• 대한전자공학회논문지SD
• /
• 제47권4호
• /
• pp.75-87
• /
• 2010

표준 CMOS 공정에서 제작 가능한 보호용 싸이리스터 소자와 다이오드 소자를 사용하는 RF IC용 두 가지 입력 ESD 보호회로 방식을 대상으로, 2차원 소자 시뮬레이터를 이용하는 DC 해석, 혼합모드 과도해석 및 AC 해석을 통해 보호용 소자내 격자온도 상승 및 입력버퍼단의 게이트 산화막 인가전압 측면에서의 HBM ESD 보호강도에 대한 심도있는 비교 분석을 시도한다. 이를 위해, 입력 ESD 보호회로가 장착된 CMOS 칩의 입력 HBM 테스트 상황에 대한 등가회로를 구성하고, 5가지 HBM 테스트 모드에 대해 최대 6개의 보호용 소자를 포함하는 혼합모드 과도 시뮬레이션을 시행하고 그 결과를 분석함으로써 실제 테스트에서 발생할 수 있는 문제점들에 대한 상세한 분석을 시도한다. 이 과정에서 보호용 소자 내 바이폴라 트랜지스터의 트리거를 수월케 하는 방안을 제안하며, 두 가지 보호회로 방식에서 내부회로의 게이트 산화막 파괴는 보호용 소자 내에 존재하는 NMOS 구조의 접합 항복전압에 의해 결정됨을 규명한다. RF IC용 입력 보호회로로서의 두 가지 보호방식의 특성 차이에 대해 설명하는 한편, 각 보호용 소자와 회로의 설계와 관련되는 유용한 기준을 제시한다.

• Archives of Plastic Surgery
• /
• 제39권6호
• /
• pp.649-654
• /
• 2012

Background Deep burns of the elbow lead to soft tissue necrosis and infection, with exposure of deep structures. Adequate wound coverage of this area requires thin, pliable, and durable tissue, while optimal functional recovery requires early coverage and functional rehabilitation. We have found 3 types of island flaps that provide reliable coverage for the elbow. Methods A retrospective study was performed on all patients who underwent flap coverage of an elbow defect at our hospital. The patients' data including age, sex, cause of injury, wound dimensions, timing of flap coverage, postoperative elbow motion, and complications were investigated. Results Between 2001 and 2012, 16 patients were treated at our hospital. The mean age was 53.3 years. Three kinds of flaps were performed: 9 latissimus dorsi flaps, 4 lateral arm flaps, and 4 radial forearm flaps. The average defect size was 183.5 $cm^2$ (range, 28 to 670 cm2). Wound coverage was performed at mean duration of 45.9 days (range, 14 to 91 days). The mean postoperative active elbow flexion was $98^{\circ}$ (range, $85^{\circ}$ to $115^{\circ}$). Partial flap failure occurred in 1 latissimus dorsi flap. Minor complications included partial flap loss (11.8%), hematoma (23.5%), seroma (35.3%), and wound infection (5.9%). Conclusions Flap selection for elbow reconstruction is determined by the defect size and the extent of the adjacent tissue injury. Elbow reconstruction using an island flap is a single-staged, reliable, and relatively simple procedure that permits initiation of early rehabilitation, thereby improving a patient's functional outcome.

• 한국간호교육학회지
• /
• 제6권2호
• /
• pp.171-185
• /
• 2000

The twenty-first century may be said to be entering into a specialized qualification age to meet the needs of new technical innovations such as environmental changes, demographical changes, changes in the constitution of diseases, changes in the needs of the national health, reforms of information and knowledge, etc., which requires the provision of competitive services that can fulfill the high level needs of consumers. In consequence, it is needed to apply a practical nursing model that can serve as a guide for healthy society and to secure the sphere that can affect nursing policy-making by keeping pace with the changing environment. Furthermore, it is also urgent to expand more the activity sphere of nurse specialists with authority and autonomy, establish their legal foundation, establish a qualification accreditation system for nurse specialists, and develop educational programs. In Korea, the law relative to organ transplant past the national assembly on February 9, 2000, legally acknowledged brain death, which indicated to us the emergence of an age of organ transplant. Therefore, it necessitates to find out those of brain death from whom organ transplant is feasible in clinical practices, with their families' consent link to those terminal organ failure patients who are in need of an organ, and mediate both parties so that smooth transplant can be accomplished. A series of these complicated procedures require systematically trained specialists with high level techniques of organic management. With this in mind, this study was conducted on 69 clinical nurse specialists for organ transplant, accredited by the hospital, who are in active service in clinical practices. The resultant findings were revealed, as follows: 1. The qualifications of clinical nurse specialists for organ transplant should be accredited by Ministry of Health and Welfare or Korea Nurses Association. 2. The validity of qualifications should be for three years, and their renewal should be based on marks of a supplemental training or an education course for more than 12 hours a year. 3. The qualification of the clinical nurse specialist necessitates theoretical lectures and practices on those nurses who have had clinical experience in the pertinent field. 4. The course of training is required to be one year in the length of training and take more than 20 credits (320 hours) and 5 credits (240 hours).

• 한국산학기술학회논문지
• /
• 제18권12호
• /
• pp.400-413
• /
• 2017

출소 후 건전한 사회복귀를 위해서는 법무보호대상자(이하 보호대상자)들은 반드시 진로자본을 회복해야 하는 과제를 안고 있다. 그들의 진로적응 실패는 개인은 물론 사회안전망에 불안을 가중시킬 수 있기 때문에 진로자본 회복에 대한 연구는 매우 중요하다. 본 연구를 위해 한국법무보호복지공단에서 지원을 받고 있는 보호대상자 10명에 대해 심층 인터뷰를 진행하였다. 질적 내용분석 방법으로 보호대상자들의 진로자본 손상에 따른 어려움과 그 어려움을 극복하기 위한 노력, 극복하는데 도움이 된 요인, 직업생활에 적응하기 위한 요건 등 진로 주제를 심도 있게 분석하였다. 분석 결과 보호대상자들은 수감생활로 진로자본 손상을 경험하며, 사회적 자기에 대한 부정적인 개념, 사회적 낙인의 두려움, 자기에 대한 평가절하가 진로자본 회복과정에서 자신감 결여와 소극적인 태도로 나타났다. 또한 부정적 평가에 대한 두려움 등이 사회적 관계를 더욱 어렵게 하는 요인이었다. 한편, 진로자본 회복과정에서 사회적 지지는 긍정적인 영향을 미친 것으로 나타났다. 특히 배우자, 고용주, 가족, 친구들의 정서적 지지가 가장 큰 도움이 된 것으로 분석되었다. 직업적응을 위한 노력으로 진로에 대한 적극적이고 주도적인 태도와 긍정적인 자세가 중요하며 가족관계, 사회적 관계에서의 긍정적인 평가와 인정, 진로 성공경험 등이 일에 대한 자신감 상승으로 나타났다. 종합하면 진로자본 회복과정에서 역기능적 신념은 부정적인 영향을 미치고, 사회적 지지는 긍정적으로 영향을 미치는 것으로 분석되었다.

• Clinics in Shoulder and Elbow
• /
• 제14권1호
• /
• pp.105-110
• /
• 2011

목적: 견관절 역행성 인공관절 치환술의 합병증을 이해하고 이에 대한 최신의 예방 및 치료 방법을 고찰하는 것이 본 논문의 목적이다. 대상 및 방법: 기존의 구속형 인공관절 기구 (구-소켓 관절 혹은 역행성 구형 관절 디자인)는 견갑골의 외측에 회전 중심이 유지되어 제한된 관절 운동과 관절와 기구에 발생한 과도한 회전력으로 인해 조기 해리를 유발하여 실패해왔다. Grammont 역행성 인공관절 기구는 삼각근이 작용하는 새로운 생역학적 환경을 도입하여 회전근개 결손을 보상할 수 있도록 해준다. 결과: 임상적 경험이 생역학 개념에 부응하면 역행성 인공관절은 회전근 개 결손 견관절 환자에서 $90^{\circ}$이상의 능동적 거상을 회복하게 한다. 그러나 외회전은 특히 소원근 지방침윤 내지 결손이 있는 환자들에서는 종종 제한이 남는다. 내회전 역시 역행성 인공관절 후에는 거의 회복되지 않는다. 삼각근에 충분한 긴장을 회복하지 못하면 인공관절 불안성이 초래된다. 결론: 인공관절 치환술 후 재수술에서 그 결과는 예측가능성이 떨어지고, 합병증 및 재치환술 비율이 더 높음을 인지해야만 한다. 합병증을 인지하고 예방하기 위해서는 명확한 정의와 평가 지침을 포함한 표준화된 감시 장치가 필요할 것으로 사료된다.

• 대한수의학회지
• /
• 제39권2호
• /
• pp.247-256
• /
• 1999

A disease of young Holstein calves characterized by recurrent pneumonia, ulcerative and granulomatous stomatitis, enteritis with bacterial overgrowth, periodontitis, delayed wound healing, persistent neutrophilia and death at an early age had been originally described in 1983 and again in 1987. Most of these calves had stunted growth and a persistent, progressive neutrophilia (often exceeding 100,000/ml). By investigation of pedigrees, all of the affected calves have now been traced to a common sire and confirmed by polymerase chain reaction (PCR) diagnostic DNA testing to be homozygous carriers of a defective allele for bovine CD18. Neutrophils from these calves have several functional deficits and, most importantly, fail to adhere in a ${\beta}_2$-integrin dependent manner. The ${\beta}_2$-integrins represent a family of glycoproteins which participate in various leukocyte adhesion reactions during host defense. The presence or absence of ${\beta}_2$-integrin molecules can be demonstrated on the surface of neutrophils, monocytes and lymphocytes from normal or affected calves using specific monoclonal antibodies and flow cytometry, or by colloidal gold immunolabeling and scanning electron microscopy in backscatter mode. Deficiency of the ${\beta}_2$-integrins on all leukocyte types in Holstein calves is analogous to leukocyte adhesion deficiency (LAD) seen in humans. Neutrophils in bovine (BLAD) and human LAD patients are unable to adhere to the endothelial lining of the cardiovascular system thus interrupting egression of neutrophils into infected tissues. Other leukocytes, while still deficient in expression of the ${\beta}_2$-integrins, are still able to efficiently egress from the blood stream due to interactions of other adhesion molecules that are not as highly expressed on neutrophils. Both BLAD cattle and LAD children (who do not receive bone marrow transplants) often die at an early age as a result of the failure of neutrophils to extravasate into infected tissues. In 1991, Shuster, et $al^{27}$, identified two point mutations within the alleles encoding bovine CD18 in a Holstein calf afflicted with leukocyte adhesion deficiency. One mutation causes an aspartic acid to glycine substitution at amino acid 128 (D128G) in an extracellular region of this adhesion glycoprotein that is highly conserved (> 95% identity) between humans, cattle and mice. The other mutation is silent. Numerous calves with clinical symptoms of leukocyte adhesion deficiency have since been tested and all have been found homozygous for the D128G allele. In addition, calves homozygous far the D128G allele have been identified during widespread DNA testing in the United States. All cattle with the mutant allele are related to one bull, who through artificial insemination (A.I.), sired many calves in the 1950's and 1960's. The carrier frequency of the D128G CD18 allele among U.S. Holstein cattle had reached approximately 15% among active A.I. bulls and 8% among cows. By 1993, the organization of the dairy industry and the diagnostic test developed to genotype cattle, enabled virtually complete eradication of bovine leukocyte adhesion deficiency among current and future A.I. bulls.

• 대한유전성대사질환학회지
• /
• 제12권2호
• /
• pp.108-112
• /
• 2012

제 3형 당원병 (Glycogen Storage disease, Type III: OMIM #232400)은 상염색체 열성 유전을 하는 매우 드문 유전 질환으로, 1p21 염색체에 존재하는 AGL 유전자 (OMIM *610860)로부터 전사되는 글리코겐을 분해하는 효소인 가지제거효소(amylo-1,6 Glucosidase; EC 3.2.1.33 and 1,4-${\alpha}$-D-glucan 4-${\alpha}$-D-glycosyltransferase; EC 2.4.1.25)의 결함으로 인해 유발되는 질환이다. 제 3형 당원병의 환자들은 분해되지 못한 글리코겐이 조직에 축적되면서 증상이 발생하는데, 효소가 분포하던 조직에 따라 그 증상은 다양하게 나타난다. 제 3a형 당원병에서 간비대, 저신장, 그리고 저혈당증 증상은 아동기에 주로 나타나나 나이가 들면서 증상이 호전되어 사춘기를 전후하여 정상이 되는 경우가 많으며, 심근병증 및 근무력감, 운동발달지연 등의 근질환 증상은 영아기나 아동기에는 뚜렷하지 않지만 나이가 들면서 심해져 30-40대 이후 성인기에 나타나는 경우가 많다. 저자들은 간비종대, 심근 약화 증상, 근무력증 등의 전형적인 제 3a형 당원병의 임상증상 및 생화학적 특성이 관찰된 25세 여환에게서, AGL 유전자의 분석을 통해 제 3a형 당원병을 확진하였기에 이를 보고하는 바이다.

• 한국문헌정보학회지
• /
• 제12권
• /
• pp.165-200
• /
• 1985

We have come to the time when we no longer ask why we computerize, but we need to concentrate on how to effectively accomplish the task. Application of computers has been very active in many fields in Korea during the last few years. And yet libraries are rather slow in taking adventage of computers most likely due to the lack of adequate funds and proper understanding of administrators, but also it seems that the majority of librarians are not quite prepared to adopt it. The purpose of this paper is to study the various aspects of computerization of library work, mainly for library administrators and librarians; although they need not understand the electronical and technical aspects of computers, but they should prepare themselves enough at least to be able to make proper requests to computer specialists in relation to what they want to accomplish with computers in order to improve the work of the library. In preparing this paper, not only successful cases of computer application which had been carried out in many libraries of advanced countries have been studied, but also various reasons for failure have been reviewed in order not to make the same mistakes. The paper covers those areas of library work where computers can be applied, such as feasibility, cost effectiveness, planning, implementation and some other aspects of computerization. As a conclusion, two viewpoints need to be discussed. First, each library should work cooperatively with other libraies instead of trying to develop its own computer programs, since we cannot affort to waste financial and technical resources as well as time. Computer applicable library work can be divided and assumed by certain libraries with responsibility to develop turn-key systems applicable to Korean university libraries. In order to carry out this task, there should be complete financial assistance from government, and in turn those libraries shouldf be required to offer assistance to any other interested libaries in Korea. Secondly, library school curriculum should offer such courses where future librarians can learn decision making, business administration and independent thinking in addition to traditional courses. Future librarians as well as those who are already in the profession should prepare themselves to meet the challenge of the professional requirements in order to meet the ever increasing and diverse needs for good quality service generated from the library users.

• 한국지반환경공학회 논문집
• /
• 제14권7호
• /
• pp.19-29
• /
• 2013

동토지역에서 지반의 역학적인 특징은 기존 토질역학이론과 다르기 때문에 동토지반 내 응력분포와 파괴조건을 묘사하기 위하여 기존 토질역학을 동토에 적용하는 것은 효과적이지 못하거나 적합하지 않다고 할 수 있다. 따라서, 동토지역에서 구조물의 설계 및 시공을 위해서는 동토역학에 관한 기술 자료의 수집 및 분석, 그리고 체계적이고 전문화된 연구가 필수적으로 요구된다. 극한지에서 나타나는 영구동토지역은 계절에 따라 활동층이 동결 융해를 반복하게 되며, 이에 따라 구조물에 영향을 끼치는 하중조건 또한 변화된다. 특히, 동토의 역학적인 성질들은 온도, 함수비, 입도분포, 상대밀도, 하중을 가하는 속도에 따라 민감하게 반응하기 때문에 동토지역 구조물 설계 및 시공에 있어 다양한 조건에 따른 동토의 역학적인 특징들을 신뢰성 있게 분석할 수 있는 방법이 필수적으로 요구된다. 본 연구에서는 동토의 전단강도 특성을 분석하기 위하여 영하 30도에서 작동 가능한 직접전단시험장비와 대형 냉동 챔버를 활용하였으며, 동결온도, 수직응력, 함수비 및 상대밀도를 달리하여 화강풍화토의 전단강도 특성을 분석하였다. 본 연구에 따르면 수직응력, 함수비 및 상대밀도는 동결온도 조건하에서 화강풍화토의 전단강도 특성에 영향을 끼치는 것으로 나타났다.

• Clinical and Experimental Reproductive Medicine
• /
• 제29권4호
• /
• pp.323-335
• /
• 2002

Object: The present study was accomplished to obtain a gene expression profile of the luminal epithelium during embryo apposition in comparison of implantation (1M) and interimplantation (INTER) sites. Material and Method: The mouse uterine luminal epithelium from IM and INTER sites were sampled on day 4.5 (Day of vaginal plug = day 0.5) by Laser Captured Microdissection (LCM). RNA was extracted from LCM captured epithelium, amplified, labeled and hybridized to microarrays. Results from microarray hybridization were analyzed by Significance Analysis of Microarrays (SAM) method. Differential expression of some genes was confirmed by LCM followed by RT-PCR. Results: Comparison of IM and INTER sites by SAM identified 73 genes most highly ranked at IM, while 13 genes at the INTER sites, within the estimated false discovery rate (FDR) of 0.163. Among 73 genes at IM, 20 were EST/unknown function, and the remain 53 were categorized to the structural, cell cycle, gene/protein expression, immune reaction, invasion, metabolism, oxidative stress, and signal transduction. Of the 24 structural genes, 14 were related especially to extracellular matrix and tissue remodeling. Meanwhile, among 13 genes up-regulated at INTER, 8 genes were EST/unknown function, and the rest 5 were related to metabolism, signal transduction, and gene/protein expression. Among these 58 (53+5) genes with known functions, 13 genes (22.4%) were related with $Ca^{2+}$ for their function. Conclusions: Results of the present study suggest that 1) active tissue remodeling is occurring at the IM sites during embryo apposition, 2) the INTER sites are relatively quiescent than IM sites, and 3) the $Ca^{2+}$ may be a crucial for apposition. Search for human homologue of those genes expressed in the mouse luminal epithelium during apposition will help to understand the implantation process and/or implantation failure in humans.