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Inhibitory effect of ethanol extract of Gryllus bimaculatus on platelet aggregation and glycoprotein IIb/IIIa activation (쌍별귀뚜라미 에탄올 추출물의 혈소판응집반응과 당단백질 IIb/IIIa 활성화 억제 효과)

  • Hyuk-Woo Kwon;Man Hee Rhee;Jung-Hae Shin
    • Journal of Applied Biological Chemistry
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    • v.66
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    • pp.236-243
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    • 2023
  • Platelets act a fundamental role in primary- and secondary-hemostasis, however, platelet activation may cause thrombosis simultaneously. Therefore, control of platelet aggregation is crucial in preventing thrombosis-mediated diseases. Recently, the development of insect materials is attracting attention. Among the highly nutritious functional food sources, insects such as two-spotted cricket (Gryllus bimaculatus). Gryllus bimaculatus (G. bimaculatus) contains high protein and unsaturated fatty acids and has been registered as a food material September 2015 by the Ministry of Food and Drug Safety of Korea. In this study, we examined whether G. bimaculatus extract (GBE) inhibits platelet aggregation, intracellular calcium mobilization, thromboxane A2 production and glycoprotein IIb/IIIa (integrin αIIb/β3) activation. We investigated whether GBE can regulate signaling molecules, such as 1, 4, 5-triphosphate receptor type I, extracellular signal-regulated kinase, cytosolic phospholipase A2, mitogen-activated protein kinases p38, vasodilator-stimulated phosphoprotein, phosphatidylinositol-3 kinase, Akt, glycogen synthase kinase-3α/β, and SYK. Taken together, GBE is a potential therapeutic drug candidate to prevent platelet-related thrombosis and cardiovascular disease.

Study on Improvement of Status Survey Form for the Effective Management of Grassland (초지법에서 초지의 사후관리를 위한 실태조사서 개선방안)

  • Byung Ku Yoon;Ji Yung Kim;Kyung Il Sung;Byong Wan Kim
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.44 no.1
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    • pp.30-39
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    • 2024
  • The current survey form of grassland has not played its role in managing the grassland effectively because of the ambiguous questionnaire items and the absence of method and time of the investigation. Therefore, this study was conducted to clarify and add the items for effective of grassland management. The survey form of grassland was regulated in Article 16 of the Enforcement Rules of the Grassland Act (Survey on Grasslands Management Status, etc.). The five contents that needed improvement were the grassland owner, the survey timing and method of established grassland, grassland used livestock, grassland usage condition, and grassland grade. In the improved survey form of grassland, the grassland owner was changed to the grassland manager. In addition, 'Survey by each land' was added to the improved survey form in which the managers can survey each land. The dimension of each grassland establishment method was deleted in the grassland establishment time and method. In the livestock using grassland, the number of livestock and the area where livestock are used were added, and the number of other livestock was added, too. The grassland grade was decided as the combined score by three evaluation categories; grassland usage, the ratio of forage production in grassland and kinds of forage. The high, middle, and low grades were over 8, 6~7, and under 5 points in the combined score, respectively. The results show that the changed survey form of grassland can make grassland management more efficient by materializing the subject of grassland management and the survey terminology and methods.

Some Thoughts on Reestablishing Appraisal System of Presidential Records (대통령기록물 평가제도 재정립을 위한 몇 가지 단상)

  • Kim, Myoung-hun;Lee, Seung-il
    • The Korean Journal of Archival Studies
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    • no.79
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    • pp.271-303
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    • 2024
  • In our country, which has a strong presidential system, the power and responsibilities of the president are truly enormous. He is the head of state and diplomatic representative, and at the same time exercises authority over all areas of the country, including the legislature, judiciary, and constitutional institutions, along with his responsibilities as head of the executive branch. Considering these aspects, it can be said that presidential records created during the president's rule have a high level of national and historical significance and value compared to other public records. Considering these importance of presidential records, the Presidential Records Management Act was enacted in 2007 to establish an institutional mechanism to systematically manage presidential records. However, the current institutional basis for appraisal of presidential records is very weak. In this regard, there is a need to begin discussions on the appraisal of presidential records in earnest. Considering the national importance and symbolism of presidential records, it is necessary to establish a new direction for appraisal of presidential records that is different from general public records. Accordingly, in this paper, as part of reestablishing Korea's presidential records appraisal system, this article analyzed the status and problems of the current presidential records appraisal system and presented directions needed to find future improvement measures. To this end, as a premise for discussing the importance and value of presidential records, it examined the powers and responsibilities of the presidency as defined in our country's Constitution.Next, we looked at the appraisal system and method for presidential records that are currently in operation, and then analyzed the problems that emerged here in connection with the characteristics of presidential records. Based on this, it presented five perspectives on issues that need to be discussed publicly in the records management community in order to reestablish Korea's presidential records appraisal system in the future.

An Analysis of The Relationship Among Nursing Students' Perception of Target Vulnerability and Target Advocacy, Child Rights Awareness, and Child Abuse Reporting Intention (간호대학생이 지각한 대상자 취약성 및 옹호, 아동권리인식, 아동학대 신고의도 간의 관계 분석)

  • Ji-Ah Song;Jae Woo Oh
    • Journal of Industrial Convergence
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    • v.22 no.3
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    • pp.155-163
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    • 2024
  • Nursing students, as prospective nurses, are expected to act as child abuse reporters and advocates for child targets. Therefore, this study aimed to provide a basis for developing a child abuse prevention education program for nursing students by determining the extent of nursing students' perceived target vulnerability and target advocacy, child rights awareness, and intention to report child abuse, and analyzing the relationships among the variables. This study is a descriptive survey study to identify the effects of target vulnerability, target advocacy, and child rights awareness on intention to report child abuse among 154 nursing students, and the data collection period was from July 3 to July 31, 2023, and the collected data were analyzed using SPSS 25.0 program. As a result of identifying the influential factors on nursing students' intention to report child abuse, child abuse education, championing social justice as a sub-variable of target advocacy, and target vulnerability, the explanatory power of these variables was 35.8%. Based on the results of this study, it is suggested that it is necessary to increase activities through the development and application of simulation education based on actual clinical cases in order to increase nursing students' interest in and education about child abuse.

Symptoms of the subject in a movie based on Lacan's work on psychosis - Focusing On Lars von Trier's film (라캉의 정신병 연구에 근거한 영화 속 주체의 증상 - 라스 폰 트리에의 <살인마 잭의 집>을 중심으로)

  • HAN JINGZHI
    • Trans-
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    • v.16
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    • pp.69-105
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    • 2024
  • The House that Jack Built (2018), a film about how the protagonist Jack is reborn as a "mad artist" with psychotic symptoms during a 12-year killing spree, provides an interesting opportunity to analyze the film in terms of psychoanalysis and religion. Jack, an engineer who suffers from OCD, finds pleasure in the accidental murder of a character and considers killing people as an art form, overcoming his OCD in the process. The question we are interested in is whether the symptoms of OCD are truly overcome by the act of repeated killing. The idea is that Jack's OCD is not overcome by killing, but rather that the symptoms disappear as he moves from neurosis to a stabilized psychotic state. According to the theory of the famous French psychoanalyst Lacan, the hallucinations or delusions that human subjects experience when they lose their realistic stability are a phenomenon that occurs when they are confronted with The Real, which penetrates through the cracks of the symbolic system. Phenomena such as Jack's illusory reality and delusions in the movie are pathological symptoms of the absence of a paternal figure in his life, causing the Name-of-the-Father to fail to take hold. This paper deciphers the psychotic structure of Jack, the protagonist of Lars von Trier's House of Jack, through Lacanian psychoanalysis.

A Study on Health Impact Assessment and Emissions Reduction System Using AERMOD (AERMOD를 활용한 건강위해성평가 및 배출저감제도에 관한 연구)

  • Seong-Su Park;Duk-Han Kim;Hong-Kwan Kim;Young-Woo Chon
    • Journal of the Society of Disaster Information
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    • v.20 no.1
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    • pp.93-105
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    • 2024
  • Purpose: This study aims to quantitatively determine the impact on nearby risidents by selecting the amount of chemicals emitted from the workplace among the substances subject to the chemical emission plan and predicting the concentration with the atmospheric diffusion program. Method: The selection of research materials considered half-life, toxicity, and the presence or absence of available monitoring station data. The areas discharged from the materials to be studied were selected as the areas to be studied, and four areas with floating populations were selected to evaluate health risks. Result: AERMOD was executed after conducting terrain and meteorological processing to obtain predicted concentrations. The health hazard assessment results indicated that only dichloromethane exceeded the threshold for children, while tetrachloroethylene and chloroform appeared at levels that cannot be ignored for both children and adults. Conclusion: Currently, in the domestic context, health hazard assessments are conducted based on the regulations outlined in the "Environmental Health Act" where if the hazard index exceeds a certain threshold, it is considered to pose a health risk. The anticipated expansion of the list of substances subject to the chemical discharge plan to 415 types by 2030 suggests the need for efficient management within workplaces. In instances where the hazard index surpasses the threshold in health hazard assessments, it is judged that effective chemical management can be achieved by prioritizing based on considerations of background concentration and predicted concentration through atmospheric dispersion modeling.

A Study on Microbial Contamination according to Effective Management Strategies of Indoor Climbing Gym Holds (실내 클라이밍 짐 홀드의 관리방법에 따른 미생물 오염에 관한 연구)

  • Ji-In Kim;Hyejin Shin;Yujeong Jeong;Haesong Sher;Gitaek Oh;Yonghoo Park;Sungkyoon Kim
    • Journal of Environmental Health Sciences
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    • v.50 no.2
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    • pp.102-112
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    • 2024
  • Background: Despite the rise in the number of domestic indoor climbing gyms, there is a lack of specific hygiene standards and research on the holds installed in them. Holds can act as vectors for microbial transmission through the hands, posing a risk of infectious diseases, especially with damaged skin. Objectives: The aim of this study is to investigate the contamination level and species of microorganisms on holds according to the management methods practiced in indoor climbing gyms and identify effective strategies for reducing microbial contamination. Methods: We investigated factors that may influence microbial contamination of holds, including hold management methods, user information, and hygiene management at three climbing gyms in Seoul. A total of 72 holds were sampled, 18 for each management method of brushing, high-pressure washing, and ethanol disinfection. Samples were cultured on LB and blood agar at 37℃ for 48 hours to calculate CFUs. PCR assay targeting 16S rRNA was carried out to identify microorganisms. Dunn-Bonferroni was employed to see the microbial reduction effect of the management method and the difference in microbial contamination by management method and climbing gym. Results: As a result of microbial identification, microorganisms such as Bacillus, Staphylococcus, and Micrococcus, which were derived from various environments such as skin and soil, were discovered on the surface of the climbing hold. Among the discovered microorganisms, some species had potential pathogenic properties that could cause food poisoning, gastrointestinal disease, bacteremia, and sepsis. All hold management methods were effective in reducing microorganisms (p<0.05), with ethanol disinfection being the most effective (p<0.001). Conclusions: Our results indicate that there are potential pathogens on holds that demand thorough management for microbial prevention. Proposed methods include regular brushing and ethanol disinfection in addition to high-pressure washing with long cycles, which are the existing forms of hold management. Further studies on shoe management are advised to curb soil-derived microorganisms.

Developing educational videos to inform rightly about school foodservice from kindergarten to high school: a case study

  • Gyoungok Gang;Chaewon Park;Haejin Kang;Wan Soo Hong;Yoo Kyoung Park;Sook Hee Choi;Seung Hye Kim;Jieun Choi;Jihyun Park;Hyeja Chang
    • Korean Journal of Community Nutrition
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    • v.29 no.2
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    • pp.97-113
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    • 2024
  • Objectives: Since the enactment of the School Nutrition Act in 1981, school lunch programs in South Korea have grown quantitatively and qualitatively with a current student participation rate of 99.8%. Nonetheless, educational materials are needed to reduce misunderstanding and ignorance about school lunch programs. This study aimed to develop 3 educational videos that help students of various ages (kindergarteners/lower-grade elementary, upper-grade elementary, and secondary school, respectively), understand the school lunch program. Methods: A scenario was created, was made, and the opinions on the scenario from experts in foodservice sectors were collected. A survey was conducted to students and parents to determine topics they wanted to know about school foodservice. The final videos were produced using this information and the expert opinions. The data were analyzed using SPSS 27.0 for Mac (IBM Corp., Armonk, NY, USA); a P-value of < 0.05 was considered significant. Results: Three videos on school foodservice were developed for various age levels of students: kindergarten/lower-grade elementary, upper-grade elementary, and secondary school. Additionally, English subtitles were included for the multicultural student population. These videos, each lasting about 7 minutes, cover topics such as nutrition, hygiene, and the cultural significance of the school lunch program. The survey results showed that parents and students wanted to know the following topics about the school lunch program: "nutritionally balanced diet" (11.9%), "purchasing safe food ingredients" (10.9%), and "healthy eating habits" (9.9%). Conclusions: The developed videos will serve as valuable educational resources on school foodservice, foster a deeper understanding of the school lunch program in parents and students, and potentially address their inquiries regarding production processes, nutrition, hygiene, cultural heritage, and health.

Characteristics and Changes of Policy Responses to Local Extinction: A Case of Comprehensive Strategy and Basic Policy on Community-Population-Job Creation in Japan (지방소멸 대응 정책의 특징 및 변화 분석: 일본의 마을·사람·일자리 창생 종합전략 및 기본방침을 사례로)

  • Jang, Seok-Gil Denver;Yang, Ji-Hye;Gim, Tae-Hyoung Tommy
    • Journal of the Korean Regional Science Association
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    • v.40 no.1
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    • pp.37-51
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    • 2024
  • To respond to local extinction, South Korea, under the leadership of the Ministry of the Interior and Safety, identified depopulated areas in 2021 and launched the Local Extinction Response Fund in 2022. However, due to its early stage of implementation, analyzing the characteristics and changes of policy response to local extinction at the central government level remains a challenge. In contrast, Japan, facing similar issues of local extinction as South Korea, has established a robust central government-led response system based on the Regional Revitalization Act and the Comprehensive Strategy and Basic Policy on Community-Population-Job Creation. Hence, this study examines Japan's policy responses to local extinction by analyzing the first and second periods of the Comprehensive Strategy and Basic Policy on Community-Population-Job Creation. For the analysis, topic modeling was employed to enhance text analysis efficiency and accuracy, complemented by expert interviews for validation. The results revealed that the first-period strategy's topics encompassed economy and society, start-up, local government, living condition, service, and industry. Meanwhile, the second-period strategy's topics included resource, the New Normal, woman, digital transformation, industry, region, public-private partnership, and population. The analysis highlights that the policy target, policy direction, and environmental change significantly influenced these policy shifts.

Estimate Customer Churn Rate with the Review-Feedback Process: Empirical Study with Text Mining, Econometrics, and Quai-Experiment Methodologies (리뷰-피드백 프로세스를 통한 고객 이탈률 추정: 텍스트 마이닝, 계량경제학, 준실험설계 방법론을 활용한 실증적 연구)

  • Choi Kim;Jaemin Kim;Gahyung Jeong;Jaehong Park
    • Information Systems Review
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    • v.23 no.3
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    • pp.159-176
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    • 2021
  • Obviating user churn is a prominent strategy to capitalize on online games, eluding the initial investments required for the development of another. Extant literature has examined factors that may induce user churn, mainly from perspectives of motives to play and game as a virtual society. However, such works largely dismiss the service aspects of online games. Dissatisfaction of user needs constitutes a crucial aspect for user churn, especially with online services where users expect a continuous improvement in service quality via software updates. Hence, we examine the relationship between a game's quality management and its user base. With text mining and survival analysis, we identify complaint factors that act as key predictors of user churn. Additionally, we find that enjoyment-related factors are greater threats to user base than usability-related ones. Furthermore, subsequent quasi-experiment shows that improvements in the complaint factors (i.e., via game patches) curb churn and foster user retention. Our results shed light on the responsive role of developers in retaining the user base of online games. Moreover, we provide practical insights for game operators, i.e., to identify and prioritize more perilous complaint factors in planning successive game patches.