth to perceive Heavenly frame and the power of lung-spleen-liver-kidney to practice Humanly activity in the four constitution's weak system, which lead to the Interruption in processing of four Qi in each weak system. 4. The four constitutions must be careful about the occurrence of covetous desire in the process of recognizing Heavenly frame and doing Humanly activity so that intellectual and behavioral abilities can be exerted to overcome the poor area of the recognition of Heavenly frame and the formation of Humanly activity to prevent deepening-Seong and exploding-Jeong from occurring.

• 한국정보과학회:학술대회논문집
• /
• 한국정보과학회 2008년도 한국컴퓨터종합학술대회논문집 Vol.35 No.1 (A)
• /
• pp.114-115
• /
• 2008

• 한국정보과학회:학술대회논문집
• /
• 한국정보과학회 2008년도 한국컴퓨터종합학술대회논문집 Vol.35 No.1 (A)
• /
• pp.90-91
• /
• 2008

• 한국정보과학회:학술대회논문집
• /
• 한국정보과학회 2007년도 가을 학술발표논문집 Vol.34 No.2 (A)
• /
• pp.72-73
• /
• 2007

• 보건의료산업학회지
• /
• 제5권3호
• /
• pp.13-23
• /
• 2011

This paper investigated the operating environment for the representative of each agency and the facility workers on the basis of analytical result of recognition changes of the operating environment changes under the operating the long-term care insurance. It was described plans to take positive effect on the operating as follows. The first, on the result of regression analysis, the service administrative range takes the biggest effect on the general recognition of executing the long-term care insurance off and on. The affirmative recognition of the service administrative range had the general recognition on the system be positive effect. But the operator of facility asserts that the care manager's professionalism related quality of service be strengthened. The second, on the result of regression analysis, in the financial accounting administrative it is revealed the more positive recognition it is, the more positive effects it has. From the difference verification of an operation size from operation subject, the small operation size and personal facility recognize the long term care insurance positively. On the other side the facilities where the operation size is big recognize the system negatively. The long-term care facility should rearrange a support program newly and the government needs to promote the donation activity, because it is needed to reduce the financial burden of facilities.