• Asian Pacific Journal of Cancer Prevention
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• 제17권11호
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• pp.4935-4937
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• 2016

Objective: To compare dosimetric parameters of 3 dimensional conformal radiotherapy (3 DCRT) and intensity modulated radiotherapy (IMRT) in terms of target coverage and doses to organs at risk (OAR) in the management of rectal carcinoma. Methods: In this prospective study, conducted between August 2014 and March 2016, all patients underwent CT simulation along with a bladder protocol and target contouring according to the Radiation Therapy Oncology Group (RTOG) guidelines. Two plans were made for each patient (3 DCRT and IMRT) for comparison of target coverage and OAR. Result: A total of 43 patients were recruited into this study. While there were no significant differences in mean Planning Target Volume (PTV) D95% and mean PTV D98% between 3 DCRT and IMRT, mean PTV D2% and mean PTV D50% were significantly higher in 3 DCRT plans. Compared to IMRT, 3 DCRT resulted in significantly higher volumes of hot spots, lower volumes of cold spots, and higher doses to the entire OAR. Conclusion: This study demonstrated that IMRT achieves superior normal tissue avoidance (bladder and bowel) compared to 3 DCRT, with comparable target dose coverage.

• International Journal of Fuzzy Logic and Intelligent Systems
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• 제6권3호
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• pp.264-269
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• 2006

This paper presents the strategy for searching a hidden object in an unknown area for using by multiple distributed autonomous robotic systems (DARS). To search the target in Markovian space, DARS should recognize th ε ir surrounding at where they are located and generate some rules to act upon by themselves. First of all, DARS obtain 6-distances from itself to environment by infrared sensor which are hexagonally allocated around itself. Second, it calculates 6-areas with those distances then take an action, i.e., turn and move toward where the widest space will be guaranteed. After the action is taken, the value of Q will be updated by relative formula at the state. We set up an experimental environment with five small mobile robots, obstacles, and a target object, and tried to research for a target object while navigating in a un known hallway where some obstacles were placed. In the end of this paper, we present the results of three algorithms - a random search, an area-based action making process to determine the next action of the robot and hexagon-based Q-learning to enhance the area-based action making process.

• 한국지능시스템학회논문지
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• 제15권4호
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• pp.406-411
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• 2005

본 논문에서는 다수 로봇의 목표물 탐색을 위한 area-based Q-learning 알고리즘에 대해 논한다. 선험적 정보가 없는 공간내의 목표물을 탐색하기 위해, 로봇들은 주위의 환경을 인식하고 스스로 다음 행동에 대한 결정을 내릴 수 있어야 한다. Area-based Q-learning에서, 먼저 각 로봇은 정육각형을 이루도록 배치된 6개의 적외선 센서를 통해 자신과 주변 환경 사이의 거리를 구한다. 다음으로 이 거리데이터들로부터 6방향의 면적(area)을 계산하여, 보다 넓은 행동반경을 보장해주는 영역으로 이동(action)한다. 이동 후 다시 6방향의 면적을 계산, 이전 상태에서의 이동에 대한 Q-value를 업데이트 한다. 본 논문의 실험에서는 5대의 로봇을 이용하여 선험적 지식이 없고, 장애물이 놓여 있는 공간에서의 목표물 탐색을 시도하였다. 결론에서는 3개의 제어 알고리즘-랜덤 탐색, area-based action making (ABAM), hexagonal area-based Q-learning - 을 이용하여 목표물 탐색을 시도한 결과를 보인다.

• Environmental Engineering Research
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• 제18권3호
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• pp.191-197
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• 2013

Republic of Korea announced the reduction target to be around 30% of business as usual greenhouse gas emissions by 2020. College campuses were ranked at the 5th of high energy consumption areas in the building sectors. Target management scheme was designed to set greenhouse gas emissions target including several college campuses. Previous studies showed the amount of greenhouse gas emissions with several assumptions such as the applications of renewable energy systems and light emitting diode lamps, etc. Long-range Energy Alternatives Planning model was utilized to simulate future greenhouse gas emissions. This study sets standard model labs for energy saving action programs by applying guidance studies. It has been deduced that energy saving action programs was responsible for reducing 949.5 kWh for each standard model lab and the total reduction of all 59 model labs in the Engineering College building has been calculated to 56,020.5 kWh. The objective of the study is to provide guidelines on standard model laboratory for greenhouse gas emissions reduction on the campus.

• Clinical and Experimental Reproductive Medicine
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• 제46권3호
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• pp.99-106
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• 2019

Bisphenol A (BPA) is an endocrine-disrupting chemical that is capable of interfering with the normal function of the endocrine system in the body. Exposure to this chemical from BPA-containing materials and the environment is associated with deleterious health effects, including male reproductive abnormalities. A search of the literature demonstrated that BPA, as a toxicant, directly affects the cellular oxidative stress response machinery. Because of its hormone-like properties, it can also bind with specific receptors in target cells. Therefore, the tissue-specific effects of BPA mostly depend on its endocrine-disrupting capabilities and the expression of those particular receptors in target cells. Although studies have shown the possible mechanisms of BPA action in various cell types, a clear consensus has yet to be established. In this review, we summarize the mechanisms of BPA action in spermatozoa by compiling existing information in the literature.

• Biomolecules & Therapeutics
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• 제31권3호
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• pp.241-252
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• 2023

The era of innovative RNA therapies using antisense oligonucleotides (ASOs), siRNAs, and mRNAs is beginning. Since the emergence of the concept of ASOs in 1978, it took more than 20 years before they were developed into drugs for commercial use. Nine ASO drugs have been approved to date. However, they target only rare genetic diseases, and the number of chemistries and mechanisms of action of ASOs are limited. Nevertheless, ASOs are accepted as a powerful modality for next-generation medicines as they can theoretically target all disease-related RNAs, including (undruggable) protein-coding RNAs and non-coding RNAs. In addition, ASOs can not only downregulate but also upregulate gene expression through diverse mechanisms of action. This review summarizes the achievements in medicinal chemistry that enabled the translation of the ASO concept into real drugs, the molecular mechanisms of action of ASOs, the structure-activity relationship of ASO-protein binding, and the pharmacology, pharmacokinetics, and toxicology of ASOs. In addition, it discusses recent advances in medicinal chemistry in improving the therapeutic potential of ASOs by reducing their toxicity and enhancing their cellular uptake.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권3호
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• pp.1614-1632
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• 2017

Bag of visual words is a popular model in human action recognition, but usually suffers from loss of spatial and temporal configuration information of local features, and large quantization error in its feature coding procedure. In this paper, to overcome the two deficiencies, we combine sparse coding with spatio-temporal pyramid for human action recognition, and regard this method as the baseline. More importantly, which is also the focus of this paper, we find that there is a hierarchical structure in feature vector constructed by the baseline method. To exploit the hierarchical structure information for better recognition accuracy, we propose a tree regularized classifier to convey the hierarchical structure information. The main contributions of this paper can be summarized as: first, we introduce a tree regularized classifier to encode the hierarchical structure information in feature vector for human action recognition. Second, we present an optimization algorithm to learn the parameters of the proposed classifier. Third, the performance of the proposed classifier is evaluated on YouTube, Hollywood2, and UCF50 datasets, the experimental results show that the proposed tree regularized classifier obtains better performance than SVM and other popular classifiers, and achieves promising results on the three datasets.

• Journal of Microbiology and Biotechnology
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• 제17권12호
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• pp.2056-2060
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• 2007

Transcription factor GATA-3 is the critical transcription factor for Th2 cell differentiation. In spite of its importance in Th2 cell differentiation, the molecular mechanism for its action in Th2 differentiation is poorly understood. Previous studies have suggested that GATA-3 may be involved in the chromatin remodeling in the Th2 cytokine locus. To determine whether GATA-3 exerts its effect on its target sites in the extrachromosomal status, cell transfection assay was performed. In this assay, 800 bp IL4 promoter-luciferase constructs linked with GATA-3 target sites were transfected into the M12 B cell line, D10 mouse Th2 cell lines, and human T lymphoma Jurkat cell lines with or without the GATA-3 expression vector. The GATA-3 effects on its target sites were minimal in the extrachromosomal status, supporting the previous propositions that GATA-3 functions at the chromatin level by remodeling chromatin structure.

• 한국콘텐츠학회논문지
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• 제20권1호
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• pp.245-258
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• 2020

이 연구는 한국 포털사이트 네이버에 연재된 학원물 웹툰 열편의 폭력 장면에서 나타난 폭력의 빈도, 유형, 그리고 맥락을 분석했다. 내용 분석 결과 작품 1회 당 2.15건의 PAT(Perpetrator-Action-Target)이 나타났다. 폭력의 유형으로는 물리적 폭력이 전체 PAT의 73.2%를 차지하며 가장 많이 나타났다. 등장인물의 캐릭터 특성을 보면 폭력 가해자의 외모가 뛰어난 것으로 설정된 경우가 53.6%인 것으로 나타났다. 폭력 가해자의 캐릭터가 영웅인 경우가 35.9%, 악당인 경우는 37.3%인 것으로 나타났다. 가해자와 피해자가 친구 사이인 경우가 60.8%를 차지했다. 과도한 신체표현, 오버액션, 말풍선과 같은 표현 기법으로 폭력 장면을 희화한 한 장면이 66.7%인 것으로 나타났다. 폭력 동기로는 개인과 집단의 이익과 신념을 위한 수단(29.4%)이 가장 많은 것으로 나타났고, 단순 재미(20.9%)가 그 다음을 차지했다. 폭력에 대한 처벌이나 보상을 알 수 없는 경우(79.9%)가 많은 것으로 나타났다.

• 대한의생명과학회지
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• 제29권3호
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• pp.103-108
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• 2023

Enhancers are cis-elements to regulate transcription of cell/tissue-specific genes in multicellular organisms. These elements locate in upstream or downstream regions of target genes and are found in a long distance up to 100 Kb in some cases. Transcription factors and coactivators bind to enhancers in a chromatin environment. Enhancers appear to facilitate the transcription of target genes by communicating with promoters and activating them. As transcription activation mechanism of enhancers, chromatin looping between enhancers and promoters, tracking of enhancer activity to promoters along the intervening regions, and movement of enhancers and promoters into transcription condensates have been suggested based on various molecular and cellular biology studies. These mechanisms are likely to act together rather than exclusive each other for gene transcription. Understanding of enhancer action mechanism may provide a way to regulate the transcription of cell/tissue-specific genes relating with aging or various diseases.