• Computational Structural Engineering : An International Journal
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• 제2권1호
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• pp.11-17
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• 2002

Cost-effectiveness in design is considered for determining the target reliability of concrete bridges under seismic actions. This objective can be achieved based on the economic optimization of the expected life-cycle cost of a bridge, which includes initial cost, direct losses, and indirect losses of a bridge due to strong earthquakes over its lifetime. A separating factor is defined to consider the redundancy of a transportation network. The Park-Ang damage model is employed to define the damage of a bridge under seismic action, and a Monte Carlo method based on the DRAIN-2DX program is developed to assess the failure probability of a bridge. The results for an example bridge analyzed in this paper show that the optimal target failure probability depends on the traffic volume carried by the bridge and is between 1.0×10/sup -3/ to 3.0×10/sup -3/ over a life of 50 years.

• 셀메드
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• 제3권2호
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• pp.12.1-12.4
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• 2013

Identification of target protein is an important procedure in the course of drug discovery. Because of complexity, action mechanisms of herbal medicine are rather obscure, unlike small-molecular drugs. Inverse docking simulation is a reverse use of molecular docking involving multiple target searches for known chemical structure. This methodology can be applied in the field of target fishing and toxicity prediction for herbal compounds as well as known drug molecules. The aim of this review is to introduce a series of in silico works for predicting potential drug targets and side-effects based on inverse docking simulations.

• 인지과학
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• 제28권3호
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• pp.133-147
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• 2017

인간의 지각은 외부환경을 객관적으로 반영하기 보다는 다양한 요인들에 의해 영향을 받은 결과이다. 이 요인들 중 행동-특정 지각은 환경에 대한 행위가능성에 의해 지각이 달라지는 현상이다. 기존 연구들은 행동-특정 지각이 과제를 수행하는 중에 발생하는지 아니면 수행 후 결과에 대한 지식 혹은 기억왜곡에 의한 것인지에 대해 상충된 결과를 보고하였다. 본 연구에서는 행동-특정 지각이 언제 발생하는지 확인하기 위해 다트를 사용하여 세 개의 실험을 실시하였다. 참가자들은 일정한 거리에서 다트를 수행하였으며 각 시행 후 지각된 표적의 크기를 응답지에 보고하였다. 그 결과 실험 1, 2에서 참가자들은 다트를 실패했을 때 보다 성공했을 때 표적을 더 크게 지각하였으며, 그 효과는 수행 후 표적을 볼 수 없을 때 더 강하게 발생하였다. 그러나 참가자들이 자신의 수행결과에 대해 알 수 있었기 때문에 응답에서 편파가 발생했을 가능성이 있었다. 이 가능성을 제거한 실험 3에서도 행동-특정 지각이 발생하였으며, 따라서 행동-특정 지각은 과제수행 후가 아닌 과제를 수행하는 동안 발생한다는 결론을 내릴 수 있었다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3735-3742
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• 2013

Background: Cardamom (Elettaria cardamom), also known as "Queen of Spices", has been traditionally used as a culinary ingredient due to its pleasant aroma and taste. In addition to this role, studies on cardamom have demonstrated cancer chemopreventive potential in in vitro and in vivo systems. Nevertheless, the precise poly-pharmacological nature of naturally occurring chemo-preventive compounds in cardamom has still not been fully demystified. Methods:In this study, an effort has been made to identify the proapoptopic, anti-inflammatory, anti-proliferative, anti-invasive and anti-angiogenic targets of Cardamom's bioactive principles (eucalyptol, alpha-pinene, beta-pinene, d-limonene and geraniol) by employing a dual reverse virtual screening protocol. Experimentally proven target information of the bioactive principles was annotated from bioassay databases and compared with the virtually screened set of targets to evaluate the reliability of the computational identification. To study the molecular interaction pattern of the anti-tumor action, molecular docking simulation was performed with Auto Dock Pyrx. Interaction studies of binding pose of eucalyptol with Caspase 3 were conducted to obtain an insight into the interacting amino acids and their inter-molecular bondings. Results:A prioritized list of target proteins associated with multiple forms of cancer and ranked by their Fit Score (Pharm Mapper) and descending 3D score (Reverse Screen 3D) were obtained from the two independent inverse screening platforms. Molecular docking studies exploring the bioactive principle targeted action revealed that H- bonds and electrostatic interactions forms the chief contributing factor in inter-molecular interactions associated with anti-tumor activity. Eucalyptol binds to the Caspase 3 with a specific framework that is well-suited for nucleophilic attacks by polar residues inside the Caspase 3 catalytic site. Conclusion:This study revealed vital information about the poly-pharmacological anti-tumor mode-of-action of essential oils in cardamom. In addition, a probabilistic set of anti-tumor targets for cardamom was generated, which can be further confirmed by in vivo and in vitro experiments.

• 한국신뢰성학회지:신뢰성응용연구
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• 제13권3호
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• pp.175-190
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• 2013

This study considers reliability growth management as the excellent method for construction equipment development with the effect on decreasing COPQ(Cost of Poor Quality Cost) of new products. MIL-HDBK-189A(1981) and RADC-TR-84-20(1984) standards provide a general concept of reliability growth management including to reliability growth test, models and FRACAS(Failure Reporting and Corrective Action System). There is no study how to apply reliability growth management to construction equipment(or machine) development. This paper propose the method to apply it to construction equipment development process from the reliability target setting for developing products to launching them at market. It is expecially showing how to set target reliability for new developing equipment and the development risk to reach the reliability target in detail.

• 한국환경과학회지
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• 제23권5호
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• pp.839-852
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• 2014

The Ministry of Environment (MOE) has made more effort in managing point source pollution rather than in nonpoint source pollution in order to improve water quality of the four major rivers. However, it would be difficult to meet water quality targets solely by managing the point source pollution. As a result of the comprehensive measures established in 2004 under the leadership of the Prime Minister's Office, a variety of policies such as the designation of control areas to manage nonpoint source pollution are now in place. Various action plans to manage nonpoint source pollution have been implemented in the Soyang-dam watershed as one of the control areas designed in 2007. However, there are no tools to comprehensively assess the effectiveness of the action plans. Therefore, this study would assess the action plans (especially, BMPs) designed to manage Soyang-dam watershed with the WinHSPF and the CE-QUAL-W2. To this end, we simulated the rainfall-runoff and the water quality (SS) of the watershed and the reservoir after conducting model calibration and the model validation. As the results of the calibration for the WinHSPF, the determination coefficient ($R^2$) for the flow (Q, $m^3/s$) was 0.87 and the $R^2$ for the SS was 0.78. As the results of the validation, the former was 0.78 and the latter was 0.67. The results seem to be acceptable. Similarly, the calibration results of the CE-QUAL-W2 showed that the RMSE for the water level was 1.08 and the RMSE for the SS was 1.11. The validation results(RMSE) of the water level was 1.86 and the SS was 1.86. Based on the daily simulation results, the water quality target (turbidity 50 NTU) was not exceeded for 2009~2011, as results of maximum turbidity in '09, '10, and '11 were 3.1, 2.5, 5.6 NTU, respectively. The maximum turbidity in the years with the maximum, the minimum, and the average of yearly precipitation (1982~2011) were 15.5, 7.8, and 9.0, respectively, and therefore the water quality target was satisfied. It was discharged high turbidity at Inbuk, Gaa, Naerin, Gwidun, Woogak, Jeongja watershed resulting of the maximum turbidity by sub-basins in 3years(2009~2011). The results indicated that the water quality target for the nonpoint source pollution management should be changed and management area should be adjusted and reduced.

• 해양환경안전학회지
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• 제25권3호
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• pp.259-268
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• 2019

Even if only two ships are encountered, a collision may occur due to the mistaken judgment of the positional relationship. In other words, if an officer does not know a target ship's intention, there is always a risk of collision. In this paper, the experiments are conducted to investigate how the intention affects the action of collision avoidance in cooperative and non-cooperative situations. In non-cooperative situation, each ship chooses a course that minimizes costs based on the current situation. That is, it always performs a selfish selection. In a cooperative situation, the information is exchanged with a target ship and a course is selected based on this information. Each ship uses the Distributed Stochastic Search Algorithm so that a next-intended course can be selected by a certain probability and determines the course. In the experimental method, four virtual ships are set up to analyze the action of collision avoidance. Then, using the actual AIS data of eight ships in the strait of Dover, I compared and analyzed the action of collision avoidance in cooperative and non-cooperative situations. As a result of the experiment, the ships showed smooth trajectories in the cooperative situation, but the ship in the non-cooperative situation made frequent big changes to avoid a collision. In the case of the experiment using four ships, there was no collision in the cooperative situation regardless of the size of the safety domain, but a collision occurred between the ships when the size of the safety domain increased in cases of non-cooperation. In the case of experiments using eight ships, it was found that there are optimal parameters for collision avoidance. Also, it was possible to grasp the variation of the sailing distance and the costs according to the combination of the parameters, and it was confirmed that the setting of the parameters can have a great influence on collision avoidance among ships.

• Journal of Applied Biological Chemistry
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• 제44권3호
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• pp.105-112
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• 2001

Insect pests can be controlled through direct application of insecticides. Insect control by residual protectants is relatively inexpensive and has an advantage of destroying all stages of infestations. The efficacy of control is largely determined by the concentration of insecticides to which the pest species is exposed. A reduction in the period of control in the field afforded by a specific level of a protectant indicates that resistance has developed. An increase in the level of protectant is required to maintain control, and the efficacy of currently used insecticides has been severely reduced by insecticide resistance in pest species. Development of resistance to particular insecticide varies with species because insecticide resistance is often correlated with increased levels of certain enzymes, which are cytochrome P450-dependent monooxygenases, glutathione S-transferases and esterases. Some sections of insecticide molecules can be modified by one or more of these primary enzymes. A reduction in the sensitivity of the action site of a xenobiotic also constitutes a mechanism of resistance. Acetylcholinesterase is a major target site for insecticide action, as are axonal sodium ion channels and ${\gamma}$-aminobutyric acid receptors. Development of reduced sensitivity of these target sites to insecticides usually occurs. This review not only may contribute to a better understanding of insecticide resistance, but also illustrates the gaps still present for a full biochemical understanding of the resistance.

• 생약학회지
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• 제45권2호
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• pp.127-134
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• 2014

A great interest is emerging about green tea as a tool against human cancer proliferation or inflammation, as pointed out by recent reports describing the inhibitory action of epigallocatechin gallate (EGCG) on angiogenesis, urokinase, metalloproteinases, and induction of inducible nitric oxide synthase. We proposed that EGCG may regulate a multi target signaling having wider spectra of action than those actions of single enzymes. CSK (c-terminal Src kinase) protein is a non-receptor tyrosine kinase involved in the cross-talk and mediation of many signaling pathways that promote cell proliferation, adhesion, invasion, migration, and tumorigenesis. Based on the knowledge that CSK activation is important for cancer proliferation we hypothesized that CSK could be a target of EGCG. Here we showed that EGCG effectively suppressed the growth of CSK MEF cell when compare with CSK knockout MEF cell growth. These results indicate that EGCG could be used as a chemoprevention to modulate CSK signal pathway in inflammatory processes and tumor formation.

• Communications for Statistical Applications and Methods
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• 제16권3호
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• pp.429-436
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• 2009

통합공정관리의 기본절차는 잡음이 내재하는 공정에 수정조치를 취하여 공정 편차를 백색잡음으로 전환하도록 하여 공정제곱편차를 최소화하게 된다. 이러한 수정활동 중 공정에 이상원인이 발생하면 관리도를 통하여 이를 탐지하고 제거하게 된다. 수정된 공정은 이상원인 발생 전에는 백색잡음이 되지만, 이상원인 발생 후에는 다양한 형태의 시계열 모형으로 변환하게 된다. 만일 수정된 공정을 탐지하여 이상원인의 신호가 있을 경우 교정활동을 통하여 이를 제거해야 하지만, 교정활동의 비용이 많이 발생하거나 또는 구조적으로 이를 제거할 수 없는 경우에는 이상원인의 효과를 감안하여 수정활동을 재조정해야 할 것이다. 이 논문에서는 공정모형으로 IMA(1,1) 모형을 가정하고 통합공정관리 절차를 수행하는 경우, 이상신호 발생 후 재수정 절차를 제안한다.