• The Journal of the Korea Contents Association
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• v.8 no.10
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• pp.198-207
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• 2008

The purpose of this study supplies the basic data to plan the optimum mental health service that is reflected needs of the elderly people with mental illness by checking how their demographic-sociological distinctive feature and function level have an effect on their needs of mental health service by being absent situation of a study of the elderly people with mental illness. As results of analysis, the residental type, the disease period, and the decision person of admission-discharge control of demographic-sociological distinctive feature is much effect on needs of programs and also effect commonly on the needs of the health promotion program and the discharge support program. Generally, the function level of the elderly people with mental illness is favorable and the order of function level is the group activity program, the counseling program, and the resource network program.

• Biomolecules & Therapeutics
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• v.21 no.2
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• pp.114-120
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• 2013

Most patients with mutant B-Raf melanomas respond to inhibitors of oncogenic B-Raf but resistance eventually emerges. To better understand the mechanisms that determine the long-term responses of mutant B-Raf melanoma cells to B-Raf inhibitor, we used chronic selection to establish B-Raf (V600E) melanoma clones with acquired resistance to the new oncogenic B-Raf inhibitor UI-152. Whereas the parental A375P cells were highly sensitive to UI-152 ($IC_{50}$ < $0.5{\mu}M$), the resistant sub-line (A375P/Mdr) displayed strong resistance to UI-152 ($IC_{50}$ < $20{\mu}M$). Immunofluorescence analysis indicated the absence of an increase in the levels of P-glycoprotein multidrug resistance (MDR) transporter in A375P/Mdr cells, suggesting that resistance was not attributable to P-glycoprotein overexpression. In UI-152-sensitive A375P cells, the anti-proliferative activity of UI-152 appeared to be due to cell-cycle arrest at $G_0/G_1$ with the induction of apoptosis. However, we found that A375P/Mdr cells were resistant to the apoptosis induced by UI-152. Interestingly, UI-152 preferentially induced autophagy in A375P/Mdr cells but not in A375P cells, as determined by GFP-LC3 puncta/cell counts. Further, autophagy inhibition with 3-methyladenine (3-MA) partially augmented growth inhibition of A375P/Mdr cells by UI-152, which implies that a high level of autophagy may protect UI-152-treated cells from undergoing growth inhibition. Together, our data implicate high rates of autophagy as a key mechanism of acquired resistance to the oncogenic B-Raf inhibitor, in support of clinical studies in which combination therapy with autophagy targeted drugs is being designed to overcome resistance.

• Journal of Korean Elementary Science Education
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• v.35 no.2
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• pp.181-193
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• 2016

We examined the inquiry activities in the material domain of the elementary science textbooks and experimental workbooks based on 2009 revised curriculum. The analysis framework was SEP (Science and Engineering Practices) - 'Asking questions and defining problems', 'developing and using models', 'planning and carrying out investigations', 'analyzing and interpreting data', 'using mathematics and computational thinking', 'constructing explanations and designing solutions', 'engaging in argument from evidence', and 'obtaining, evaluating, and communicating information'. Sub-SEP of each grade band were also used. The results showed that the $3^{rd}{\sim}5^{th}$ grade science textbooks and workbooks mainly emphasized 'make observations and/or measurements', 'represent data in tables and/or various graphical displays', or 'use evidence to construct or support an explanation or design a solution to a problem' among around 40 sub-SEP. In the case of the inquiry activities for $6^{th}$ grade, majority of sub-SEP included were also only 'collect data to produce data to serve as the basis for evidence to answer scientific questions or test design solutions', 'analyze and interpret data to provide evidence for phenomena' or 'construct a scientific explanation based on valid and reliable evidence obtained from sources'. The type of 'asking questions and defining problems', 'using mathematics and computational thinking' or 'obtaining, evaluating, and communicating information' were little found out of 8 SEP. Educational implications were discussed.

• Journal of the Korean housing association
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• v.26 no.4
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• pp.75-82
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• 2015

Although the government has revised the child welfare act, institutionalized the establishment of local children's centers, and given financial support for them, there are a number of problems with respect to their operation. Specifically, one of main problems is their limited space. Diverse problems that go with the arrangement of limited space and usability have occurred, however there are only a few strategies to use limited space flexibly. This study assumed variability as one of the methods to solve spatial problems. As a basic research for the assumption, Analyzing the variable method and characteristics of domestic and foreign child-care facility guidelines was performed trying to take advantage of as a basic data in order to seek a variable scheme of local children centers' indoor space. For this purpose, study analysed the methods and characteristics of variability centering on aspects related to variability which are environmental design elements required by local children's centers as suggested in previous studies. The results are as follows. First, the variability of space should be planned according to activity and time, and consider the methods of division, storage, and other facilities necessary. Second, methods of variability in space can be classified into creating areas and structures that are variable. Third, as a result of analysing the environmental design elements required by local children's centers, this study discovered the following characteristics: multi-purpose usability through a combination of variable devices, transition through a variable space medium and setting up areas and expansion of indoor variability assuming usability through internal and external connections.

• Journal of the Economic Geographical Society of Korea
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• v.14 no.4
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• pp.568-582
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• 2011

This study aims to discover the characteristics of Sino-South Korean cross-border small-scale trade, which involves various players. Through this characteristics, this study ultimately intends to identify an operational mechanism of Sino-South Korean cross-border small-scale trade by investigating social capital as mobilized by small-scale traders. The results of this study can be expected to help understand how small-scale merchants address the uncertainty or risks surrounding their trade. Although it is an informal economic activity, the cross-border small-scale trade between South Korea and China is related to issues of the formal economy, such as job creation, benefits for local economies, and profit-seeking. Owing to this characteristics, small-scale trade is being conducted with the connivance of, or even with the tacit support from formal organizations, including municipal governments, customs, corporations, and shipping companies. Like trade in other countries, Sino-South Korean cross-border small-scale trade also requires different types of social capital, such as family networks, ethnic networks, social networks, and trust.

• 한국신재생에너지학회:학술대회논문집
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• 2010.11a
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• pp.86.2-86.2
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• 2010

In order to improve polymer electrolyte membrane fuel cell (PEMFC) durability, the durability of membrane electrode assemblies (MEA), in which the electrochemical reactions actually occur, is one of the vital issues. Many articles have dealt with catalyst layer degradation of the durability-related factors on MEAs in relation to loss of catalyst surface area caused by agglomeration, dissolution, migration, formation of metal complexes and oxides, and/or instability of the carbon support. Degradation of catalyst layer during long-term operation includes cracking or delamination of the layer which result either from change in the catalyst microstructure or loss of electronic or ionic contact with the active surface, can result in apparent activity loss in the catalyst layer. Membrane degradation of the durability-related factors on MEAs can be caused by mechanical or thermal stress resulting in formation of pinholes and tears and/or by chemical attack of hydrogen peroxide radicals formed during the electrochemical reactions. All of these effects, the mechanical damage of membrane and degradation of catalyst layers are more facilitated by uneven stress or improper MEA fabrication process. In order to improve the PEMFC durability, therefore, it is most important to minimize the uneven stress or improper MEA fabrication process in the course of the fabrication of MEA. We analyzed the effects of the MEA fabrication condition on the PEMFC durability with MEA produced using CCM (catalyst coated membrane) method. This paper also investigated the effects of MEA fabrication condition on the PEMFC durability by adding additional treatment process, hot pressing and pressing, on the MEA produced using CCM method.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2009.11a
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• pp.26-26
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• 2009

Vertically aligned arrays of mm-long multi-walled carbon nanotubes (MWCNTs) on Si substrates have been synthesized by water-assisted thermal chemical vapor deposition (CVD). The growth of CNTs was investigated by changing the experimental parameters such as growth temperature, growth time, gas composition, annealing time, catalyst thickness, and Al underlayer thickness. The 0.5-nm-thick Fe served as catalyst, underneath which Al was coated as a catalyst support as well as a diffusion barrier on the Si substrate. We grew CNTs by adding a little amount of water vapor to enhance the activity and the lifetime of the catalyst. Al was very good at producing the nm-size catalyst particles by preventing "Ostwald ripening". The Al underlayer was varied over the range of 15~40 nm in thickness. The optimum conditions for the synthesis parameters were as follows: pressure of 95 torr, growth temperature of $815^{\circ}C$, growth for 30 min, 60 sccm Ar + 60 sccm $H_2$ + 20 sccm $C_2H_2$. The water vapor also had a great effect on the growth of CNTs. CNTs grew 5.03 mm long for 30 min with the water vapor added while CNTs were 1.73 mm long without water vapor at the same condition. As-grown CNTs were characterized by using scanning electron microscopy (SEM), high resolution transmission electron microscopy (HRTEM), and Raman spectroscopy. High-resolution transmission electron microscopy showed that the as-grown CNTs were of ~3 graphitic walls and ~6.6 nm in diameter.

• Asian-Australasian Journal of Animal Sciences
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• v.21 no.7
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• pp.988-994
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• 2008

The purpose of the investigation was to establish how the pineal-adrenal axis plays an important role in thermoregulation in female goats under short-term heat stress. The study was conducted to observe the influence of glucocorticoids on pineal function in goats and its influence on stress alleviation capability. Melatonin and glucocorticoid secretions and several other endocrine and biochemical blood parameters reflecting the animals well being were determined over a one week period after goats had been exposed to $40^{\circ}C$ and 60% relative humidity for 10 days. Six female goats were used in the study. These animals served as self controls prior to the start of the experiment. The study was conducted for a period of seventeen days in a psychrometric chamber at $40^{\circ}C$ and 60% relative humidity. Chemical pinealectomy was achieved using propranolol followed by exogenous hydrocortisone treatment. Blood samples were drawn twice daily after each treatment to find the effect of hydrocortisone on plasma glucose, total protein, total cholesterol, cortisol, insulin, aldosterone, melatonin and corticosterone. Chemical pinealectomy significantly ($p{\leq}0.05$) affected plasma levels of the parameters studied and these could be significantly ($p{\leq}0.05$) counteracted by administration of hydrocortisone. Chemical pinealectomy aggravated thermal stress, although administration of hydrocortisone could ameliorate the condition. This indicated a role of the pineal in support of thermoregulation. The study establishes the modulating effect of glucocorticoids on pineal activity to relieve thermal stress in goats.

• Spatial Information Research
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• v.8 no.2
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• pp.191-201
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• 2000

Recently, tourism industry is on the trend of expanding its activity arena, boosted by revitalization of regional economy and reorganization of urban environment, undertaken for the purpose of place marketing. However, Korea has not been able to develop a variety of tourism itineraries that can attract the interest of tourists because most tourism resources are isolated with single function. This constraint has prevented tourism industry in Korea from attaining competitiveness. In attempting to overcome this constraint, this study seeks to develop tourism itineraries by constructing and utilizing database on historical and cultural tourism resources based on the case of Kangneung City. Through the construction of information system on historical and cultural resources and tourism support facilities, optimal tourism itineraries that take into account maintenance conditions, types, values, lodging availabilities and accessibility of tourism resource areas can be developed. Moreover, it is expected that this information system will have a high level of usage in the future, for it can provide a wide range of tourism services on the internet and education materials as well as facilitate resources management.

• Journal of The Korean Association of Information Education
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• v.12 no.3
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• pp.347-354
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• 2008

Many advanced technologies of computer and internet make the information communication technology education to be changed in elementary schools. The transition from the education of computer utilization to the education of computer science knowledge in ICT education area helps the child to enhance his or her logical thinking and the abilities of problem solving. In this study, we did some analysis of textbooks which have the updated information communication technology education, supporting these features. We collected six textbooks developed according to the guideline of information communication technology education since 2007. The main contents of this study are systematic analysis, quantity analysis and Romey's analysis about six textbooks. Specially, we found that 'Understanding of Information Society', 'Understanding of Information Processing' and 'Various Activity' among the ICT five area in textbooks support student's inquiry activities in elementary schools.