• Proceedings of the Korean Institute of Building Construction Conference
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• 2021.05a
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• pp.289-290
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• 2021

The PC system has advantages in terms of project management, such as shortening the construction period and reducing costs. However, it is difficult to activate the technology due to insufficient application of the technology. Therefore, there is a need for a strategy to expand and activate the PC system. This study is a basic research for PC construction project management, and its purpose is to derive the entire construction process from factory production of PC components to on-site construction. In this study, the construction process of the PC system was derived through literature review, and the main matters for the construction process management of PC system were confirmed in the analysis process. In the future, the results of this study are expected to be used as basic data for research for PC project management, such as deriving construction classification and calculating construction periods.

• Proceedings of the Korea Society of Design Studies Conference
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• 2003.05a
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• pp.16-17
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• 2003

• Korean Architects
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• s.615
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• pp.160-163
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• 2020

• Proceedings of the Korean Society of Crop Science Conference
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• 2020.11a
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• pp.153-153
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• 2020

• Journal of Microbiology and Biotechnology
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• v.27 no.10
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• pp.1855-1866
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• 2017

The synergistic activation mediator (SAM) system can robustly activate endogenous gene expression by a single-guide RNA. This transcriptional modulation has been shown to enhance gene promoter activity and leads to epigenetic changes. Human $interferon-{\gamma}$ is a common natural glycoprotein involved in antiviral effects and inhibition of cancer cell growth. Large quantities of high-purity $interferon-{\gamma}$ are important for medical research and clinical therapy. To investigate the possibility of employing the SAM system to enhance endogenous human $interferon-{\gamma}$ with normal function in innate immunity, we designed 10 single-guide RNAs that target 200 bp upstream of the transcription start sites of the $interferon-{\gamma}$ genome, which could significantly activate the $interferon-{\gamma}$ promoter reporter. We confirmed that the system can effectively and highly activate $interferon-{\gamma}$ expression in several humanized cell lines. Moreover, we found that the $interferon-{\gamma}$ induced by the SAM system could inhibit tumorigenesis. Taken together, our results reveal that the SAM system can modulate epigenetic traits of non-immune cells through activating $interferon-{\gamma}$ expression and triggering JAK-STAT signaling pathways. Thus, this strategy could offer a novel approach to inhibit tumorigenesis without using exogenous $interferon-{\gamma}$.

• Proceedings of the Korean Vacuum Society Conference
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• 2015.08a
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• pp.158-158
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• 2015

Myoblast are myogenic precursors that proliferate, activate, and differentiate on muscle injury to sustain the regenerative capacity of skeletal muscle; The neuronal isoform of nitric oxide synthase (nNOS, termed also NOS-I) is expressed in normal adult skeletal muscle, suggesting important functions for Nitric oxide (NO) in muscle biology1,2,3. However, the expression and subcellular localization of NO in muscle development and myoblast differentiation are largely unknown. In this study, we examined effects of the nitric oxide generated by a microwave plasma torch, on proliferation/differentiation of rat myoblastic L6 cells. Experimental data pertaining to nitric oxide production are presented in terms of the oxygen input in units of cubic centimetres per minute. The various levels of nitric oxide are observed depending on the flow rate of nitrogen gas, the ratio of oxygen gas, and the microwave power4. In order to evaluate the potential of nitric oxide as an activator of cell differentiation, we applied nitric oxide generated from the microwave plasma torch to L6 skeletal muscles. Differentiation of L6 cells into myotubes was significantly enhanced the differentiation after nitric oxide treatment. Nitric oxide treatment also increase the expression of myogenesis marker proteins and mRNA level, such as myogenin and myosin heavy chain (MHC), as well as cyclic guanosine monophosphate (cGMP), However during the myotube differentiation we found that NO activate oxidative stress signaling erks expression. Therefore, these results establish a role of NO and cGMP in regulating myoblast differentiation and elucidate their mechanism of action, providing a direct link with oxidative stress signalling, which is a key player in myogenesis. Based on these findings, nitric oxide generated by plasma can be used as a possible activator of cell differentiation and tissue regeneration.

• The Journal of Industrial Distribution & Business
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• v.8 no.6
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• pp.61-73
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• 2017

Purpose - Aviation control, navigation, and aircraft control in the air transportation area are very specialized. Each part is in progress for safety, efficiency, automation, and further. On the other hand co-work among each part including knowledge sharing has been inattentive for many reasons. The purpose of this research is to show how practicians and professionals in the air transportation area perceive the issue of knowledge sharing and to recall the necessity of knowledge sharing in the area. And we try to find ways to activate the knowledge sharing in the area. Research design, data, methodology - For the research, we inquired into whether practicians and professionals think knowledge sharing can effect safe aviation positively or not and what steps are necessary to activate knowledge sharing in the area. We adopted survey method using questionnaires for current practicians and interview for specialists. The survey and interview results were analyzed using regression analysis and AHP method. The interview for specialists and analyzing the results using AHP was to investigate what are the precedence factors to activate the knowledge sharing. Results - First, practicians perceive that knowledge sharing will affect aviation safe positively. Second objective knowledges such as, tower air traffic control procedure of aviation control area, flight principle and structure of aircraft control area, instrument landing system of navigation area, for knowledge sharing of each area were identified. Also the precedence factors such as, knowledge absorbability of personal factor, personal expectation of result of expectation factor, leadership of management of Structure factor, method of knowledge spread of application factor for knowledge sharing were found. Conclusions - Knowledge sharing for practicians and professionals in the aviation area is very important especially from the perspective of safety. However, for various many reasons including the environment of each special area that focusing on their own area, knowledge sharing has not been emphasized. We found that practicians in the area feel that knowledge sharing is necessary and helpful. For it, each practician's active participation is the most important and many ways such as chatting room to share knowledge are to be developed. And the organization culture should be changed to encourage knowledge sharing.

• Journal of Korean Society of Transportation
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• v.23 no.5 s.83
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• pp.93-104
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• 2005

Transit-Oriented Development Model, which is recently proposed to activate transit use, is suitable for solving environmental erosion problems of sprawl cities with low urban density. Accordingly this model is inadequate to apply to Muti-Nucleated City with high urban density like Seoul. With this background. this study proposes ways to effectively implement changes from automobile-oriented Seoul to transit-oriented city through comparative analysis of the urban design policy of Station Impact Zone (SIZ) of Seoul and Transit-Oriented Development Policy of Singapore and Tokyo. First, the study suggests that the implementation strategies for Transit-Oriented Development in the job-oriented SIZ and the neighborhood-oriented SIZ should be made separately. In addition, the job-oriented SIZ should be designated as 'Strategic Centers' in Seoul Comprehensive Plan in order to make Transit-Oriented Centers. Lastly, the SIZ should be designated as 'the Empowerment Zones' in order to make the blighted areas around stations viable for redevelopment and new incentive system should be applied to activate setting up transit-transfer facilities.

• Journal of the Korean Institute of Landscape Architecture
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• v.31 no.5
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• pp.31-42
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• 2003

This study looked at worked on remaining landscapes in terms of landscape ecology. It presented some ways to conserve and to activate remaining landscapes with examples of agricultural lands in Hwa-won Gun, Ok-po Myun. The results are as follows: We investigated 20 remaining landscape types and 90 remaining landscapes, and classified them in terms of forest and water zones. To evaluate the investigated remaining landscapes, we produced a grading system using 8 criteria such as vitality, stability, field suitability, type of inner scenery formation, connection, recreation, and culture/tradition. Our evaluation of the vitality found that Grade I had the mast remaining landscapes; Grade II had 28, Grade III had 16, Grade V had four, and Grade IV had none. We evaluated the outer landscape influence using 3 criteria such as divisibility, vitality, and indication. We found from evaluating the type of inner scenery formation that most of the landscapes superior to Grade III were adjacent to water zones and that linear landscapes evaluated as Grade I, and II played an important role in this connection. We evaluated the recreation probability using marks, frequencies, and emergencies of peculiar types. Based on the results, we proposed some ways to conserve and to activate the remaining landscapes classified by grades using the results of the last evaluation. Additionally, we proposed some ways to activate the restoration of the linear axis of the green space function the formation of a buffer green space around matric space, the improvement of the axis of the green space center, and the formation of additional green tracts of land to play the role of stepping stones. We proposed the possibility of improving uniformed farm land structures. This study did not consider the weighting values of the evaluation index. Therefore a more objective study will be needed with an expert-survey in the future.

• Journal of the Korea Institute of Building Construction
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• v.18 no.1
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• pp.59-65
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• 2018

Radon gas is a colorless, odorless, tasteless gas that occurs when uranium, a natural radioactive material in rocks and soils, collapses. 85% of the annual radiation exposure of the human body is due to natural radiation, of which 50% is radon. According to the US Environmental Protection Agency (EPA) survey, 62 out of 1,000 smokers and 7 out of 1,000 nonsmokers are exposed to lung cancer when exposed to radon gas for a long time. In order to reduce the risk of radon gas, activate carbon was used to fabricate matrix, and the pore properties and radon reduction properties were investigated. When the activate carbon was used, the radon gas concentration was drastically reduced and the graph was changed as the measurement period became longer. The pore distribution and microporous properties, which are one of the material properties of activate carbon, can be grasped.