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http://dx.doi.org/10.14776/piv.2018.25.1.50

Panton-Valentine Leukocidin Positive Methicillin-Susceptible Staphylococcus aureus: A Case Report of Two Pediatric Patients with Thrombotic Complications  

Ng, David Chun Ern (Department of Pediatric, Tuanku Ja'afar Hospital)
Anand, L. Alexis (Department of Pediatric, Tuanku Ja'afar Hospital)
Khiu, Fu Lung (Department of Pediatric, Tuanku Ja'afar Hospital)
Tan, Kah Kee (Department of Pediatric, Tuanku Ja'afar Hospital)
Publication Information
Pediatric Infection and Vaccine / v.25, no.1, 2018 , pp. 50-53 More about this Journal
Abstract
Staphylococcus aureus is a well-recognized human pathogen that causes a wide range of infections as a result of its extensive virulence factors. One of these factors is Panton-Valentine leukocidin (PVL), a potent pore-forming cytotoxin that has been linked to invasive S. aureus infections. PVL is one of the important virulence factors for S. aureus and has been largely recognized as one of the markers for community-acquired methicillin-resistant S. aureus. However, the presence of PVL in methicillin-susceptible S. aureus infections is not widely reported in the literature. Thrombotic sequelae of S. aureus infections associated with PVL expression are uncommon in children. We hereby report two children with thrombotic complications associated with PVL-producing methicillin-susceptible S. aureus. Both patients responded well to antibiotic and anticoagulant therapies, and survived without any long-term sequelae.
Keywords
Panton-Valentine leukocidin; Staphylococcus aureus; Child;
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