• Journal of Fashion Business
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• v.26 no.6
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• pp.105-115
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• 2022

Wearing a mask is still advised since COVID-19 continues to spread. However, masks may also irritate the skin and cause mask acne, often known as "maskne", which is a type of acne mechanica caused by friction between the skin and clothing. Therefore, there is a need to develop an effective maskne cosmetic. In this study, we made the maskne cosmetics containing humulus lupulus extract and copper tripeptide-1 and investigated its stability and safety. To measure stability, a centrifugation test and heat-cool cycling were done, and changes in viscosity and pH were measured for 8 weeks. The Cumulative Irritation Test (CIT, WKIRB-202111-HR-096) was performed and positive reactions were determined by the ICDRG criteria. The results indicated that the samples were stable after centrifugation, temperature cycling, viscosity, and pH tests. In addition, cosmetic safety test results revealed that maskne cosmetics containing humulus lupulus extract and copper tripeptide-1 did not cause any skin responses. These findings indicate that prepared maskne cosmetics' stability and safety were comparable to those of currently available commercial cosmetics.

• Journal of Society of Preventive Korean Medicine
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• v.3 no.2
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• pp.129-150
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• 1999

This study was carried out to analyse a perception on acne for the Junior college students to provide basic data for the suitable treatment of acne to the students and the specialists. For this study, self-administering questionnaires were distributed to 480 students from 13 departments at a suburban women's junior college from May 1 to May 3, 1996. Of the students, 399 were responded and included in the analysis. The questionnaire includes the general question of objects, the question of knowledge and attitude of acne, and its treatment. The results were as follows: 1. Age distribution for the group less than 20 years was 63.7% and over 20 years was 36.3%, the group with acne was 66.2% and the group without acne was 33.8%. Proportions of acquiring the knowledge on acne was 49.6% from newspaper or magazine, 47.15 from friends, and 26.85 from TV or radio. 2. With regard to the knowledge on the presence of acne, a proportion of correctly answered for the question on the cause of acne was $3.41{\pm}1.02$ for the group with acne compared with $3.16{\pm}0.89$ for those without acne. This difference was statistically significant (p<0.05). 3. With regard to the knowledge levels on the treatment of acne, a proportion answered' skin-care center' for the question on where to select for the profer treatment was $13.21{\pm}1.88$ compared with $12.09{\pm}1.88$ for the other group. This difference was statistically significant (p〈0.05). A proportion of answered 'squeezing out acne by themselves' for the question of how to treat was $12.26{\pm}1.91$ compared with $10.83{\pm}1.25$ for the other group. 4. In the treatment according to the attitude of the group with acne, the positive group replied 'YES' in the intention of treatment by themselves was 55.9%. In conclusion, the differences in the knowledge and attitude on the presence of acne are not significant and it was found that the knowledge and attitude for the group with acne did not significantly influenced the treatment behavior. Accordingly, it is important to understand the cause of acne, provoking factors, remedy etc. For this, it is necessary to a provide an accurate information to professionals to enhance the knowledge of acne and to treat it properly.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.3
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• pp.247-254
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• 2021

Acne vulgaris is a chronic inflammatory skin disease related to pilosebaceous unit. In acne lesions, hyperseborrhea, dysseborrhea, inflammatory event, and an imbalance in skin microflora, particularly an increase in Cutibacterium acnes (C. acnes) colonization comparing to other bacteria, have been observed. The objective of this study was to evaluate anti-acne effects of Artemisia annua extract (AAE) on antibacterial activity related to preservation of the balance in skin microbiome, inhibition of inflammation, and reduction of excessive sebum production. When C. acnes and Staphylococcus epidermidis (S. epidermidis) were co-cultured in the presence of AAE, the reduction of C. acnes growth by AAE was greater than that of S. epidermidis. In addition, when C. acnes was cultured in a medium containing AAE (C. acnes AAE), levels of cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and IL-6 and toll-like receptors-2 activity were decreased in comparison with C. acnes cultured in a medium without AAE (C. acnes CM). Moreover, AAE significantly inhibited excessive sebum production induced by palmitic acid. These results suggest that AAE, as a natural extract with various targets, can inhibit selective growth of C. acnes and inflammatory reactions derived from C. acnes, which are the main causes of acne, and consequently can be used as a substance to alleviate acne by reducing excessive sebum formation.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.18 no.1
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• pp.135-153
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• 2005

Herbal mixture water extract of (Phellodendron amurense, Scuellaria baiklensis, Spphora flavescens, Lithospermum erythrorhizon, Mellaphis chinesis, Alumite, Zanthoxylum schinifolium, Glycyrrhiza uralensis), which exhibit several beneficial effects including acne and skin diseases, was tested for anti-microbial activity and anti-inflammation effects. The herbal mixture extract showed antimicrobial activity against Stapylococcus epidermis, Propionibacterium acne, and Malassezia furfur. The growth of Stapylococcus epidermis, Propionibacterium acne, and Malassezia furfur was inhibited allergy and LPS induced cyclooxygenase-2(COX-2)gene expression in RAW24.7macrophage. The results indicated th ear swelling and histamine release induced by compound 48/80 were dose-dependently reduced, ranging 11-38% and 11-56%, respectively. Furthermore the extract inhibited the expression of LPS-induced COX-2 proteins and mRNAs without an appreciable cytotoxic effects on RAW264.7 cells. The cytotoxicity of the extract using M7T assay showed the cytotoxicity of 7 and 18% against L929 cell line. Based on these results, it is concluded that the herbal mixture water extract can be applied to the acne and skin diseases therapy.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.18 no.1
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• pp.154-171
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• 2005

Herbal mixture water extract of (Rheum coreanum Scutellaria baikalensis, Phellodendron amurese), which exhibit several beneficial effects including acne and skin diseases, was tested for anti-microbial activity and anti-inflammation effects. The herbal mixture extract showed antimicrobial activity against Stapylococcus epidermis and Propionbacterium acne. The growth of Stapylococcus epidermis and Propionibacterium acne was inhibited completely by addition of 1.0% of the extract. Also in the present study we examined the mixture extract on compound 48/80 induced allergy and LPS induced cyclooxygenase-2(COX-2) gene expression in RAW264.7 macrophage. The results indicated the ear swelling and histamine release induced by compound 48/80 were dose-dependently reduced, ranging 18-36% and 10-61%, respectively. Furthermore the extract inhibited the expression of LPS-induced COX-2 proteins and mRNAs without an appreciable cytotoxic effects on RAW264.1 cells. The cytotoxicity of the extract using MTT assay showed the cytotoxicity of 6% and 13% against L929 cell line. Based on these results, it is concluded that the herbal mixture water extract can be applied to this acne and skin diseases therapy.

• Journal of Community Nutrition
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• v.3 no.2
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• pp.87-95
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• 2001

This study was conducted to investigate nutritional knowledge, dietary attitudes, and dietary behaviors of adult women, and to examine if these characteristics were different by acne status. Subjects were 106 adult women residing in Seoul recruited from clients and employers at skin care centers, and housewives from apartment complexes. Surrey instrument was adapted or modified based on literature review and dietary intakes were assessed using 24-hour recalls for two days and CAN-pro. All data was statistically analyzed using x$^2$test and ANOVA. When examined by acne status, 41.5% of subjects were categorized into acne group, 20.8% were as ex-acne group, and 37.7% as no-acne group. Parental experience of acne was significantly related to acne status(p〈 0.01). Education, employmental status, and smoking or drinking status were not related to acne status. Subjects had a moderate level of nutritional knowledge(72.7 point) and the nutritional knowledge store was not significantly different by acne status. When examined by individual items, the groups showed significant difference on the items regarding vitamin C and necessity of carbohydrates(p 〈 0.05). Subjects showed favorable dietary attitudes. Although the acne group showed more favorable attitudes on the importance of nutrition on acne, the overall dietary attitudes of the acne group were not significantly different from the ex-acne group or no-acne group. Similarly only small differences were noticed in dietary behaviors or nutrient intakes by acne status. Cholesterol consumption was hitgher in the no-acne group than in the acne group or ex-acne group(p 〈 0.01). The intakes of energy, iron, and calcium was much below the RDA in three groups. Although there were not many significant differences in nutritional knowledge, dietary attitudes, and dietary behaviors by acne status, this study provided some baseline information regarding study variables by acne status.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.4
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• pp.653-660
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• 2010

Pulsatillae Radix and Cicadidae Periostracum have long been used for treatment of injuries, inflammations or itchiness in Korea. This study was carried out to examine the acne-remedy effects of the mixture made with equal parts of Pulsatillae Radix extract and Cicadidae Periostracum extract (PRCP) compared with 2%-benzoyl peroxide (Standard) used commercially as anti-acne. The results showed the mixture (PRCP) was more effective than each crude drug extract. The 10%-PRCP showed significant antimicrobial activity against Propionibacterium acnes, the major cause of acne, and also showed significant inhibition from type 1 $5{\alpha}$-reductase ($5{\alpha}R$), another cause of acne, And the cream made with PRCP demonstrated anti-sebum and acne-improvement effects on examinee's facial skin.

• Journal of the Korean Applied Science and Technology
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• v.37 no.5
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• pp.1441-1453
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• 2020

The purpose of this study was to compare acne recognition and management methods for those in their 20s and 30s who live in China and have acne. A total of 600 questionnaires were distributed and 533 copies were used for final analysis, excluding 27 of the 560 collected questionnaires. As a result of the study, the difference in perception of the cause of acne, management perception, and exacerbation factor of Chinese people according to age showed'management perception' t=3.380, and deteriorating factor recognition' t=2.314, indicating that there was a difference in perception of acne according to age. It was found that the recognition degree of acne is higher in the 20s than in the 30s. Through this study, by comparing and analyzing the perceptions and management methods of acne according to the age of Chinese people, the changes in acne management perception and behavior according to the change of the times were identified, and the difference between Korean and Chinese perceptions of acne, and later acne skin It is believed that it can be provided as a basic data for finding an effective management method.

• Journal of the Korean Applied Science and Technology
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• v.35 no.1
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• pp.43-54
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• 2018

The purpose of this study is to observe how Panax Notoginseng Flos Ethanol Extract has anti-oxidant activity, cytotoxicity for skin cells, and anti-inflammatory effects and Cosmetics Panax Notoginseng Flos Ethanol Extract was applied to acne skin to analyze moisture, erythema, pores, and blackberries to identify potential as cosmetics material .According to the analysis, Panax Notoginseng Flos Ethanol Extract was found to have high contents of polyphenols and flavonoids and excellent DPPH radical scavenging activity. The extract had no significant cytotoxicity for Raw 264.7 cell and significantly inhibited the creation of NO induced LPS in Raw 264.7 cell so as to present anti-inflammatory effect. After applying an Panax Notoginseng Flos Ethanol Extract of 3% skin toner and spot Solutions to the skin of the skin of the acne for 3 weeks, Increased skin moisture, erythema, pores, black head count were found to be statistically signigicant, and reduced red spots were found in skin condition questions following management. Given the results, it is considered that Panax Notoginseng Flos Ethanol Extract is applicable as the ingredient of a functional cosmetic product that has low cytotoxicity for skin cells, high anti-oxidant activity, anti-inflammatory effect, and acne improvement effect.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.39 no.3
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• pp.215-224
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• 2013

It has been reported that certain ingredients added to cosmetics clog the skin pores and this can cause outbreaks of comedones which are the primary sign of acne leading to inflammatory acne. This research aims to establish objective evaluation criteria for non-comedogenic cosmetics suitable for acne prone skin. The research has been carried out to examine non-comedogenic test performed in foreign clinical institutions and to establish the evaluation method for detecting comedones outbreaks through repetitive closed back-patch test, Also, usability evaluation on face skin is performed additionally to the same subjects. The analysis of the comedones collected through repetitive closed back-patch test confirmed that the test products, moisturizer and sunscreen product, did not cause comedones. These results had no correlation with the analysis result of the comedones collected from face skin or visual evaluation of acne by Global Acne Grading System (GAGS) in face usability test. Additionally, Oil red O staining was performed on the collected comedones specimen for easy distinction of comedones from hair follicle in image analysis. The analysis result of stained specimen showed higher precision than that of non-stained specimen. This study established a new version of non-comedogenic test for cosmetics, whose objectivity and reliability were improved by inclusion of comedones staining step.