Browse > Article
http://dx.doi.org/10.5762/KAIS.2019.20.12.555

Development of trans-cinnamaldehyde self-microemulsifying drug delivery system(SMEDDS) with superior stability  

Bang, Kyu-Ho (Department of Pharmaceutical Engineering, Gyeongnam National University of Science and Technology)
Kim, Kyeong Soo (Department of Pharmaceutical Engineering, Gyeongnam National University of Science and Technology)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.20, no.12, 2019 , pp. 555-562 More about this Journal
Abstract
This study was undertaken to develop a stable self-microemulsifying drug delivery system (SMEDDS) for trans-cinnamaldehyde, a known antibacterial and antifungal agent. A simultaneous analytical method was established for quantification of trans-cinnamaldehyde and its degradant, cinnamic acid. Various surfactants were applied to assess their effect on the aqueous solubility of trans-cinnamaldehyde, and pseudo-ternary phase diagrams were plotted. Of the various formulations tested, the liquid SMEDDS composed of trans-cinnamaldehyde (oil), Cremophor EL (surfactant) and Transcutol P (cosurfactant) at a volume ratio of 10/70/20, produced the smallest emulsion droplet size (around 23 nm). The stability test determined the superior stability of the trans-cinnamaldehyde SMEDDS with constant trans-cinnamaldehyde content and z-average diameter of emulsion, under accelerated and heat stressed condition. Thus, we believe that this novel trans-cinnamaldehyde SMEDDS formulation has the potential to be applied for the development of trans-cinnamaldehyde medicines in the pharmaceutical industry.
Keywords
Trans-Cinnamaldehyde; SMEDDS; Surfactant; Nanoemulsion; Stability;
Citations & Related Records
연도 인용수 순위
  • Reference
1 S. Ashakirin, M. Tripathy, U. K. Patil, A. Baker, A. Majeed, "Chemistry and bioactivity of cinnamaldehyde : a natural molecule of medicinal importance", International Journal of Pharmaceutical Sciences and Research, Vol.8, No.6, pp.2333-2340, 2017. DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.8(6).2333-40
2 K-H. Bang, D-W. Lee, H-M. Park, Y-H. Rhee, "Inhibition of Fungal Cell Wall Synthesizing Enzymes by trans -Cinnamaldehyde", Bioscience, biotechnology and biochemistry, Vol.64, No.5, pp.1061-1063, 2000. DOI: https://doi.org/10.1271/bbb.64.1061   DOI
3 A. Arfa, L. Preziosi-Belloy, P. Chalier, N. Gontard, "Antimicrobial Paper Based on a Soy Protein Isolate or Modified Strach Coating Including Carvacrol and Cinnamaldehyde", Agricultural and food chemistry, Vol.55, No.6, pp.2155-2162, 2007. DOI: https://doi.org/10.1021/jf0626009   DOI
4 K-H. Bang, Y-H. Lee, B-S. Min, "Purification and properties of an antifungal component, AF-001, from Cinnamomi Cortex", The Korean Journal of Mycology, Vol.25, No.4, pp.348-353, 1997.
5 E. Chen, S. Wu, D. McClements, B. Li, Y. Li, "Influence of pH and cinnamaldehyde on the physical stability and lipolysis of whey protein isolate-stabilized emulsions", Food Hydrocolloids, Vol.69, pp.103-110, 2017. DOI: https://doi.org/10.1016/j.foodhyd.2017.01.028   DOI
6 A. Singh, A. Chaurasiya, M. Singh, S. C. Upadhya, R. Mukherjee et al.,, "Exemestane Loaded Self- Microemulsifying Drug Delivery System (SMEDDS): Development and Optimization", AAPS PharmSciTech, Vol.9, pp.628-634, 2008. DOI: https://doi.org/10.1208/s12249-008-9080-6   DOI
7 H. Moon, A. Yousaf, K. Cho, C. Yong, J. Kim et., "Evaluation of stability and simultaneous determination of fimasartan and amlodipine by a HPLC method in combination tablets", Asian Journal of Pharmaceutical Sciences, Vol.9, pp.123-128, 2014. DOI: https://doi.org/10.1016/j.ajps.2014.04.002   DOI
8 C. Pouton, "Lipid formulation for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems", European Journal of Pharmaceutical Sciences, Vol.11, pp.93-98, 2000. DOI: https://doi.org/10.1016/S0928-0987(00)00167-6   DOI
9 L. Li, C. Zhou, Z. Xu, "Self-nanoemulsifying drug-delivery system and solidified self -nanoemulsifying drug-delivery system", Nanocarriers for Drug Delivery, pp.421-449, 2019. DOI: https://doi.org/10.1016/B978-0-12-814033-8.00014-X
10 K. Bouchemal, S. Briancon, E. Perrier, H. Fessi, "Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimisation", International Journal of Pharmaceutics, Vol.280, pp.241-251, 2004. DOI: https://doi.org/10.1016/j.ijpharm.2004.05.016   DOI
11 A. Sprunk, C. Strachan, A. Graf, "Rational formulation development and in vitro assessment of SMEDDS for oral delivery of poorly water soluble drugs", European Journal of Pharmaeutical Sciences, Vol.46, pp.508-515, 2012. DOI: http://dx.doi.org/10.1016/j.ejps.2012.04.001   DOI
12 D. Patel, K. Sawant, "Self Micro-Emulsifying Drug Delivery System: Formulation Development and Biopharmaceutical Evaluation of Lipophilic Drugs", Current Drug Delivery, Vol.6, pp.419-424, 2009. DOI: https://doi.org/10.2174/156720109789000519   DOI
13 P. Balakrishnan, B-J. Lee, D. Oh, J. Kim, Y. Lee et al., "Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems", International Journal of Pharmaceutics, Vol.374, pp.66-72, 2009. DOI: https://doi.org/10.1016/j.ijpharm.2009.03.008   DOI
14 H. Zayas, N. Truong, D. Valade, Z. Jia, M. Monteiro, "Narrow molecular weight and particle size distributions of polystyrene 4-arm stars synthesized by RATF-mediated miniemulsions", Polymer Chemistry, Vol.4, pp.592-599, 2013. DOI: https://doi.org/10.1039/c2py20709e   DOI
15 O. Mustapha, K. Kim, S. Shafique, D. Kim, S. Jin et al., "Development of novel cilostazol-loaded solid SMEDDS using a SPG-membrane emulsification technique: Physicochemical characterization and in vivo evaluation", Colloids and Surfaces B: Biointerfaces, Vol.150, pp.216-222, 2017. DOI: https://doi.org/10.1016/j.colsurfb.2016.11.039   DOI
16 A. Sail, W. Mustapha, S. Yusop, M. Maskat, A.Shamsuddin, "Optimisation of Cinnamaldehyde-in -water Nanoemulsion Formulation using Central Composite Rotatable Design", Sains Malaysiana, Vol.47, No.9, pp.1999-2008, 2018. DOI: http://dx.doi.org/10.17576/jsm-2018-4709-07   DOI
17 D. Kim, J. Cho, J. Park, Jung. Kim, E. Song et al., "Self-microemulsifying drug delivery system(SMEDDS) for improved oral delivery and photostability of methotrexate", International Journal of Nanomedicine, Vol.14, pp.4949-4960, 2019. DOI: https://doi.org/10.2147/IJN.S211014   DOI
18 W-L. Tian, L-L. Lei, Q. Zhang, Y. Li, "Physical Stability and Antimicrobial Activity of Encapsulated Cinnamaldehyde by Self-Emulsifying Nanoemulsion", Journal of Food Process Engineering, Vol.39, No.5, pp.462-471, 2016. DOI: https://doi.org/10.1111/jfpe.12237   DOI
19 K. Kim, J. Kim, S. Jin, D. Kim, D. Kim et al., "Development of novel prasugrel base microsphereloaded tablet with enhanced stability: Physicochemical characterization and in vivo evaluation in beagle dogs", Colloids and Surfaces B: Biointerfaces, Vol.146, pp.754-761, 2016. DOI: http://dx.doi.org/10.1016/j.colsurfb.2016.07.025   DOI