• Membrane and Water Treatment
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• 제12권1호
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• pp.23-35
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• 2021

A POM-membrane was fabricated by immobilizing a keggin type polyoxometalate (POM) H5PV2Mo10O40 onto the surface of microporous flat-sheet polymeric polyvinylidene fluoride (PVFD) membrane using a chemical deposition method. The POM-membrane was characterized by FT-IR, SEM and EDX to confirm existing of the POM onto the membrane surface. The POM-membrane was used to remove an anionic textile dye (Reactive Black 5 named as an RB5) from aqueous phases with a cross-flow membrane filtration and a batch adsorption system. The dye removal efficiency of the POM-membrane using the cross-flow membrane filtration system and the batch adsorption system was about 88% and 98%, respectively. The influence factors such as contact time, adsorbent dosage, pH, and initial dye concentration were investigated to understand the adsorption mechanism of the RB5 dye onto the POM-membrane. To find the best fitting isotherm model, Langmuir, Freundlich, BET and Harkins-Jura isotherm models were used to analyze the experimental data. The isotherm analysis showed that the Langmuir isotherm model was found to the best fit for the adsorption data (R2 = 0.9982, qmax = 24.87 mg/g). Also, adsorption kinetic models showed the pseudo second order kinetic model was found the best model to fit the experimental data (R2 = 0.9989, q = 8.29 mg/g, C0 = 15 ppm). Moreover, after four times regeneration with HNO3 acid, the POM-membrane showed high regenerability without losing dye adsorption capacity.

• Asian Journal of Atmospheric Environment
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• 제12권2호
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• pp.139-152
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• 2018

The urban model inter-comparison study (UMICS) was conducted in order to improve the performance of air quality models (AQMs) for simulating fine particulate matter ($PM_{2.5}$) in the Greater Tokyo Area of Japan. UMICS consists of three phases: the first phase focusing on elemental carbon (UMICS1), the second phase focusing on sulfate, nitrate and ammonium (UMICS2), and the third phase focusing on organic aerosol (OA) (UMICS 3). In UMICS2/3, all the participating AQMs were the Community Multiscale Air Quality modeling system (CMAQ) with different configurations, and they similarly overestimated $PM_{2.5}$ nitrate concentration and underestimated $PM_{2.5}$ OA concentration. Various sensitivity analyses on CMAQ configurations, emissions and boundary concentrations, and meteorological fields were conducted in order to seek pathways for improvement of $PM_{2.5}$ simulation. The sensitivity analyses revealed that $PM_{2.5}$ nitrate concentration was highly sensitive to emissions of ammonia ($NH_3$) and dry deposition of nitric acid ($HNO_3$) and $NH_3$, and $PM_{2.5}$ OA concentration was highly sensitive to emissions of condensable organic compounds (COC). It was found that $PM_{2.5}$ simulation was substantially improved by using modified monthly profile of $NH_3$ emissions, larger dry deposition velocities of $HNO_3$ and $NH_3$, and additionally estimated COC emissions. Moreover, variability in $PM_{2.5}$ simulation was estimated from the results of all the sensitivity analyses. The variabilities on CMAQ configurations, chemical inputs (emissions and boundary concentrations), and meteorological fields were 6.1-6.5, 9.7-10.9, and 10.3-12.3%, respectively.

• Journal of Korean Society for Atmospheric Environment
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• 제10권E호
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• pp.357-370
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• 1994

지역 규모 대기 모형과 결합된 오일러 장거리수송 모형이 제시되었다. 이 모형을 Cross-Appalachian Tracer Experiment (CAPITX)의 2개 사례에 나타난 추적물 농도 분포 모사에 적용하였다. 기상장은 CSU RAMS에 4차원 자료 동화 기법을 도입하여 도출하였고, 추적물 수송은 오일러 확산 모형으로 계산된다. 4차원 자료 동화 기법을 포함한 대기 모형은 관측과 잘 일치하는 기상장을 도출하였으며, 장거리 수송 예측에 이용될 다양한 기상 자료의 도출을 위한 매우 적절한 도구가 될 수 있음을 보였다. 이 연구에서 개발된 수송 모형은 관측 농도 분포가 복잡한 구조를 보인 사례에 대해서는 부분적인 성공을 거두었으나, 대체로 관측된 추적물 수송을 유사하게 모사하였다. Bott's 2nd-order scheme을 사용한 결과는 Bott's 4th-order scheme을 사용하고 명시적인 수평 확산을 증가시킨 경우와 유사한 수행 능력을 보였다. 이 대기 모형과 수송 모형은 상세한 구름 및 화학 과정들을 고려한 산성 침적 모형의 훌륭한 기본 틀이 될 수 있을 것으로 생각된다.

• 혜화의학회지
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• 제12권1호
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• pp.11-26
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• 2003

Alzheimer's disease (AD) is characterized by amyloid deposition and associated loss of neunons in brain regions involved in learning and memory processes. Several causes of evidence support that the congnitive disturbance is closed associated with the deficit of cerebral acetylcholine neurotransmission, and the effect of carboxyl terminal 105 amino acid fragment (CT105) of the amyloid precursor protein (APP) on the gene expression of proinflammatory cytokines. We tested it on the scopolamine-induced amnesia model of the ICR mouse using the Morris water maze with repeated orally administration of 1st Green-Tea extract (200 mg/kg) and 2nd Green-Tea extract (200 mg/kg). The Green-Tea prevents impairment of learning and memory and neuronal loss in mouse models of cognitive disturbance and it demonstrated selectivity for inhibition of acetylcholinesterase (AChE). Furthermore, the repeated administration of Green-Tea, CT105-induced alzheimer's mouse model showed central cholinergic activity by ameliorates learning and memory impairment, and isolation of CD14 microglia showed significantly decreases intracellular release of the proinflammatory cytokines tumor necrosis factor-${\alpha}$, interleukin-$1{\beta}$ and reactive oxygen species (ROS). Because of its composite profile, oral therapeutic index and a prophylactic, Green-Tea is considered the better therapeutic candidate for the treatment of Alzheimer's disease.

• Asian-Australasian Journal of Animal Sciences
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• 제27권9호
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• pp.1244-1249
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• 2014

Goose fatty liver is one of the most delicious and popular foods in the world, but there is no reliable genetic marker for the early selection and breeding of geese with good liver-producing potential. In our study, one hundred and twenty-four 78-day-old Landes geese bred in Shunda Landes goose breeding farm, Jiutai, Jilin, China were selected randomly. The fatty livers were sampled each week after overfeeding during a three week period. Polymerase chain reaction-single strand conformation polymorphism and DNA sequencing were used to identify single nucleotide polymorphisms (SNPs) of fatty acid synthase (FAS), which is an important enzyme involved in the synthesis of fat under both physiological and pathological conditions. Least-squares correlation was established between these SNPs and fatty liver weight, abdominal fat weight, and intestinal fat weight of the overfed Landes geese, respectively. The results showed that fatty liver weight of geese with EF and FF genotypes (amplified by primer P1) was significantly higher than that of the EE genotype (p<0.05), and liver weight of CD and DD genotypes (amplified by primer P2) was significantly higher than that of the CC genotype (p<0.05). Different genotype combinations showed different liver weights, and from highest to lowest were ABDD, DDEF, DDFF, DDEE, ABEF, ABFF, AADD, and CDEF. Further analysis of DNA sequencing showed that there were two SNPs within the 5' promoter region the FAS gene. The geese of EF and FF genotypes carried a change of T to C, and the geese of CD and DD genotypes carried a change of A to G. The changes of the bases could potentially influence the binding of some transcription factors to this region as to regulate FAS gene. To our knowledge, this is the first report of SNPs found within the 5' promoter region of the Landes goose FAS gene, and our data will provide an insight for early selection of geese for liver production.

• 한국대기환경학회지
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• 제29권2호
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• pp.186-198
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• 2013

The present work is an attempt to improve the performance of a regional air quality model by means of liking it with a global chemistry transport model. The global chemical transport model of GEOS-Chem is used to provide BC (Boundary Condition)s which reflect temporal and spatial variations at boundaries of regional chemical transport model of CMAQ over East Asia. First, GEOS-Chem outputs are evaluated by comparing predicted concentrations with observed monthly data of gas phase species and secondary inorganic aerosols from EANET (Acid Deposition Monitoring Network in East Asia) sites. The results show that predicted PM10 concentrations are in good agreement with the observations. This implies that GEOS-Chem outputs could be used to provide BCs to CMAQ. Simulated daily and monthly mean PM10 concentrations of CMAQ with the linkage of GEOS-Chem's BCs and constant BCs are then evaluated by comparing predicted concentrations with observations at API (Air Pollution Index) sites in China as well as EANET sites in Korea. CMAQ with the GEOS-Chem outputs improves model simulation in depicting observed PM10 concentrations comparing with those with constant BCs. It is also found that influence of aerosol species are largely dependent on the BCs over East Asia and Korea. Mean biases between simulated versus observed daily and monthly mean concentrations of PM10 with the GEOS-chem were improved by 1~8 ${\mu}g/m^3$ in China region, 3.26 ${\mu}g/m^3$ in Korea.

• Journal of Nutrition and Health
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• 제33권2호
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• pp.147-157
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• 2000

This study examined the effects of excess intake of calcium (Ca) and iron (Fe) supplement on bone loss, nephrocalcinosis and renal function in osteoporotic model rats. Seven-week-old female rats were first fed a Ca-deficient diet for four weeks after ovariectomy operation, and then one of nine experimental diets for additional eight weeks, containing three levels of Ca, normal (0.5%) or high (1.5%) or excess (2.5%) and three levels of Fe, normal (35ppm) or high (210ppm) or excess (350ppm). The osteoporotic model rats showed a remarkable increase in body weight, serum alkaline phosphatase (ALP) and decrease in breaking force, Ca, P, Mg contents of femur. Serum Ca concentration was not significantly affected by dietary Ca and Fe levles. Liver Ca content increased in rats fed a high-and excess-Ca diet. Kidney Ca content and microscopic Ca deposition remarkably increased in osteoporotic model rats compared to control group, and showed a tendency to decrease in rats fed a excess-Ca diet. Breaking force of femur increased with increasing dietary Ca levels, but Ca, P contents of femur and serum ALP were not significantly affected by dietary Ca and Fe levels. Serum total protein decreased in rats fed a excess-Ca diet, BUN increased in rats fed a excess-Ca diet, while serum uric acid and creatinine were not significantly affected by dietary Ca levels. Urinary creatinine, GFR increased in rats fed a high-and excess-Ca, diet, and GFR was highest in rats fed a excess-Ca/excess-Fe diet. These results suggest that excess intake of Ca may increase breaking force of femur, but not increase mineral contents of femur, and decrease kidney function. Furthermore, excess intake of Fe and Ca concurrently may aggravate kidney function leading to potential health problems in ovariectomized osteoporotic model rats.

• 융합정보논문지
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• 제10권6호
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• pp.28-34
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• 2020

본 논문에서는 VCSEL (Vertical Cavity Surface Emitting Laser) 레이저를 만드는 구조와 유사한 GaAs 웨이퍼상에 MOCVD (Metal Organic Chemical Vapor Deposition) 장비로 GaAs와 AlGaAs 에피층을 형성시킨 구조를 사용한다. 3차원 공진현상에 의해 자연 발생되는 광양자테 (PQR: Photonic Quantum Ring) 소자를 건식 식각 방법인 CAIBE (Chemically Assisted Ion Beam Etching) 기술로 제작하였지만, 진공 분위기에서 진행해야 하는 문제점 때문에 저가격으로 쉽게 소자를 제작할 수 있는 방법이 연구되었고, 그 결과 인산, 과산화수소, 메탄올이 혼합된 용액의 습식식각 기술로 가능성을 확인하였으며, 이 방법을 적용하여 소자를 제작한 내용에 대해 논한다. 또한, 제작된 광소자의 스펙트럼을 측정하였고, 이 결과들을 이론적으로 해석하여 얻은 파장값과 비교한다. 광양자테 소자는 3차원 형상으로 세포를 모델링하거나, 디스플레이 분야로의 응용이 가능할 것으로 기대한다.

• 한국식품영양학회지
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• 제33권2호
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• pp.174-182
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• 2020

Probiotics improve the immune system. However, the effects of its lactic acid bacteria on atopic dermatitis relief and inflammation improvement is not fully understood. Recently, one of the probiotics, Lactobacillus helveticus HY7801 (HY7801), was found to have an anti-inflammatory effect. In this study, we investigated the effects of HY7801 on atopic dermatitis-induced animal models. After four weeks of oral administration, the group treated with HY7801 showed amelioration of the atopic dermatitis compared to the group receiving placebo. In the HY7801 treated group, the epidermal hyper-proliferation and collagen deposition were inhibited compared to the placebo group, and the secretion amount of the inflammatory factors, such as TNF-α, IL-4 were reduced. In conclusion, these results suggest that HY7801 acts as a functional probiotic via amelioration of the atopic dermatitis such as a decrease of epidermal hyper-proliferation, and collagen deposition and anti-inflammatory effects.

• Asian-Australasian Journal of Animal Sciences
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• 제21권10호
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• pp.1383-1388
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• 2008

Because of high growth rate and large deposition of fat in the abdomen, the chicken has been used as a model organism for understanding lipid metabolism, fattening and growing. In this study, differentially expression of proteins in chicken liver, one of the important organs for lipid metabolism, has been investigated at four different growing stages. After separation of proteins using two-dimensional electrophoresis (2-DE), more than 700 protein spots were detected. Among them, 13 growing stage specific proteins in chicken liver were selected and further investigated by matrix-assisted laser adsorptions ionization-time of flight mass spectrometry (MALDI-TOF MS). Of these, 12 proteins were matched to existing proteins based on a database search. The identified fat-related proteins in this study were fatty acid synthase (FASN) and malic enzyme (ME1). These proteins were more highly expressed at week 32 than at other weeks. In order to confirm the differential expression, one of the proteins, FASN, was confirmed by western blotting. The identified proteins will give valuable information on biochemical roles in chicken liver, especially for lipid metabolism.