• Nutrition Research and Practice
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• v.12 no.2
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• pp.101-109
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• 2018

BACKGROUD/OBJECTIVES: The objective of this study was to investigate the effects of vitamin C on inflammation, tumor development, and dysbiosis of intestinal microbiota in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced inflammation-associated early colon cancer mouse model. MATERIALS/METHODS: Male BALB/c mice were injected intraperitoneally with AOM [10 mg/kg body weight (b.w)] and given two 7-d cycles of 2% DSS drinking water with a 14 d inter-cycle interval. Vitamin C (60 mg/kg b.w. and 120 mg/kg b.w.) was supplemented by gavage for 5 weeks starting 2 d after the AOM injection. RESULTS: The vitamin C treatment suppressed inflammatory morbidity, as reflected by disease activity index (DAI) in recovery phase and inhibited shortening of the colon, and reduced histological damage. In addition, vitamin C supplementation suppressed mRNA levels of pro-inflammatory mediators and cytokines, including cyclooxygenase-2, microsomal prostaglandin E synthase-2, tumor necrosis $factor-{\alpha}$, Interleukin $(IL)-1{\beta}$, and IL-6, and reduced expression of the proliferation marker, proliferating cell nuclear antigen, compared to observations of AOM/DSS animals. Although the microbial composition did not differ significantly between the groups, administration of vitamin C improved the level of inflammation-related Lactococcus and JQ084893 to control levels. CONCLUSION: Vitamin C treatment provided moderate suppression of inflammation, proliferation, and certain inflammation-related dysbiosis in a murine model of colitis associated-early colon cancer. These findings support that vitamin C supplementation can benefit colonic health. Long-term clinical studies with various doses of vitamin C are warranted.

• Korean Institute of Interior Design Journal
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• v.18 no.6
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• pp.104-114
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• 2009

The purpose of study was understanding necessity of environment design for underground parking lot in residential design plan and grasping design plans of 'Activity Support' that considerate women, exclude women's unsecured feeling at underground parking lot. The inquiry analyzed 6 design plan in design competition that considerate women according to precede studies, a theory of CPTED, a design guide for wayfinding, and survey. A ramp, circulation, entrance, lighting, ventilation, and space design plan are proceed on this study The result are as below. First, a rectilinear figure ramp suits entrance plan on the circulation, but if it is not possible, cross-using of rectilinear and curvilinear figure ramp plan is desirable. Second, on the circulation plan, vehicles circulation plan and equality parking distribution plan got accomplished generally, and help senses of direction because it is planed network systemize. On a large scale underground parking lot, simplify parking circulation to convenience entrance and exit for weak in sense of direction. Third, the shape and material that‘s environmentally conscious will be in use to the entrance plan. As the first stage to the underground, artwork that women prefer can modulate the rejection of underground space. Forth, natural lighting system and ventilation can make the environment-friendly space, decrease the women’s rejection to the underground, it can also keep a natural watch on the space. Fifth, on the space design plan, it can use bright and comfortable design of wall and ground to decrease the women‘s rejection, also it is useful to the sense of direction. LED indirect lighting plan that 58.7% of women prefers on survey reflects women’s state of desire that bright and atmosphere. In addition, proper use of plans that subsidiary facilities, rest area with Sunken, and nature-friendly material can minimize differences of underground and ground parking lot.

• Korean Institute of Interior Design Journal
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• v.19 no.1
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• pp.16-26
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• 2010

In recent, as rediscovery of the modern value is developed through the support by the government and the reinterpretation of the traditional culture, a Korean-style house(Hanok) also becomes an object of interest. Among these various viewpoints to see the Korean-style house, the necessity of a new spatial design approach to contain the types and functions of the architectural space of the Hanok appropriate to the modern society is raised which is not a passive approach to preserve the existing cultural assets. Out of the methods of the new spatial design of the Hanok which reflect the paradigm of the times, this study has the purpose to make an approach from the viewpoint of 'Restoration design'. As the 21 st century started, the recycle design whose active discussion and performance is made largely by Europe and Japan can be called a design method in the hardware part which enables continuous adaptive use of a building by applying a new use purpose and method to a building which doesn't use the recycle design or has low efficiency. In that meaning, it can be considered to be a very important architectural activity historically, archltecturally and spatially. Based on the methodological characteristics of the recycle design, this study largely divides the types of recycle into coherent recycle and imagery recycle and dedto s detailed methods of space, consinto ion and material and wardrobe used for each case to analyze the methods of concrete recycle design through the methodological analysis of recycle cases of the existing modern buildings. For the objects of recycle cases of the Hanok made recently based on the design methods acquired here, it was examined how the architectural and spatial characteristics of the Hanok can be reconsinto ed through what kinrecycmethods. The approach of the recycle design is considered to be a cornerstone to show a new architectural and spatial value in the viewpoint of the Hanok existence in modern times.

• KIISE Transactions on Computing Practices
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• v.21 no.7
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• pp.464-469
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• 2015

Long-term electrocardiogram data can be acquired by linking a Holter monitor to a mobile phone. However, most systems are designed to detect arrhythmia through heartbeat classification, and not just for supporting clinical decisions. In this paper, we propose an Abstracting algorithm, and introduce an analogous pateint search system using this algorithm. An analogous patient searcher summarizes each patient's typical pattern using the results of heartbeat, which can greatly simplify clinical activity. It helps to find patients with similar arrhythmia patterns, which can help in contributing to diagnostic clues. We have simulated these processes on data from the MIT-BIH arrhythmia database. As a result, the Abstracting algorithm provided a typical pattern to assist in reaching rapid clinical decisions for 64% of the patients. On an average, typical patterns and results generated by the abstracting algorithm summarized the results of heartbeat classification by 98.01%.

• Journal of Korean Society of Rural Planning
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• v.26 no.2
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• pp.117-126
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• 2020

In this study, demands of smart technology development were analyzed for rural village communities. Questionnaire items were derived by grasping the current status of information and communication technology. 49 villages in 8 regions were selected and surveys and statistical analysis were conducted. The main results of the study are as follows. First, 92% of community leaders use smartphones, search for information (38%), communicate with the Internet (36%) using smartphones, use KakaoTalk (31%), and Facebook (24%). Second, in the rural and urban exchange activities, promote support information service (51%) and promote method suggestion service (48.5%) showed that the demand for services in promote field was high. It is linked to the creation of economic opportunities. Third, in the income and production activities, demand for distribution services technology (39.3%) was high in the field of production and distribution, and cold chains that help maintain freshness until food, such as meat, fish, and vegetables are delivered to consumers when agricultural products are distributed. The constant temperature control system needs to be actively introduced. Fourth, autonomy activities showed the highest demand for air conditioning and control systems (34.2%) of community building, and the lowest demand for electronic voting (9.4%) and videoconferencing (9.4%) services. Lastly, in the general activity area of the community, the demand for technology of emergency services (37.1%) and health self-diagnosis service (35.4%), which are technologies in the welfare sector, ranked first and second respectively.

• Natural Product Sciences
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• v.14 no.4
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• pp.260-264
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• 2008

To find the antidiabetic activity of the tripterpenoid-rich fractions of Rubus coreanus (TRF-cor) and R. crataegifolius (TRF-cra) leaves or its main component niga-ichigoside $F_1$ (Niga-$F_1$), anti-hyperglycemic and antihyperlipidemic effects were investigated in the diabetic rat model induced by streptozotocin (STZ). Treatments of rats with 200 mg/kg of the TRF-cor, TRF-cra (each, p.o.) or 20 mg/kg of Niga-$F_1$ significantly inhibited the increase of blood glucose concentration about 44.8%, 28.7% or 20.6%, respectively, in the diabetic rats. In addition, treatments with those fractions inhibited the increase of serum concentrations of triglyceride, total cholesterol or LDL-cholesterol caused by STZ. The inhibitory rate on atherogenic index (AI) values of the TRFcor (200 mg/kg), TRF-cra (200 mg/kg) or Niga-$F_1$ (20 mg/kg)-treated groups were decreased about 55.7%, 36.3% or 22.6%, respectively, comparable to STZ-treated group. In the oral glucose tolerance test, treatment of TRF-cor or TRF-cra inhibited the increase of blood glucose concentration in the STZ-induced rats. Administration of 20 mg/kg of Niga-$F_1$ (p.o.) also exhibited similar effects with the effects of both TRFs at 200 mg/kg dose (p.o.). These results support that the triterpenoids, in particular Niga-$F_1$, are contributed to the antidiabetic effects of R. coreanus or R. crataegifolius.

• Korean Journal of Pharmacognosy
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• v.48 no.2
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• pp.97-107
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• 2017

There is no doubt that the effect of ginseng on blood pressure could be different depending upon the type of ginseng employed for the experiment and methodology, thereby can exert bilateral modulatory activity on blood pressure. It has been reported that ginseng induced no significant change in blood pressure in those subjects with normal blood pressure, but had a normalizing effect on the subjects with abnormal blood pressure. Especially, experimental evidence indicates that ginsenoside Rg3, a major component of red ginseng, has been found to lower blood pressure, which is mediated by release of endothelium-derived NO, enhancing the accumulation of cGMP in the rat aorta. This clinical results further support the beneficial effect of Korean ginseng on blood pressure elucidated by animal experiment. As expected, a multicentric non-controlled clinical study shows that the effect of ginseng consumption has been found to normalize blood pressure in hypertensive or hypotensive individuals as compared to virtually no effect in normotensives. In addition, ginseng has been known to exhibit blood pressure decreased with no significant side effect and deteriorated QOL during the combination therapy of ginseng and anti-hypertensive drugs. This review provides a comprehensive overview on the effects of Korean ginseng on blood pressure.

• Korean Journal of Microbiology
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• v.36 no.3
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• pp.228-235
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• 2000

Until now, it was diIliculi to overproduce lignin peroxidase(LiP) fiom Pl~anemchaete ch~ysosporium since the lack of optimized growth conditions. In this paper, we optimized the LIP production conditions and monitored LIP isozyines of fl chqsospoi.ium PSBL-1. The optimized condition includes sponge matrix support, no addition of $MnSO_4$, excess addition of niixogen source(48 inM diarmnonium), and addition of stabilizer(2 mM verakyl alcohol). Finally we obtained Lip activity of 1,800 unitsll. HI isozyne was overproduced when inyceliuin was cultivated in media containing $Mn^{2+}$ (2.73 inM) and excess nitrogen(48 11d4 diannnonium). Three azo dyes(acid yellow 9, congo ued, orange IT; each concenimtion of50 $\mu$M) we1-e rapidly decolorized within 2 inins by 0.4 un~t or Lip.

• Information Systems Review
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• v.5 no.2
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• pp.91-108
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• 2003

The number of companies which use Internet and Web grow at an explosive rate and most of them made use of the Web sites for business activity such as publicity, advertising, customer support, and online retailing. However, there are very few empirical studies on web sites evaluation based on theoretical framework. The primary purpose of this study is to evaluate motivational effectiveness of Web sites using the WebMAC Business instrument. In this paper, we introduced a lot of Web sites evaluation studies and several IS studies based on the motivation theory. Web sites evaluation was performed by four motivational factors which include stimulating, meaningful, organized, and easy-to-use. There are significant differences among the industry type about motivational factors. This study identifies areas for improvement of existing Web sites and suggests several guidelines for development of Web sites from the user's perspective.

• Applied Chemistry for Engineering
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• v.23 no.2
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• pp.190-194
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• 2012

10 wt% Mn supported on various commercial $TiO_2$ catalysts were prepared by wet-impregnation method for the low temperature selective catalytic reduction (SCR) of NO with $NH_3$. A combination of various physico-chemical techniques such as BET, XRD, XPS and TPR were used to characterize these catalysts. MnOx surface densities on MnOx/$TiO_2$ catalyst were related to surface area. As MnOx surface density lowered with high dispersion, the SCR activity for low temperature was increased and the reduction temperature ($MnO_2$ ${\rightarrow}$ $Mn_2O_3$) of surface MnOx was lower. For a high SCR, MnOx could be supported on a high surface area of $TiO_2$ and should be existed a high dispersion of non-crystalline species.