• Natural Product Sciences
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• v.12 no.3
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• pp.166-173
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• 2006

Silymarin is an antihepatotoxic substance isolated from the fruits of silybum mariamum. Possibly due to their antioxidant and membrane stabilizing properties, the compounds was shown to protect various organs and cells against a number of insults (Kvasnicka et al., 2003). Among the main silymarin components, [silybin($SB_A,\;SB_B$, isosilybin ($ISB_A,\;ISB_B$) silydianin (SD) and silychristin (SC)], silybin is the major pharmacologically active compound. Korean Pharmaceutical Codex (2nd ed.) describes silybin as the main substance of Cardus Marianus extract as supportive treatment of chronic inflammatory liver disorders. The aim of this work was to analyze silybin from various preparations containing cardus marianus extract, nicotinamide, and riboflavin (CNR). Nine commercial products were tested using reversed-phase HPLC-PDA assay. The limits of detection and quantification were $0.2\;{mu}g/ml$ and $1\;{mu}g/ml$, respectively. Calibration curve showed a good linearity ($r^2$=1.00000) in the range of $1{\sim}500\;{\mu}g/ml$ of silybin standard solutions.

• JSTS:Journal of Semiconductor Technology and Science
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• v.9 no.3
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• pp.160-165
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• 2009

A 12b 2 MS/s cyclic ADC processing 3.3 Vpp single-ended rail-to-rail input signals is presented. The proposed ADC demonstrates an offset voltage less than 1 mV without well-known calibration and trimming techniques although power supplies are directly employed as voltage references. The SHA-free input sampling scheme and the two-stage switched op-amp discussed in this work reduce power dissipation, while the comparators based on capacitor-divided voltage references show a matched full-scale performance between two flash sub ADCs. The prototype ADC in a $0.18{\mu}m$ 1P6M CMOS demonstrates the effective number of bits of 11.48 for a 100 kHz full-scale input at 2 MS/s. The ADC with an active die area of $0.12\;mm^2$ consumes 3.6 m W at 2 MS/s and 3.3 V (analog)/1.8 V (digital).

• New & Renewable Energy
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• v.9 no.1
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• pp.12-16
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• 2013

The nacelle anemometer mounted behind the blade roots of a wind turbine measures distorted wind speed comparable with free-stream wind because of the wake effects caused dependent upon the operation of the wind turbine and the rotation of its blades. The field campaign was carried out to measure free-stream wind speed at a height identical to the height of the nacelle anemometer by deploying a ground-based remote-sensing equipment, LIDAR. It is derived that a third-order polynomial equation for correcting wind speed measured by the nacelle anemometer to undistorted free-stream wind speed incident to a wind turbine. It is anticipated that the derived correction equation enables wind speed measured by the nacelle anemometer to be used as a precise input for a wind turbine performance test and for developing an active control logic.

• IEIE Transactions on Smart Processing and Computing
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• v.3 no.6
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• pp.416-424
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• 2014

This paper presents an 8-bit pipelined analog-to-digital converter. The supply voltage applied for comparators and other sub-blocks of the ADC were 0.7V and 0.5V, respectively. This low power ADC utilizes the capacitive charge pump technique combined with a source-follower and calibration to resolve the need for the opamp. The differential charge pump technique does not require any common mode feedback circuit. The entire structure of the ADC is based on fully dynamic circuits that enable the design of a very low power ADC. The ADC was designed to operate at 1MS/s in 90nm CMOS process, where simulated results using ADS2011 show the peak SNDR and SFDR of the ADC to be 47.8 dB (7.64 ENOB) and 59 dB respectively. The ADC consumes less than 1mW for all active dynamic and digital circuitries.

• The Bulletin of The Korean Astronomical Society
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• v.41 no.1
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• pp.70.4-71
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• 2016

The links between super-massive black hole masses and their host galaxy properties are observed, indicating that black hole growth and host galaxy evolution are closely related. Reverberation mapping, which uses the time delay from the central black hole to broad line regions, is one of the best methods to estimate masses of black holes of active galactic nuclei (AGNs). However, only masses of about 50 black holes have been determined in reverberation mapping studies so far, and most of them are limited to optical luminosities below 10^45 erg/s due to the challenges of long-term time domain observations in both photometry and spectroscopy. In this project, we expand reverberation mapping samples to higher luminosities of > 10^44.5 erg/s at 0.1 < z < 0.35, that have expected time lags of 40 - 250 light days. Photometric (using LOAO 1-m and MDM 1.3-m) and spectroscopic (using MDM 2.4-m and Lick 3-m) monitoring campaigns are being conducted for a 3 year duration and 20 day cadence. Precedent photometric observations in 2015B show some targets with variability and follow-up spectroscopic observations are on-going. In this presentation, we introduce our project, present reverberation mapping simulation results, and preliminary results on photometry. These reverberation mapping masses of relatively high luminous AGNs will provide a strong constraint on black hole mass calibration, e.g., the single-epoch mass estimation.

• Structural Engineering and Mechanics
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• v.42 no.1
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• pp.73-93
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• 2012

With an active structural involvement in spiral case structure (SCS) that is always the design and research focus of hydroelectric power plant (HPP), the compressible membrane sandwiched between steel spiral case and surrounding reinforced concrete was often assumed to be linear elastic material in conventional design analysis of SCS. Unfortunately considerable previous studies have proved that the foam material serving as membrane exhibits essentially nonlinear mechanical behavior. In order to clarify the effect of membrane (foam) material's nonlinear stress-strain behavior on SCS, this work performed a case study on SCS with a compressible membrane using the ABAQUS code after a sound calibration of the employed constitutive model describing foam material. In view of the successful capture of fitted stress-strain curve of test by the FEM program, we recommend an application and dissemination of the simulation technique employed in this work for membrane material description to structural designers of SCS. Even more important, the case study argues that taking into account the nonlinear stress-strain response of membrane material in loading process is definitely essential. However, we hold it unnecessary to consider the membrane material's hysteresis and additionally, employment of nonlinear elastic model for membrane material description is adequate to the structural design of SCS. Understanding and accepting these concepts will help to analyze and predict the structural performance of SCS more accurately in design effort.

• Journal of Pharmaceutical Investigation
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• v.30 no.4
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• pp.279-282
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• 2000

Simple and precise high-performance liquid chromatographic (HPLC) assay was developed and validated for the determination of a HMG-CoA reductase inhibitor, $lovastatin^{TM}$ and its active metabolite (mevinolinic acid) in human plasma. The method involved solid phase extraction of mevinolinic acid and internal standard using Sep-Pak Cartridge. Samples were analyzed by reversed-phase HPLC using $Capcell-Pak\;C_{18}$ column with ultraviolet detection at 238 nm. The quantitation limit of mevinolinic acid was 2 ng/ml and the calibration curve was linear over the range of 2-50 ng/ml $(r^2>0.999)$ with human plasma. The analyses of quality control samples indicated that the normal values could be predicted with an accuracy >97%. The intra- and inter-day coefficients of variation for the analyses were <10%. The average recoveries were similar (79%) for mevinolinic acid and methylmevinolinic acid. The method described has been successfully applied to the quantification of mevinolinic acid in about 1,000 human plasma samples over six-month period.

• Journal of information and communication convergence engineering
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• v.11 no.1
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• pp.56-61
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• 2013

Modern integrated circuits (ICs) are becoming an integrated parts of analog, digital, and radio frequency (RF) circuits. Testing these RF circuits on a chip is an important task, not only for fabrication quality control but also for tuning RF circuit elements to fit multi-standard wireless systems. In this paper, RF test circuits suitable for embedded testing are introduced: RF power detectors, power control circuits, directional couplers, and six-port reflectometers. Various types of embedded RF power detectors are reviewed. The conventional approach and our approach for the RF power control circuits are compared. Also, embedded tunable active directional couplers are presented. Then, six-port reflectometers for embedded RF testing are introduced including a 77-GHz six-port reflectometer circuit in a 130 nm process. This circuit demonstrates successful calibrated reflection coefficient simulation results for 37 well distributed samples in a Smith chart. The details including the theory, calibration, circuit design techniques, and simulations of the 77-GHz six-port reflectometer are presented in this paper.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.20 no.10
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• pp.1050-1060
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• 2009

In this paper, a X-Band T/R-module for SAR(Synthetic Aperture Radar) systems based on active phased array antennas is designed and fabricated. The T/R modules have a and width of more than 800 MHz centered at X-Band and support dual, switched polarizations. The output power of the module is 7 watts over a wide bandwidth. The noise figure is as low as 3.9 dB. Phase and amplitude are controlled by a 6-bit phase shifter and a 6-bit digital attenuator, respectively. Further the fabricated T/R module has est and calibration port with directional coupler and power divider. Highly integrated T/R module is achieved by using LTCC(Low Temperature Co-fired Ceramic) multiple layer substrate. RMS gain error is less than 0.8 dB max. in Rx mode, and RMS phase error is less than $4^{\circ}$ max. in Rx/Tx phase under all operating frequency band, or the T/R module meet the required electrical performance m test. This structure an be applied to active phase array SAR Antennas.

• Journal of Korean Society of Transportation
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• v.24 no.3 s.89
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• pp.17-27
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• 2006

Car following model is a theory that examines changes of condition and interrelationship of acceleration deceleration. headway, velocity and so on closely based on the hypothesis that the Posterior vehicle always follows the preceding vehicle. Car following mode) which is one of the research fields of microscopic traffic flow was first introduced in 1950s and was in active progress in 1960s. However, due to the limitation of data gathering the research depression was prominent for quite a while and then soon was able to tune back on track with development in global positioning system using satellite and generalization of computer use. Recently, there has been many research studies using reception materials of global Positioning system(GPS). Introducing GPS technology to traffic has made real time tracking of a vehicle position possible. Position information is sequential in terms of time and simultaneous measurement of several vehicles in continuous driving is also practicable. Above research was focused on judging whether it is feasible to overcome the following model research by adopting the GPS reception device that was restrictively proceeded due to the limitation of data gathering. For practical judgment, we measured the accuracy and confidence level of the GPS reception devices material by carrying out a practical experiment. Car following model is also being applied in simulations of traffic flow analysis, but due to the difficulty of estimating parameters the basis of the above result. it is our goal to produce an accurate calibration of car following model's parameters that is suitable in this domestic actuality.