• KSBB Journal
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• v.32 no.2
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• pp.108-116
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• 2017

Omeprazole, a benzimidazole derivative, suppresses gastric acid secretion by inhibiting $H^+/K^+$ ATPase in gastric parietals cells, and by reducing $H^+$ concentration. To improve stability of esomeprazole magnesium dihydrate (ESMD), enteric-coated preperation was composed of core tablet, subcoating and enteric coating layer. We were evaluated in vitro dissolution characteristics between test and reference ESMD preparation and stability. We could prepare enteric-coated formulation of ESMD by controlling disintegrating agent and coating ratio which could rapidly dissolved in neutral or alkali medium. The formulation D5 with crospovidone of 1.25% and coating ratio of 16.25% had a similar dissolution behavior compare to reference preparation. Difference factor ($f_1$) and similarity factor ($f_2$) were 0~15 and 50~100 and there was no significant difference in bioequivalence between formulations. The content and dissolution rate of formulation D5 were $96.54{\pm}0.21$ and $78.56{\pm}0.87%$ without change of color in accelerated condition ($40^{\circ}C$, RH 75%, high density polyethylene (HDPE) container) for 6 months. This study concluded that our enteric coated preparation of ESMD could be an useful method to improve stability of unstable drug without direct contact with coating material.

• Transactions of the Korean hydrogen and new energy society
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• v.30 no.6
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• pp.531-539
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• 2019

The development of cost-effective electrocatalysts with high durability is one of the most important challenges for the commercialization of polymer electrolyte fuel cells (PEFCs). The durability of the electrocatalyst has been studied in terms of structural change in the active metal and the support. In particular, in fuel cell vehicles, degradation of the carbon-based support is known to have a significant effect on the electrocatalyst deterioration since the start-up/shut-down cycle is frequently repeated. The requirements for the support of the electrocatalyst include high surface area, electrical conductivity, chemical stability, and so on. In this study, we propose the evaluation methods for choosing better support materials and present the physicochemical properties that promising carbon supports should have. Three kinds of carbon materials with different crystallinity are compared. From in-depth study using X-ray diffraction, Raman spectroscopy, thermogravimetric analysis, and accelerated stress test, it is clearly confirmed that the durability of carbon-supported electrocatalysts is closely related to the physicochemical properties of the carbon supports.

• Journal of the Korean Recycled Construction Resources Institute
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• v.9 no.4
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• pp.633-641
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• 2021

The study performed long-term performacne evaluation on the hot mix asphalt using the steel slag aggregates and Reclaimed Asphalt Pavement (RAP). The laboratory comparative evaluation was conducted between conventional Hot Mix Asphalt (HMA) which is entitled WC-2 and HMA containing steel slag and RAP which is entitled ES WC-2(R). Dynamic stability test, dynamic modulus test, and fatigue crack test were conducted during the comparative evaluation process. The dynamic stability test result showed that ES WC-2(R) was 140% higher than WC-2. It is noted that ES WC-2(R) showed no inflection point whereas WC-2 showed inflection point during the dynamic stability test which implies ES WC-2(R) has the higher moisture susceptability than WC-2. The dynamic modulus of ES WC-2(R) were 342.3%, 486.7%, and 350.0% higher than WC-2 at medium temperature of 21℃, low temperature of -10℃, and high temperature of 38℃ respectively. The test result showed that rutting resistance of ES WC-2(R) is higher than WC-2 at all temperature spectrum. The fatigue resistance of ES WC-2(R) were 31.7%, 325.3%, 899.9% higher at low stress level, medium stress level, and high stress level, respectively. The test result showed that ES WC-2(R) is higher than WC-2 at all stress levels. Based on the laboratory comparative evaluation, The in-situ scale Accelerated Pavement Test (APT) was conducted comparing WC-2 and WC-2(R). APT found that the rutting resistance of WC-2(R) was 45% higher than WC-2.

• Transactions of the Korean Society of Automotive Engineers
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• v.14 no.1
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• pp.159-166
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• 2006

Chassis system has a large influence on ride quality, stability and NVH performance of a car. To improve the performance and reduce cost, the development of chassis modular assemblies is emphasized. To develop chassis corner modules, it is necessary to predict the performance of full vehicle motion such as ride, handling performance, NVH characteristics and durability of modules. In this paper, full vehicle test is performed to acquire the road load data of chassis corner module of passenger car. 3-axis simulator modeling are carried out to simulate reaction force analysis and fatigue analysis of new developed modules. Also, real simulator tests to validate performance of new developed modules are performed. We had developed the accelerated durability test procedure of KATECH PG and it is used to test chassis corner modules at laboratory and simulate durability performance. All these results have been provided to module and parts company and make an important role to develop chassis corner modules.

• Current Photovoltaic Research
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• v.11 no.4
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• pp.108-113
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• 2023

Pressure to reduce costs in the current solar market is driving the development and implementation of new module designs and prompting the use of new materials and components. In order to utilize the variability of each material that makes up the module, it is essential to understand the basic characteristics of the material. In this article, we evaluate light degradation after UV irradiation as an encapsulation material. Measure and analyze the results of various characteristic tests for discoloration, optical and electrical property degradation before and after UV accelerated testing. To evaluate weathering stability, UV tests were performed comparing existing EVA and UVT-EVA, POE and improved low-cost POE. Even in the weather resistance test with a total UV exposure of 60 kW/m², the properties of the encapsulants were mostly stable. EVA and POE-based encapsulants showed slight differences, and these slight differences are believed to pose a threat to long-term stability. This study is a basic analysis of encapsulation research for PV modules and will be helpful in understanding future development and encapsulant properties.

• The Transactions of the Korean Institute of Electrical Engineers
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• v.39 no.8
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• pp.856-867
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• 1990

In this paper, the convergence and the learning accuracy of the back-propagation (BP) method in neural network are investigated by 1) analyzing the reason for decelerating the convergence of BP method and examining the rapid deceleration of the convergence when the learning is executed on the part of sigmoid activation function with the very small first derivative and 2) proposing the modified logistic activation function by defining, the convergence factor based on the analysis. Learning on the output patterns of binary as well as analog forms are tested by the proposed method. In binary output patter, the test results show that the convergence is accelerated and the learning accuracy is improved, and the weights and thresholds are converged so that the stability of neural network can be enhanced. In analog output patter, the results show that with extensive initial transient phenomena the learning error is decreased according to the convergence factor, subsequently the learning accuracy is enhanced.

• Journal of the Korean Society for Railway
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• v.17 no.4
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• pp.251-259
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• 2014

The transition zone between an earthwork and a bridge effect to the vehicle's running stability because support stiffness of the roadbed is suddenly changed. The design criteria for the transition structure on ballast track were not particular in the past. However with the introduction of concrete track is introduced, it requires there is a higher performance level required because of maintenance and running stability. In this present paper, a transition structure reinforced with geosynthetics is suggested to improve the performance of existing bridge-earthwork transition structures. The suggested transition structure, in which there is reinforcing of the approach block using high-tension geosynthetics, has a structure similar to that of earth reinforced abutments. The utilized backfill materials are cement treated soil and gravel. These materials are used to reduce water intrusion into the approach block and to increase the recycling of surplus earth materials. An experiment was performed under the same conditions in order to allow a comparison of this new structure with the existing transition structure. Evaluation items are elastic displacement, cumulative settlement, and earth pressure. As for the results of the real-scale accelerated testing, the suggested transition structure has excellent performance for the reduction of earth pressure and settlement. Above all, it has high resistance the variation of the water content.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.12
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• pp.555-562
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• 2019

This study was undertaken to develop a stable self-microemulsifying drug delivery system (SMEDDS) for trans-cinnamaldehyde, a known antibacterial and antifungal agent. A simultaneous analytical method was established for quantification of trans-cinnamaldehyde and its degradant, cinnamic acid. Various surfactants were applied to assess their effect on the aqueous solubility of trans-cinnamaldehyde, and pseudo-ternary phase diagrams were plotted. Of the various formulations tested, the liquid SMEDDS composed of trans-cinnamaldehyde (oil), Cremophor EL (surfactant) and Transcutol P (cosurfactant) at a volume ratio of 10/70/20, produced the smallest emulsion droplet size (around 23 nm). The stability test determined the superior stability of the trans-cinnamaldehyde SMEDDS with constant trans-cinnamaldehyde content and z-average diameter of emulsion, under accelerated and heat stressed condition. Thus, we believe that this novel trans-cinnamaldehyde SMEDDS formulation has the potential to be applied for the development of trans-cinnamaldehyde medicines in the pharmaceutical industry.

• Journal of Korea Foresty Energy
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• v.21 no.2
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• pp.34-42
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• 2002

This research was carried out to investigate water repellent effectiveness of natural oil treated wood. Linseed oil, castor oil, olive oil, bean oil, perilla oil and sunflower oil were used in this test. For evaluation of water repellent of natural oil treated wood, moisture absorption test, water-drop contact angle test and color difference test of accelerated decomposition by UV and water were used. The moisture absorption amount of natural oil treated wood was less than untreated wood until 3 hours, but it was increased with time, there was no big difference with oil treated wood and untreated wood after 48hours. Oil treated wood and untreated wood showed big difference on contact angle test. It was no big difference by kind and oil concentration. Natural oil treated wood did not showed stability on the weather aging test. Contact angle test could be used on evaluation of wood surface status treated with natural oil.

• Journal of Industrial Technology
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• v.23 no.A
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• pp.131-137
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• 2003

This thesis is results of centrifuge model experiments to investigate the behavior of replacement method in dredged and reclaimed ground. For experimental works, centrifuge model tests were carried out to investigate the behavior of replacement method in soft clay ground. Basic soil property tests were performed to find mechanical properties of clay soil sampled from the southern coast of Korea which was used for ground material in the centrifuge model tests. Reconstituted clay ground of model was prepared by applying preconsolidation pressure in 1g condition with specially built model container. Centrifuge model tests were carried out under the artificially accelerated gravitational level of 50g. Replacing material of leads having a certain degree of angularity was used and placed until the settlement of embankment of replacing material was reached to the equilibrium state. Vertical displacement of replacing material was monitored during tests. Depth and shape of replacement, especially the slope of penetrated replacing material and water contents of clay ground were measured after finishing tests. Model tests of investigating the stability of embankment after backfilling were also performed to simulate the behavior of the dike treated with replacement and backfilled with sandy material. As a result of centrifuge model test, the behavior of replacement, the mechanism of the replacing material being penetrated into clay ground and depth of replacement were evaluated.