• Journal of Practical Engineering Education
• /
• v.12 no.1
• /
• pp.187-202
• /
• 2020

Can job training be considered a social right? Who must bear the costs of individual job training? This paper studies these two issues by examining the Korean Individual Learning Accounts (ILA) revised in 2020 and proposes future policy directions. Although there is no explicit legal provision stipulating job training as a lawful right in Korea, such absence does not negate the government's role of providing vulnerable people, etc with necessary training. Korean ILA heavily depends on the Skills Development Scheme under the Employment Insurance System which succeeded the past mandatory training levy system and it becomes harder to maintain principle of insurance because of sizable volume of atypical workers who are not insured. For future policy directions, it is desirable to increase the burden of general budget and self-financing as they are below 30% combined and the coverage of the ILA needs to be steadily expanded to all economically active people. Also, labor-management should step up joint efforts to stimulate the use of already existing policies such as paid training leave and request for reduction of working hours.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.42 no.9
• /
• pp.802-808
• /
• 2014

MEMS based solid propellant thruster researched for the purpose of an academic research will be verified at space environment through CubeSat program. For this, the temperature of the MEMS thruster should be within allowable operating temperature range by proper thermal control to prevent the ignition failure caused by ignition time delay and to guarantee the structural safety of the MEMS thruster in the low temperature. In this study, we proposed an effective thermal control strategy, that is to use micro-igniter as a heater and temperature sensor for active thermal control instead of using additional heater. The effectiveness of the strategy has been verified through on-orbit thermal analysis of CubeSats with MEMS thruster.

• Journal of the Korea Institute of Building Construction
• /
• v.10 no.1
• /
• pp.155-162
• /
• 2010

Following the successful entry of Korean builders into overseas construction markets, Korean architects have also become active abroad, and have expanded their market share centered on the Southeast Asia and Middle Eastern areas through Design-Build contracts. However, there have also been However, conflict can arise among the project applicants in the contract stage due to the special characteristics of overseas construction. This sometimes leads to the failure of a project. Using statistics and case studies, this study identified problems in the overseas construction market. It analyzed inefficient factors of the architectural design contract phase in the overseas through a survey and an interview of specialists. Based on the results, this study suggested a master architect system, and some resolutions to the problems of organizing an internal evaluation system. It is expected that the results can be used as practical data for companies that want to advance into the overseas market.

• Korean Journal of Construction Engineering and Management
• /
• v.14 no.2
• /
• pp.22-34
• /
• 2013

As construction project has been becoming larger, specialized and complicated, it is important to utilize a lot of information that is made by diverse participants. Especially this information is mainly produced in construction site that plays a leading role in construction project. The problem of information exchange between participants of construction site causes decline of construction productivity. So as to resolve this problem, there is a many interest in BIM(Building Information Modeling) that makes and manages a necessary data during building life cycle. But in Korea construction industry, applying BIM in construction phase is less active than in design phase. Through studying previous research, this study classify the main cause of failure related to information exchange in framework construction. And by interviewing expert, it draw a work that is possible to apply BIM. Next through analyzing framework construction site that is applied with BIM, this study proposes specific information flow model for supporting work by BIM.

• Steel and Composite Structures
• /
• v.23 no.6
• /
• pp.633-646
• /
• 2017

The compressive behavior of special-shaped concrete filled tube (CFT) mega column coupled with multiple cavities is studied by testing six columns subjected to cyclically uniaxial compressive load. The six columns include three pentagonal specimens and three hexagonal specimens. The influence of cavity construction, arrangement of reinforcement, concrete strength on failure feature, bearing capacity, stiffness, and residual deformation is examined. Experimental results show that cavity construction and reinforcements make it possible to form a combined confinement effect to in-filled concrete, and the two groups of special-shaped CFT columns show good elastic-plastic compressive behavior. As there is no axial bearing capacity calculation method currently available in any Code of practice for special-shaped CFT columns, values predicted by normal CFT column formulas in GB50936, CECS254, ACI-318, EC4, AISCI-LRFD, CECS159, and AIJ are compared with tested values. The calculated values are lower than the tested values for most columns, thus the predicted bearing capacity is safe. A reasonable calculation method by dividing concrete into active and inactive confined regions is proposed. And high accuracy shows in estimating special-shaped CFT columns either coupled with multiple cavities or not. In addition, a finite element method (FEM) analysis is conducted and the simulated results match the test well.

• Journal of Korean Association for Spatial Structures
• /
• v.7 no.1 s.23
• /
• pp.79-85
• /
• 2007

Steel plate bonding method with epoxy is common applied to repair and strengthen RC structures, but Steel is apt to corrode quickly, hard to manufacture and heavy. To overcome these defects, it is carried out research on strengthening RC structures with FRP(Fibre Reinforced Polyrner/Plastic) FRP is generally used in the shape of Plate or Sheet, but it has weak point such as premature failure, difficult work. To cope with these problem, NSMR(Near Surface Mounted Reinforcement) which uses CFRP in the shape of Rod is proposed and carried out active research on strengthening effect of variables such as quantity, anchorage length and space of CFRP-Rod. Strengthening with CFRP-Rod is carried out under loading to some degree in fact, and so the amount of pre-loading is selected as variable in this research. The amount of pre-loading is chosen in proportion to nominal strength of non-strengthened specimen with CFRP-Rod.

• Smart Structures and Systems
• /
• v.17 no.1
• /
• pp.91-105
• /
• 2016

One of the most commonly used techniques to strengthen steel reinforced concrete structures is the application of externally bonded patches in the form of carbon fiber reinforced polymers (CFRP) or recently, textile reinforced cements (TRC). These external patches undertake the tensile stress of bending constraining concrete cracking. Development of full-field inspection methodologies for fracture monitoring are important since the reinforcing layers are not transparent, hindering visual observation of the material condition underneath. In the present study acoustic emission (AE) and digital image correlation (DIC) are applied during four-point bending tests of large beams to follow the damage accumulation. AE helps to determine the onset of fracture as well as the different damage mechanisms through the registered shifts in AE rate, location of active sources and change in waveform parameters. The effect of wave propagation distance, which in large components and in-situ can well mask the original information as emitted by the fracture incidents is also discussed. Simultaneously, crucial information is supplied by DIC concerning the moments of stress release of the patches due to debonding, benchmarking the trends monitored by AE. From the point of view of mechanics, conclusions on the reinforcing contribution of the different repair methodologies are also drawn.

• Molecules and Cells
• /
• v.38 no.10
• /
• pp.843-850
• /
• 2015

The1hepatic cell death induced by acetaminophen (APAP) is closely related to cellular adenosine triphosphate (ATP) depletion, which is mainly caused by mitochondrial dysfunction. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a key sensor of low energy status. AMPK regulates metabolic homeostasis by stimulating catabolic metabolism and suppressing anabolic pathways to increase cellular energy levels. We found that the decrease in active phosphorylation of AMPK in response to APAP correlates with decreased ATP levels, in vivo. Therefore, we hypothesized that the enhanced production of ATP via AMPK stimulation can lead to amelioration of APAP-induced liver failure. A769662, an allosteric activator of AMPK, produced a strong synergistic effect on AMPK Thr172 phosphorylation with APAP in primary hepatocytes and liver tissue. Interestingly, activation of AMPK by A769662 ameliorated the APAP-induced hepatotoxicity in C57BL/6N mice treated with APAP at a dose of 400 mg/kg intraperitoneally. However, mice treated with APAP alone developed massive centrilobular necrosis, and APAP increased their serum alanine aminotransferase and aspartate aminotransferase levels. Furthermore, A769662 administration prevented the loss of intracellular ATP without interfering with the APAP-mediated reduction of mitochondrial dysfunction. In contrast, inhibition of glycolysis by 2-deoxy-glucose eliminated the beneficial effects of A769662 on APAP-mediated liver injury. In conclusion, A769662 can effectively protect mice against APAP-induced liver injury through ATP synthesis by anaerobic glycolysis. Furthermore, stimulation of AMPK may have potential therapeutic application for APAP overdose.

• The Korean Journal of Physiology and Pharmacology
• /
• v.24 no.5
• /
• pp.373-384
• /
• 2020

Paeonol, quercetin, β-sitosterol, and gallic acid extracted from Moutan Cortex had been reported to possess anti-oxidative, anti-inflammatory, and anti-tumor activities. This work aimed to illustrate the potential anti-oxidative mechanism of monomers in human liver hepatocellular carcinoma (HepG2) cells-induced by hydrogen peroxide (H₂O₂) and to evaluate whether the hepatoprotective effect of monomers was independence or synergy in mice stimulated by carbon tetrachloride (CCl₄). Monomers protected against oxidative stress in HepG2 cells in a dose-response manner by inhibiting the generation of reactive oxygen species, increasing total antioxidant capacity, catalase and superoxide dismutase (SOD) activities, and activating the antioxidative pathway of nuclear factor E2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) signaling pathway. We found that the in vitro antioxidant capacities of paeonol and quercetin were better than those of β-sitosterol and gallic acid. Furthermore, paeonol apparently diminished the levels of alanine transaminase and aspartate aminotransferase, augmented the contents of glutathione and SOD, promoted the expressions of Nrf2 and heme oxygenase-1 proteins in mice stimulated by CCl₄. In HepG2 cells, paeonol, quercetin, β-sitosterol, and gallic acid play a defensive role against H₂O₂-induced oxidative stress through activating Nrf2/Keap1 pathway, indicating that these monomers have anti-oxidative properties. Totally, paeonol and quercetin exerted anti-oxidative and hepatoprotective effects, which is independent rather than synergy.

• Journal of Radiopharmaceuticals and Molecular Probes
• /
• v.1 no.2
• /
• pp.137-144
• /
• 2015

Hypoxia is an important adverse prognostic factor for tumor progression and is a major cause of failure of radiation therapy. In case of short-term hypoxia, the metabolism can recover to normal, but if hypoxia persists, it causes irreversible cell damage and finally leads to death. So a hypoxia marker would be very useful in oncology. In particular, 2-nitroimidazole can be reduced to form a reactive chemical species, which can bind irreversibly to cell components in the absence of sufficient oxygen, thus, the development of radiolabeled nitroimidazole derivatives for the imaging of hypoxia remains an active field of research to improve cancer therapy result. 2-nitroimidazole based hypoxia marker, [$^{18}F$]FMISO holds promise for the evaluation of tumor hypoxia by Positron emission tomography (PET), at both global and local levels. In the present study, [$^{18}F$]FMISO was synthesized using an automatic synthesis module with high radiochemical purity (>99%) in 60 min. Immunohistochemical analysis using pimonidazole confirmed the presence of hypoxia in xenografted CT-26 tumor tissue. A biodistribution study in CT-26 xenografted mice showed that the increased tumor-to-muscle ratio and tumor-to-blood ratios from 10 to 120 min post-injection. In the PET study, [$^{18}F$]FMISO also showed increased tumor-to-muscle ratios from 10 to 120 min post-injection. In conclusion, this study demonstrates the feasibility and utility of [$^{18}F$]FMISO for imaging hypoxiain mouse colon cancer model using small animal PET.