Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Understanding the molecular mechanisms of bisphenol A action in spermatozoa

  • Rahman, Md Saidur (Department of Animal Science and Technology and BET Research Institute, Chung-Ang University) ;
  • Pang, Myung-Geol (Department of Animal Science and Technology and BET Research Institute, Chung-Ang University)
  • Received : 2019.05.13
  • Accepted : 2019.07.25
  • Published : 2019.09.30
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Abstract

Bisphenol A (BPA) is an endocrine-disrupting chemical that is capable of interfering with the normal function of the endocrine system in the body. Exposure to this chemical from BPA-containing materials and the environment is associated with deleterious health effects, including male reproductive abnormalities. A search of the literature demonstrated that BPA, as a toxicant, directly affects the cellular oxidative stress response machinery. Because of its hormone-like properties, it can also bind with specific receptors in target cells. Therefore, the tissue-specific effects of BPA mostly depend on its endocrine-disrupting capabilities and the expression of those particular receptors in target cells. Although studies have shown the possible mechanisms of BPA action in various cell types, a clear consensus has yet to be established. In this review, we summarize the mechanisms of BPA action in spermatozoa by compiling existing information in the literature.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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