• 노동경제논집
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• 제27권1호
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• pp.1-25
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• 2004

인적자원이 가장 중요한 경쟁력이 되는 지식정보화 산회에서 숙련의 주기는 짧으며, 노동력의 유동화는 심화되고 있어 자격의 신호기제로서의 역할이 크게 부각되고 있다. 이에 우리나라 자격의 기능을 취득요인, 취업 및 임금효과 측면에서 검토하기 위해 한국노동패널 1~4차년도(1998~2001) 자료를 개인별로 묶어 고정효과 로짓모형, 임의효과모형으로 회귀분석하였다. 추정의 결과 고졸 미만 저학력층의 자격취득 확률이 높게 나타났다. 남자는 실업상태에 있는 경우에 자격취득이 많았고, 여성은 비경제활동의 기타 상태(잠재적 구직상태)에 있는 경우 자격취득이 많았다. 자격의 취업효과는 여성의 경우 1년차, 2년차에 유의하게 나타나나, 남자의 경우는 유의하지 않았다. 취득한 자격의 임금효과는 남녀 공히 유의하지 않았다. 이러한 결과는 현재 우리나라에서 자격취득으로 얻어지는 직업능력이 시장에서 제대로 인정받고 있지 못하는 현실을 반영한다.

• Tuberculosis and Respiratory Diseases
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• 제44권5호
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• pp.1072-1082
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• 1997

연구배경 : 중증 지역사회획득 폐렴은 진단방법의 향상, 항생제의 개발, 조기진단 및 치료에도 불구하고 여전히 높은 사망률을 보이는 질환으로 알려져 있다. 중증 지역사회획득 폐렴의 임상적 특정을 분석하고 예후에 영향을 미치는 인자를 규명하여 치료 및 예후 판정에 도움을 주고자 한다. 방 법 : 1989년 1월부터 1996년 7월까지 한림대학교 의료원에 내원한 40명의 중증 지역사회획득 폐렴환자를 대상으로 후향적으로 분석하였다. 원인균 동정을 위해 객담배양, 혈액배양, 기관지폐포세척액배양 및 Mycoplasma pneumoniae에 대한 항체검사를 시행하였고, 초치료로 2세대 혹은 3세대 cephalosporin, amoxicillin/clavulanic acid 등이 사용되었으며 aminoglycoside와 macrolide가 상황에 따라 병용 투여되었다. 대상군을 생존군과 사망군으로 분류하여 연령, 흡연 및 알콜중독 유무, 기저질환 유무, 저산소 혈중, 기계적 환기의 필요, 흉부 방사선상 양측성 폐 침윤 소견, 분당 호흡수, 쇼크의 유무, 혈중요소질소 및 알부민 농도 등을 비교 분석하였다. 결 과 : 남자가 2.07 : 1의 비율로 많았고 평균 연령은 $63.1{\pm}17.5$세(범위 : 25~90세)였으며 60세 이상이 65%로 다수를 차지하였다. 흡연자가 62.5%, 알콜중독자가 30%였고, 60%에서 기저질환이 발견되었으며 종류별로는 과거의 폐결핵 병변(12.5%), 만성 폐쇄성 폐질환(7.5%), 기관지 천식(5%), 기관지 확장증(2.5%), 당뇨병(22.5%) 등이었다. 가장 흔한 원인균은 S. Pneumoniae로 17.5%였으며 S. aureus 15%, K. pneumoniae 13.5%, Mycobacterium tuberculosis 7.5%였고 그 외에 coagulase negative staphylococcus, H. influenzae, P. aeruginosa, E. cloaceae, E. coli가 각각 2.5%씩 동정되어 65%의 동정율을 나타내었다. 단독 및 병용요법에서 흔히 사용된 항생제는 aminoglycoside계(75% : 30/40), 2세대 및 3세대 cephalosporin계(40% : 16/40, 27.5% : 11/40), macrolide계(27.5% : 11/4), amoxicillin/clavulanic acid(22.5% : 9/40)의 순이었다. 사망률은 37.5%였으며 사망환자의 50%가 입원후 72시간 내에 사망하였다. 예후에 영향을 미치는 인자로는 기계적 환기의 필요, 흉부 방사선 소견상 양측성 폐침윤, 혈중 알부민 농도의 저하(3.0g/dl 이하) 등이 통계적으로 유의한 차이를 보였다. 결 론 : 본 연구에서 나타난 중중 지역사회획득 폐렴의 임상적 특징과 예후인자를 바탕으로 적절한 항생제의 선택과 초기에 적극적인 진료로 치료성적을 향상시킬 것으로 기대된다.

• BMB Reports
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• 제51권12호
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• pp.660-665
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• 2018

Human epidermal growth factor receptor 2 (HER2) inhibitors, such as trastuzumab and lapatinib are used to treat HER2-positive breast and gastric cancers. However, as with other targeted therapies, intrinsic or acquired resistance to HER2 inhibitors presents unresolved therapeutic problems for HER2-positive gastric cancer. The present study describes investigations with AUY922, a heat shock protein 90 (HSP90) inhibitor, in primary lapatinib-resistant (ESO26 and OE33) and lapatinib-sensitive gastric cancer cells (OE19, N87, and SNU-216) harboring HER2 amplification/over-expression. In order to investigate whether AUY922 could overcome intrinsic and acquired resistance to HER2 inhibitors in HER2-positive gastric cancer, we generated lapatinib-resistant gastric cancer cell lines (OE19/LR and N87/LR) by continuous exposure to lapatinib in vitro. We found that activation of HER2 and protein kinase B (AKT) were key factors in inducing intrinsic and acquired lapatinib-resistant gastric cancer cell lines, and that AUY922 effectively suppressed activation of both HER2 and AKT in acquired lapatinib-resistant gastric cancer cell lines. In conclusion, AUY922 showed a synergistic anti-cancer effect with lapatinib and sensitized gastric cancer cells with intrinsic resistance to lapatinib. Dual inhibition of the HSP90 and HER2 signaling pathways could represent a potent therapeutic strategy to treat HER2-positive gastric cancer with intrinsic and acquired resistance to lapatinib.

• Tuberculosis and Respiratory Diseases
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• 제83권1호
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• pp.81-88
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• 2020

Background: Use of appropriate antibiotics for the treatment of pneumonia is integral in patients admitted to intensive care units (ICUs). Although it is recommended that empirical treatment regimens should be based on the local distribution of pathogens in patients with suspected hospital-acquired pneumonia, few studies observe patients admitted to ICUs with nursing home-acquired pneumonia (NHAP). We found factors associated with the use of inappropriate antibiotics in patients with pneumonia admitted to the ICU via the emergency room (ER). Methods: We performed a retrospective cohort study of 83 pneumonia patients with confirmed causative bacteria admitted to ICUs via ER March 2015-May 2017. We compared clinical parameters, between patients who received appropriate or inappropriate antibiotics using the Mann-Whitney U, Pearson's chi-square, and Fisher's exact tests. We investigated independent factors associated with inappropriate antibiotic use in patients using multivariate logistic regression. Results: Among 83 patients, 30 patients (36.1%) received inappropriate antibiotics. NHAP patients were more frequently treated with inappropriate antibiotics than with appropriate antibiotics (47.2% vs. 96.7%, p<0.001). Methicillin-resistant Staphylococcus aureus was more frequently isolated from individuals in the inappropriate antibiotics-treated group than in the appropriate antibiotics-treated group (7.5% vs. 70.0%, p<0.001). In multivariate analysis, NHAP was independently associated with the use of inappropriate antibiotics in patients with pneumonia admitted to the ICU via ER. Conclusion: NHAP is a risk factor associated with the use of inappropriate antibiotics in patients with pneumonia admitted to the ICU via the ER.

• Management Science and Financial Engineering
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• 제16권1호
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• pp.1-16
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• 2010

In Nigeria, Igbemo-Ekiti is synonymous with a popular local rice which, nevertheless, is characterized with contaminations. Efforts of Government through the Agricultural Development Project (ADP) to improve rice quality in the state, have failed to yield the desired results. This study, therefore, reports the peculiar factors influencing the processing of rice in Igbemo-a major local producing town in Ekiti State, Nigeria. 72 respondents were interviewed, which was a census of the rice processors in 21 residential quarters of the town. Using the multiple linear regression models for analysis, the study discovered that; (i) status of the processors, (ii) expenditure on processing (iii) training acquired before commencing work, and (iv) storage facilities are crucial factors impacting rice processing activities in the town. The paper canvasses for policy measures based on research findings.

• 한국군사과학기술학회지
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• 제10권2호
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• pp.180-187
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• 2007

In this paper, we propose an automatic method which combines two or more images acquired by camera on the air-vehicle into a larger image mosaics. The shift, scaling, rotation factors between two images can be calculated by using the correspondences between the points of the images. In order to estimate these factors, we find the relative positions of two images with respect to each other by using the SIFT descriptor and the RANSAC algorithm. After estimating the factors, the images can be merged into a single image mosaic by warping the target image. To avoid seams when mosaics are constructed from overlapped images, we apply the average gray level value of points within a overlapped zone. We have tested our proposed method on various image sets and have confirmed that our method produced good result subjectively.

• 한국실내디자인학회논문집
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• 제39호
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• pp.20-27
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• 2003

The purpose of this study is to provide a practical guide for selecting architectural artwork and analyze relationship between artwork and interior space & facade. The problems with many outdoor artwork did not make the characteristics of the specific environment and did not form a big flow in the urban contextualism. Choosing the artwork, architectural environment for artwork is very much part of the designers' task. When artwork is to be specifically acquired for a particular projects, designer and client must work together to make choices and plan placement. The data are collected through evaluation surveys of college students and graduate students majoring in interior architecture & design, and analyzed by using SPSS-WIN program to find the major characterized factors. It is concluded that architectural artwork should be constituted with nine major factors of interior space - theme/scale, situation/contemporay accord, finished materials harmony, line/two-three dimensional form, proportion/rhythm, sequence, natural/artificial form, abstract/reality expression, originality - and eight major factors of facade - situation, abstract/reality expression, finished materials harmony, theme/sequence, natural/artificial form, proportion/rhythm, static/dynamic expression, originality/. contemporay accord.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2005년도 추계학술대회 논문집 전기설비전문위원
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• pp.56-59
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• 2005

In this paper, electrical risk factors due to the powered recovery equipments thrown to escape the dangerous condition that electrical apparatuses were submerged were derived and analyzed. After surveying several underground flooding sites, we could find out the status quo of the underground electrical equipments and what the most dangerous factors to a human body under water were. The results acquired from this study are applying to safely assessment algorithm.

• Pediatric Infection and Vaccine
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• 제25권1호
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• pp.50-53
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• 2018

Staphylococcus aureus is a well-recognized human pathogen that causes a wide range of infections as a result of its extensive virulence factors. One of these factors is Panton-Valentine leukocidin (PVL), a potent pore-forming cytotoxin that has been linked to invasive S. aureus infections. PVL is one of the important virulence factors for S. aureus and has been largely recognized as one of the markers for community-acquired methicillin-resistant S. aureus. However, the presence of PVL in methicillin-susceptible S. aureus infections is not widely reported in the literature. Thrombotic sequelae of S. aureus infections associated with PVL expression are uncommon in children. We hereby report two children with thrombotic complications associated with PVL-producing methicillin-susceptible S. aureus. Both patients responded well to antibiotic and anticoagulant therapies, and survived without any long-term sequelae.

• Current Optics and Photonics
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• 제5권2호
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• pp.93-100
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• 2021

Three factors that degrade the accuracy of modal decomposition are extensively studied using simulated and measured beams. These include a beam size mismatch, beam center mismatch, and signal-to-noise ratio of the images. The beam size and beam center are scanned using simulated noisy beams, and the result of the modal decomposition is compared with that of real beams. Based on the suggested procedure, error functions of approximately 1-4 × 10-3 can be acquired for real beams. This study provides important information regarding the impact of the three factors on the practical modal decomposition and tolerances of a mismatch, helping estimate the achievable values of the error function in a real beam modal decomposition.