• Communications for Statistical Applications and Methods
• /
• 제29권4호
• /
• pp.421-439
• /
• 2022

Phase I dose-finding trials are essential in drug development. By finding the maximum tolerated dose (MTD) of a new drug or treatment, a Phase I trial establishes the recommended doses for later-phase testing. The primary toxicity endpoint of interest is often a binary variable, which describes an event of a patient who experiences dose-limiting toxicity. However, there is a growing interest in dose-finding studies regarding non-binary outcomes, defined by either the weighted sum of rates of various toxicity grades or a continuous outcome. Although several novel methods have been proposed in the literature, accessible software is still lacking to implement these methods. This study introduces a newly developed R package, UnifiedDoseFinding, which implements three phase I dose-finding methods with non-binary outcomes (Quasi- and Robust Quasi-CRM designs by Yuan et al. (2007) and Pan et al. (2014), gBOIN design by Mu et al. (2019), and by a method by Ivanova and Kim (2009)). For each of the methods, UnifiedDoseFinding provides corresponding functions that begin with next that determines the dose for the next cohort of patients, select, which selects the MTD defined by the non-binary toxicity endpoint when the trial is completed, and get oc, which obtains the operating characteristics. Three real examples are provided to help practitioners use these methods. The R package UnifiedDoseFinding, which is accessible in R CRAN, provides a user-friendly tool to facilitate the implementation of innovative dose-finding studies with nonbinary outcomes.

• 대한인간공학회지
• /
• 제24권3호
• /
• pp.29-34
• /
• 2005

Little research has been performed regarding auditory icons even though auditory icons have great potentials as a strategy for creating informative, intuitively accessible, and unobtrusive interface. Therefore, this study was conducted to design new auditory icons through the iconic mapping for ten most frequently used mobile phone menus, and to show the usability of auditory icons. Two most familiar auditory sounds for each menu were collected and compared to the current button-pressing sound. The results show that the newly designed auditory icons had shorter recognition times, better satisfaction than the current icons. In other words, auditory icons could be an effective interface to provide a redundant feedback along with visual feedbacks in navigating mobile devices.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2016년도 제50회 동계 정기학술대회 초록집
• /
• pp.105.2-105.2
• /
• 2016

For the rational design and facile fabrication of novel nanostructures, we present a new approach to generating arrays of three-dimensionally tunable nanostructures by exploiting light-matter interaction. To create controlled three-dimensional (3D) nanostructures, we utilize the 3D spatial distribution of light, induced by the light-matter interaction, within the matter to be patterned. As a systematic approach, we establish 3D modeling that integrates the physical and chemical effects of the photolithographic process. Based on a comprehensive analysis of structural formation process and nanoscale features through this modeling, we are able to realize three-dimensionally tunable nanostructures using facile photolithographic process. Here we first demonstrate the arrays of three-dimensionally controlled, stacked nanostructures with nanoscale, tunable layers. We expect that the promising strategy would open new opportunities to produce the arrays of tunable 3D nanostructures using more accessible and facile fabrication process for various biomedical applications ranging from biosensors to drug delivery devices.

• 한국유기농업학회지
• /
• 제28권2호
• /
• pp.189-208
• /
• 2020

The purpose of this study aims to estimate consumption selection attribute, part-worth of organic instant rice through the use of conjoint analysis method. The conjoint analysis is to trace the development of consumer preference among multi-attribute alternatives. The selection attribute was including 4 factors preferred Type of rice, Capacity, Brand and payment price. For this research, a total of 192 questionnaires was collected of which 200 were completed. The research design was a full profile method by orthogonal design then 9 main profiles, 3 holdout sets were created. The results of this research were as follows. Consumers of organic instant rice are consider their importance of selection attributes was in order to price (25.87%), Type of rice (27.231%), Brand/Purchase channel (24.013%) and Capacity (18.494%). The findings of this study have identified 3 clusters for each experience visitors. Each cluster has a different and showed the relative importance or preference values for each accessible attribute of the segmentation.

• 한국CDE학회논문집
• /
• 제8권3호
• /
• pp.175-183
• /
• 2003

This paper introduces a Web-based vibration analysis system for rotary-type refrigerator compressors. Concern for vibration reduction in compressors has been growing for many years. What is important in vibration reduction is to easily predict the vibration without using a physical compressor. The dynamic model of the compressor is represented as a multi-body dynamic system. Solving the dynamic model is run on a high-performance server. The interfaces of the system are accessible via Web browsers, such as Netscape or Explorer. Anyone who wants to analyze the vibration of the rotary compressor or share the results data can access the system over the Internet regardless of their OS, platform, or location.

• 대한물리치료과학회지
• /
• 제3권1호
• /
• pp.881-894
• /
• 1996

The most frustrating of all problems to physically disabled individuals are building and facilities, supposedly created for the public. that are designed and constructed in such a manner that probit the full participation of the physically. The first problem is to determine what might be done to make accessible and fuctional existing buildings that are now nonaccessible. The second task, the simpler of the two, is the development of the standards for proper design and construction of new building and facilities. thus the purpose of this study was co obtain precise information about the inconvenience of architectural barriers in the pubic building and facilities that having the physically disabled. Those listed in this survey 22 pubic building and facilities and 3 general hospital in An-dong city from December 20 to 28. 1995. Measurement obtained were compare with available international criteria and standards. These findings are offered to the appropriate autority as a guide for developing barriers-free design suit able to the Korean situation.

• 한국실내디자인학회:학술대회논문집
• /
• 한국실내디자인학회 2008년도 춘계학술발표대회 논문집
• /
• pp.258-263
• /
• 2008

This study aims to investigate the changing roles of Local Government and the ways to improve the space plan, especially focusing on the Local Government civil service space of Seoul City. Recently, many Local Government have endeavored to get rid of the authoritative images and change themselves to a space featuring cultural functions and efficient performance. Local Government buildings in Seoul City are trying to decorate the inner and outer images through new construction or extension of buildings so as to become more friendly to residents. Such efforts are visualized especially in civil service space. Civil service space represents the whole image and role of the Local Government. In addition, civil service space and resting space, which are frequently used, are correlated and more and more accessible to each other as administrative and civil services are increasing. By integrating and developing such features, civil service space of Local Government that meets the requirements of the new era will be presented.

• 한국컴퓨터산업학회논문지
• /
• 제9권2호
• /
• pp.83-92
• /
• 2008

컴퓨터 사용의 역사를 보면 인터페이스 메타포는 사람들이 컴퓨터를 더 사용하기 쉽게 만드는데 쓰여왔다. 심지어 초기의 command line 인터페이스에서도 메타포를 사용해 왔었다. 사용자 인터페이스에 있어서 메타포는 사용자들을 시스템에 접근하기 쉽게 만드는 것을 도울 뿐 아니라 사용자들과 시스템과의 연결 통로라고 할 수 있다. 따라서 본 논문은 사용자 인터페이스에 있어서 성공적인 메타포 구축을 위해 conceptual model을 고려하여 Gestalt 원리를 활용한 지침을 제시함으로써 도움을 주고자 한다.

• 한국정보처리학회:학술대회논문집
• /
• 한국정보처리학회 2020년도 추계학술발표대회
• /
• pp.12-15
• /
• 2020

Data access characteristics can directly affect the efficiency of the system execution. This research is to design an accurate predictor by using historical memory access information, where highly accessible data can be migrated from low-speed storage (SSD/HHD) to high-speed memory (Memory/CPU Cache) in advance, thereby reducing data access latency and further improving overall performance. For this goal, we design a locally weighted linear regression prefetch scheme to cope with irregular access patterns in large graph processing applications for a DARM-PCM hybrid memory structure. By analyzing the testing result, the appropriate structural parameters can be selected, which greatly improves the cache prefetching performance, resulting in overall performance improvement.

• Child Health Nursing Research
• /
• 제30권1호
• /
• pp.45-53
• /
• 2024

Purpose: This study develops a chatbot for school violence prevention (C-SVP) among elementary school students. Methods: Among the analysis, design, development, implementation, and evaluation (ADDIE) models, ADD phases were applied to develop a C-SVP. Students' learning needs were identified by constructing content with a design that attracted their attention. Subsequently, a formative evaluation was conducted on the developed C-SVP to test its applicability by ten elementary school students targeting the 5th and 6th grades. Results: The chatbot was designed using KakaoTalk and named "School Guardian Angel." The formative evaluation revealed that the developed C-SVP was easily accessible and useful for elementary school students. Conclusion: The developed C-SVP is expected to be effective in preventing violence among elementary school students. However, further research involving children of various age groups is required.