• 셀메드
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• 제4권1호
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• pp.3.1-3.8
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• 2014

Spa represents a treatment widely used in many rheumatic diseases (RD). The mechanisms by which immersion in mineral or thermal water ameliorates RD are not fully understood. The net benefit is probably the result of a combination of factors, among which the mechanical, thermal and chemical effects are most prominent. Buoyancy, immersion, resistance and temperature play important roles. According to the gate theory, pain relief may be due to the pressure and temperature of the water on skin; heat may reduce muscle spasm and increase the pain threshold. Mud-bath therapy increases plasma ${\beta}$-endorphin levels and secretion of corticotrophin, cortisol, growth hormone and prolactin. It has recently been demonstrated that thermal mud-bath therapy induces a reduction in circulating levels of prostaglandin E2, leukotriene B4, interleukin-$1{\beta}$ and tumour necrosis factor-${\alpha}$, important mediators of inflammation and pain. Furthermore, balneotherapy has been found to cause an increase in insulin-like growth factor-1, which stimulates cartilage metabolism, and transforming growth factor-${\beta}$. Beneficial anti-inflammatory and anti-degenerative effects of mineral water were confirmed in chondrocytes cultures, too. Various studies in vitro and in humans have highlighted the positive action of mud-packs and thermal baths, especially sulphurous ones, on the oxidant/antioxidant system. Overall, thermal stress has an immunosuppressive effect. Many other non-specific factors may also contribute to the beneficial effects observed after spa therapy in some RD, including effects on cardiovascular risk factors (e.g. adipokines) and changes in the environment, pleasant surroundings and the absence of work duties.

• Asian-Australasian Journal of Animal Sciences
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• 제20권7호
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• pp.1156-1168
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• 2007

The somatotropic (GH-IGF-I) axis consists of many hormonal and nutritional factors that control GH release from the somatotrophs in the anterior pituitary. The GH-releasing substances are GHRH and GHS (GHRP or ghrelin), while the GH release-inhibiting substances are somatostatin (SRIF), insulin-like growth factor-I (IGF-I), leptin and glucocorticoids. However, there is evidence showing that nutrition is involved in the control of the somatotropic axis. In addition, weaning is a drastic event for neonates because their alimentary and endocrine circumstances are changed due to the switch, even if gradual, from a liquid milk diet to one composed of such solids as hay and grains. The biological role of ghrelin is one of the hormonal factors that have been focused on ever since ghrelin was discovered at the end of the last century. A 27-amino acid peptide that is mainly synthesized and released from the abomasum epithelium, ghrelin has not been fully evaluated in relation to the somatotropic axis of the ruminant. It has also proven difficult even to investigate the cellular mechanisms of ghrelin action, because this hormone exerts animal-species-dependent actions via a complex set of intracellular signaling pathways. This is also the case for the action of leptin. Another substance, IGF-I, shows a partial inhibitory action on GH secretion in the ruminant. The effect of nutrition is also different among animal species. This is evident by the fact that undernutrition suppresses the circulating GH levels in rodents, but increases it in ruminants and humans. Recently, weaning has been shown to change the postprandial GH responses in ruminants; milk feeding increases, but hay and concentrate feeding suppress, the postprandial circulating GH levels. Even if the postprandial GH level is increased, the ghrelin level is decreased by milk feeding. Macronutrients also possess stimulatory and inhibitory actions on GH secretion in vivo and in vitro. These findings indicate the complexity of the control mechanisms of the somatotropic axis. In the present review, we summarize recent findings on the factors controlling the axis of the ruminant.

• 한국과학교육학회지
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• 제27권4호
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• pp.354-365
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• 2007

이 연구는 작용 반작용 과제와 전기회로 과제에서 인지갈등 정도와 실험결과 예측에 따른 대학생의 인지갈등 특성을 알아보는 데 목적이 있다. 연구대상은 일반물리실험을 수강중인 공과 대학 학생 147명이었다. 인지갈등 정도와, 예측이 실험결과와 일치하는가를 기준으로 학생들을 네 집단으로 나누어 학생들의 응답을 분석하였다. 첫째, 작용 반작용 과제에서는 실험결과를 의심하고 오류를 찾아내려고 하는 경향을 나타내었으나, 전기회로 과제에서는 현상을 그대로 인정하는 경향이 나타났다. 둘째, 인지갈등 정도에 따라 인지갈등 요인별 응답 원인이 다르다. 학생의 인지갈등은 학생의 과거 지식, 경험, 학습습관, 학습동기, 인식론적 신념 등의 영향을 받는다. 인지갈등 점수가 높은 학생은 불일치 상황을 잘 인식하고 자신이 모르는 것을 지각하고 있었고, 재평가의 의지가 높았다. 반면에 인지갈등 점수가 낮은 학생들은 상황을 의심 없이 받아들이는 경향이 있었고 물리에 대한 관심이 적었다. 결론적으로, 이 연구는 이러한 응답특성을 근거로 학생과 과제의 특성을 파악하고 그에 따른 적절한 인지갈등 전략이 마련될 필요가 있음을 제안하였다.

• Journal of Preventive Medicine and Public Health
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• 제19권2호
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• pp.203-212
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• 1986

Hypertension is one of the most well known risk factors for cerebrovascular or coronary heart disease and is a major public health problem. Early detection and treatment of hypertension are essential, but the compliance of treatment on hypertension is not easy to achive. Hypertensive workers are being detected by the annual screening under the Labour Standard Law in Korea but the solidified control system for them is not existing. This study about workers 'Motive-Belief-Action in non-drug and drug treatment of their hypertension would be worthwhile to interpret how the workers actually behave in coping with hypertension, and also would be advisable to construct the follow-up program in Korea. In the field research process two criteria were used to select sample group. The first criterion included the workers who were screened to be hypertensive with their blood pressure above 160/95 in this survey. The second one was used to classify study-group respondents who had known their hypertension by successive annual screening. From such criteria a total of 156 male workers were sampled in 21 industries, the author interviewed them using the structured questionnaire which consisted of Belief-Motive-Action items about non-drug and drug treatment for hypertension with open-ended question on symptom of hypertension. The summary is as follows: 1) Sixty-one percent of respondents had ever checked their blood pressure somewhere besides the annual screening. 2) Most respondents(97.2%) complained no symptoms of hypertension at all. 3) Belief level of non-drug treatment was relatively high (82.1%-64.7%), but motive(55.1%-28.2%) and action(38.5%-16.7%) levels were low. 4) Belief level of drug treatment was relatively lower than that of non-drug treatment, blue collar workers showed higher artier level of drug treatment than white collar workers, and correlation coefficient between belief and motive on drug treatment was lower in group of not-recognizing their family history of hypertension than recognized group. Such findings indicated that belief on drug treatment of hypertensive workers would be problematic. 5) White collar workers showed significant lower correlation coefficients between Motive and Action of salt restriction, restriction of fatty diet and relaxation than blue collar workers. 6) Mild hypertension group showed low levels of Motive and Action of non-drug treatment(salt restriction, restriction of fatty diet and relaxation) and also showed low correlation coefficient between Belief and Motive of above non-drug treatment.

• 한국동물학회지
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• 제37권3호
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• pp.377-384
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• 1994

The present study examines the inhibitow effect of progesterone (P) on luteinizing hormone $(LH)\beta$ subunit gene expression in anterior pituitary of ovariectomized, estradiol-treated adult rats. A single injection of P (1mg) further decreased the estradiol-Induced decrease in $LH\beta$ mRNA levels in ovariectomTzed rats in a time-dependent manner. p suppressed UIP mRNA levels at lower doses (0.1 and 1mg), but increased $LH\beta$ mRNA levels 81 a high dose (toms). The inhibitor action of P on $Uf\beta$ mRNA was restored when Ru486, a P receptor antagonist, was administered 1h before P treatment. These data clearly indicate that P inhibits gene expression of $LH\beta$ in the rift pituitary in a swersic manner with estrogen.

• 디지털산업정보학회논문지
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• 제11권4호
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• pp.129-141
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• 2015

This study evaluates user experience of streaming stick service through usability testing. Streaming stick services such as Roku, Chromecast, and Everoncast were tested in ten levels belonging to five usability variables that are composed of efficiency of use, accuracy, meaningfulness, flexibility, and consistency. Each variable has two levels respectively that are responsiveness, minimal action, error prevention, error detection, error recovery, understandability, learnability, substitutivity, predictability, and familiarity in order. Twenty five participants volunteerly joined this research, and the results showed that Roku is superior to another two OTTs in most levels and variables. It implies that participants prefer to remote control, many channels, and personalized service during experiencing the service.

• Biomolecules & Therapeutics
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• 제10권4호
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• pp.211-217
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• 2002

Hepatoprotective activity of methanol extract of Angelica tenuissima Nakai on the $CCl_4$-induced hepatotoxicity was investigated. To elucidate the hepatoprotective activity and free radical scavenging effect, we examined alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, total protein, cholesterol, malondialdehyde (MDA) levels in serum and activities of superoxide dismutase (SOD), catalase (CAT) in hepatic tissue as compared with those of carbon tetrachloride-induced rats. The action mechanism also has been estimated by quantative analysis of cytochrome P450 (CYP), NADPH-CYP reductase for phase I metabolism and glutathion (GSH), glutathion S-transferase (GST) level for phase II metabolsim. Treatment of Angelica tenuissima methanol extract significantly lowered the levels of alanine aminotransferase and aspartate aminotransferase. In addition, the levels of cholesterol, triglyceride, MDA, CAT were decreased, and SOD was activated. This result indicates that the hepatoprotective effect of Angelica tenuissima methanol extract on the CCl4-induced hepatotoxicity would be originated from reduction of the NADPH-CYP reductase, GSH and the enhancement of the activities of GST, CYP.

• 한국학교수학회논문집
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• 제9권4호
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• pp.575-595
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• 2006

본 연구는 교육대학교의 교육현장에서 '놀이수학' 강의를 실행하고, 이를 통해 예비초등교사와 초등학교 수학교육에 적용할 수 있는 놀이수학에 대해 살펴봄으로써 이들이 초등학교 수학수업을 준비함에 있어 새로운 동기와 흥미를 가질 수 있도록 하는 것을 목적으로 한다. 연구대상으로 선정된 교육대학교 3학년 43명의 학생들은 강의시간을 통해 조작교구와 구체물을 활용한 놀이수학활동을 직접 경험해보고, 이러한 놀이수학의 주제들이 초등학교 수학의 어떤 영역과 학년에서 적용가능한지를 살펴보았다. 또한 초등학교 수학수업에 적용할 수 있는 놀이수학 학습자료를 개발하는 등 예비초등교사로서 이후 수학수업에서 놀이수학을 활용하는데 필요한 기초적인 지식을 다루고자 하였다.

• 정보처리학회논문지B
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• 제13B권4호
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• pp.449-456
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• 2006

본 논문에서는 대전형 액션 게임을 위한 지능 캐릭터 구현에 있어서 기존 연구보다 실제적인 구현을 위하여 에너지 점수를 적용한 지능 캐릭터를 제안한다. 제안한 지능 캐릭터는 기존연구에서 사용한 상대 캐릭터의 현재 행동, 행동의 단계, 유효거리, 과거 행동 뿐 만 아니라 자신의 에너지 양을 고려하여 행동을 결정하게 된다. 에너지는 현재 온라인 게임 등에서 많이 사용하는 것으로 HP (Health Point)와 MP(Mana Point) 두 가지를 사용하였다. 에너지 점수를 적용한 지능캐릭터가 학습하는지 그리고 에너지점수를 적용했을 때 어떻게 행동하는지를 알아보기 위한 여러 가지 실험을 하였다. 실험 결과 에너지가 양이 많은 경우에는 상대방에게 피해를 크게 줄 수 있는 행동으로 대응하고 그렇지 않은 경우에는 에너지를 재충전하기 위한 행동들을 하는 것을 관찰하였다. 이런 결과로 볼 때 본 논문에서 제안한 에너지를 적용한 지능캐릭터가 잘 동작하며 에너지를 고려하여 효과적인 반응을 보임을 알 수 있다.

• 한국컴퓨터산업학회논문지
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• 제7권3호
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• pp.163-170
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• 2006

본 논문에서는 대전형 액션 게임을 위한 지능 캐릭터 구현에 있어서 기존 연구보다 실제적인 구현을 위하여 에너지 개념을 적용한 지능 캐릭터를 제안한다. 제안한 지능 캐릭터는 기존연구에서 사용한 상대 캐릭터의 현재 행동, 행동의 단계, 유효거리, 과거 행동 뿐 만 아니라 자신의 에너지양을 고려하여 행동을 결정하게 된다. 에너지는 현재 온라인 게임등에서 많이 사용하는 것으로 HP (Health Point)와 MP(Mana Point) 두 가지를 사용하였다. 에너지를 적용한 지능캐릭터가 제대로 학습 하는지 그리고 에너지를 고려하여 효과적으로 대처하는 지를 알아보기 위한 여러 가지 실험을 하였다. 실험 결과 에너지가 충분한 경우에는 상대방에게 타격을 가장 많이 줄 수 있는 행동으로 대응하고 그렇지 않은 경우에는 에너지를 재충전하기 위한 행동들을 하는 것을 관찰하였다. 이런 결과로 볼 때 본 논문에서 제안한 에너지를 적용한 지능캐릭터가 잘 동작하며 에너지를 고려하여 효과적인 반응을 보임을 알 수 있다.