• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.2
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• pp.745-754
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• 2021

The purpose of this study was to evaluate and verify the effectiveness of sustainable cosmetic raw materials developed from Gynostemma pentaphyllum, a plant native to Ulleungdo, in improving the skin barrier function and treating atopic dermatitis. Cells were derived from adult Gynostemma pentaphyllum plants, and suitable conditions for mass culture of the cells were established in a bioreactor. DNA components and amino acids extracted from this mass culture were identified from the HPLC fraction. In the in vitro efficacy evaluation results, changes in the expression levels of skin barrier-related proteins such as filaggrin (FLG) and Zonula occludens-1 (Zo-1) were insignificant. It was confirmed that the expression levels of the proteins thymic stromal lymphopoietin (TSLP) and interleukin-33 (IL-33) were significantly reduced. These results lead to the conclusion that Gynostemma pentaphyllum cell extracts have significant anti-inflammatory effects and that these extracts can be widely used as sustainable, nature-friendly active material in cosmetics with anti-inflammatory effects and targeted at improving atopic dermatitis.They may find use in anti-aging cosmetic products as well.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2008.11a
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• pp.131-134
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• 2008

The numbers of the elderly who suffer Empty Nest Syndrome have been accelerated as an aging population has increased vastly and nuclear families have been a dominating family type in modern Korean society. To make the elderly get out of this phenomenon and live actively, the scheme of converting their existing houses into shared houses was set as a hypothetical solution in this study, and finding out the responses of the elderly who owns their own houses is the purpose of the study. A small workshop panel method was used and the elderly aged 55 years upwards took part and they own a detached house that is relatively large for the elderly or the elderly couple to live alone. The workshop was consisted of 3 stages: 1. a survey 2. an interview 3. a site visit. Through this, problems that the elderly have been experiencing within their houses were looked into and the responses of the elderly on converting their houses to shared houses by introducing developed schematic plans. As a result, positive responses from the house owners were carried out based on the fact that subsidies from the government on house renovation and tenants matching programs are supported. Shared houses could provide home owners economical support with rents and help them to feel less lonely. This is one way of supporting the elderly to live and age actively in their later lives. Therefore, this idea should be established in connection with preparing aging, aged, and super-aged society.

• Journal of Microbiology and Biotechnology
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• v.25 no.8
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• pp.1307-1314
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• 2015

Leukemia inhibitory factor (LIF) is a member of the IL-6 cytokine family, having pleiotropic actions such as maintaining stem cell pluripotency and enabling blastocyst implantation. Because the action of LIF is mediated by a ligand-receptor interaction with the LIF receptor (LIF-R), an antagonist for LIF-R has been developed to inhibit LIF-induced signaling. In this study, we present a novel method for the production and purification of an antagonist to human LIF-R (hLA). His-tagged hLA was expressed in E. coli, and simple purification methods without any endopeptidase cleavage were designed. In addition, we determined the optimal temperature conditions for enhancing the production of soluble hLA. Finally, the bioactivity of His-tagged hLA was examined using STAT3 phosphorylation and receptivity of human endometrial ECC-1 cells. Our strategy provides a rapid and efficient method to produce biologically active recombinant hLA.

• Journal of Cancer Prevention
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• v.21 no.3
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• pp.144-151
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• 2016

Background: Immunoregulatory elements have emerged as useful immunotherapeutic agents against cancer. In traditional medicine, Mori folium, the leaf of Morus alba L. (Moraceae), has been used for various medicinal purposes; however, the immunomodulatory effects have not been fully identified. We evaluated the immunoenhancing potential of water extract of Mori folium (WEMF) in murine RAW264.7 macrophages. Methods: RAW264.7 cells were treated with WEMF for 24 hours and cell viability was detected by an MTT method. Nitric oxide (NO) levels in the culture supernatants were assayed using Griess reagent. The productions of prostaglandin $E_2$ ($PGE_2$) and immune-related cytokines was measured using ELISA detection kits. The mRNA and protein expression levels of Inducible NO synthase, COX-2, and cytokines were assayed by reverse transcription-PCR and Western blotting, respectively. The effect of WEMF on phagocytic activity was measured using a Phagocytosis Assay Kit. Results: WEMF significantly stimulated the production of NO and $PGE_2$ as immune response parameters at noncytotoxic concentrations, which was associated with the increased expression of inducible NO synthase and COX-2. The release and expression of cytokines, such as $TNF-{\alpha}$, interleukin $(IL)-1{\beta}$, IL-6, and IL-10, were also significantly increased in response to treatment with WEMF. Moreover, WEMF promoted the macrophagic differentiation of RAW264.7 cells and the resulting phagocytosis activity. Conclusions: WEMF has the potential to modulate the immune function by regulating immunological parameters. Further studies are needed to identify the active compounds and to support the use of WEMF as an immune stimulant.

• 한국노년학
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• v.32 no.3
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• pp.913-926
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• 2012

The purpose of this study is to review Saeromaji Plan 2015 (the Second Basic Plan for the Low Fertility and Aging Society) with the framework of WHO's (2007) guidelines for building age-friendly cities and to provide suggestions for improvements in planning for the aging society. The contents of the Plan pertaining to the aging society sections were reviewed by two independent researchers to examine the extent to which the Plan fulfilled 169 checklists across 8 themes proposed by WHO. The results indicate that all 8 themes were partially reflected in the Plan. Suggested improvements for planning for the aging society include taking an inclusive approach to bring generations together, providing more options for older adults, and including more active involvement of the private sector in planning.

• Journal of the Korean Applied Science and Technology
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• v.38 no.1
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• pp.136-146
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• 2021

This study is a descriptive research to determine the degree of self-esteem, menopausal symptom, spousal support of middle-aged women and investigate the factors affecting aging anxiety. For 3 weeks from May 23 to June 13, 2020, data total of 110 people were collected using online questionnaires for late middle-aged women. As a result of date analysis, factors affecting aging anxiety in late middle-aged women were menopausal symptoms(B=17.943, p<.001), self-esteem(B=-.585, p=.001) and the explanatory power of the regression model was 41.4%. Therefore, in order to lower againg anxiety, active intervention for menopausal symptoms of late middle-aged women is required, and measures should be taken to increase self-esteem.

• 한국정보디스플레이학회:학술대회논문집
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• 2004.08a
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• pp.277-280
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• 2004

Thin-film photosensors on organic light emitting diode (OLED) glass substrates using active-matrix OLED TFT manufacturing processes have been constructed and optimized, and their performance has been characterized. Suitable control circuitry and applications are proposed. The photosensors may be integrated into OLED displays for detection of ambient illumination and for detection of OLED light emission, thereby enabling output, uniformity, and aging compensation.

• Anxiety and mood
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• v.2 no.1
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• pp.9-16
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• 2006

As an aging population is increasing, more elderly people are exposed to traumatic stress. Although this issue has received more attention in some literature, it is clear that numerous questions exist in aftermath of trauma exposure in elderly people. In case of Korean elderly suffers, traumatic experience includes the Korean war, military dictatorship and violent demonstration. Studies regarding elderly PTSD is not active and a lot of patients are not still engaged in treatment. We suggest that concerns that are unique to this population are necessary.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.317.2-317.2
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• 2002

Peroxynitrite, formed from the reaction of .O2- and .NO, is a cytotoxic species that can oxidize several cellular components such as proteins. lipids and DNA. Oxidative stress is considered to be the major cause of aging and many age-related diseases including Alzheimer's disease. rheumatoid arthritis. cancer. and atherosclerosis. ONO-, a powerful oxidant, can cause damage of proteins, lipid and DNA through nitration and oxidation. (omitted)

• Korean Journal of Family Social Work
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• no.57
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• pp.159-182
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• 2017

With using the 4th and 5th wave of KLoSA(Korean Longitudinal Study of Aging), this study analyzed the effect of the factors of Rowe and Kahn's successful aging model on the life satisfaction of older adults. The target population of this study was 1,385 who is older than 65. As data analysis, hierarchical multiple regression was used. The variables such as demographics, avoiding diseases and disability, high cognitive and physical function and engagement with life, relationship with adult children were entered hierarchically for the regression analysis. Since there are differences of longevity by gender, the difference of factors of successful aging were compared by marital status. In this study (besides Rowe and Kahn's successful aging model such as avoiding disease and disability, high cognitive and physical function, and engagement with life), the relationships with adult children were analyzed additionally. Findings show that married older adults were older and reside with their adult children twice more than those who do not have a spouse. According to research results, regular exercise and memory skills were important factors of affecting life satisfaction. Among the categories of active engagement, meeting with friends, relatives and neighbors were significant. Contact with their adult children by mail or phone were the most important factors affecting the older adults' life satisfaction. The three parts of successful aging were various depending on the operationalization of variables.